| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| C ANCA IgG from eight patients with active WG significantly inhibited PR 3 proteolytic activity , particularly towards elastin ( median 84 . 2 % inhibition ) . ^^^ C ANCA IgG from eight patients with active WG significantly inhibited PR 3 proteolytic activity , particularly towards elastin ( median 84 . 2 % inhibition ) . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NE and PR 3 assist in the destruction of phagocytosed microorganisms , cleave the important connective tissue protein elastin , and generate chemotactic activities by forming alpha 1 proteinase inhibitor complexes and elastin peptides . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| Proteinase 3 ( PR 3 ) is a human polymorphonuclear leukocyte ( PMNL ) serine proteinase that degrades elastin in vitro and causes emphysema when administered by tracheal insufflation to hamsters ( Kao , R . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| We also studied the effect of C ANCA on PR 3 proteolytic activity towards elastin and inactivation by alpha 1 antitrypsin ( alpha 1AT ) . ^^^ C ANCA IgG from 8 patients with active Wegener ' s granulomatosis were tested and found to inhibit elastin degradation by PR 3 and to prevent the inactivation of PR 3 by alpha 1AT . . ^^^ C ANCA IgG from 8 patients with active Wegener ' s granulomatosis were tested and found to inhibit elastin degradation by PR 3 and to prevent the inactivation of PR 3 by alpha 1AT . . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| Glycosaminoglycans such as chondroitin sulfate , dermatan sulfate and a chondroitin polysulfate , interacted with myeloblastin as non essential activators in the presence of peptide substrates ( activation up to a 6 . 7 fold factor ) and as partial inhibitors ( about 50 % inhibition at saturation ) in the presence of elastin . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| Proteinase 3 ( PR 3 ) and neutrophil elastase ( NE ) are polymorphonuclear leukocyte serine proteinases that degrade extracellular matrix proteins including elastin and appear to be involved in the pathogenesis of several diseases characterized by tissue destruction most notably emphysema and Wegener ' s granulomatosis . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| An excess of proteinase 3 ( Pr 3 ) is an assumed risk factor for elastin loss in chronic obstructive pulmonary disease . ^^^ This study compared the degradation of [ ( 14 ) C ] elastin by Pr 3 and its inhibition by alpha ( 1 ) proteinase inhibitor ( alpha ( 1 ) PI ) with the analogous reactions involving two other neutrophil serine proteases , human leukocyte elastase ( HLE ) and cathepsin G ( CatG ) . ^^^ However , two findings reported here , namely the low rate of elastolysis by Pr 3 and the high efficacy of alpha ( 1 ) PI against ongoing elastolysis by Pr 3 , imply that Pr 3 might not necessarily be a major contributor to neutrophil mediated elastin loss . . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| Neutrophil proteinase 3 ( Pr 3 ) cleaves elastin and other matrix proteins , and is thought to cause lung tissue destruction in emphysema and cystic fibrosis . ^^^ We show that ( 1 ) . the oxidized inhibitor does not inhibit Pr 3 ; ( 2 ) . the inhibitor competes favorably with elastin for the binding of Pr 3 , but is less efficient for inhibiting elastin bound proteinase than for complexing free enzyme ; and ( 3 ) . the inhibition takes place in at least two steps : the enzyme and the inhibitor first form a high affinity reversible inhibitory complex EI * with an equilibrium dissociation constant K * i of 38 nM ; EI * subsequently transforms into an irreversible complex EI with a first order rate constant k 2 of 0 . 04 s 1 . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| In this study , we establish that human elastin exon 24 derived peptides containing at least two repeated VGVAPG sequences are hydrolyzed by the proteinase 3 ( Pr 3 ) . ^^^ The characterization of the Pr 3 generated products indicate that they contain at least one GXXPG sequence known to stimulate cellular effects after binding to the elastin receptor . . ^^^ |
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| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P24158 |
Pubmed |
SVM Score :0.0 |
| NA |
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