| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Both control and PXE elastin fibres were positive for heparan , dermatan and chondroitin 0 sulphates , decorin and biglycan . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| By in situ hybridization , the transcripts for elastin nd biglycan were primarily localized to smooth muscle cells in the intima and were diminished by heparin in proportion to the decrease in intimal mass . ^^^ Transcripts for the heparan sulfate proteoglycans perlecan , syndecan , and ryudocan ; the chondroitin sulfate proteoglycan versican ; the dermatan sulfate proteoglycan biglycan ; type 1 procollagen ; and tropoelastin all were increased on Northern blots beginning at 1 week after injury . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Several matrix molecules ( glycosaminoglycans , decorin , biglycan , osteopontin ) have been found to be associated with elastin into the normal fiber , and several others have been recognized within pathologic elastic fiber ( osteonectin , vitronectin , alkaline phosphatase in PXE ) . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| The versican positive regions also immunostained for biglycan , a small leucine rich dermatan sulfate proteoglycan , and sparsely for elastin . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| LTD 4 ( 0 . 1 or 10 microM ) did not increase the total messenger RNA expression of the extracellular matrix proteins ( pro alpha [ 1 ] type 1 or alpha 1 [ 4 ] type 4 collagen ) , elastin , biglycan , decorin , and fibronectin , and did not influence tumor growth factor beta ( 10 ng / ml ) induced effects on the expression of these proteins in HASM cells . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Because the normal association between EBP and tropoelastin can be disrupted on contact with galactosugar bearing moieties , and the fibroblasts from patients with Costello syndrome revealed an unusual accumulation of chondroitin sulfate bearing proteoglycans ( CD 44 and biglycan ) , we postulate that a chondroitin sulfate may be responsible for shedding EBP from Costello cells and in turn for their impaired elastogenesis . ^^^ |
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| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Molecular interactions of biglycan and decorin with elastic fiber components : biglycan forms a ternary complex with tropoelastin and microfibril associated glycoprotein 1 . ^^^ The interactions of the dermatan sulfate proteoglycans biglycan and decorin have been investigated with the elastic fiber components , tropoelastin , fibrillin containing microfibrils , and microfibril associated glycoproteins ( MAGP ) 1 and 2 . ^^^ The specificity of the binding of biglycan and decorin to tropoelastin was confirmed by co immunoprecipitation experiments and by the blocking of the interactions with elastin derived peptides . ^^^ Isolated core proteins from biglycan and decorin bound to tropoelastin more strongly than the intact proteoglycans , and there were no differences in the tropoelastin binding characteristics of distinct glucuronate rich and iduronate rich glycoforms of biglycan . ^^^ Scatchard analysis showed that biglycan bound more avidly than decorin to tropoelastin with K ( d ) values estimated as 1 . 95 10 10 ( 7 ) m and 5 . 3 10 10 ( 7 ) m , respectively . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of collagens ( 1 , 2 , 3 , 9 , 10 , 12 ) , proteoglycans ( decorin , aggrecan , versican , biglycan , fibromodulin ) , and other extracellular matrix proteins ( elastin , osteocalcin , alkaline phosphatase ) were evaluated at the healing tendon to bone insertion site . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study showed that all aortic layers of AAA were characterized by a significant loss of elastin , biglycan and other PGs / GAGs and replacement of these molecules with collagen fibrils and decorin . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Prominent among the differentially expressed genes were those with established fibrogenic potential , including CTGF , collagen 1 , elastin , thrombospondin , decorin , biglycan , and fibromodulin . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| After 6 weeks of culture , there were significantly lower gene expression of SMC specific markers , such as alpha actin , caldesmon , and vimentin , and proteoglycans , such as biglycan , decorin , and versican , and other ECM components , such as collagen 1 and elastin , in TEBVs , with and without pulsatile conditions , compared to that of native arteries . ^^^ |
|
| Interacting proteins: P21810 and P15502 |
Pubmed |
SVM Score :0.0 |
| Moreover , sectioned elastin fibers were positive towards antibodies raised against synthetic peptides corresponding to amino acid sequences near the N terminus of the protein core of small matrix proteoglycans PGI and PGII , respectively ( Fisher et al . , J . ^^^ |
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