| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Moreover , sectioned elastin fibers were positive towards antibodies raised against synthetic peptides corresponding to amino acid sequences near the N terminus of the protein core of small matrix proteoglycans PGI and PGII , respectively ( Fisher et al . , J . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Both control and PXE elastin fibres were positive for heparan , dermatan and chondroitin 0 sulphates , decorin and biglycan . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Several matrix molecules ( glycosaminoglycans , decorin , biglycan , osteopontin ) have been found to be associated with elastin into the normal fiber , and several others have been recognized within pathologic elastic fiber ( osteonectin , vitronectin , alkaline phosphatase in PXE ) . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Collagen , elastin and decorin mRNA levels in the patient fibroblasts were also unaltered . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| LTD 4 ( 0 . 1 or 10 microM ) did not increase the total messenger RNA expression of the extracellular matrix proteins ( pro alpha [ 1 ] type 1 or alpha 1 [ 4 ] type 4 collagen ) , elastin , biglycan , decorin , and fibronectin , and did not influence tumor growth factor beta ( 10 ng / ml ) induced effects on the expression of these proteins in HASM cells . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Since collagen was induced in SHR with heart failure , decorin and elastin were decreased and the ratios of gelatinase A and elastase to tissue inhibitor of metalloproteinase 4 were increased , we conclude that heart failure is associated with adverse extracellular matrix remodeling . . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Enzyme linked immunosorbent assays were done with antibodies to human fibronectin ; perlecan ; elastin ; the laminin beta ( 1 ) , gamma ( 1 ) , beta ( 2 ) , alpha ( 1 ) chains ; thrombospondin ; chondroitin sulfate ; collagen types 1 , 3 , 4 , and 5 ; versican ; and decorin . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| The mRNA of decorin was also stimulated , but elastin , and fibrillin 1 and 2 were not modified by the vitamin . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Finally , PrpL cleaves casein , lactoferrin , transferrin , elastin , and decorin and contributes to PAO 1 ' s ability to persist in a rat chronic pulmonary infection model . . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Comparison of messenger RNA gene expression of extracellular matrix proteins ( procollagen 1 , collagenase , elastin , hyaluronic acid synthase 2 , hyaluronidase , fibronectin , cd 44 , fibromodulin , and decorin ) across cell passages ( 3 , 4 , 5 , 6 , 10 , and 12 fornormal laminapropria and 3 , 4 , 5 , 6 , and 10 for tracheal scar ) revealed varied growth patterns . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies specific for major ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Expression patterns of collagens ( 1 , 2 , 3 , 9 , 10 , 12 ) , proteoglycans ( decorin , aggrecan , versican , biglycan , fibromodulin ) , and other extracellular matrix proteins ( elastin , osteocalcin , alkaline phosphatase ) were evaluated at the healing tendon to bone insertion site . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Our results showed that 192 genes were highly expressed in both DCM and HCM ( e . g . , atrial natriuretic peptide , CD 59 , decorin , elongation factor 2 , and heat shock protein 90 ) , and 51 genes were downregulated in both conditions ( e . g . , elastin , sarcoplasmic / endoplasmic reticulum Ca2+ ATPase ) . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Immunohistochemical study showed that all aortic layers of AAA were characterized by a significant loss of elastin , biglycan and other PGs / GAGs and replacement of these molecules with collagen fibrils and decorin . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Expression of elastin , decorin , lumican and the extracellular matrix remodeling factor TIMP 3 were reduced in facioscapulohumeral muscular dystrophy myoblasts . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| METHODS : The mRNA steady state level of a large spectrum of proteolytic enzymes ( matrix metalloproteinases : MMP 1 , 2 , 3 , 8 , 9 , 11 , 12 , 13 , 14 ; urokinase plasminogen activator : u PA ) , their physiological inhibitors ( tissue inhibitors of MMPs : TIMP 1 , 2 , 3 ; plasminogen activator inhibitor : PAI 1 ) and that of structural matrix proteins ( collagens type 1 and 3 , decorin , elastin , fibrillins 1 and 2 ) was determined by RT PCR made quantitative by using a synthetic RNA as internal standard in each reaction mixture . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| METHODS : Postembedding immunoelectron microscopic studies were performed with antibodies against myocilin and other ECM components , including fibronectin , laminin , vitronectin , tenascin , elastin , fibrillin 1 , microfibril associated glycoprotein ( MAGP ) 1 , decorin , versican , hyaluronic acid , and five types of collagen ( 1 , 3 , 4 , 5 , and 6 ) . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Other matrikines in collagen , elastin , decorin , and laminin 1 can promote chemotaxis , mitogenesis , and metastasis in cancers , such as melanoma . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Prominent among the differentially expressed genes were those with established fibrogenic potential , including CTGF , collagen 1 , elastin , thrombospondin , decorin , biglycan , and fibromodulin . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Diabetes affected the gene expression of several collagens ( types 1 , 3 , 4 , 5 , 6 , and 15 ) , some noncollagenous glycoproteins , and proteoglycans ( e . g . , elastin , thrombospondin 1 , laminin 2 , decorin ) . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| After 6 weeks of culture , there were significantly lower gene expression of SMC specific markers , such as alpha actin , caldesmon , and vimentin , and proteoglycans , such as biglycan , decorin , and versican , and other ECM components , such as collagen 1 and elastin , in TEBVs , with and without pulsatile conditions , compared to that of native arteries . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Molecular interactions of biglycan and decorin with elastic fiber components : biglycan forms a ternary complex with tropoelastin and microfibril associated glycoprotein 1 . ^^^ The interactions of the dermatan sulfate proteoglycans biglycan and decorin have been investigated with the elastic fiber components , tropoelastin , fibrillin containing microfibrils , and microfibril associated glycoproteins ( MAGP ) 1 and 2 . ^^^ The specificity of the binding of biglycan and decorin to tropoelastin was confirmed by co immunoprecipitation experiments and by the blocking of the interactions with elastin derived peptides . ^^^ Isolated core proteins from biglycan and decorin bound to tropoelastin more strongly than the intact proteoglycans , and there were no differences in the tropoelastin binding characteristics of distinct glucuronate rich and iduronate rich glycoforms of biglycan . ^^^ Scatchard analysis showed that biglycan bound more avidly than decorin to tropoelastin with K ( d ) values estimated as 1 . 95 10 10 ( 7 ) m and 5 . 3 10 10 ( 7 ) m , respectively . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| Young ischemic hearts demonstrated down regulation of gene expression associated with early remodeling including down regulation of tissue inhibitor of metalloproteinase 1 , decorin , collagen , tropoelastin , and fibulin , as well as decreases in hypertrophy related transcripts . ^^^ |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15502 and P07585 |
Pubmed |
SVM Score :0.0 |
| NA |
|