| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| We show that the regulatory protein FosB , but not FosB / SF or Fra 1 , specifically and stably associates with the TATA box binding protein ( TBP ) and the multiprotein complex TFIID . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| During exponential growth , the synthesis of Fra 1 and Fra 2 is maintained at a significant level , in contrast to c Fos and FosB , which are expressed at very low or undetectable levels . ^^^ To determine whether the Fos proteins are differentially required during the G 0 to G 1 transition and exponential growth for the entrance into S phase , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , and Fra 2 . ^^^ We have found that while the activities of c Fos and FosB are required mostly during the G 0 to G 1 transition , Fra 1 and Fra 2 are involved both in the G 0 to G 1 transition and in asynchronous growth . . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The deduced amino acid sequence of the gene ( 323 amino acids ) contains a `` leucine zipper ' ' and includes five distinct regions that exhibit strong sequence homology to the recently identified fos related antigens Fra 1 ( rat ) and FosB ( mouse ) as well as c Fos . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Transrepression of glucocorticoid mediated induction involves a region of Fos , located between amino acids 40 and 111 , to which no function has been previously assigned , and which is poorly conserved among Fos , FosB and Fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The Fos family of proteins now includes seven members : the retroviral proteins FBR 5 Fos and FBJ 5 Fos and the cellular proteins c Fos , FosB , FosB 2 , Fra 1 , and Fra 2 . ^^^ Four proteins ( FBR 5 Fos , FBJ 5 Fos , c Fos , and FosB ) transform established rodent fibroblast cell lines , while three ( FosB 2 , Fra 1 , and Fra 2 ) do not . ^^^ The nontransforming proteins Fra 1 and Fra 2 can be converted to transforming proteins by fusion of a transactivation domain from either FosB or VP 16 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Likewise , expression of fra 1 , c jun and junB continued to be high in serum stimulated senescent cells , while induction of fosB was reduced approximately fivefold . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| BHQ induced expression of c jun , junB , fra 1 , and fra 2 , which encode AP 1 components , but was a poor inducer of c fos and had no effect on fosB . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Constitutive expression of c Fos , FosB , Fra 1 , or c Jun in rat fibroblasts leads to up regulation of the immediate early gene fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The Fos family of transcription factors , c Fos , FosB , Fra 1 and Fra 2 , are rapidly induced in quiescent fibroblasts following serum or growth factor stimulation . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Using in situ hybridization , the expression of c fos , fosB , fra 1 , fra 2 , c jun and junB was studied after 15 min of normothermic and hypothermic ( 33 degrees C ) transient forebrain ischaemia in the rat , induced by common carotid occlusion combined with systemic hypotension . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Withdrawal studies demonstrated robust induction of several known acute Fras , including c Fos , FosB , Fra 1 , Fra 2 , and delta FosB , at 6 hr after naltrexone precipitation of withdrawal in the striatum , nucleus accumbens , and several other brain regions . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| TSH induced a rapid and transient expression of c fos , fosB , and fra 1 with different kinetics . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| USF specifically interacts with Fra 1 but not with other closely related family members , c Fos , Fra 2 , FosB , or with c Jun . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| TNFa increased c Jun protein , but only weakly induced FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) whereas cAMP increased the abundance of several FOS proteins ( c Fos , FosB , Fra 1 , and Fra 2 ) , with little effect on c Jun levels . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| We found a rapid induction of c fos , c jun and junB at the mRNA level after about 30 min of EGF treatment and a more delayed upregulation of fosB and fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The levels of two other immediate early genes , fosb and c jun , also increased transiently after fibroblast contraction , whereas the levels of fra 1 , fra 2 , c myc , and the transcription factor NF kappaB remained the same , indicating that fibroblast contraction caused changes in a selective group of genes . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The densities of Fos , FosB , Fra 1 , Jun and JunD immunoreactive nuclei induced by haloperidol and sulpiride in the hippocampus , piriform cortex and accumbens nucleus were higher than those in the control groups . ^^^ The same regions showed higher densities of FosB , Fra 1 and JunD immunoreactive nuclei induced by SCH 23390 compared with the control groups . ^^^ These results suggested that induced Fos , FosB , Fra 1 , Jun and JunD proteins constitute the activator protein 1 complex after the administration of haloperidol and sulpiride . ^^^ In contrast , FosB , Fra 1 and JunD appear to constitute the activator protein 1 complex after the administration of SCH 23390 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| One hour after the intraperitoneal administration of delta 9 THC at a dose of 10 or 15 mg / kg , AP 1 DNA binding activity in the nucleus accumbens increased by 33 and 49 % , respectively , while Western blot showed an increase in both c Fos , FosB , Fra 1 ( Fos related antigen ) and Fra 2 . ^^^ While in the caudate putamen the increase in AP 1 DNA binding was mainly due to an elevation of the c Fos and FosB proteins , the same phenomenon depended on the FosB , Fra 1 and Fra 2 peptides in the cingulate cortex . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The brains were processed using an antibody that recognizes Fos , FosB , Fra 1 , and Fra 2 for the detection of Fra LI and using an antibody that only recognizes Fos like immunoreactivity ( Fos LI ) . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^ Expression of 2 fra 1 specific bands of 33 and 36 . 5 kDa showed significant negative correlation with fosB expression , as well as with estrogen receptor status and differentiation . ^^^ We conclude that strong differences in the expression pattern of AP 1 family members are present in breast tumors , and that certain members of this family , such as fosB and fra 1 , might be involved in the pathogenesis of these tumors . . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^ Structure function analysis demonstrated that the major carboxy terminal transactivation domains of c Fos and FosB are dispensable and that Fra 1 ( which lacks transactivation domains ) has the highest rescue activity . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The activated AP 1 contained c fos but not c jun , fosB , and Fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Extensive studies have established that light regulates c fos gene expression in the suprachiasmatic nucleus , the site of an endogenous circadian clock , but relatively little is known about the expression of genes structurally related to c fos , including fra 1 , fra 2 and fosB . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The members of the Fos protein family might be subdivided in two groups , according to their ability to transform rodent fibroblasts , transforming ( c Fos and FosB ) and non transforming ( Fra 1 and Fra 2 ) proteins . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Supershift analysis suggests that activated AP 1 contained c Jun , JunD , c Fos , FosB , and Fra 1 subunits . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ The labeling intensity of the c Jun , JunD , and Fra 2 antibodies was stronger than that of JunB , FosB , and Fra 1 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Expression of fosB or fra 1 was not detected with either peptide . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of JunB was diminished in the undifferentiated , more aggressive tumour phenotype compared with the well differentiated , less aggressive keratinocytes , whereas the expression of other AP 1 family members ( c jun , junD , c fos , fra 1 , fra 2 and fosB ) was either very weak or variable . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Expression of egr 1 ( krox 24 ) , egr 2 ( krox 20 ) , egr 3 , c jun , junB , c fos , fosB , fra 1 , fra 2 , and CREB genes was analyzed by reverse transcription polymerase chain reaction ( RT PCR ) in Schwann cells isolated from neonatal rat sciatic nerves and in the cell lines MSC 80 ( mouse Schwann cells ) , NIH 3T3 ( mouse fibroblasts ) , and CHO ( Chinese hamster ovary cells ) . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| By contrast , the fos family member fra 1 was up regulated in the human colon tumors , suggesting a compensatory mechanism for the reduction in fos and fosB expression . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^ All cells expressed fos , fra 1 and jun proteins and none expressed fosB . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Expression of c fos , fosB , fra 1 , fra 2 , and junB was low during early gestation , with a 5 to 10 fold increase on Day 23 during labor , and returned to low levels 1 day postpartum . ^^^ Administration of progesterone ( P 4 ; 16 mg / kg s . c . / day ) beginning on Day 20 ( to maintain elevated plasma P 4 levels ) prevented the onset of labor and blocked the expected rise in c fos , fosB , fra 1 , fra 2 , and junB expression on Day 23 . ^^^ In unilaterally pregnant rats , stretch imposed by the growing fetus was found to increase the expression of c fos , fosB , fra 1 , fra 2 , and junB only in the gravid horn on the day of labor . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| A functional activating protein 1 ( AP 1 ) site regulates matrix metalloproteinase 2 ( MMP 2 ) transcription by cardiac cells through interactions with JunB Fra 1 and JunB FosB heterodimers . ^^^ Nuclear extracts isolated from hypoxic rat cardiac fibroblasts contained Fra 1 , JunB and also included FosB . ^^^ Co transfection of cardiac fibroblasts with Fra 1 JunB and FosB JunB expression plasmids led to significant increases in transcriptional activity . ^^^ These studies demonstrate that a functional AP 1 site mediates MMP 2 transcription in cardiac cells through the binding of distinctive Fra 1 JunB and FosB JunB heterodimers . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| This effect was specific because palytoxin had little effect on c Jun , JunB , JunD , FosB , Fra 1 , or Fra 2 binding or on overall levels of transcription factor binding . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Transcriptionally active AP 1 in combinations of c Jun , JunD and JunB with Fra 1 , Fra 2 and possibly FosB , are expressed in cardiac myocytes . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Instead , a C terminal domain located between amino acids 235 and 296 , which is conserved in FosB but not in the nontransforming Fos family members , FosB / SF or Fra 1 , is essential for c Fos GATA interaction . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Static stretch induced an increase in the expression of c fos , fosB , fra 1 , c jun , and junB . ^^^ The peak induction for fosB and c jun occurred at 1 h , whereas the peak of fra 1 induction occurred between 1 and 2 h after application of stretch . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| The role of the AP 1 transcription factors c Fos , FosB , Fra 1 and Fra 2 in the invasion process of mammary carcinomas . ^^^ Members of the Fos family of AP 1 transcription factors ( c Fos , FosB , FosB 2 , Fra 1 and Fra 2 ) are able to form dimers with Jun proteins which bind to the regulatory sequences of target genes . ^^^ Therefore , we performed transient transfections with expression vectors for c Fos , FosB , FosB 2 , Fra 1 and Fra 2 , followed by matrigel invasion assays . ^^^ Interestingly , high FosB levels were significantly associated with MMP 1 overexpression , whereas expression of c Fos and phosphorylated Fra 1 correlated with MMP 9 protein levels . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Gel shift experiments with nuclear extracts of hypertrophic chondrocytes revealed FosB and Fra 1 as candidates regulating AP 1 factors binding to the TRE site . ^^^ In fact , coexpression of FosB and Fra 1 in reporter gene assays greatly stimulated transcriptional activity of enhancer bearing reporter genes . ^^^ Quantitative analysis of AP 1 factor mRNA levels in distinct fractions of fetal bovine epiphyseal chondrocytes by real time PCR confirmed significant levels of FosB and Fra 1 mRNA besides other AP 1 factors in hypertrophic chondrocytes . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Bcl 2 induced the nuclear transcription factor activator protein 1 family , including the c Jun , JunD , c Fos , FosB , and Fra 1 proteins . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Immunodepletion gel shift assays demonstrated that GP 5 EpRE bound JunB , c Jun , FosB , and Fra 2 from unstimulated cells , and that after exposure to HNE , EpRE binding complexes contained nuclear factor erythroid 2 related factor ( Nrf ) 1 , Nrf 2 , JunB , c Jun , FosB , c Fos , Fra 1 , and Fra 2 . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| Members of the Fos family ( c Fos , FosB and its smaller splice variants , Fra 1 and Fra 2 ) dimerise with Jun proteins to form the AP 1 transcription factor complex . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^ |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53539 and P15407 |
Pubmed |
SVM Score :0.0 |
| NA |
|