Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
We have shown that while c Fos is the major Fos protein associated with the Jun proteins ( c Jun , JunB , and JunD ) soon after serum stimulation , at later times Fra 1 and Fra 2 are the predominant Fos proteins associated with the different Jun proteins . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Northern analysis indicates that mRNAs for at least six members of the Fos / Jun family ( c fos , fosB , fra 1 , c jun , junB , and junD ) are expressed in activated Ar 5 cells ; thus the AP 1 sites of the IL 2 promoter may bind different dimeric Fos / Jun complexes at different times after T cell activation , perhaps mediating both positive and negative regulation of the IL 2 promoter . . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Okadaic acid treatment was found to dramatically increase mRNA transcripts of the jun family of proto oncogenes including c jun , junD , and junB and to a lesser extent the fos family including c fos and fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Consistent with this result , these cell lines expressed increased levels of mRNAs encoding the AP 1 proteins , c Fos , Fra 1 , c Jun , JunB , and JunD . ^^^ By using the human T cell line ( JPX 9 ) , in which expression of the Tax 1 is inducible , we showed that expression of mRNAs for Fra 1 , c Jun , and JunD was also transactivated by Tax 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
To determine whether these proteins are required for cell cycle progression , we microinjected affinity purified antibodies directed against c Fos , FosB , Fra 1 , c Jun , JunB , and JunD , and antibodies that recognize either the Fos or the Jun family of proteins , into Swiss 3T3 cells and determined their effects in cell cycle progression by monitoring DNA synthesis . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Like c Fos and Fra 1 , Fra 2 formed stable heterodimers with c Jun , JunB or JunD in vitro and all these complexes had specific DNA binding activity to AP 1 binding sites ( AP 1 sites ) or related sequences . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Fos related antigen ( Fra 1 ) , junB , and junD activate human involucrin promoter transcription by binding to proximal and distal AP 1 sites to mediate phorbol ester effects on promoter activity . ^^^ Gel supershift experiments indicate the interaction of these sites with Fra 1 , junB , and junD . ^^^ We conclude that ( 1 ) two AP 1 sites in the hINV promoter are important elements required for keratinocyte specific expression , ( 2 ) these AP 1 1 sites mediate the phorbol ester dependent increase in promoter activity , and ( 3 ) Fra 1 , junB , and junD may be important regulators of hINV expression in epidermis . . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
These elements include a proximal cyclic AMP response element ( CRE ) / AP 1 like motif ( TGACATCA ) that binds c Jun , JunD , CRE binding ( CREB ) , and ATF proteins , a near consensus glucocorticoid response element , and a distal consensus AP 1 site that binds c Fos , Fra 1 , and JunD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Although several members of the AP 1 family were able to activate the PLF gene promoter in transient cotransfection experiments , the predominant AP 1 components interacting with the PLF gene promoter in serum stimulated cells were Fra 1 , JunB , and JunD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Compared with the wild type JunD , none of them showed enhanced transactivating activity in the forms of homodimers or of heterodimers with c Fos or Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Differential expression of the fos and jun family members c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD during human epidermal keratinocyte differentiation . ^^^ In the present study we describe the localization of c fos , fosB , Fra 1 , Fra 2 , c jun , junB and junD in the normal human epidermis . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Calcium induced AP 1 DNA binding complexes consist of Fra 1 , Fra 2 , c Jun , JunB and JunD and are independent of c Fos , since the induction of DNA binding activity and the composition of the AP 1 binding complexes are identical in differentiating keratinocytes derived from c fos null and wild type mice . ^^^ In vivo expression patterns suggest that the predominant AP 1 heterodimer in the granular layer consists of Fra 2 and JunB while a JunD and Fra 1 complex predominates the spinous layer of mouse epidermis . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In the endothelial cells , all Jun and Fos forms ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) were part of the AP 1 complex after PMA induction . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The GR AP 1 site bound protein complexes composed of JunD , JunB , Fra 2 , and Fra 1 from L 929 nuclear extracts . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In the present study , overexpression of fra 1 , fra 2 , c jun , junB , and junD mRNAs was demonstrated in RCs by Northern blot analysis . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
We have investigated the effect of a 30 min running bout in untrained subjects on the expression of the mRNAs of all members of the fos and jun gene families , including c fos , fosB , fosBdel , fra 1 , and fra 2 as well as c jun , junB , and junD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Supershift analysis demonstrated that JunD was the major moiety contributing to AP 1 DNA binding in unstimulated cells and that c Jun , Fra 1 , and Fra 2 DNA binding were increased whereas JunD DNA binding was decreased in TGF beta 1 stimulated cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The densities of Fos , FosB , Fra 1 , Jun and JunD immunoreactive nuclei induced by haloperidol and sulpiride in the hippocampus , piriform cortex and accumbens nucleus were higher than those in the control groups . ^^^ The same regions showed higher densities of FosB , Fra 1 and JunD immunoreactive nuclei induced by SCH 23390 compared with the control groups . ^^^ These results suggested that induced Fos , FosB , Fra 1 , Jun and JunD proteins constitute the activator protein 1 complex after the administration of haloperidol and sulpiride . ^^^ In contrast , FosB , Fra 1 and JunD appear to constitute the activator protein 1 complex after the administration of SCH 23390 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The delayed increase in COX 2 mRNA expression was accompanied by the induction of the proto oncogenes c jun , junB , junD , and c fos ( but not FosB or Fra 1 ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
This finding is paralleled by the observation that among the various members of the Fos and Jun family analysed ( c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunD , JunB ) fra 1 is the only gene to be exclusively expressed in NSCLC cells but not in cells of SCLC origin . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The activator protein 1 ( AP 1 ) transcriptional complex is made up of members of the Fos ( c Fos , FosB , Fra 1 , Fra 2 ) and Jun ( c Jun , JunB , JunD ) families and is stimulated by insulin in several cell types . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
This article reviews findings up to the end of 1997 about the inducible transcription factors ( ITFs ) c Jun , JunB , JunD , c Fos , FosB , Fra 1 , Fra 2 , Krox 20 ( Egr 2 ) and Krox 24 ( NGFI A , Egr 1 , Zif 268 ) ; and the constitutive transcription factors ( CTFs ) CREB , CREM , ATF 2 and SRF as they pertain to gene expression in the mammalian nervous system . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Supershift analysis of AP 1 / DNA complexes with antibodies against the AP 1 sub units , c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB , and JunD , revealed that the AP 1 / DNA complexes in the various clones had different compositions . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
AP 1 stands as a synonym for different proteins such as c Jun , JunB , JunD , c Fos , FosB as well as the Fos related antigens Fra 1 and Fra 2 , which can either homo or heterodimerize to build up a functional transcription complex . ^^^ In nuclear extracts obtained from non tumorigenic cells , Jun family members ( in the order c Jun > JunD > JunB ) were mainly heterodimerized with Fra 1 , a protein , known to be involved in the abrogation of AP 1 activity under certain experimental conditions . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The presence of several transcription factor proteins , including JunB , JunD , c Fos , Fra 1 , CREB 1 , activating transcription factor 2 , NF KB p 50 , p 52 , and p 65 , and CAAT / enhancer binding protein delta , was demonstrated by supershift analysis . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Here , we demonstrate , by supershift analysis , that JunB , JunD , Fra 1 , Fra 2 , and c Fos bound to AP 1 but that prior treatment of the cells with TGFbeta reduced dramatically c Fos binding , suggesting that c Fos might be playing a negative regulatory role in clusterin gene expression . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Constitutive urokinase receptor expression in HCT 116 cells required an intact AP 1 motif in the promoter ( at 184 ) and electrophoretic mobility shifting assays indicated less c Jun , JunD , c Fos and Fra 1 bound to this motif in the K Ras disrupted cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In the present study , the expression of members of the AP 1 family of transcription factors in breast tumors ( n = 53 ) was investigated by Western blot with antibodies specific for each of the AP 1 family members ( c jun , junB , junD and c fos , fosB , fra 1 and fra 2 ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Supershift analysis with antibodies specific for NF kappaB , AP 1 , and NF IL 6 binding proteins showed that the NF kappaB binding protein included p65 / Rel A and p 50 ; AP 1 activity included c jun , junB , junD , and Fra 1 ; and NF IL 6 included C / EBPbeta . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Mice lacking Fos ( encoding c Fos ) develop osteopetrosis due to an early differentiation block in the osteoclast lineage . c Fos is a component of the dimeric transcription factor activator protein 1 ( Ap 1 ) , which is composed mainly of Fos ( c Fos , FosB , Fra 1 and Fra 2 ) and Jun proteins ( c Jun , JunB and JunD ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The AP 1 complex induced by DCA consisted of JunD , Fra 1 , and c Fos . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In addition , AA also increased several AP 1 proteins , such as c Fos , Fra 1 , Fra 2 , JunB , JunD , and c Jun , or AP 1 and ENKCRE 2 DNA binding activity . ^^^ However , as well as proto oncoprotein levels , such as Fra 1 , Fra 2 , c Jun , JunB , but not JunD , AA induced increase of proENK mRNA was significantly reduced by the pretreatment with 10 microM of PD 98059 ( 1 . 3 fold ) or 10 microM of SB 203580 ( 1 . 8 fold ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
After cell seeding on an extracellular matrix which allows polarization and expression of the mvdp gene in response to androgens , AP 1 protein accumulation is greatly altered and consists in a loss of JunB , Fra 1 , FosB and a decrease in c Fos , c Jun and Fra 2 , while JunD remained at the same level . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Immunoelectrophoretic mobility shift ( supershift ) assays identified JunD , Fra 1 , and Fra 2 as the major factors that bind to the AP 1 element . ^^^ Western analysis of the proteins in the nuclear extracts showed that the levels of c Jun , JunB , JunD , FosB , and Fra 2 increased and the levels of c Fos and Fra 1 decreased slightly with calcium treatment . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The activator protein 1 complex in human keratinocytes consists of dimers of Fra 1 , Fra 2 , c Jun , JunD , and c Fos . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The AP 1 sequence specifically bound to fra 1 , junD , and junB in H 441 lung adenocarcinoma nuclear extracts . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Therefore , we studied protein expression of 6 cell cycle regulatory proteins ( Rb , p 16 , p 21 , p 27 , cyclin D 1 , and cyclin E ) in protein extracts from 53 breast cancer samples and 4 mammary cell lines and correlated the data with expression of the 7 AP 1 family members ( c jun , junB , junD , c fos , fosB , fra 1 , and fra 2 ) as determined in a previous study . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Supershift analysis suggests that activated AP 1 contained c Jun , JunD , c Fos , FosB , and Fra 1 subunits . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
We examined by immunocytochemistry the localization of the AP 1 family proteins c Jun , JunB , JunD , c Fos , FosB , Fra 1 , and Fra 2 in rat incisor ameloblasts . ^^^ The labeling intensity of the c Jun , JunD , and Fra 2 antibodies was stronger than that of JunB , FosB , and Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In 2 DIV cells ( in which glutamate is nontoxic ) , AP 1 comprised combinations of only Fra 1 , Fra 2 , c Jun , and JunD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
We previously showed that Tax induces the expression of various family members of the transcription factor AP 1 such as c Jun , JunD , c Fos , and Fra 1 at the mRNA level in T cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
While c Fos , Fra 2 and JunB were increased in response to either stimuli , only Fra 1 , c Jun and JunD were increased by PMA . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Human T cell leukemia virus type 1 ( HTLV 1 ) Tax protein induces the expression of various family members of the transcription factor AP 1 , such as c Jun , JunD , c Fos , and Fra 1 , at the level of RNA expression in T cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The constitutive expression of JunB was diminished in the undifferentiated , more aggressive tumour phenotype compared with the well differentiated , less aggressive keratinocytes , whereas the expression of other AP 1 family members ( c jun , junD , c fos , fra 1 , fra 2 and fosB ) was either very weak or variable . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Supershifts with the AP 1 oligonucleotide showed the presence of the Jun ( c Jun , JunB , JunD ) and Fos ( c Fos , FosB , Fra 1 , Fra 2 ) proteins in the untreated and TGF beta treated OA chondrocytes , whereas only Smad proteins ( Smad 2 , 3 , 4 ) were present in the AP 1 binding proteins from the TGF beta treated chondrocytes . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
This was followed , after 44 cPD , by a loss of fra 1 and both junD species . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
METHODS : We performed Western blot experiments with specific antibodies for each of the AP 1 proteins ( c jun , junB , junD , c fos , fosB , fra 1 , fra 2 ) with 41 endometrial carcinomas . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Fra 1 , Fra 2 , FosB , JunB , JunD , c Jun , and c Fos levels are increased by EGCG treatment , as is AP 1 factor binding to hINV promoter AP 1 site . ^^^ Gel mobility shift studies show that this complex contains Fra 1 and JunD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In unstimulated cells , the 150 to 84 bp region is weakly bound by AP 1 proteins , mainly JunD and Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
We have investigated the expression of the AP 1 transcription factor proteins , fos , fosB , fra 1 , fra 2 , jun , junB , junD , using Western blot analysis , in several types of asynchronously proliferating cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The DNA binding activities of c Fos , FosB / Delta FosB , Fra 1 , Fra 2 , and JunB were up regulated whereas JunD activity was decreased . c Fos , FosB / Delta FosB , and JunB were associated with Smad 4 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Utrophin enhancer activity was dependent on an AP 1 site , and in satellite cells of regenerating muscle the AP 1 factors Fra 1 , Fra 2 , and JunD were strongly induced . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Using DNA protein gel shift assays we determined that nerve growth factor stimulates AP 1 binding in both PC 12 and B5P cells , and identified c Fos , FosB , Fra 1 , Fra 2 , c Jun , JunB and JunD in AP 1 complexes . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In contrast , ERK1 / 2 , p 38 ( MAPK ) and src kinases treatment blocked nuclear translocation of almost all the AP 1 members in both models , except Fra 1 , JunD after deformation and Fra 1 , JunB after clinorotation . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Gene disruption studies indicate that the AP 1 family members c jun , junB , and fra 1 are essential for embryonic development , whereas junD , c fos , and fosB are required for normal postnatal growth . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
This effect was specific because palytoxin had little effect on c Jun , JunB , JunD , FosB , Fra 1 , or Fra 2 binding or on overall levels of transcription factor binding . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Phosphorylated c Jun , JunB , JunD , and Fra 1 , but not c Fos , FosB , or ATF 2 , are detected in the AP 1 DNA binding complex in cells exposed to trivalent arsenicals . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Immunoblot analyses confirmed that c Jun , JunD , JunB , c Fos , Fra 1 , Fra 2 , and FosB immunoreactive proteins were present in whole cell extracts ( WCE ) of all antral follicles and midluteal phase corpora lutea ( CL ) as well as granulosa cells ( GC ) isolated from different sized antral follicles . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
An electrophoretic mobility shift assay confirmed the AP 1 binding activity in SMCs and showed that the protein bound to the AP 1 site consisted predominantly of c Jun , JunD and Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The JNK deficient cells exhibited decreased expression of c Jun , JunD , c Fos , Fra 1 , and Fra 2 ; decreased phosphorylation of c Jun and JunD ; and decreased AP 1 DNA binding activity . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Constitutive activation of nuclear factor kappaB p50 / p65 and Fra 1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer . ^^^ Deregulated activation of the IL 6 promoter is for the most part mediated by a combined constitutive activation of the nuclear factor ( NF ) kappaB p 50 and p 65 and the activator protein 1 ( AP 1 ) JunD and Fra 1 family members as demonstrated by electrophoretic mobility shift assays , site directed mutagenesis , and transfection experiments . ^^^ Our data demonstrate for the first time that a combined aberrant activation of NF kappaB p 50 and p 65 and AP 1 JunD and Fra 1 in androgen independent prostate cancer cells results in deregulated IL 6 expression , suggesting a novel potential entry point for therapeutic intervention in prostate cancer . . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In a Gal 4 fusion assay , Pdcd 4 specifically inhibited activation of c Jun and c Fos activation domains , but did not inhibit activation of JunB , JunD , Fra 1 , or Fra 2 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Here we surveyed human lymphoma samples for expression of JunB and other AP 1 members ( c Jun , c Fos , Fra 1 , JunD ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The AP 1 complex typically comprises two proteins , a Jun ( c Jun , JunB , and JunD ) and a Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
RESULTS : Transcriptionally active AP 1 in combinations of c Jun , JunD and JunB with Fra 1 , Fra 2 and possibly FosB , are expressed in cardiac myocytes . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Activator protein 1 ( AP 1 ) binding to DNA increased more in VSMC from old versus young rats ( P < 0 . 02 ) and was related to increased expression of its components , c Fos , Fra 1 , and JunD . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In w 3211 , c Jun , JunD and Fra 1 were involved in AP 1 binding , while in w 1205 , overall AP 1 binding activity was decreased significantly and supershift binding was detected only with JunD antibodies . ^^^ In metastatic c 81 46A and A 375 cells , only JunD was involved in AP 1 binding activity , but in a third ( c 83 2c ) c Jun , JunD and Fra 1 were present . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
To determine whether NF kappaB activity is involved in the regulation of fos expression in response to various stimuli , we analyzed activity of AP 1 and expression of fos , fosB , fra 1 , fra 2 , jun , junB , and junD , as well as AP 1 downstream target gene VEGF , using MDAPanc 28 and MDAPanc 28 / IkappaBalphaM pancreatic tumor cells and wild type , IKK 1 / , and IKK 2 / murine embryonic fibroblast cells . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
It was demonstrated that stellate cells possess nuclear TRE binding proteins that were identified as JunB , JunD , Fra 1 , and Fra 2 , which were unaffected by either electrophiles or PMA treatment . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Resveratrol reduced both activator protein 1 ( AP 1 ) DNA binding and transcriptional activities , and supershift assay revealed that AP 1 composition was shifted from c Jun / JunD / Fra 1 to JunD / Fra 1 / Fra 2 , with markedly increased JunD , Fra 1 , and Fra 2 protein expression levels in the nucleus . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In our study , we investigated the AP 1 binding activity and the expression pattern of different members of the AP 1 transcription factor family ( c Jun , JunB , JunD , c Fos , FosB , Fra 1 and Fra 2 ) in different grades of cervical lesions starting from mild dysplasia to invasive cervical tumors , including normal control tissues , using specific antibodies raised against each of the AP 1 members . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
HTLV 1 encoded Tax elevates AP 1 activity through the induction of AP 1 family member gene expression , including c Jun , JunD , c Fos , and Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Moreover , fra 1 transgenic mice simultaneously lacking junD reveal a spontaneous dilated cardiomyopathy associated with increased cardiomyocyte apoptosis and a primary mitochondrial defect . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
AP 1 DNA binding activity consists primarily of JunD , c Fos , and Fra 1 , and is accompanied with the increased expression and phosphorylation of these subunits . ^^^ While inhibition of JNK mainly prevents expression and phosphorylation of JunD and c Jun , inhibition of the ERK pathway suppresses both phosphorylation and expression of Jun proteins , and expression of c Fos and Fra 1 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
For this reason in this study , we investigated the expression pattern of the AP 1 family in GTDs and compared it with the expression in normal placenta using immunohistochemistry with specific polyclonal antibodies against all members of the AP 1 family ( JunB , JunD , c Jun , c Fos , FosB , Fra 1 , Fra 2 ) . ^^^ In choriocarcinomas , there was a strong expression for c Jun , JunD , Fra 1 , and Fra 2 . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 induced the nuclear transcription factor activator protein 1 family , including the c Jun , JunD , c Fos , FosB , and Fra 1 proteins . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
The effect of HP seems to be due to the binding of Fra 1 , JunD , and phospho c Jun to the HARP promoter . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Subgroup analysis showed tumor specific binding for c Fos in 58 % , for c Jun in 50 % , for JunD in 39 % , and for Fra 1 in 4 % of cases . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
Converging results consolidate activator protein 1 ( AP 1 ) transcription factor as the pivotal downstream effector in the early response of stress sensitive cells to mechanical loading , and the Fra 1 , Fra 2 , JunB and JunD members of the AP 1 transcription factor family , as mediators in bone remodelling and apoptotic phenomena . ^^^ The aim of the present study was to examine the involvement of the Fra 1 , Fra 2 , JunB and JunD proteins in the biochemical response of functionally loaded mandibular condylar cartilage , and the subsequent initiation of cartilage maturation and apoptotic phenomena . ^^^ The condylar cartilage of both groups was immunostained using specific antibodies against Fra 1 , Fra 2 , JunB and JunD . ^^^ Statistical analysis of the data revealed over expression of Fra 1 , Fra 2 , JunB and JunD proteins in all stages of differentiation of chondrocytes derived from the mandibular condylar cartilage of animals fed on a hard diet . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
For this reason , nine homologues of the AP 1 leucine zipper region have been characterized : Fos ( c Fos , FosB , Fra 1 , and Fra 2 ) , Jun ( c Jun , JunB , and JunD ) , and semirational library designed winning peptides FosW and JunW . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
In addition , hnRNP G overexpression led to up regulation of the expression of TXNIP , a cell cycle inhibitory gene , and significantly reduced the expression of the genes that promote cellular proliferation , such as EGR 1 , JUND , JUNB , FOS , FOSL 1 , ROS , and KIT . ^^^
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
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Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15407 and P17535	Pubmed	SVM Score :0.0
NA