| Interacting proteins: P15289 and P07711 |
Pubmed |
SVM Score :0.0 |
| Of the 18 bands resolvable by SDS polyacrylamide gel electrophoresis , seven bands were NH 2 terminally sequenced and identified as the known lysosomal enzymes cathepsin L , cathepsin A , cathepsin D , alpha galactosidase A , arylsulfatase A , and alpha iduronidase . ^^^ |
|
| Interacting proteins: P15289 and P07711 |
Pubmed |
SVM Score :0.0 |
| Forty five ASA physical status 1 or 2 patients scheduled for elective hallux valgus repair with thigh tourniquet were randomized to receive combined sciatic femoral block with 0 . 75 % ropivacaine ( ROPI , n = 15 ) , 0 . 5 % bupivacaine ( BUPI , n = 15 ) , and 2 % mepivacaine ( MEPI , n = 15 ) . ^^^ |
|
| Interacting proteins: P15289 and P07711 |
Pubmed |
SVM Score :0.0 |
| P426L ASA , but not wild type ASA , was cleaved by purified cathepsin L at threonine 421 yielding 54 and 9 kDa fragments . 10 ray crystallography at 2 . 5 A resolution showed that cleavage is not due to a difference in the protein fold that would expose the peptide bond following threonine 421 to proteases . ^^^ In cathepsin L deficient fibroblasts , degradation of P426L ASA and A464R ASA to the 54 kDa fragment was reduced , while further degradation was blocked . ^^^ This indicates that defective oligomerization of ASA allows degradation of ASA to a catalytically active 54 kDa intermediate by lysosomal cysteine proteinases , including cathepsin L . ^^^ |
|
| Interacting proteins: P15289 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15289 and P07711 |
Pubmed |
SVM Score :0.0 |
| NA |
|