Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.78739168
These correspond to regions of the LIF protein which are thought to be highly important for interaction with the LIF receptor and thus lead to reduced biological activity of the LIF protein . 0.78739168^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.80153163
Because the action of LIF is indirect and mediated by stromal cells , we hypothesized that LIF binds to the LIF receptor on AC6 . 21 stromal cells , leading to up regulated production of stem cell expansion promoting factor ( SCEPF ) and / or down regulated production of stem cell expansion inhibitory factor ( SCEIF ) . 0.80153163^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.51979492
Because corticosterone is known to have a broad range of effects and LIF function has been associated with the hypothalamo pituitary adrenal axis , this study was designed to determine the role for LIFR in the fetus when exposed to the elevated maternal glucocorticoid levels of late gestation . 0.51979492^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Pregnancy associated increase in mRNA for soluble D factor / LIF receptor in mouse liver . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Three different cDNAs encoding mouse D factor / LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The D factor / LIF receptor can be subdivided into several regions ; cytokine receptor homologous domain 1 , an Ig like domain , cytokine receptor homologous domain 2 , three fibronectin type 3 domains , a transmembrane domain and a cytoplasmic region . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 , is also an affinity converter for the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In murine M 1 cells , binding of labeled OSM is completely inhibited by excess LIF or OSM , reflecting the binding of OSM to the high affinity form of the murine LIF receptor . ^^^ These results suggest that , in human leukemia cells , OSM may act through the LIF receptor and an OSM specific receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Reconstitution of high affinity leukaemia inhibitory factor ( LIF ) receptors in haemopoietic cells transfected with the cloned human LIF receptor . cDNA clones encoding the human leukaemia inhibitory factor ( hLIF ) receptor were isolated by screening a placental cDNA expression library in COS 7 cells with 125I hLIF . ^^^ The cloned LIF receptor is a member of the haemopoietin receptor family and comprises a signal sequence ( 44 amino acids ) , an extracellular region of two haemopoietin receptor domains and three fibronectin type 3 domains ( 789 amino acids ) , a transmembrane domain ( 26 amino acids ) and a cytoplasmic domain ( 238 amino acids ) . ^^^ The LIF receptor is expressed in COS 7 cells as a 190 kDa glycoprotein that specifically binds human LIF with low affinity , but does not bind mouse LIF . ^^^ Clones encoding a soluble form of the homologous mouse LIF receptor have been isolated , suggesting complex interactions between the various forms of LIF ligand and receptor in vivo . ^^^ The LIF receptor is most related to the gp 130 signal transducing component of the IL 6 receptor , a feature that may provide a molecular basis for the intertwined biologies of LIF and IL 6 in the absence of obvious structural similarly between the ligands . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF receptor is structurally related to the gp 130 signal transducing component of the IL 6 receptor and to the G CSF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The purified LIF binding protein ( LBP ) is a glycoprotein with an apparent molecular mass of 90 kDa that specifically binds 125I labeled murine LIF with an affinity comparable to that of the low affinity cellular LIF receptor ( Kd = 600 pM ) . ^^^ N terminal sequencing has identified this protein as a soluble truncated form of the alpha chain of the cellular LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We have investigated the binding of each cytokine to a variety of cellular receptors including those on solid tumor lines , leukemic cells , endothelial cells , macrophages , and cells transfected with the recently cloned low affinity LIF receptor , and to a soluble form of the LIF receptor . ^^^ LIF is incapable of binding either high or low affinity OSM receptors , yet OSM is capable of binding the high affinity but not the low affinity LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The IL 6 signal transducer , gp 130 : an oncostatin M receptor and affinity converter for the LIF receptor . ^^^ LIF is structurally and functionally related to another cytokine , Oncostatin M ( OSM ) , that binds to the high affinity LIF receptor but not to the low affinity LIF receptor . ^^^ A complementary DNA was isolated that encodes the high affinity converting subunit of the LIF receptor . ^^^ The converter conferred high affinity binding of both LIF and OSM when expressed with the low affinity LIF receptor and is identical to the signal transducing subunit of the IL 6 receptor , gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
When binding was examined at 4 degrees C , the majority of cells were found to express a single class of high affinity LIF receptor ( KD = 20 100 pM ; ka = 2 8 10 10 ( 8 ) min 1 M 1 ; kd = 0 . 0004 0 . 0011 min 1 ) . ^^^ In contrast , certain activated macrophage populations expressed apparently independent classes of high and low affinity LIF receptor . ^^^ These results are discussed in terms of a structural model for the LIF receptor in which interaction of a low affinity binding subunit and a second nonbinding subunit is required for the generation of the high affinity receptor . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Structural information on the LIF receptor is not yet available , whereas recent cloning of the IL 6 receptor has shown it to be bipartite , with a signal transducing subunit that lacks sequence homology to known protein kinases and produces second messengers of unknown nature . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library . ^^^ The LIF receptor is related to the gp 130 ' signal transducing ' component of the IL 6 receptor and to the G CSF receptor , with the transmembrane and cytoplasmic regions of the LIF receptor and gp 130 being most closely related . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
One class of neurotrophic factor acts through receptor complexes involving the low affinity leukaemia inhibitory factor receptor subunit ( LIF R ) . ^^^ Recently it was reported that mice lacking LIF R die shortly after birth unlike mice lacking CNTF or LIF which are viable . ^^^ These findings point to the existence of a ligand for LIF R that is required for the normal development of motor neurons in both brainstem nuclei and spinal cord . . ^^^ Essential function of LIF receptor in motor neurons . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , oncostatin M ( OSM ) , and interleukin 6 ( IL 6 ) compose a family of distantly related cytokines that initiate signaling by inducing either homodimerization of the `` beta ' ' signal transducing receptor component gp 130 ( in the case of IL 6 ) or heterodimerization between gp 130 and the gp 130 related LIFR beta ( in the case of CNTF , LIF , and OSM ) ; dimerization of beta receptor components in turn activates members of the Jak / Tyk family of receptor associated tyrosine kinases . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The presence of leukaemia inhibitory factor ( LIF ) binding and expression of the gp 130 component of the LIF receptor were studied in the rabbit uterus during pregnancy . ^^^ The coexpression of LIF binding and gp 130 may indicate the presence of high affinity LIF receptor , which matches the pattern of LIF protein expression and , as in mice , suggests its importance for implantation . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OM was also suggested to bind to the LIF receptor ( LIF / OM receptor ) , which consists of a signal transducing subunit for LIF and IL 6 ( gp 130 ) and a LIF receptor alpha subunit . ^^^ PCR amplification clearly revealed high levels of gp 130 expression in AIDS KS cells , while the transcript of LIF receptor alpha subunit or IL 6 receptor alpha subunit was not observed . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Transfection of the LIF receptor into Hep3B hepatoma cells reconstituted LIF and oncostatin M regulation of acute phase plasma protein genes . ^^^ Co expression of the LIF receptor and the CNTF receptor , but not expression of either subunit alone , generated CNTF responsiveness in Hep3B cells , suggesting cooperativity of these receptor subunits . ^^^ Evidence is presented for direct interaction of the LIF receptor with the intracellular signal transduction machinery . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We show here that transcripts for the low affinity LIF receptor ( LIFR ) , an integral component of the functional LIF receptor complex , are expressed in the developing gonad . ^^^ Fluorescence activated cell sorter ( FACS ) analysis , using an anti LIFR antiserum , demonstrates that LIFR is present on the surface of PGCs , suggesting that PGCs are likely to be a direct target of LIF action in culture . ^^^ Signalling via LIFR is essential for PGC growth in culture since the anti LIFR antiserum , which blocks LIF binding to its receptor , abolishes PGC survival in culture . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Both ligands can be specifically cross linked to a protein on M 1 cells with the mobility of the LIF receptor ( approximately 200 kDa ) . ^^^ In addition , CT 1 binds directly to a purified , soluble form of the LIF receptor in solution ( Kd approximately 2 nM ) . ^^^ These data show that CT 1 has a wide range of hematopoietic , neuronal , and developmental activities and that it can act via the LIF receptor and the gp 130 signaling subunit . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Indeed , phosphorylation of the cytoplasmic domain of the low affinity LIF receptor alpha subunit ( LIFR ) in Mono Q fractionated , LIF stimulated 3T3 L 1 extracts occurred only in those fractions containing activated MAPK ; Ser 1044 served as the major phosphorylation site in the human LIFR for MAPK both in agonist stimulated 3T3 L 1 lysates and by recombinant extracellular signal regulated kinase 2 in vitro . ^^^ Phosphorylation of the human leukemia inhibitory factor ( LIF ) receptor by mitogen activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Competition binding studies demonstrate that OSM binds to the LIF receptor on MBL 5 ES cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Previously it had been thought that the gp 130 alone is sufficient to bind ligand and transduce signal and that oncostatin M could bind to and activate the LIF receptor , but these data show this is not always the case . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OSM appears , therefore , to act as a weak agonist of LIF dependent processes on murine cells , however , with a 10 fold lower specific activity than that of LIF , which is in agreement with human OSM cross reacting with the murine LIF R . ^^^ A 549 epithelial cells are subjected to growth inhibition only in the presence of OSM ( ED 50 = 6 ng / ml ) , even though they expressed LIF R and gp 130 transcripts . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF binding chain gene ( LIFR ) was expressed only in the two HMCL responsive to LIF and OM . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We also demonstrate a rapid and transient increase in Hck tyrosine kinase activity in parental ES cells stimulated by LIF and , finally , show that Hck is physically associated with gp 130 , an affinity converter and signal transducing component of the LIF receptor . ^^^ Thus , these results provide biological and biochemical evidence that Hck participates in signal transduction from the LIF receptor . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Human leukaemia inhibitory factor ( hLIF ) binds to both human and mouse LIF receptors ( LIF R ) , while mouse LIF ( mLIF ) binds only to mouse LIF R . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
A radio receptor competition assay showed the presence of a molecule in ULF specifically binding to human LIF receptor ( LIF R ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In addition to including a CNTF specific component , known as CNTFR alpha , the CNTF receptor complex utilizes two receptor components , gp 130 and LIFR beta , that are shared with members of a family of broadly acting cytokines , including leukemia inhibitory factor ( LIF ) and interleukin 6 ( IL 6 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To investigate the possible target for the endometrial LIF , we undertook reverse transcription PCR analysis of early human embryos to determine whether they contain the mRNA encoding the LIF receptor . ^^^ This study indicated that at the time of implantation in humans , the maternal endometrium produces LIF and that the blastocyst expresses LIF receptor mRNA and therefore may be capable of responding to this signal . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIFR ) , in combination with the signal transducing subunit for interleukin 6 type cytokine receptors , gp 130 , and LIF , activates transcription of acute phase plasma protein genes in human and rat hepatoma cells and the vasoactive intestinal peptide gene in a human neuroblastoma cell line . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The beta receptor components for this cytokine family , gp 130 and LIF receptor beta , constitutively associate with Jak Tyk kinases . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Coexpression of the LIF receptor and gp 130 in these cells conferred high affinity LIF and OSM binding and responsiveness to LIF and OSM . ^^^ Coexpression of LIF receptor and CNTFR alpha resulted in a nonfunctional high affinity binding site . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To begin defining whether NG neurons were capable of responding to CNTF and LIF in vivo , Northern blots were used to examine expression of mRNAs coding for CNTF and LIF receptor components ( CNTFR alpha , gp 130 , and LIFR beta ) in the intact ganglion . mRNAs for all three receptor components were present in both E16 . 5 and newborn ganglia , suggesting that LIF and CNTF receptors are expressed in the NG in vivo . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The properties of ECM localized 140 kD species are very similar to those of the secreted form of the LIF receptor suggesting that the ECM localization of LIF and LIF signal transduction may be closely coupled . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here we identify another prominent tyrosine phosphorylated protein as LIF receptor ( LIFR ) beta , which was originally cloned as a LIF binding protein . ^^^ Cross linking experiments with iodinated factors were carried out on a cell line responsive to CNTF and LIF , as well as on COS cells that were cotransfected with various combinations of gp 130 , LIFR beta , and CNTF receptor ( CNTFR ) alpha , the previously cloned CNTF binding protein . ^^^ These experiments reveal that LIF cross links to LIFR beta alone , as well as to gp 130 when it is coexpressed with LIFR beta . ^^^ These and other data show that the two known LIF receptor components are recruited by CNTF and CNTFR alpha to form a trimeric CNTF receptor complex . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Using the reverse transcriptase polymerase chain reaction , we found that the human breast carcinoma MCF 7 cell line expressed the message for both LIF receptor and its signal transducing protein gp 130 , suggesting that these receptors might be biologically active . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF receptor was known in these cells , but the cell internal part of the signal cascade and the transcription factors through which LIF controls its growth promoting target genes in embryonal stem cells , had not been identified . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
These cells were examined by the reverse transcriptase polymerase chain reaction ( RT PCR ) using nested internal primer pairs for the following cytokines : CSF 1 , GM CSF , TNF alpha , TGF beta 1 , IFN gamma , IL 2 , LIF and also for LIF receptor . ^^^ IFN gamma , IL 2 and LIF mRNA were not found , although all samples contained LIF receptor mRNA . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We report here rapid and transient phosphorylation of the LIF receptor , and similarly , we detect phosphorylation of predominantly JAK 1 and to a minor extent JAK 2 in response to LIF treatment in MC3T3 E 1 cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The ciliary neurotrophic factor ( CNTF ) receptor complex is shown here to include the CNTF binding protein ( CNTFR alpha ) as well as the components of the leukemia inhibitory factor ( LIF ) receptor , LIFR beta ( the LIF binding protein ) and gp 130 [ the signal transducer of interleukin 6 ( IL 6 ) ] . ^^^ Unlike the IL 6 receptor complex in which homodimerization of gp 130 appears to be critical for signal initiation , signaling by the CNTF and LIF receptor complexes depends on the heterodimerization of gp 130 with LIFR beta . ^^^ Thus , the conversion of a bipartite LIF receptor into a tripartite CNTF receptor apparently occurs by the addition of the specificity conferring element CNTFR alpha . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The IL 6 induced gp 130 homodimer appears to be similar in function to the heterodimer formed between the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) and gp 130 in response to the LIF or ciliary neurotrophic factor ( CNTF ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The recent finding that genes for the IL 3 and GM CSF receptor alpha chain subunits colocalise to a small region of the pseudoautosomal region and the observation that the LIF receptor locus is present in a cluster of receptor genes on chromosome 5 suggest the possibility that subsets of cytokine receptor genes may be organised into clusters . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Residues in human leukemia inhibitory factor ( hLIF ) crucial for binding to both the human LIF receptor ( R ) and gp 130 were identified by analysis of alanine scanning mutants of hLIF in assays for both receptor binding and bioactivity . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor , LIF receptor , and gp 130 in the mouse uterus during early pregnancy . ^^^ The present study was designed to investigate the changes of LIF protein , LIF receptor , and gp 130 in the mouse uterus during the early pregnancy . ^^^ LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy . gp 130 was highest on days 3 and 4 of pregnancy . ^^^ Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus , at a time when LIF protein was low . ^^^ The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and LIF receptor expression in human endometrium suggests a potential autocrine / paracrine function in regulating embryo implantation . ^^^ Here , we describe the expression of LIF , related members of this group of cytokines , oncostatin M and ciliary neurotrophic factor , and the LIF receptor beta and glycoprotein gp 130 in normal human tissues and in the endometrium of fertile women . ^^^ The LIF receptor beta is expressed during the proliferative and secretory phases of the cycle and is restricted to the luminal epithelium . ^^^ The associated signal transducing component of the LIF receptor , gp 130 , is also expressed in both the luminal and glandular epithelium throughout the cycle . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Dexamethasone inhibited both basal and LIF induced ACTH secretion ( P < 0 . 05 ) and LIF induction of ACTH was also attenuated by immuneutralization of either the LIF receptor ( 35 % , P < 0 . 05 ) or the gp 130 affinity converter ( 41 % , P < 0 . 05 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Both cytokine receptors contain gp130 / interleukin 6 receptor transducer as well as gp190 / low affinity LIF receptor . ^^^ Similar results were obtained in the JEG cell line , which only expressed the gp130 / gp190 high affinity LIF receptor , by adding a soluble form of the alpha CNTF receptor to the system to reconstitute the high affinity type CNTF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Interaction of the human IL 11R alpha with murine gp 130 was demonstrated : expression of the human IL 11R alpha in murine M 1 cells which constitutively express murine gp 130 ( and murine LIF receptor ) , resulted in the generation of specific high affinity binding sites for IL 11 ( Kd = 250 pM ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This report documents the mRNA expression profiles of LIF and the two components of the LIF receptor complex , LIF R and gp 130 , during early mouse embryogenesis . ^^^ In contrast , LIF R mRNA was found in the inner cell mass but not in the trophectoderm . ^^^ High levels of LIF R and gp 130 mRNAs were observed in the deciduum , however . ^^^ Complementary tissue specific expression of LIF and LIF receptor mRNAs in early mouse embryogenesis . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Thus , we studied the level of expression and cellular distribution of transcripts for LIF , its receptor ( LIFR ) , and signal transducing subunit gp13O during rat liver regeneration after both simple partial hepatectomy ( PH ) and the oval cell activation induced by the combination of 2 acetylaminofluorene and PH . ^^^ In situ hybridization clearly revealed a strong expression of LIF , LIFR , and gp13O in the oval cells and demonstrated only a weak expression in the parenchyma . ^^^ We hypothesize that the LIF / LIFR gp 130 system may be involved in the expansion and differentiation of the liver stem cell compartment . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We have further investigated this role and show here that the generation of neurons in cultures of embryonic day 10 spinal cord cells is inhibited by antibodies to the beta subunit of the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Moreover , other members of the CNTF cytokine family that use gp 130 and / or LIF receptor beta as their signal transducing receptors LIF , oncostatin M , interleukin 6 , and interleukin 11 had similar effects on increasing ChAT activity and reducing 5HT expression in RN46A cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Using the reverse transcription polymerase chain reaction ( RT PCR ) we found that , in culture , normal human keratinocytes ( KC ) expressed mRNA transcripts for both LIF and the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In this study , in vivo and in vitro expression of LIF and its signal transducer genes , LIFR and gp 130 in medulloblastoma cells and its role ( s ) in the cell proliferation were investigated by different approaches . ^^^ The results revealed that 12 out of 13 cases examined were found to express LIF and more than 90 % of the samples to express LIFR and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We now use qualitative and semiquantitative RT PCR to demonstrate that LIF and LIF receptor ( LIF R ) are constitutively expressed in the normal mouse hypothalamus and pituitary . ^^^ Hypothalamic and pituitary LIF and LIF R are significantly induced ( up to 6 and 4 fold , respectively ) in vivo in response to lipopolysaccharide endotoxin ( LPS ) administered to B6D2F1 and C57BL / 6 mice . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
IL 6 triggers homodimerization of gp 130 , whereas CNTF and LIF induce heterodimerization of gp 130 and LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF receptor mRNA was expressed in fetal , neonatal and adult murine hearts and cultured murine cardiac myocytes . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We recently reported LIF and LIF receptor expression in human fetal pituitary corticotrophs in vivo and demonstrated LIF stimulation of adrenocorticotrophin ( ACTH ) transcription in vitro , suggesting a role for LIF in corticotroph development . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
IL 10 , by inducing the receptor for LIF ( LIFR ) , produced a functional autocrine OM loop in XG 1 and XG 2 cells and in primary myeloma cells from 2 patients . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
DT ( 1 389 ) LIF ( 2 184 ) peptide was selectively cytotoxic for cultured neuroblastoma cells bearing the LIF receptor , and for sympathetic neurons . ^^^ Mutational analysis suggested that the C terminal helix ( helix D ) of human LIF may , in part , constitute or contribute to the active site for LIF receptor binding and cell activation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This LIFR . gp130 complex is also a functional receptor for LIF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leptin stimulation induces tyrosine phosphorylation of neither gp 130 nor LIFR , while LIF stimulation does both . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Other cytokines oncostatin M ( OM ) , leukemia inhibitory factor ( LIF ) or ciliary neurotrophic factor ( CNTF ) also use the gp 130 transducer and induce its heterodimerization with LIF receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This last effect seems to be a direct one , because we found that LIF receptor ( LIF R ) is expressed in cells isolated from growing in vitro human erythroid BFU E colonies . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To continue these studies , we examined the mRNA expression of signal transducing molecule , gp 130 , and the LIF R as associated members of a receptor family . ^^^ The levels of gp 130 and LIF R mRNA expression had a maximum 2 3 fold increase over a 24 h period . ^^^ Maximum LIF R mRNA levels also differed depending on the type of treatment the rats received . ^^^ Injection of purified recombinant rat IL 6 ( rIL 6 ) had little effect on LIF R mRNA levels , but had a dramatic inducing effect on gp 130 mRNA levels . ^^^ Rats were also injected ( i . p . ) with Dexamethasone ( Dex ) and this had no effect on either gp 130 or LIF R mRNA level expression . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To define the specificity of the signal transduction by the LIF / OSM receptor ( a heterodimer of gp 130 and LIF receptor ( LIFR ) ) and the OSM specific receptor ( a heterodimer of gp 130 and OSM receptor ( OSMR ) ) , we reconstituted the receptor function by transfection into receptor negative Hep3B hepatoma cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Human OSM ( hOSM ) and LIF share a functional high affinity receptor that is composed of gp 130 and LIF receptor beta subunit ( LIFRbeta ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Human OSM is known to exhibit biological activities similar to LIF , because they share the same functional receptor composed of the LIF receptor and gp 130 . ^^^ These results indicate that mOSM functions through a receptor which is distinct from that of the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Although the expression of LIF was also up regulated , the LIF receptor gene was not expressed in the uninduced or induced JCS cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Taken together these results demonstrate that transcription of LIFR beta and gp 130 takes place throughout human preimplantation development , and suggest that functional LIF receptors might be present at these stages . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Contrary to the membrane anchored leukemia inhibitory factor receptor ( LIFR ) , the mouse soluble LIFR is an inhibitor of LIF action , possibly through a ligand titration effect . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
These responses are thought to be mediated through the functional LIF receptor ( LIFR ) , consisting of a heterodimeric complex of LIFR alpha chain ( LIFRalpha ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We have used insertional mutagenesis in an attempt to isolate molecules that participate in LIF signal transduction via the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a hematopoietic cytokine which elicits its effects on diverse cell types via both gp 130 and a more specific LIF receptor . ^^^ This may have implications for interactions with the specific LIF receptor , which binds in this region . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Carcinoma cells constitutively express LIF mRNA , and 23 lines ( 92 . 0 % ) and all ( 100 % ) of 25 lines express LIF receptor mRNAs of LIFRbeta and gp 130 , respectively . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) is a polyfunctional cytokine that is known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional , receptor complex . ^^^ Human LIF binds with unusually high affinity to a naturally occurring mouse soluble LIF receptor alpha chain , and this property was used to purify a stable complex of human LIF and mouse LIF receptor alpha chain from pregnant mouse serum . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Cytokines which signal through the LIF receptor and their actions in the nervous system . ^^^ The phenotypes of the receptor knockouts show clear deficits in nervous system development , indicating a crucial role for LIF receptor signalling . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In the present study we show that CT 1 binds to the KB epidermoid cancer cell surface through a tripartite receptor complex which includes the gp 130 signal transducing protein , LIF receptor beta ( LIFR beta ) and a third component displaying a molecular weight of 80 kDa . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The leukemia inhibitory factor receptor ( LIF R ) is activated not only by LIF , but also by cardiotrophin 1 , ciliary neurotrophic factor with its receptor , and oncostatin M ( OSM ) . ^^^ Each of these cytokines induces the hetero oligomerization of LIF R with gp 130 , a signal transducing subunit shared with interleukin 6 and interleukin 11 . ^^^ The introduction of mutations into human LIF that reduced the affinity for gp 130 while retaining affinity for LIF R has generated antagonists for LIF . ^^^ In the current study , a LIF antagonist that was free of detectable agonistic activity was tested for antagonism against the family of LIF R ligands . ^^^ On cells that express LIF R and gp 130 , all LIF R ligands were antagonized . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Treatment of HepG 2 cells with CT 1 resulted in the induction of tyrosine phosphorylation of both transducing receptor subunits , gp 130 and LIF receptor , and this phosphorylation was completely inhibited by a neutralizing anti gp 130 mAb . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In this study , we analyzed the structure and expression of rat LIF receptor alpha chain ( rLIFR alpha ) cDNA . ^^^ The rLIFR alpha protein shows a high degree of similarity to mouse and human LIF receptor alpha chain protein ( 89 % and 76 % amino acid sequence identities , respectively ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Gene expression for LIF receptor ( LIFR ) ( p < 0 . 02 ) was similar to that for 17alpha hydroxylase , while brachyury gene expression began in 6 mm conceptuses and increased ( p < 0 . 001 ) throughout development . ^^^ LIFR expression is highly associated with steroidogenic enzyme production with an initial peak preceding rapid trophoblastic elongation , suggesting that LIF may be involved in early conceptus development in the pig . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF , CNTF , and CT 1 act through the known receptors LIF receptor beta ( LIFRbeta ) and gp 130 and well defined signaling pathways including receptor phosphorylation and STAT 3 activation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Strong candidates for peripheral factors regulating Reg 2 production are cytokines of the LIF / CNTF family , because Reg 2 is not expressed in developing motor or sensory neurons of mice carrying a targeted disruption of the LIF receptor gene , a common component of the receptor complexes for all of the LIF / CNTF family . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Each of the antibodies reacted with a distinct epitope on gp 190 expressed either by gp 190 transfected Chinese hamster ovary cells or by the LIF receptor positive choriocarcinoma JAR cell line . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
METHODS : Active transcription of LIF , IL 6 , and OSM , their related receptors ( LIF R , IL 6 R , and gp 130 ) , and the consecutive signal transducing molecules ( STAT 1 , STAT 3 , and STAT 5a ) were analyzed in reverse transcriptase polymerase chain reaction experiments . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
However , because this reduction is only partial it suggests that LIF may not be the predominant endogenous ligand signaling through the LIFR . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The percentage of neurones surrounded by TH IR baskets within the L 3 and L 4 dorsal root ganglia following sciatic axotomy was significantly reduced in animals treated continuously for 2 weeks with a monoclonal antibody against the LIF receptor motif , gp 130 ( 0 . 833 mg ml 1 ) ( P < 0 . 05 , Mann Whitney U test ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF receptor is expressed in endometrial tissue throughout the menstrual cycle and on human blastocysts in a stage dependent manner . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Additionally , LIF enhances association of SHP 2 with the gp 130 subunit of the LIF receptor signaling complex . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Testicular leukemia inhibitory factor ( LIF ) and LIF receptor mediate phosphorylation of signal transducers and activators of transcription ( STAT ) 3 and STAT 1 and induce c fos transcription and activator protein 1 activation in rat Sertoli but not germ cells . ^^^ LIF receptor mRNA was demonstrated in rat somatic cells , rat elongating spermatids , and all of the mouse germ cells . ^^^ Species specificity in the expression of LIF receptor as well as ligand binding may play a role in LIF signaling in these germ cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a polyfunctional cytokine known to require at least two distinct receptor components ( LIF receptor alpha chain and gp 130 ) in order to form a high affinity , functional receptor complex . ^^^ Both forms of gp 130 bound LIF specifically and were capable of forming heterotrimeric complexes with soluble human LIF receptor alpha chain in the presence of human LIF . ^^^ In addition to the soluble forms of gp 130 , a soluble form of LIF receptor alpha chain was also detected in human urine and plasma . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF signal transducing complex contains two receptor molecules , the LIF receptor ( LIFR ) and gp 130 . ^^^ Although some mutagenesis data on LIF are available , it is not yet known which regions of LIFR or gp 130 bind LIF . ^^^ Analyses of the electrostatic isopotential surfaces of the CBD models suggest that gp 130 and the membrane proximal CBD of LIFR hetero dimerize and bind LIF through contacts similar to those seen in the growth hormone receptor dimer . ^^^ LIF receptor gp 130 interaction investigated by homology modeling : implications for LIF binding . ^^^ This work further demonstrates the utility of electrostatic analyses of homology models and suggests a strategy for biochemical investigations of the LIF receptor complex . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
A soluble form of the LIF R alpha , called LIF binding protein ( LBP ) has been isolated from mouse serum . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To begin to understand the in vivo relevance of these observations , we investigated the expression of LIF and LIFR in human breast cancer specimens . ^^^ Specimens from 50 cases were immunostained with mouse monoclonal antibodies D62 . 3 and M 1 ( to stain for LIF and LIFR , respectively ) . ^^^ Coexpression of LIF and LIFR was associated with diploidy ( P = 0 . 02 ) and low SPF ( P = 0 . 05 ) . ^^^ LIF staining was primarily cytoplasmic whereas LIFR staining was cytoplasmic in the majority of cases and membranous in a minority of cases . ^^^ The presence of LIFR in the primary tumor specimens correlated with the growth stimulation of tumor cells ( derived from the same specimens ) by exogenous LIF in methylcellulose colony assays . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Immunoneutralization studies demonstrated the dependence of LIF action on both the specific LIF receptor ( 35 % inhibition ; p < 0 . 05 ) and also the gpl 30 affinity converter ( 41 % inhibition ; p < 0 . 05 ) . ^^^ Thus LIF action in pituitary corticotrophs is dependent on LIF receptor heterodimerisation with gpl 30 and involves STAT protein tyrosyl phosphorylation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Differential temporal expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha and gp 130 ) in injured peripheral nerves . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIFR beta was expressed by more cells than CNTFR alpha ; therefore , although the factors were equipotent , the maximal effect of LIF > CNTF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
There was a change in the expression of ciliary neurotrophic factor , but the expression of cardiotrophin 1 ( CT 1 ) and the common receptor subunit LIF receptor beta ( LIFRbeta ) did not change after neurotoxin treatment . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF receptor complex is composed of a heterodimer of LIF receptor alpha ( LIFR alpha ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We have expressed wild type human gp 130 or three mutants in murine myeloid M 1 UR21 cells that lack functional endogenous gp 130 but express the IL 6 receptor ( IL 6R ) and the LIF receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In NIH 3T3 cells ( which endogenously express gp 130 , LIF receptor beta [ LIFRbeta ] , and the protein product , c 12 , of the cDNA described here ) , mouse LIF , human LIF , and human OSM signaled through receptors containing the LIFRbeta and gp 130 but not through the mouse OSM receptor . ^^^ Mouse OSM , however , signaled only through a c 12 gp130 complex ; it did not use the LIF receptor . ^^^ In mouse cells , only mouse OSM is capable of activating the mouse OSM receptor ; human OSM instead activates the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
As this loop is close to a receptor binding site on LIF that makes a major contribution to high affinity binding to the LIF receptor alpha chain , these differences between the solution and crystal structures should be taken into account in structural models of LIF receptor interactions . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In addition , cytokines or their receptors not known to be expressed in RPE were included to widen our picture of cytokine gene expression in the eye : stem cell factor ( SCF ) , its receptor ( SCF R ) , low affinity nerve growth factor receptor p 75 ( p 75 ( NGF R ) , ciliary neutrothropic factor ( CNTF ) , and its receptor ( CNTF R ) , glycoprotein 130 interleukin 6 transducer ( gp 130 ( IL 6 SD ) , leukemia inhibitory factor ( LIF ) , and its receptor ( LIF R ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The functional receptor for ciliary neurotrophic factor ( CNTF ) is comprised of a CNTF binding entity termed CNTF receptor alpha ( CNTFRalpha ) , and 2 signaling molecules called LIF receptor beta and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
However , as neither mice lacking LIF nor mice lacking the LIF receptor show defects in PGC growth , an alternate cytokine for PGC growth has been postulated . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The propagation of pluripotential mouse embryonic stem ( ES ) cells is sustained by leukemia inhibitory factor ( LIF ) or related cytokines that act through a common receptor complex comprising the LIF receptor subunit ( LIF R ) and the signal transducer gp 130 . ^^^ However , the findings that embryos lacking LIF R or gp 130 can develop beyond gastrulation argue for the existence of an alternative pathway ( s ) governing the maintenance of pluripotency in vivo . ^^^ This activity , which we name ES cell renewal factor ( ESRF ) , is distinct from members of the IL 6 / LIF family because ( 1 ) it is effective on ES cells lacking LIF R ; ( 2 ) it is not blocked by anti gp 130 neutralizing antibodies ; and ( 3 ) it acts without activation of STAT 3 . ^^^ These findings establish that ES cell pluripotency can be sustained via a LIF R / gp130 independent , STAT 3 independent , signaling pathway . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
RNA expression of leukaemia inhibitory factor ( LIF ) and its receptor subunits glycoprotein 130 and LIF receptor beta in bovine embryos derived in vitro or in vivo . ^^^ Leukaemia inhibitory factor ( LIF ) plays an essential role during cell differentiation and implantation in the mouse exerting its effects via the two dimerizing receptor subunits glycoprotein 130 ( gp 130 ) and LIF receptor beta ( LR beta ) . ^^^ These results indicate perturbation of the mRNA expression pattern of the specific LIF LIF receptor system in embryos generated in vitro that could lead to abnormal differentiation of the cell compartments forming the blastocyst . ^^^ Cumulus cells , frequently used as supportive factor in co culture in bovine in vitro embryo production , are a rich source of the LIF LIF receptor system acting in a paracrine and / or autocrine manner . ^^^ The biological function of the LIF LIF receptor system during bovine preimplantation development warrants further investigation . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This pattern of specificity was accounted for by the finding that EF cells express gp 130 , but not the ligand binding subunit of the IL 6 receptor ( gp 80 ) nor the LIF receptor beta . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukaemia inhibitory factor ( LIF ) signals via a heterodimeric receptor complex comprised of the LIF receptor ( LIFR ) and the interleukin ( IL ) 6 signal transducer gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Cell type specific responses to the leukemia inhibitory factor ( LIF ) / interleukin 6 cytokine family are mediated by dimerization of the LIF receptor alpha chain ( LIFRalpha ) with the signal transducer gp 130 or of two gp 130 molecules followed by activation of the JAK / STAT and Ras / mitogen activated protein kinase cascades . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The distribution and regulation of leukemia inhibitory factor ( LIF ) and its receptor ( LIFR ) in human lung tissue is unknown . ^^^ The present study aimed to determine the cellular distribution and regulation of gene transcripts for LIF and LIFR in human lung , and measured the release of LIF in response to anti immunoglobulin ( Ig ) E , interleukin ( IL ) 1beta , and IL 6 . ^^^ Expression of LIFR mRNA was not influenced by exposure to IL 1beta or LIF in any of the cell lines used . ^^^ Leukemia inhibitory factor ( LIF ) and LIF receptor in human lung . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Enforced secretion of this protein demonstrated that it could act as a LIF receptor agonist . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
IL 6 ) , whereas CNTF and leukemia inhibitory factor ( LIF ) signal via a heterodimer of gp 130 and LIF receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The functional receptor for LIF is composed of LIFR alpha chain ( LIFRalpha ) and gp 130 both of which are shared in the functional receptors for oncostatin M , ciliary neurotrophic factor , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The expression of LIF R and LIF was examined in human trophoblast and decidua using in situ hybridization and immunocytochemistry . ^^^ LIF R mRNA and immunoreactivity was localized in villous and extravillous trophoblast throughout pregnancy , and in endothelial cells of the fetal villi . ^^^ Extravillous trophoblast , which invades the maternal decidua , therefore expresses LIF R as it moves past decidual leukocytes , which express LIF mRNA . ^^^ LIF may also play a critical role in controlling angiogenesis in the placental villi , since human fetal endothelial cells express LIF R , and mice lacking a functional LIF receptor gene show altered vascular development in the placenta . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Two types of functional hOSM receptors are known : the type 1 OSM receptor is identical to the LIF receptor that consists of gp 130 and the LIF receptor beta subunit ( LIFRbeta ) , and the type 2 OSM receptor consists of gp 130 and the OSM receptor beta subunit ( OSMRbeta ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induces growth arrest and macrophage differentiation of mouse myeloid leukemic cells through the functional LIF receptor ( LIFR ) , which comprises a heterodimeric complex of the LIFR subunit and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OM signals are transduced through two different OM receptor complexes : a leukemia inhibitory factor ( LIF ) / OM receptor ( a heterodimer of LIFR beta and gp 130 ) and an OM specific receptor ( a heterodimer of OMR beta and gp 130 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We demonstrate that Schwann cells express mRNAs for LIF and the LIF receptor components LIF receptor subunit beta and glycoprotein 130 in vitro . ^^^ Not only does exogenous LIF promote survival under these conditions , but addition of the soluble LIF receptor ( LIF binding protein ) and anti LIF antibodies significantly reduced cell survival , suggesting that LIF exerts autocrine effects . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
RESULTS : Peripheral blood eosinophils express LIF and messenger RNA for LIF and LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF acts through a receptor complex composed of a low affinity LIF receptor ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
It is shown herein that expression of leukemia inhibitory factor ( LIF ) and LIF receptor is developmentally regulated during adipocyte differentiation . ^^^ Preadipocytes secrete bioactive LIF , and an antagonist of LIF receptor inhibits adipogenesis . ^^^ Genetically modified embryonic stem ( ES ) cells combined with culture conditions to commit stem cells into the adipocyte lineage were used to examine the requirement of LIF receptor during in vitro development of adipose cells . ^^^ These results are in favor of a model that implicates stimulation of LIF receptor in the commitment of preadipocytes to undergo terminal differentiation by controlling the early expression of C / EBPbeta and C / EBPdelta genes via the mitogen activated protein kinase cascade . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Presence of leukaemia inhibitory factor ( LIF ) and LIF receptor chain ( gp 190 ) in osteoclast like cells cultured from human giant cell tumour of bone . ^^^ The direct effect of LIF on MNC was examined by a post embedding colloidal gold immunocytochemistry process using human anti LIF and anti LIF receptor ( chain gp 190 ) antibodies . ^^^ Immunolocalization of LIF and LIF receptor revealed the presence of this cytokine and its receptor within the cytoplasm and nucleus of active resorbing MNC . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Since EC cell lines also expressed LIF receptor transcripts , the novel LIF transcription profiles and proteins identified here suggest a role for autocrine and / or cell autonomous LIF signaling during germ cell tumorigenesis . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
These results suggest that TrkB , a functional high affinity receptor of BDNF and NT 4 / 5 , and LIFR beta , a receptor component contained in CNTF and LIF receptor complex , might be involved in the observed synergistic effects . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OBJECTIVE : To examine the expression of leukemia inhibitory factor ( LIF ) and its receptor ( LIF R ) transcripts in human and murine preimplantation embryos . ^^^ MAIN OUTCOME MEASURE ( S ) : The transcript levels of LIF and LIF R in these embryos were examined and semiquantitated using single cell reverse transcription polymerase chain reaction methodology . ^^^ RESULT ( S ) : Leukemia inhibitory factor and LIF R transcripts were detectable in most human preimplantation embryos ( 30 of 34 and 31 of 34 embryos showed LIF and LIF R messenger RNA , respectively ) . ^^^ The expression of LIF and LIF R genes in murine embryos was inconsistent . ^^^ CONCLUSION ( S ) : Preimplantation human embryos express LIF and LIF R messenger RNA . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OSM and LIF can bind to the same functional receptor complex ( LIF receptor beta and gp 130 heteromultidimers ) and thus mediate overlapping spectra of biological activities . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 , ciliary neurotrophic factor , and oncostatin M ( OSM ) lead to heterodimerization of LIF receptor ( LIFR ) or the OSM specific receptor ( OSMR ) with glycoprotein ( gp ) 130 , the common receptor subunit for IL 6 type cytokines . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of CNTF / LIF receptor components and activation of STAT 3 signaling in axotomized facial motoneurons : evidence for a sequential postlesional function of the cytokines . ^^^ To investigate the role of CNTF / LIF signaling in regenerative responses of motoneurons , we studied the expression of the three receptor components , CNTF receptor alpha ( CNTFRalpha ) , LIF receptor beta ( LIFRbeta ) , and gp 130 , and the activation of the STAT 3 signal transduction pathway in the rat facial nucleus following peripheral nerve transection . ^^^ In agreement with previous studies showing a complementary regulation of CNTF and LIF in the lesioned facial nerve , our observations on the postlesional regulation of CNTF / LIF receptor components in the facial nucleus indicate a direct and sequential action of the two neurotrophic proteins on axotomized facial motoneurons . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Therefore , in vivo and in vitro expression of LIF , IL 6 and their signal transducer genes encoding LIF receptor ( LIFR ) , IL 6 receptor ( IL 6R ) and gp 130 in human medulloblastoma cells were investigated by multiple cellular and molecular biology approaches . ^^^ The results revealed that LIF expression could be found in 26 out of 28 tumors / cell line and over 90 % of the samples expressed LIFR , IL 6R and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Using in situ hybridization histochemistry , we characterized the spatiotemporal gene expression patterns of leukemia inhibitory factor ( LIF ) and glial cell line derived neurotrophic factor ( GDNF ) , and their receptor components ( LIFR , GFR alpha 1 , RET ) induced in muscle cells , intramuscular nerves , and motoneurons in the regeneration processes of both muscle cells and nerves following muscle contusion . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Residues involved in LIF receptor binding showed no consistent pattern of backbone mobilities , with S 2 values ranging from 0 . 71 to 0 . 95 , but residues contributing to receptor binding site 3 had relatively lower S 2 values , implying higher amplitude motions than for the backbone of sites 1 and 2 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The neurally active cytokine leukemia inhibitory factor ( LIF ) signals through a bipartite receptor complex composed of LIF receptor alpha ( LIFR ) and gp 130 . gp 130 and LIFR contain consensus binding motifs for the protein tyrosine phosphatase SHP 2 surrounding tyrosines 118 and 115 ( Y 118 and Y 115 ) of their cytoplasmic domains , respectively . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the LIF receptor and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Pregnancy dependent expression of leukaemia inhibitory factor ( LIF ) , LIF receptor beta and interleukin 6 ( IL 6 ) messenger ribonucleic acids in the porcine female reproductive tract . ^^^ We examined the relative expression of the mRNAs encoding LIF and IL 6 , as well as the LIF binding subunit ( LIFR beta ) of the LIF receptor and , as a potential downstream cytokine responsive gene , beta ( 2 ) microglobulin ( beta ( 2 ) m ) , in porcine peri implantation conceptuses , and in placenta and endometrium during early and mid pregnancy . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The two cytokines bind with high affinity to the same receptor ( LIF / OSM receptor ) , which consists of the LIF receptor alpha chain ( LIFRalpha ) and the signal transduction unit gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The levels of the LIF receptor and insulin like growth factor 1 receptor levels were markedly decreased in the muscles of dy mice during the entire postnatal period observed in this study . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To generate type 1 or type 2 OSM receptors , gp 130 mutants were expressed together with either LIF receptor beta or OSM receptor beta . ^^^ The present study demonstrates that positions 189 192 of gp 130 cytokine binding domain are essential for OSM binding to both gp130 / LIF receptor beta and gp130 / OSM receptor beta heterocomplexes . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This region of the lif protein ( AB loop ) interacts with the lif receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
One of the conundrums regarding signalling through the LIF receptor is how it can have multiple , often conflicting roles in different cell types , such as enhancing the differentiation of astrocytes while inhibiting the differentiation of some neuronal cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Since LIF together with LIFRalpha appear to form a more stable complex with gp 130 than OSM with gp 130 and OSMRbeta , co activation of LIFR and OSMR resulted in a predominant LIF like response . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of leukemia inhibitory factor ( LIF ) and LIF receptor ( LIF R ) in the human adrenal cortex : implications for steroidogenesis . ^^^ The current study was designed to analyze whether the pleiotropic cytokine leukemia inhibitory factor ( LIF ) and / or its receptor ( LIF R ) are expressed in the normal human adrenal cortex , and whether they may play a role in regulating steroidogenesis . ^^^ Using LIF and LIF R specific primers , we show by RT PCR that both mRNAs are expressed in this tissue , as well as in the NCI H 295 adrenal carcinoma cell line . ^^^ Immunohistochemistry , employing specific antibodies against LIF and LIF R , reveals expression of both proteins in the normal human adrenal cortex . ^^^ Our stimulation experiments indicate that the intraadrenal LIF / LIF R system may participate in regulating adrenal steroidogenesis . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF receptor shares a common gp 130 receptor subunit with the IL 6 cytokine superfamily . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) signals via the heterodimeric receptor complex comprising the LIF receptor alpha subunit ( LIFRalpha ) and the common signal transducing subunit for interleukin 6 cytokine receptors , gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This study examined changes in the expression , localization , and hormonal regulation of LIF receptor ( LIFRbeta ) gene expression in the uterus of the skunk . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Specific LIF receptors ( LIFR ) were immunolocalized to both cholinergic and sensory nerves . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In peripheral blood lymphocytes LIF receptor alpha expression was downregulated in the presence of 10 microg / ml OM 85 BV . ^^^ Suppression of IL 12 and LIF receptor alpha further contributes to organ protection . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Furthermore , almost no phosphorylated STAT 3 ( signal transducer and activator of transcription 3 ) , downstream of the LIF receptor and the gp 130 signaling subunit , was observed in the ventricles of JVS and control mice . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This goal of this study was to examine immunohistochemical distribution of leukemia inhibitory factor ( LIF ) , LIF receptor ( LIFR ) , and glycoprotein ( gp ) 130 in rhesus monkey uterus during the menstrual cycle and early pregnancy . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Since the LIF receptor also contains an SHP 2 recruitment site whereas the OSM receptor lacks such a module , we propose that two SHP 2 binding modules within a homo or heterodimeric receptor are necessary to mediate the PMA inhibitory effect . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We found that expression of c Fos , c Jun , and JunB was induced upon LIF treatment whereas that of JunD , the tyrosine phosphatase ESP , and the components of the LIF receptor remained unaffected . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The biological actions of interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , and ciliary neurotrophic factor ( CNTF ) are mediated via respective functional receptor complexes consisting of a common signal transducing component , gp 130 , and other specific receptor components , IL 6 receptor alpha ( IL 6R ) , LIF receptor beta ( LIFR ) , and CNTF receptor alpha ( CNTFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
After all types of injury , the mRNAs for GDNF receptors ( GFRalpha 1 and c RET ) and the LIF receptor LIFR were distinctly ( up to 300 % ) up regulated in motoneurons . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
All of these cell lines express the receptor components of OSM and leukemia inhibitory factor ( LIF ) gp 130 , LIFR and the OSM specific OSMRbeta . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Structural and functional studies on the leukemia inhibitory factor receptor ( LIF R ) : gene and soluble form of LIF R , and cytoplasmic domain of LIF R required for differentiation and growth arrest of myeloid leukemic cells . ^^^ The leukemia inhibitory factor receptor ( LIF R ) subunit is a component of cell surface receptor complexes for the multifunctional cytokines , LIF , cardiotrophin 1 , ciliary neurotrophic factor , and human oncostatin M . ^^^ The structure of the human LIF R gene is similar to that of the mouse gene . ^^^ On the other hand , LIF R mRNAs containing unspliced introns are abundantly present in human tissues . ^^^ Human choriocarcinoma cells expressing these mRNAs release soluble LIF R . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF , LIF receptor , gp 130 , as well as type 1 and 2 T helper cytokine expressions were investigated by reverse transcription polymerasse chain reaction , in situ hybridization , and histological studies . ^^^ LIF and LIF receptor mRNA expressions were observed 24 hr and 21 days posttransplantation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Eighteen pituitary adenoma biopsies removed in transsphenoidal surgery ( six corticotrophic adenomas , four nonfunctioning adenomas , four somatotrophinomas , four prolactinomas ) and six normal anterior pituitaries were examined for the expression of IL 6 receptor ( R ) , leukemia inhibitory factor ( LIF ) , LIF R , IL 11 , IL 11 R , oncostatin M ( OSM ) , OSM R , ciliary neurotrophic factor ( CNTF ) , CNTF R and cardiotrophin 1 ( CT 1 ) . ^^^ The expression of all other cytokines ( LIF , IL 11 , CNTF ) and receptors ( IL 6 R , LIF R , IL 11 R , OSM R , CNTF R ) was found in different patterns in the adenoma subtypes and normal pituitaries . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Western blot analysis showed that bone marrow derived mast cells failed to express both LIF receptor ( LIFR ) and gp 130 , whereas 3T3 fibroblasts expressed both LIFR and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Involving of the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit , IL 6 related signal transducer gp 130 or fas death domain for MAPK p42 / 44 activation in HL 60 cell with LIF or anti Fas IgG . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The expression of LIF by these cells caused resistance to this cytokine due to loss of the LIF receptor ( LIFR ) , from the cell surface , suggesting its retention . ^^^ The amount of LIFR was down regulated in both LIF and OSM producing cells and this effect was not found in wild type U 373 MG cells treated with externally added cytokines . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The mRNA expressions of IL 6 , IL 6 receptor , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) receptor alpha , and LIF receptor beta showed no significant differences by the addition of IL 6 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Indeed , by immunohistochemistry , LIF and LIF receptor proteins were identified in Leydig and Sertoli cells but not in other testicular cell types , except for LIF receptor in spermatogonia . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of mRNAs for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , interleukin 6 ( IL 6 ) , and their receptors ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) in human peripheral neuropathies . ^^^ The mRNA levels of neuropoietic cytokines , ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor ( LIF ) , and interleukin 6 ( IL 6 ) , and their receptor components ( CNTFR alpha , LIFR beta , IL 6R alpha , and gp 130 ) were examined in seventy six patients with various peripheral neuropathies to determine the extent of expression of these cytokines and receptors , and their relationship to nerve fiber pathology and cell infiltration in the diseased nerves . ^^^ In contrast , the mRNA levels of LIF , IL 6 and the ligand binding receptor components ( CNTFR alpha , LIFR beta and IL 6R alpha ) were elevated to variable extent in the diseased nerves . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This study focuses on the expression of the neuropoietic cytokines leukemia inhibitory factor ( LIF ) and its receptor ( LIFR ) and interleukin 6 ( IL 6 ) and its receptor ( IL 6R ) in intercellular signaling pathways in the olfactory mucosa after target ablation . ^^^ LIF expression was up regulated transiently at 2 days post OBX , when up regulated expression of LIFR also was detected on globose basal cells ( GBCs ) , a subpopulation of which are immediate progenitors of olfactory receptor neurons . ^^^ In the olfactory nerve ( ON ) , LIF positive and IL 6 positive macrophage infiltration was followed by the transient up regulation of expression of LIFR , IL 6 , and IL 6R in ensheathing cells by 3 days post OBX . ^^^ The mRNAs for LIF / LIFR , IL 6 / IL 6R , and their common signal transduction molecule , gp 130 , in olfactory nasal mucosa from control mice and from 3 day post OBX mice were detected with reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Dual control of LIF expression and LIF receptor function regulate Stat 3 activation at the onset of uterine receptivity and embryo implantation . ^^^ The responsiveness of the LE to LIF is regulated temporally , with Stat activation being restricted to day 4 of pregnancy despite the presence of constant levels of LIF receptor throughout the preimplantation period . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In preadipocytes , their expression is up regulated by the activation of leukemia inhibitory factor receptor ( LIF R ) and prostacyclin receptor ( IP R ) via the extracellular signal regulated kinase ( ERK ) pathway and cAMP production , respectively . ^^^ LIF R and IP R activation induced binding of CREB and / or ATF 1 to C / EBP promoters and CREB dependent transcription . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Increased proliferation of parietal endoderm in lifr / embryoid bodies and addition of conditioned lif / cell culture supernatant promoted cardiomyogenesis , demonstrating for the first time that parietal endoderm also contributes to cardiomyogenesis in embryoid bodies in a paracrine and leukemia inhibitory factor and its receptor independent pathway . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The truncated forms of LIFR alpha subunit ( gp190EX ) and gp 130 ( gp130EX ) which can compete with the wild type receptor for binding to leukemia inhibitory factor ( LIF ) were expressed on the membrane of U 937 cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The level of staining within the connective tissue of injured nerves was elevated compared to control nerves , which may be due to the presence of LIF bound to the soluble secreted form of the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Binding of LIF to LIF receptor and gp 130 activates signal transduction pathways . ^^^ LIF receptor is expressed in endometrium , oocytes , and blastocysts . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Relative quantitative RT PCR was used to demonstrate that within hours of OBX , mRNAs encoding three key components in the leukemia inhibitory factor ( LIF ) signaling pathway , including LIF , LIF receptor ( LIFR ) , and STAT 3 , as well as cyclin D 1 , a growth factor sensor indicative of progenitor cell transformation , were upregulated . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Enhanced growth is rescued in vitro in LIF / mice by the addition of exogenous LIF , and the effect blocked by human LIF 05 , an LIF receptor antagonist . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The pericryptal fibroblast cells expressed messenger RNA ( mRNA ) for interleukin 6 ( IL 6 ) , leukemia inhibitory factor ( LIF ) , LIF receptor alpha , and the common coreceptor glycoprotein 130 ( GP 130 ) , but not the IL 6 receptor alpha . ^^^ In comparison , normal colonic epithelial cells express mRNA for LIF but not IL 6 as well as the receptors for GP 130 , IL 6 receptor alpha but not LIF receptor alpha . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The present study demonstrates an upregulation of both the LIF receptor ( LIFR ) alpha subunit and the signal transducing subunit gp 130 following endothelial denudation of the carotid artery by balloon catheter . ^^^ Continuous infusion of LIF ( 30 microg / kg / day ) resulted in the downregulation of LIFR alpha in injured arteries in vivo . ^^^ Similarly , smooth muscle cells in vitro treated with LIF exhibited a time dependent reduction in LIFR alpha protein expression and the subsequent reduction in transcription of the TIMP 1 gene . ^^^ However , in the presence of an intact endothelium , LIFR alpha was upregulated in response to LIF , and accordingly the downstream induction of iNOS expression was also increased . ^^^ Regulation of LIF receptor expression in vascular smooth muscle . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Either the NH ( 2 ) terminal ( chimera RILLIFdeltaI ) or the COOH terminal LIFR CBM ( chimera RILLIFdeltaII ) were replaced by the structurally related CBM of the IL 6R which does not bind LIF . ^^^ Chimera RILLIFdeltaI is functionally inactive , whereas RILLIFdeltaII binds LIF and mediates signalling as efficiently as the wild type LIFR . ^^^ Deletion mutants of the LIFR revealed that both the NH ( 2 ) terminal CBM and the Ig like domain of the LIFR are involved in LIF binding , presumably via the LIF site 3 epitope . ^^^ The main function of the COOH terminal CBM of the LIFR is to position the NH ( 2 ) terminal CBM and the Ig like domain , so that these can bind to LIF . ^^^ In analogy to a recently published model of the IL 6R complex , a model of the active LIFR complex is suggested which positions the COOH terminal CBM at LIF site 1 and the NH ( 2 ) terminal CBM and the Ig like domain at site 3 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In addition , we investigated the interaction between CT 1 / gp130 / LIF receptor and ET 1 / endothelin type A ( ET ( A ) ) receptor axis . ^^^ CT 1 and gp130 / LIF receptor were widely present in the cytoplasm of the cardiac fibroblasts . ^^^ Blockade of gp 130 or LIF receptor inhibited basal growth as well as CT 1 or ET 1 stimulated cardiac fibroblast growth . ^^^ In addition , growth of these cells stimulated by endogenous and exogenous CT 1 requires gp130 / LIF receptor as well as ET ( A ) receptor activation . ^^^ We conclude that gp130 / LIF receptor and ET ( A ) receptor activation are essential for cardiac fibroblast growth by CT 1 and that there is synergism with ET 1 / ET ( A ) receptor axis . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF receptor signaling limits immune mediated demyelination by enhancing oligodendrocyte survival . ^^^ We also demonstrate that this therapeutic effect complements endogenous LIF receptor signaling , which already serves to limit oligodendrocyte loss during immune attack . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
A functional role of the membrane proximal extracellular domains of the signal transducer gp 130 in heterodimerization with the leukemia inhibitory factor receptor . gp 130 is the common signal transducing receptor subunit of interleukin ( IL ) 6 type cytokines . gp 130 either homodimerizes in response to IL 6 and IL 11 or forms heterodimers with the leukemia inhibitory factor ( LIF ) receptor ( LIFR ) in response to LIF , oncostatin M ( OSM ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) or cardiotrophin like cytokine resulting in the onset of cytoplasmic tyrosine phosphorylation cascades . ^^^ Mutation of a specific cysteine in D 5 of gp 130 ( C458A ) leads to constitutive heterodimerization with the LIFR and increased sensitivity towards LIF stimulation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Oncostatin M can activate two related receptors , one consisting of a low affinity LIF receptor subunit , LIFR beta , which forms a heterocomplex with the gp 130 signal transducing protein and can recognize both oncostatin M and LIF , and a second heterocomplex consisting of a subunit that specifically recognizes oncostatin M , OSMR beta , and the gp 130 protein . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here , we report the construction and expression of a CNTF / soluble CNTF receptor ( sCNTF R ) fusion protein ( Hyper CNTF ) with enhanced biological activity on cells expressing gp 130 and leukemia inhibitory factor receptor ( LIF R ) , but not membrane bound CNTF R . ^^^ Hyper CNTF efficiently induced dose dependent STAT 3 phosphorylation and proliferation of BAF 3 cells stably transfected with gp 130 and LIF R cDNAs . ^^^ While on BAF3 / gp130 / LIF R cells , Hyper CNTF and LIF exhibited similar biological responses , the activity of Hyper CNTF on pheochromocytoma cells ( PC 12 cells ) was quite distinct from that of LIF . ^^^ These data indicate that although LIF and Hyper CNTF use the same heterodimeric receptor complex of gp 130 and LIFR , only Hyper CNTF induces neuronal differentiation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Continuous treatment with Dex ( 10 ( 8 ) mol / L ) inhibited the endogenous production of IL 6 , LIF , OSM , IL 11R , and OSMR , but had no detectable effect on the expression of IL 11 , CT 1 , CNTF , CNTFR , LIFR , or gp 130 . ^^^ Finally , treatment with exogenously added LIF stimulated IL 6 , LIF , LIFR , and OSMR , but had no other detectable effects . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Immunolocalization of gp 130 , IL 6R , and the LIF receptor showed that the glandular epithelium and also endothelial cells are targets for IL 6 and LIF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
IL 6 receptor , LIF receptor and gp 130 were all expressed by cultured stromal and epithelial cells , showing that the lack of effect is not due to lack of expression of the receptor components . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The aim of this study was to assess the expression and regulation of LIF receptor ( LIFR ) and gp 130 mRNA in mouse uterus during early pregnancy using in situ hybridization and reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The neurokine leukemia inhibitory factor ( LIF ) initiates signaling through heterodimerization of the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Upon binding LIF or cardiotrophin 1 , the LIF receptor alpha subunit ( LIFRalpha ) dimerizes with gp 130 , leading to activation of constitutively associated Jak 1 proteins and LIFRalpha gp 130 tyrosine phosphorylation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This was not because of the inactivity of the LIF or because the cell lines did not express components of the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) promotes giant cell differentiation in vitro , and LIF receptor ( LIFR ) deficiency results in loss of giant cell differentiation in vivo . ^^^ SOCS 3 : an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Normal human pituitary tissue expressed LIF , as well as the LIF receptor ( LIFR ) signaling subunits , gp 130 and LIFR . ^^^ Although all of 19 prolactinomas tested expressed gp 130 and LIFR subunit mRNA and immunoreactive protein , only 3 of 19 prolactinomas expressed LIF mRNA . ^^^ These results show that even though human prolactinomas express gp 130 and LIFR , and respond to exogenous LIF , albeit less than normal lactotrophs , they are largely devoid of LIF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Although antisense EGF receptor and LIF receptor ODNs inhibited EGF and LIF induced increase in differentiation , respectively , they were ineffective against hCG , suggesting that they use separate pathways , but they both converge on a common pathway requiring the hCG actions . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here we studied the expression of cytokines IL 6 , LIF , IL 1beta and TNFalpha and cytokine receptors IL 6R , LIFR and Gp 130 in the rat brain after kainic acid induced status epilepticus using Northern blot analysis and in situ hybridization histochemistry . ^^^ LIF was up regulated in the hippocampus , cortex and meninges after seizures , and LIFR mRNA was induced in the hippocampus and cortex . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OBJECTIVE : To determine cell type specific expression of leukemia inhibitory factor ( LIF ) and LIF receptor ( LIFR ) proteins relative to formation of pinopodes in human endometrial samples . ^^^ Pinopode formation and expression of LIF and LIFR were examined in endometrial samples . ^^^ Both surface and glandular epithelial cells expressed maximal levels of LIF and LIFR protein , in biopsy samples showed fully developed pinopodes . ^^^ Immunostaining of LIF was more intense in the glandular epithelium , whereas immunostaining of LIFR was most intense in the surface epithelium . ^^^ Before and after the appearance of pinopodes , LIF and LIFR immunostaining was less intense or faint . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 ( CT 1 ) , and oncostatin M ( OSM ) are four helix bundle cytokines acting through a common heterodimeric receptor composed of gp 130 and LIF receptor ( LIFR ) . ^^^ Molecular modeling of the complex of LIF with the Ig like domain of LIFR provides a clue for the superadditivity of the D214A / F284A double mutation . ^^^ Our results indicate that LIF , CT 1 , and OSM share an overlapping binding site located in the Ig like domain of LIFR . ^^^ The different behaviors of LIF and CT 1 , on one side , and of OSM , on the other side , can be related to the different affinity of their site 3 for LIFR . . ^^^ Leukemia inhibitory factor ( LIF ) , cardiotrophin 1 , and oncostatin M share structural binding determinants in the immunoglobulin like domain of LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Previous studies suggested that the NH ( 2 ) terminal CBM and the Ig like domain of the LIFR are most important for LIF binding and activity . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
IL 6 type cytokines exert their action via the signal transducers gp ( glycoprotein ) 130 , LIF receptor and OSM receptor leading to the activation of the JAK / STAT ( Janus kinase / signal transducer and activator of transcription ) and MAPK ( mitogen activated protein kinase ) cascades . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Among the family members , OSM is most closely related to leukemia inhibitory factor ( LIF ) and it in fact utilizes the LIF receptor in addition to its specific receptor in the human . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We further demonstrate that lesion induces upregulation of CNTF related cytokines ( LIF , NNT 1 ) and , interestingly , a more pronounced upregulation of cytokine receptor components ( LIF receptor beta , gp 130 ) and TGFbeta in CNTF deficient animals . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
RT PCR and Western blot analysis was used in order to detect gp 130 , IL 6 receptor , LIF receptor or OSM receptor specific protein and mRNA in human adult cardiac myocytes and for detection of VEGF 1 specific mRNA in cardiac myocytes after incubation with OSM . ^^^ We detected high levels of mRNA for gp 130 and the OSM receptor in freshly isolated human cardiac myocytes but only low amounts of mRNA for the IL 6 receptor whereas mRNA for the LIF receptor was hardly detectable by RT PCR . ^^^ OSM receptor and IL 6 receptor were also detectable by Western blotting whereas LIF receptor was only present as a faint band . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Results indicated that association of GPL to the intracellular portions of gp 130 , or LIF receptor , allowed the signaling cascade . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Differential expression ( DCM versus NF ) was observed by immunoblotting at each level of the signaling cascade , including receptor ligands ( IL 6 : 59 % , P < 0 . 01 ; leukemia inhibitory factor [ LIF ] : +54 % , P < 0 . 05 ) , receptor subunits ( LIF receptor : 16 % , P < 0 . 05 ) , signaling molecules ( the Janus kinase TYK 2 : 48 % , P < 0 . 01 ; STAT 3 : 47 % , P < 0 . 01 ) , and suppressors of cytokine signaling ( SOCS 1 : +97 % , P < 0 . 05 ; SOCS 3 : 49 % , P < 0 . 01 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) induced cell signaling occurs following sequential binding to the LIF receptor alpha chain ( LIFR ) , then to the gp 130 co receptor used by all members of the interleukin 6 family of cytokines . ^^^ By monovalently displaying human LIF on the surface of M 13 phage and randomizing clusters of residues in regions predicted to be important for human LIFR binding , we have identified mutations , which lead to significant increases in affinity for binding to LIFR . ^^^ Combining the mutations for each of these regions further increased the affinity , such that the best mutants bound to human LIFR with > 1000 fold higher affinity than wild type human LIF . ^^^ Despite increases in LIFR binding affinity , these mutants did not show any increase in activity as agonists of LIF induced proliferation of Ba / F3 cells expressing human LIFR and gp 130 compared with wild type LIF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The focus of TGFbeta inhibition is observed to be directed in genes involved in chemotaxis ( IL 15 , CXCL 1 , CXCL 2 , CCL 3 , CCL 4 , CCL 5 , CCL 9 ) , chemokine receptors ( CCR 5 , CCR 9 ) , LIF receptor , and FPR 2 , and on genes mediating cell migration ( MMP 9 , MMP 13 , MacMARCKS , endothelin receptor B , Ena / VASP , Gas 7 ) , apoptosis ( FAS , TNF , TNF receptor , caspase 1 and 11 ) , and host response to infection ( toll like receptor 6 , Mx 1 , and MARCO ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We demonstrate that RA induced differentiation of CCE ES cells is associated with ( 1 ) downregulation of the LIF receptor ( LIFR ) ; ( 2 ) decreased tyrosine phosphorylation of signal transducer and activator of transcription 3 protein ( Stat 3 ) ; and ( 3 ) increased activation of extracellular regulated kinase ( Erk1 / 2 ) . ^^^ We conclude that RA induces CCE ES cell differentiation in the presence of LIF , in part , by disrupting signaling between the LIFR / gp130 receptor and nuclear targets that are required to prevent ES cell differentiation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The phage displayed form of this peptide was able to compete with the LIF receptor alpha chain ( LIFR ) for binding to LIF ; however , the free synthetic peptide was unable to inhibit LIF LIFR binding or inhibit LIF bioactivity in vitro . ^^^ To mimic the effect of the phage particle and convert the free peptide into an antagonist of LIFR binding , a 40 kDa poly ( ethylene glycol ) ( PEG ) moiety was conjugated to the synthetic LIF binding peptide . ^^^ This PEG peptide conjugate was found to be both an antagonist of LIF LIFR binding and of LIF signaling in engineered Ba / F3 cells expressing LIFR and the gp 130 coreceptor . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Therefore , using the lithium pilocarpine status epilepticus model , we performed a detailed in situ hybridization time course study of five gp 130 cytokines ( interleukin [ IL ] 6 , leukemia inhibitory factor [ LIF ] , IL 11 , oncostatin m [ OSM ] , and ciliary neurotrophic factor ) , gp 130 , and the receptors of the cytokines we found to be induced ( IL 6 receptor [ IL 6R ] , LIF receptor [ LIF R ] , and IL 11 receptor [ IL 11R ] ) . ^^^ A mild and late induction of the IL 6R , LIF R , and IL 11R occurred after seizure with a scattered distribution . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The biological activities of LIF relevant to carcinogenesis , its expression , and signal transduction by the LIF receptor are described . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OB R is a single membrane spanning receptor most related to the gp 130 signal transducing component of the IL 6 receptor , the G CSF receptor , and the LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
While the expression of many of the markers was similar in mouse and human cells , significant differences were found in the expression of vimentin , beta 3 tubulin , alpha fetoprotein , eomesodermin , HEB , ARNT , and FoxD 3 as well as in the expression of the LIF receptor complex LIFR / IL6ST ( gp 130 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In the current study , the reverse transcription polymerase chain reaction ( RT PCR ) was employed to examine the expression patterns of LIF and its receptor ( LIFR ) genes in rabbit embryos during pre implantation development , and the uterine expression of LIF and LIFR was also evaluated by Western blotting . ^^^ Transcripts for LIFR were detected within morula and blastocyst stage embryos , while the LIF mRNA was only found in blastocysts ( from early to fully expanded blastocoel cavities ) , indicating that embryo derived LIF can act in an autocrine manner on the process of blastocyst formation . ^^^ The expression levels of LIF and LIFR in uterine epithelium were gradually increased during pre implantation period and reached their highest levels on days 6 . 5 of pregnancy , just before the time of blastocyst implantation , suggest that paracrine LIF circuit should exist between the endometrium and the early embryos , which may be involved in the embryo maternal dialogue and important for the blastocyst implantation . ^^^ The data present here show the stage specific and dynamic expression patterns of LIF and LIFR , both in embryos and endometrium , during early pregnancy in rabbits , which indicated that LIF might play an important role in the pre implantation development and subsequent implantation of rabbit embryos . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This study was carried out to test the hypothesis that LIF and LIF receptor ( LIFR ) are involved in the renal epithelial regeneration after acute renal failure . ^^^ First , the authors investigated the spatiotemporal expression of LIF and LIFR in fetal and adult rat kidney . ^^^ In developing kidney , LIF was expressed in the ureteric buds and LIFR was located in nephrogenic mesenchyme and the ureteric buds ; in adult kidney , LIF and LIFR expression was confined to the collecting ducts . ^^^ Next , the authors examined the expression of LIF and LIFR during the recovery phase after ischemia reperfusion injury . ^^^ Real time PCR analysis revealed that LIF mRNA expression was significantly increased from day 1 to day 7 after reperfusion and that LIFR mRNA was upregulated from day 4 to day 14 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This study tests the hypothesis that the reduced expression of LIF receptor ( LIFR ) observed in hepatoma cells is mediated by altered DNA methylation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To investigate this paradox , we isolated NSCs and generated neurospheres from embryonic mice either wild type , heterozygous , or homozygous null for LIF receptor ( LIFR ) beta . ^^^ In contrast , the clonogenicity of low density cultures of LIFR knockout cells was reduced in comparison with that of wild type cells grown in E+F and was unaffected by LIF . ^^^ LIF receptor signaling modulates neural stem cell renewal . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The LIF receptor ( LIF R ) / gp190 transcript was detected by reverse transcription polymerase chain reaction ( RT PCR ) in the rat testis from Day 13 . 5 postcoitum until adulthood . ^^^ These results were strengthened by in situ analysis , showing predominant LIF R immunoreactivity in spermatogonia at all ages studied . ^^^ In addition to the 190 kDa LIF R , Western blot analysis revealed the presence of a 50 to 60 kDa C terminal gp 190 isoform . ^^^ This truncated form , which is unable to bind LIF , was the only form expressed in meiotic germ cells , suggesting an original down regulation process of LIF R expression during spermatogenesis . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We show here that neural precursor cells isolated from embryonic rat cortices abundantly secrete leukemia inhibitory factor ( LIF ) and express its receptor components , gp 130 and LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Freshly collected stromal cells from both day 2 and 4 pregnant mice expressed mRNA for the LIF receptor , and the transcript level was higher in cells isolated on day 4 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Murine embryonic stem ( mES ) cells remain undifferentiated in the presence of leukemia inhibitory factor ( LIF ) , and activation of signal transducer and activator of transcription 3 ( STAT 3 ) via LIF receptor ( LIFR ) signaling appears sufficient for maintenance of mES cell pluripotency . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Mutation analysis of leukemia inhibitory factor receptor ( LIF R ) in ACTH secreting pituitary adenomas . ^^^ LIF and its receptor LIF R are abundantly expressed in normal pituitaries and in ACTH producing adenomas . ^^^ The present study was performed to evaluate the possible role of LIF R in the pathogenesis of ACTH secreting pituitary adenomas . ^^^ To test the hypothesis that a possible mutation of LIF R might be involved in pathogenesis of Cushing ' s disease we analyzed ACTH producing pituitary adenomas as well as inactive pituitary adenomas by RT PCR and direct cycle sequencing . ^^^ We thus conclude that mutations in LIF R are an unlikely cause for the development of Cushing ' s disease . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To date , more than 10 different four helix bundle ligands have been identified that incorporate gp 130 , or one of its close relatives such as LIF receptor , into functional oligomeric signaling complexes . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The mRNA levels of IL 6 , leukemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) and cardiotrophin 1 ( CT 1 ) as well as their receptor subunits , glycoprotein 130 ( gp 130 ) , IL 6 receptor ( IL 6R ) , LIFR , and CNTFR , were measured by semi quantitative RT PCR . ^^^ In TGR , the increased level of LIF was accompanied by a decrease in mRNA levels for LIFR and CNTFR . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Gene activities of cytokines and their receptors interleukin ( IL ) 6 , leukemia inhibitory factor ( LIF ) , IL 11 and IL 6 receptor ( IL 6 R ) , LIF receptor and gp 130 relevant to implantation revealed a 17 beta estradiol ( E 2 ) mediated up regulation of IL 6 and an E 2 and P 4 mediated up regulation of IL 6 R in hTERT EECs . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Both IFN gamma and LIF are produced by maternal cells and tissues at the fetal maternal interface , whereas the IFN gamma receptors ( IFN gamma R 1 and IFN gamma R 2 ) and LIF receptor are abundantly expressed on the surface of placental trophoblasts . ^^^ IFN gamma production was found to be inversely related to the IFN gamma R 2 protein expression , and LIF receptor protein expression in PE mimicked that in early placental development . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The tyrosine 974 within the LIF R chain of the gp130 / LIF R heteromeric receptor complex mediates negative regulation of LIF signalling . ^^^ Signalling of leukaemia inhibitory factor ( LIF ) , ciliary neurotrophic factor ( CNTF ) , cardiotrophin 1 ( CT 1 ) , CT 1 like factor ( CLC ) or oncostatin M ( OSM ) through gp130 / LIF R is believed to be similar due to the presence of the common signal transducer gp 130 within the receptor complexes utilized , but the difference in the composition of gp130 / gp130 homodimers and gp130 / LIF R heterodimers is likely to be reflected in different signalling . ^^^ Here , we analysed the contribution of the LIF R within the gp130 / LIF R complex to negative regulation mediated by SHP 2 and SOCS 3 . ^^^ We show that SHP 2 contributes to the negative regulation of signalling through gp130 / LIF R complexes . ^^^ The inhibitory tyrosine motifs within the cytoplasmic parts of gp 130 and the LIF R act independently . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The cytokine leukemia inhibitory factor ( LIF ) and its receptor LIFR have been extensively characterized in mammals . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Exogenous LIF attenuates ischemic brain injury by activating cytokine signaling through LIFR / gp130 . . ^^^ Leukemia inhibitory factor receptor and gp 130 were expressed in neurons , and the ischemic damage of these proteins was rescued in the high LIF group . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF acts on cells by binding to the LIF receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) and its receptor ( LIFR ) are `` twins ' ' of Oncostatin M ( OSM ) and OSMR , respectively , likely having arisen through gene duplications . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Epigenetic control of LIF receptor expression by histone acetylation can account for the gain of LIF responsiveness . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here we have provided evidence that major cell types expressing theLIF receptor ( LIFR ) and its signal transducing partner gp 130 are mostly disparate in the mouse uterus during the glandular LIF expression in the morning of day 4 . ^^^ In contrast , LIFR and gp 130 expressions overlap in the luminal epithelium at the time of blastocyst attachment on the evening of day 4 when the second phase of LIF expression occurs in stromal cells surrounding the blastocyst , suggesting that LIF participates in implantation in a paracrine manner . ^^^ Coimmunoprecipitation experiments showed that LIFR and gp 130 form heterodimers and are available for LIF signaling at the time of blastocyst attachment . ^^^ Collectively , our results have provided evidence that LIFR and gp 130 form a functional heterodimer in the uterus during the attachment reaction to direct LIF signaling . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor ( LIF ) is a member of the gp 130 cytokine family and signals through the receptor complex of gp 130 and the LIF receptor ( LIFR ) to activate the JAK / STAT signaling cascade . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This response temporally coincided with the cell type specific upregulation of the cytokine receptor components CNTF receptor alpha and LIF receptor beta in the same neurons . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The receptor for leukemia inhibitory factor ( LIF ) consists of two polypeptides , the low affinity LIF receptor ( LIFR ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We show here that signaling by CNTF , but not by LIF or oncostatin M ( OSM ) , was abolished in cells overexpressing a LIFR mutant with the N terminal cytokine binding domain deleted . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Lifr / mice demonstrate elevated pituitary glucocorticoid ( GR ) and mineralocorticoid ( MR ) receptor mRNA and protein levels , indicating the importance of LIF signaling for HPA axis development . . ^^^ The role of LIF receptor signaling in HPA axis development was examined . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Several of these cytokines ( LIF , OSM , CNTF , and CT 1 ) also utilize the LIF receptor ( LIFR ) as a component of their receptor complex . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Interleukin 6 ( IL 6 ) signals through gp 130 homodimers whereas leukaemia inhibitory factor ( LIF ) exerts its action through a heterodimer of gp 130 and the LIF receptor ( LIFR ) . ^^^ However , FRET between YFP tagged gp 130 and CFP tagged LIFR considerably increased upon LIF stimulation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
LIF activates the JAK STAT 3 pathway through the class 1 cytokine receptor gp 130 , which forms a trimeric complex with LIF and the class 1 cytokine receptor LIF receptor beta . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
These cells in vitro respond strongly to SDF 1 , HGF / SF and LIF and express CXCR 4 , c met and LIF R , respectively , and since they adhere to fibroblasts they may be coisolated with BM adherent cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We also show that administration of neutralizing antibodies results in reduced activation of the cognate LIF receptor components in the spinal cord . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
OBJECTIVE : To test the hypothesis that glycodelin is localized on pinopodes and correlates with temporal immunostaining of leukemia inhibitory factor ( LIF ) , LIF receptor ( LIFR ) , and progesterone receptor B ( PRB ) . ^^^ A weak correlation between the presence of LIFR ( but not LIF ) and glycodelin was found . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
To investigate gp 130 dimerization , we performed co precipitation experiments with the endogenous cytokine receptors gp 130 and leukemia inhibitory factor receptor ( LIF R ) and with gp 130 variants carrying two different C terminal peptide tags . ^^^ Confocal laser scanning microscopy was used for FRET detection in live cells . gp 130 and LIF R could be coprecipitated in the absence of ligand . ^^^ The present study clearly demonstrates the existence of preformed but inactive gp130 / LIF R hetero and gp130 / gp130 homo dimers . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Flow cytometric analysis of the IL 6 related cognate receptors suggested that OSM regulates PBEF via its OSM receptor beta and not its LIF receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
STUDY DESIGN : PBR , LIF , and LIF receptor messengers and proteins were analyzed in adult normal and ischemic kidney under conditions mimicking cardiac arrest : 18 pigs were studied after 60 minutes of warm ischemia and reperfusion for 7 days and compared with sham operated ( Sham , n = 12 ) and control ( CONT , n = 12 ) groups . ^^^ In turn , LIF receptor messenger and protein were not changed during reperfusion . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Immunohistochemistry was used to assay LIF , LIF receptor , and gp 130 protein expression . ^^^ RESULT ( S ) : The expression of LIF , LIF receptor , and gp 130 messenger RNA and protein was increased in spontaneously differentiated HS 237 cells compared with undifferentiated cells , with high expression of an inhibitor of LIF mediated signaling , suppressor of cytokine signaling 1 , in undifferentiated hESCs . ^^^ Supplementation with LIF did not affect the LIF receptor expression . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In human hepatoma cells ( Hep3B ) which lack the leukemia inhibitory factor receptor , CNTF was not able to induce acute phase protein synthesis , indicating that this receptor protein may be part of the functional CNTF receptor on hepatic cells . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
These cytokines initiate signaling by inducing either homodimerization of gp 130 or heterodimerization of gp 130 with leukemia inhibitory factor receptor beta components . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The receptor for granulocyte colony stimulating factor ( G CSFR ) and chimeric receptors consisting of the extracellular domain of G CSFR and the transmembrane and cytoplasmic domain of the leukemia inhibitory factor receptor , gp 130 , or c mpl function as homodimeric complexes . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Human CNTF is a neurocytokine that elicits potent neurotrophic effects by activating a receptor complex composed of the ligand specific alpha receptor subunit ( CNTFR alpha ) and two signal transducing proteins , which together constitute a receptor for leukemia inhibitory factor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The low affinity receptor for leukemia inhibitory factor ( LIFR ) interacts with gp 130 to induce an intracellular signal cascade . ^^^ Targeted disruption of the low affinity leukemia inhibitory factor receptor gene causes placental , skeletal , neural and metabolic defects and results in perinatal death . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The leukemia inhibitory factor receptor ( LIFR ) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12 p 13 . ^^^ The leukemia inhibitory factor receptor ( LIFR ) gene was localized to human chromosome 5p12 p 13 by somatic cell hybrid analysis . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Interestingly , in leukemia inhibitory factor , another cytokine that signals through gp 130 , site 3 , is topologically conserved but has evolved to bind leukemia inhibitory factor receptor . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Other growth factor ligand and receptor transcripts were expressed in a stage specific manner : these included receptors for interleukin ( IL ) 6 ( IL 6R ) , leukemia inhibitory factor ( LIFR ) , tumor necrosis factor alpha ( TNF alpha ) ( TNFRp 80 and TNFRp 60 ) , and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Molecular basis of the soluble and membrane bound forms of the murine leukemia inhibitory factor receptor alpha chain . ^^^ The murine leukemia inhibitory factor receptor alpha chain ( mLIFR ) exists in a membrane bound and a soluble form . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Assembly of sarcomeric units in series VIA gp130 / leukemia inhibitory factor receptor dependent pathways . ^^^ Similarly , a leukemia inhibitory factor receptor subunit beta ( LIFRbeta ) antagonist effectively blocks the CT 1 induction of c fos , indicating a requirement for LIFRbeta in the hypertrophic response , as well . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR alpha ) and the signal transducers gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^ Identification of ciliary neurotrophic factor ( CNTF ) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) associates with an alpha subunit ( CNTFRalpha ) of the receptor complex to initiate signal transduction by facilitating heterodimerization of the gp 130 transducing protein and the leukemia inhibitory factor receptor ( LIFR ) beta . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The distribution of leukemia inhibitory factor receptor ( LIFR ) mRNA in the adult rat brain was examined by in situ hybridization technique . ^^^ Localization of mRNA for leukemia inhibitory factor receptor in the adult rat brain . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
It is composed of a four helix bundle structure and shares the transmembrane signal transducing proteins , glycoprotein 130 ( gp 130 ) and leukemia inhibitory factor receptor ( LIF R ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The interleukin 6 ( IL 6 ) family of cytokines activates signaling through the formation of either gp 130 homodimers , as for IL 6 , or gp 130 leukemia inhibitory factor receptor ( LIFR ) heterodimers as for ciliary neurotrophic factor ( CNTF ) , leukemia inhibitory factor , oncostatinM , and cardiotrophin 1 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Refolding of soluble leukemia inhibitory factor receptor fusion protein ( gp 190 sol DAF ) from urea . ^^^ The insoluble inclusion bodies of soluble leukemia inhibitory factor receptor fusion protein ( gp 190 sol DAF ) was solubilized in 8 M urea on the unfolding transitions , and several factors on the aggregate formation were indirectly analyzed for the refolding of gp 190 sol DAF . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Chimeric receptors containing the entire or various cytoplasmic domains of either gp 130 or leukemia inhibitory factor receptor alpha ( LIFR ) were used to identify signaling molecules and regions of these polypeptides required for the stimulation of mitogen activated protein kinase ( MAPK ) . ^^^ Box 3 independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha and gp 130 mediated stimulation of mitogen activated protein kinase . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Ciliary neurotrophic factor ( CNTF ) drives the sequential assembly of a receptor complex containing the ligand specific alpha receptor subunit ( CNTFR ) and the signal transducing beta subunits gp 130 and leukemia inhibitory factor receptor beta ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The unusual species cross reactivity of the leukemia inhibitory factor receptor alpha chain is determined primarily by the immunoglobulin like domain . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Knockout of the leukemia inhibitory factor receptor ( LIFR ) gene results in disrupted placental architecture , imbalanced bone development , and losses of functional neurons . ^^^ Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This translocation leads to ectopic expression of a chimeric transcript consisting of sequences from the ubiquitously expressed gene for the leukemia inhibitory factor receptor ( LIFR ) and PLAG 1 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We recently reported a placenta specific enhancer in the human leukemia inhibitory factor receptor ( LIFR ) gene and now show detailed characterization of the 226 base pair enhancer ( 4625 / 4400 nucleotides ) . ^^^ Functional map of a placenta specific enhancer of the human leukemia inhibitory factor receptor gene . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The presence in human serum of a circulating soluble leukemia inhibitory factor receptor ( sgp 190 ) and its evolution during pregnancy . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Analyses of the activation level of leukemia inhibitory factor receptor beta and signal transducer and activator of transcription 3 signaling molecules in response to exogenous CNTF revealed an increased tyrosine phosphorylation positively correlated with the twitch tension developed by the soleus muscle of the animals . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor action is mediated by a heterodimeric receptor consisting of two subunits , gp 130 and the low affinity leukemia inhibitory factor receptor ( LIFR ) . 2 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We measured plasma levels of interleukin ( IL ) 1beta , IL 6 , tumor necrosis factor alpha ( TNF alpha ) , soluble forms of the cytokine receptor proteins gp 130 and leukemia inhibitory factor receptor ( LIF R ) , the anti inflammatory Clara cell 16 kD protein ( CC 16 ) , prolactin ( PRL ) , cortisol and 17beta estradiol in 21 anorexic women , 21 bulimic women and 21 healthy females . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NNT 1 / BSF 3 induces tyrosine phosphorylation of glycoprotein 130 ( gp 130 ) , leukemia inhibitory factor receptor beta , and signal transducer and activator of transcription 3 in the SK N MC human neuroblastoma cells . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We generated transgenic mice expressing chimeric receptors , which comprise extracellular domains of the human granulocyte macrophage colony stimulating factor ( hGM CSF ) receptor and transmembrane and cytoplasmic domains of the mouse leukemia inhibitory factor receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor had no effect on hASMCs , indicating that OSM effects on hASMCs were mediated by the OSM type 2 receptor and not by the leukemia inhibitory factor receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Serum concentrations of interleukin 6 ( IL 6 ) , IL 6 receptor ( IL 6R ) , gp 130 ( the IL 6 signaling protein ) , IL 1R antagonist ( IL 1RA ) and leukemia inhibitory factor receptor ( LIFR ) were assayed in 22 nonpregnant women and in 91 pregnant women before delivery and 1 and 3 days after delivery . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Using neutralizing antibodies to gp 130 , the OSM receptor ( OSMR ) , and the leukemia inhibitory factor receptor ( LIFR ) , we document that OSM exclusively uses the OSMR / gp 130 heterodimer in signaling events , rather than the LIFR / gp 130 heterodimer . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The Y 759 motif in gp 130 also attenuates gene induction mediated by the oncostatin M and leukemia inhibitory factor receptor complexes , which both contain gp 130 as the shared subunit . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Its receptor complex consists of a non signaling alpha chain , CNTFR , and two signaling beta chains , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of interleukin 6 receptor , leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells . ^^^ Expression of glycoprotein 130 and the related receptors , including interleukin 6 receptor and leukemia inhibitory factor receptor , was examined in the murine cerebellum at the protein level . ^^^ Western blot analysis revealed that interleukin 6 receptor , leukemia inhibitory factor receptor and glycoprotein 130 were expressed in the murine cerebellum . ^^^ Immunoreactivities for interleukin 6 receptor , leukemia inhibitory factor receptor and glycoprotein 130 were strongly localized on the cell body of Purkinje cells , indicating that both interleukin 6 and leukemia inhibitory factor could act directly on Purkinje cells in murine adult mice . ^^^ The expressions of interleukin 6 receptor , leukemia inhibitory factor receptor and glycoprotein 130 were observed on the cell membranes of Purkinje cells by immunoelectron microscopy . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of leukemia inhibitory factor receptor mRNA in sensory dorsal root ganglion and spinal motor neurons of the neonatal rat . ^^^ This study investigated the expression of leukemia inhibitory factor receptor mRNA in these neurons using in situ hybridization . ^^^ Leukemia inhibitory factor receptor mRNA was detected both in sensory neurons within the dorsal root ganglion and motor neurons of the cervical spinal cord . ^^^ Twenty four hours after axotomy these neurons continue to express leukemia inhibitory factor receptor mRNA . ^^^ This pattern of leukemia inhibitory factor receptor expression provides a mechanism by which endogenous and exogenous leukemia inhibitory factor could act on injured sensory and motor neurons . . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
A convergent set of results supports the hypothesis that the CNTF effect is due to the illegitimate binding on the leukemia inhibitory factor receptor ( LIFR ) : ( 1 ) it requires high concentration of recombinant rat CNTF ; ( 2 ) it involves the Jak / Stat and Ras MAPK pathways ; ( 3 ) it is preserved in CNTFRalpha / cells ; ( 4 ) it is potentiated by soluble CNTFRalpha added to the medium ; and ( 5 ) it is significantly decreased by a partial antagonist of LIFR . ^^^ Ciliary neurotrophic factor may activate mature astrocytes via binding with the leukemia inhibitory factor receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Its receptor complex consists of a ligand binding component , CNTF receptor ( CNTFR ) , associated with two signaling receptor components , gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
For signal transduction , CNTF requires a receptor complex , composed of the IL 6 signal transducing molecule gp 130 , leukemia inhibitory factor receptor ( LIFR ) beta , and CNTFR alpha . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Flow cytometric analyses detected both the OSM specific receptor and the gp 130 receptor at the chondrocyte cell surface , but failed to detect the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Identification of agonistic and antagonistic antibodies against gp 190 , the leukemia inhibitory factor receptor , reveals distinct roles for its two cytokine binding domains . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Using RT PCR we detected transcripts of the receptor components involved in OSM signaling , gp 130 , OSM receptor ( OSMR ) beta , and leukemia inhibitory factor receptor ( LIFR ) , in HCEC . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We demonstrated expression of three components of the OSM receptor ; gp 130 , the leukemia inhibitory factor receptor ( LIFRbeta ) and the OSM specific receptor ( OSMRbeta ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
We measured the following IRS variables in patients with major depression ( n=36 ) , somatization syndrome ( SSI 8 ; n=37 ) , major depression and somatization ( n=40 ) and healthy controls ( n=37 ) : interleukin 6 ( IL 6 ) ; interleukin 1 receptor antagonist ( IL 1RA ) ; plasma soluble interleukin 6 receptor ( IL 6R ) ; soluble suppressor / cytotoxic antigen ( CD 8 ) ; leukemia inhibitory factor ( LIF R ) ; and Clara cell protein ( CC 16 ) , an endogenous anticytokine . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The functional receptor complex of CNTF is composed of the CNTF receptor alpha ( CNTFR ) , gp 130 and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
This study was carried out to examine ( 1 ) the serum concentrations of interleukin 8 ( IL 8 ) , IL 10 , the soluble CD 8 ( sCD 8 ) and the leukemia inhibitory factor receptor ( LIF R ) in nonresponders to treatment with typical neuroleptics as compared with normal volunteers and responders to treatment ; and ( 2 ) the effects of atypical antipsychotics on the above immune variables . ^^^ Increased serum interleukin 8 and interleukin 10 in schizophrenic patients resistant to treatment with neuroleptics and the stimulatory effects of clozapine on serum leukemia inhibitory factor receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In addition , resveratrol upregulated several genes that are involved in the recruitment and activation of immune cells ( cytotoxic T lymphocyte Ag 4 , leukemia inhibitory factor receptor , and monocyte chemotactic protein 3 ) and in the inhibition of the carcinogenic process and tumor expansion ( tumor susceptibility protein TSG 101 , transforming growth factor beta , inhibin beta A subunit , and desmocollin 2 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Oncostatin M regulates the synthesis and turnover of gp 130 , leukemia inhibitory factor receptor alpha , and oncostatin M receptor beta by distinct mechanisms . ^^^ The cytokine receptor subunits gp 130 , leukemia inhibitory factor receptor alpha ( LIFRalpha ) , and oncostatin M receptor beta ( OSMRbeta ) transduce OSM signals that regulate gene expression and cell proliferation . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In addition , the expression of ciliary neurotrophic factor receptor ( CNTFR ) and leukemia inhibitory factor receptor ( LIFR ) mRNAs , but not of interleukin 6 receptor mRNA , was up regulated after systemic lipopolysaccharide treatment . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
METHODS AND RESULTS : This study was designed to determine left ventricular expression of CT 1 and its glycoprotein 130 ( gp 130 ) / leukemia inhibitory factor receptor complex in human end stage heart failure due to ischemic and dilated cardiomyopathy . ^^^ In contrast , leukemia inhibitory factor receptor and suppressor of cytokine signaling 3 protein concentrations were not changed . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Seven genes , including interleukin 1 receptor antagonist ( IL 1ra ) , IL 1receptor type 2 ( IL 1RII ) , insulin like growth factor binding protein 4 ( IGFBP 4 ) , transforming growth factor beta ( TGF beta ) , granulocyte colony stimulating factor receptor ( G CSFR ) , leukemia inhibitory factor receptor ( LIFR ) , and soluble IL 4 receptor ( sIL 4R ) were selected as probable candidate genes for the trabecular bone sparing effect of estrogen , as the mRNA levels of these genes were highly correlated ( r 2 > 0 . 65 ) to the trabecular BMD . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Novel neurotrophin 1 / B cell stimulating factor 3 ( NNT 1 / BSF 3 ) is a recently cloned gp 130 cytokine , acting through the tripartite ciliary neurotrophic factor receptor ( CNTFR ) alpha / leukemia inhibitory factor receptor ( LIFR ) / gp130 receptor complex . ^^^ Using RT PCR , expression of ciliary neurotrophic factor receptor alpha , leukemia inhibitory factor receptor , and gp 130 could be demonstrated in mRNA derived from murine corticotroph AtT 20 cells and murine pituitary tissue . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Human CNTF elicits cellular responses by induction of a receptor complex consisting of the CNTF alpha receptor ( CNTFR ) , which is not involved in signal transduction , and the beta receptors gp 130 and leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Mapping and microsatellite marker development for the porcine leukemia inhibitory factor receptor ( LIFR ) and epidermal growth factor receptor ( EGFR ) genes . ^^^ Leukemia inhibitory factor receptor ( LIFR ) , epidermal growth factor receptor ( EGFR ) , and their respective ligands have been implicated in regulating growth and development of the early pig conceptus . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The functional receptor complex of ciliary neurotrophic factor ( CNTF ) , a member of the gp 130 family of cytokines , is composed of CNTF , the CNTF receptor alpha ( CNTFR ) , gp 130 , and the leukemia inhibitory factor receptor ( LIFR ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here we report that the expression of leukemia inhibitory factor receptor ( LIFR ) , one of the signaling molecules shared by several neuropoietic cytokines of the interleukin 6 family , is specifically up regulated in PC 12 cells following treatment with NGF . ^^^ Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor induced neurite outgrowth in PC 12 cells and sympathetic neurons . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Null leukemia inhibitory factor receptor ( LIFR ) mutations in Stuve Wiedemann / Schwartz Jampel type 2 syndrome . ^^^ Through studying a series of 19 families with SWS / SJS2 , we have mapped the disease gene to chromosome 5p13 . 1 at locus D5S418 ( Zmax=10 . 66 at theta =0 ) and have identified null mutations in the leukemia inhibitory factor receptor ( LIFR or gp 190 chain ) gene . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
It acts through a membrane receptor complex comprising CNTF receptor alpha component ( CNTFRalpha ) , gp 130 , and leukemia inhibitory factor receptor to activate signal transducer and activator of transcription 3 signaling pathway . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Here we describe for the first time that these human primary cell sources contain cells that express telomerase reverse transcriptase , leukemia inhibitory factor receptor , and bone morphogenetic protein receptor 2 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Expression of CNTF and its receptors , ciliary neurotrophic factor receptor alpha ( CNTFRalpha ) and leukemia inhibitory factor receptor ( LIFR ) was studied in normal , 6 h , 1 , and 3 day optic nerve transected retinas . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
In this study , choroid plexus and other components of the CSF circulatory system were investigated by Western blotting , reverse transcriptase polymerase chain reaction and immunohistochemistry for production of interleukin 6 related cytokines characterized by neuroactivity [ cardiotrophin 1 ( CT 1 ) , ciliary neurotrophic factor , leukemia inhibitory factor , oncostatin M ] and signaling through the gp130 / leukemia inhibitory factor receptor beta receptor heterodimer . ^^^ This finding has broad implications for CT 1 functioning apart from other leukemia inhibitory factor receptor ligands as a CSF borne signal of brain homeostasis , one possibly involving regulation of the barrier itself , the ependyma or target cells in the surrounding parenchyma , including the subventricular zone . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Semi quantitative reverse transcriptase polymerase chain reaction revealed that mGM CSF enhances mRNA expression of the leukemia inhibitory factor receptor , but does not influence interleukin 6 or sodium / glucose co transporter protein gene expression in blastocyst stage parthenotes . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Leukemia inhibitory factor receptor heterozygote mice , which have less neurogenesis and fewer olfactory interneurons than their wild type counterparts , performed more poorly at fine olfactory discrimination than the wild types , suggesting that olfactory neurogenesis , rather than the total number of interneurons , was responsible for fine olfactory discrimination . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Peptides were derived from granulocyte macrophage colony stimulating factor ( GMCSF ) , the placental 27 kDa heat shock protein ( HSP ) , leukemia inhibitory factor receptor ( LIFR ) , oviduct glycoprotein ( OGP ) , proliferin ( PLF ) , prolactin ( PRL ) , sperm protein SP 56 and mouse zona pellucida subunits 1 and 3 ( ZP 1 , ZP 3 ) . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
CNTF mediates its function by activating a tripartite receptor comprising the CNTF receptor alpha chain ( CNTFRalpha ) , the leukemia inhibitory factor receptor beta chain ( LIFRbeta ) and gp 130 . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Molecular analysis of signaling events mediated by the cytoplasmic domain of leukemia inhibitory factor receptor alpha subunit . ^^^ A chimeric receptor ( 130 / 190 ) containing the cytoplasmic region of leukemia inhibitory factor receptor alpha subunit ( LIFRalpha , or gp 190 ) and the extracellular transmembrane region of gp 130 was generated . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Loss of leukemia inhibitory factor receptor beta or cardiotrophin 1 causes similar deficits in preganglionic sympathetic neurons and adrenal medulla . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Targeted disruption of SOCS 3 revealed embryonic lethality on E12 . 5 ; it was caused by placental defect with enhanced leukemia inhibitory factor receptor signaling . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
Enhancement of oligodendrocyte survival through activation of leukemia inhibitory factor receptor ( LIFR ) signaling is a candidate therapeutic strategy for demyelinating disease . ^^^ Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
RESULTS : Three genes in a distal region ( zinc finger RNA binding protein [ ZFR ] , natriuretic peptide receptor C , and a disintegrin and metalloproteinase domain with thrombospondin type 1 motif [ ADAMTS 12 ] ) were associated with BHR , whereas 4 genes in a proximal region ( prolactin receptor , IL 7 receptor [ IL7R ] , leukemia inhibitory factor receptor [ LIFR ] , and prostaglandin E 4 receptor [ PTGER 4 ] ) were associated with asthma symptoms in the Hutterites . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The cDNA of N terminal extracellular domain of human leukemia inhibitory factor receptor a subunit ( gp 190 ) , which encoded soluble gp 190 ( sgp 190 ) , was cloned into the methylotrophic yeast Pichia pastoris secreted expression vector pPIC9K . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
The cells contained proteins known to be involved in LC development , including GATA 4 , c kit receptor , and leukemia inhibitory factor receptor . ^^^
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
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Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA
Interacting proteins: P15018 and P42702	Pubmed	SVM Score :0.0
NA