| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.85940552 |
| Furthermore , DP 2 ( 792 1163 ) containing the catalytic residues for DNA polymerization , Asp 1122 and Asp 1124 , interacted with the intrasubunit domain , DP 2 ( 1 100 ) , and the intersubunit domain , DP 1 ( 1 200 ) . 0.85940552^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| We have established PCR assays for the genes coding for the major proteins of the desmosome type of cell junction , the desmosomal cadherins DGI ( desmoglein ) and DGII / III ( desmocollins ) , and the plaque proteins DPI / II ( desmoplakin ) and DPIII ( plakoglobin ) and used them to test human mouse and human rat somatic cell hybrids with different contents of human chromosomes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| It is shown that desmoplakin 3 ( about 81 kDa ) is restricted to the desmosomal cytoplasmic plaque , which possesses outer and inner dense zones . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Isolation of the non glycosylated proteins of desmosomes and immunolocalization of a third plaque protein : desmoplakin 3 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The dental pulp has no cells expressing desmocollin ( DSC ) 1 3 , desmoglein ( DSG ) 1 3 , junction plakoglobin ( JUP ) , or desmoplakin ( DPK ) 1 and 2 except for odontoblasts expressing DPK . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Mutations in 6 genes , including 4 encoding desmosomal proteins ( Junctional plakoglobin ( JUP ) , Desmoplakin ( DSP ) , Plakophilin 2 , and Desmoglein 2 ) , have been identified in patients with ARVD / C . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Twenty four hours after TGF beta 1 stimulation , DP 1 and 2 mRNA levels assessed by Northern blotting analysis had increased significantly ( DP 1 mRNA , 1 . 8 fold , P less than 0 . 05 ; DP 2 mRNA , 2 . 4 fold , P less than 0 . 04 ) , thereby indicating pretranslational regulation of DP expression . ^^^ Immunoblot analyses with polyclonal anti DP 1 antibodies showed increased levels of both DP 1 ( 250 kD ) and DP 2 ( 215 kD ) , with the DP 1 increase being more pronounced ( DP 1 , 2 . 5 fold ; DP 2 , 1 . 4 fold at 48 h relative to controls ) , suggesting translational regulation by TGF beta 1 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| In particular , it is shown that a pattern of stripes can give economical wiring when axon diameters follow a law dp = dp 1 + dp 2 with p greater than 4 , where d 1 and d 2 are the diameters of the daughter branches and d that of the parent . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Manno oligosaccharides ( DP 2 to greater than 15 ) were released by mild acid hydrolysis from the phosphopeptidomannan of a Candida albicans strain of A serotype ( VW 32 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| All seven of the clones were DPw 2 specific and indistinguishable in specificity by three approaches : ( a ) patterns of lysis of panels of targets from normal donors ; ( b ) inhibition of lysis by anti class 2 monoclonal antibodies ( mAb ) ; ( c ) lysis of mutant lymphoblastoid B cell lines ( LCL ) with isolated loss of DP 2 alpha or DP 2 beta gene expression ( as a result of selection for resistance to DPw 2 specific CTL ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The observed patterns of emptying are consistent with the hypothesis that gastric emptying of nondigestible solids is governed in part by hydrodynamics and correlate well with the gastric emptying coefficient ( GEC ) , a dimensionless grouping of variables that takes the form GEC = ( Dpy / Dp ) [ g ( rho f rho p ) Dp 2 ] / [ eta ( nu ) ] where [ g ( rho f rho p ) ] is particle buoyancy consisting of fluid ( rho f ) and particle ( rho p ) densities and g , the gravitational constant ; ( Dp ) is the particle diameter , ( Dpy ) the estimated pyloric diameter , eta the fluid viscosity , and ( nu ) the average linear velocity of fluid exiting the stomach . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Together , these data suggest that DP 1 and DP 2 are translated from two separate messages in bovine tongue and that these messages may be derived from a single gene . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The limit digest products from the alpha 2 , 8 linked polysialic acid capsule of Escherichia coli K 1 are DP 4 with some DP 3 and DP 1 , 2 . ^^^ Endo N digestion of the polysialosyl moiety on neural cell adhesion molecules yields sialyl oligomers with DP 3 and DP 4 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Diuretic peptide ( DP 1 ) has a molecular mass ca . 4500 and acts via cyclic AMP : the second diuretic peptide ( DP 2 ) has a molecular mass of ca . 1000 and operates via an unknown transduction mechanism ; the possible involvement of cGMP , calcium mobilization and the breakdown of phosphoinositides has been investigated . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The pattern of oligosaccharides produced from amylose changed with ethanol concentration ; in aqueous buffer the products are : DP 1 and 2 , 33 . 7 % ; DP 3 , 28 . 5 % ; DP 4 , 4 . 4 % and DP 5 , 33 . 4 % . ^^^ Whereas in ethanol aqueous buffer ( 7 : 3 , v / v ) the products are DP 1 and 2 , 66 . 8 % ; DP 3 , 17 . 3 % ; DP 4 , 4 . 1 % and DP 5 , 11 . 8 % . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| DP 2 was significantly correlated with DP 1 and AP 1 ( r : 0 . 92 0 . 96 ) . ^^^ The regression coefficient for the dependence of DP 2 on DP 1 was significantly greater in vivo ( 0 . 61 ) than in vitro ( 0 . 21 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The two major androgen dependent secretory proteins of rat dorsal prostate and coagulating gland , DP 1 and DP 2 , were compared by in vitro translation of total poly ( A ) RNA and by pulse chase techniques by means of [ 35S ] methionine and tissue minces of coagulating gland . ^^^ DP 1 is a major in vitro translation product of isolated poly ( A ) RNA , whereas DP 2 is undetectable in a mouse embryo fibroblast cell free system where glycosylation does not occur . ^^^ DP 2 is detectable in the medium only after 8 hr of labeling . ^^^ Inhibition of asparagine linked protein glycosylation with tunicamycin ( 10 micrograms / ml ) blocked the synthesis and secretion of DP 2 with an apparent increase in DP 1 secretion . ^^^ Inhibition of DP 2 synthesis by monensin implicates the Golgi in the processing of DP 2 oligosaccharides . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| When a second test stimulus at the optimum interval was introduced after the first , the DP ( DP 2 ) was found to be strongly dependent on that elicited by the first test stimulus ( DP 1 ) ; the relationship was positive , linear , independent of the method used to vary DP , and independent of whether DP 1 was depressed or potentiated . ^^^ The slope of the relationship was less than 1 . 0 and the line passed through the point where DP 2 = DP 1 ; this is the point of continuous stimulation at the optimum interval in a steady state . ^^^ This result is consistent with the hypothesis that the coefficient relating DP 1 to DP 2 , at constant a . p . d . of the first test pulse ( AP 1 ) , is an index of the proportion of the activator of contraction stored during relaxation of test beat 1 which is released again on beat 2 . ^^^ In order to determine the relationship between DP 2 and AP 1 it was necessary to carry out multiple regression analysis because DP 2 was already known to be strongly dependent on DP 1 ( point 3 above ) , i . e . ^^^ DP 2 = BDP ( DP 1 ) + BAP ( AP 1 D ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Sections were stained with antibodies to desmosomal proteins ( dp ) 1 / 2 , dp 3 , desmosomal glycoproteins ( dg ) 1 , 2 / 3 , extracellular carbohydrate residues , using the lectins peanut agglutinin ( PNA ) and soybean agglutinin ( SBA ) , proteases and cytokeratins . ^^^ Acantholytic cells were stained diffusely with dp1 / 2 ; there was markedly reduced or absent peripheral staining for dp 3 , dg 1 , dg2 / 3 , PNA and SBA . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Using a series of oligo / polySia PE with defined degrees of polymerization ( DP ) , the minimum chain length for immunoreactivity of the anti polySia antibodies was determined to be : DP 5 for mAb . 12E3 ; DP 3 for mAb . 5A5 ; DP 2 for mAb . kdn8kdn ; and DP 8 for H . 46 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| To study epitopes of HLA class 2 molecules , four mouse monoclonal antibodies ( mAbs ) 13B6 , 17F8 , 19A1 and 12G6 were made using HLA DQ 8 , DP 2 and DP 4 expressing mouse transfectants for immunization . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| This peptide ( 1 25 , 12 Arg ) could be specifically recognized by T cells restricted by either HLA DQ 7 or DP 3 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The expression of other DP proteins , such as DP 2 , is tissue restricted . ^^^ Here , we show that DP 1 and DP 2 are integrated with another growth regulating pathway which involves signal transduction emanating from activated Ras protein . ^^^ Thus , activated Ha ras can co operate with DP 1 or DP 2 in the transformation of rat embryo fibroblasts , establishing for the first time that DP proteins are endowed with proto oncogenic activity . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Those with DP 2 to 6 from each species were analysed by ion exchange high performance liquid chromatography and characterized by 13C and 1H nuclear magnetic resonance ( NMR ) spectroscopy . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Cloning and characterization of human DP 2 , a novel dimerization partner of E2F . ^^^ Here we describe the cloning and characterization of a novel human DP gene , DP 2 , whose product dimerizes efficiently with E2F . ^^^ Unlike DP 1 , there appear to be multiple transcripts for DP 2 and their distribution appears to vary in different tissues and cell lines . ^^^ DP 2 binds to E2F as detected by in vitro reconstitution assays and an E2F DP 2 heterodimer can bind to DNA in gel retardation assays . ^^^ We believe that DP 2 also plays a major role in modulating the function of E2F in cell cycle regulation and oncogenesis . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| We have isolated cDNAs that encode the functional homologue of mammalian DP 1 , X 1 DP 1 , together with a close relative , X 1 DP 2 . ^^^ Both DP 1 and DP 2 synergistically interact with members of the E2F family of proteins , E2F 1 , E2F 2 , and E2F 3 , to generate DNA binding complexes that specifically recognize the E2F site and functionally interact with E2F 1 in E2F site dependent transcriptional activation of cellular genes . ^^^ DP 1 and DP 2 encode maternally stored transcripts that are expressed during early development . ^^^ In the adult however , the expression of DP 1 and DP 2 is tissue restricted . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The other gene , dDP , is closely related to the human DP 1 and DP 2 genes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Apart from CP cells , dark Purkinje cells ( DP cells ) indeed appear in increasing numbers with ageing ; one subtype ( DP 1 cells ) has medium dark density revealing dumbbell shaped mitochondria , ring shaped Golgi apparatus and lamellated bodies ; the other subtype ( DP 2 cells ) has very dark density presenting pycnotic nuclei with complete nucleolar regression and degenerating mitochondria , but with well developed Nissl bodies and Golgi apparatus . ^^^ Some clear Purkinje cells may become DP 1 cells and others DP 2 cells . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The first measurements ( MAP , HR , and TCD of the nontumor side ) were performed before ( DP 1 ) and 60 s after ( DP 2 ) induction of anesthesia with either 2 mg / kg propofol or 4 mg / kg thiopental . ^^^ Then MAP , HR , vMCA , and VA of the tumor side were analyzed before ( DP 3 ) and 60 s after ( DP 4 ) either propofol ( 1 mg / kg ) or thiopental ( 2 mg / kg ) were given . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Although present at very different levels , DP 1 and DP 2 are evenly distributed among each of these complexes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Comparison of the acceptor properties of DP 3 and DP 6 showed that the larger oligomer was acted upon with a 10 fold higher efficiency . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| DP 2 , a heterodimeric partner of E2F : identification and characterization of DP 2 proteins expressed in vivo . ^^^ Here we report studies of DP 2 , the second member of the DP family of genes . ^^^ Our results indicate that ( 1 ) DP 2 encodes at least five distinct mRNAs , ( 2 ) a site of alternative splicing occurs within the 5 ' untranslated region of DP 2 mRNA , ( 3 ) at least three DP 2 related proteins ( of 55 , 48 , and 43 kDa ) are expressed in vivo , ( 4 ) each of these proteins is phosphorylated , and ( 5 ) one DP 2 protein ( 43 kDa ) carries a truncated amino terminus . ^^^ Our data also strongly suggest that the 55 kDa DP 2 related protein is a novel DP 2 isoform that results from alternative splicing . ^^^ Thus , we conclude that DP 2 encodes a set of structurally , and perhaps functionally , distinct proteins in vivo . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis of the expression of E2F and DP family members showed that the E2F 1 , E2F 4 , and E2F 5 mRNA was growth and senescence dependent , whereas E2F 3 , DP 1 , and DP 2 expression was constitutive and senescence independent . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Unlike E2F 1 , 2 , and 3 , E2F 4 did not accumulate in the nucleus unless it was coexpressed with DP 2 , p 107 and p 130 , but not pRb , stimulated nuclear localization of E2F 4 , either alone or in combination with DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| For zone DP 2 amputations , venous anastomosis must be performed for salvage . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Cotransfection of expression vectors encoding p 107 , p 130 , or DP 2 , but not DP 1 , resulted in the nuclear localization of E2F 4 and 5 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| SBEI predominantly transfers longer chains with dp greater than 10 , while producing few shorter chains with dp 3 to 5 . ^^^ In contrast , SBEII preferentially transfers smaller chains with dp 3 to 9 , with the most abundant chains being dp 6 and 7 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Here we describe the cloning of the chicken homologues of the mammalian DP 1 and DP 2 proteins . ^^^ This work also suggests that DP 2 isoforms have an additional 60 amino acid extension at the N terminus compared to its human counterpart . ^^^ Gel shift assays and coimmunoprecipitation show that both DP 1 and DP 2 dimerize to chE2F 1 and activate transcription efficiently , as demonstrated by transient expression assays . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Five E2F genes , E2F 1 through E2F 5 , and two DP genes , DP 1 and DP 2 , have been isolated from mammals , and heterodimeric complexes of these proteins are expressed in most , if not all , vertebrate cells . ^^^ Using recombinant E2F , DP , and Rb proteins prepared in baculovirus infected cells and a repetitive immunoprecipitation PCR procedure ( CASTing ) , we have identified consensus DNA binding sites for E2F 1 / DP 1 , E2F 1 / DP 2 , E2F 4 / DP 1 , and E2F 4 / DP 2 complexes as well as an Rb / E2F 1 / DP 1 trimeric complex . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The smallest molecule in this first series was panose or alpha D glucopyranosyl ( 1 > 6 ) D maltose ( dp 3 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| E2F 6 is a nuclear protein that can form heterodimers with the DP proteins ( both DP 1 and DP 2 ) in vitro and in vivo . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The effectivity of RDA products obtained with increasing driver / tester ratios ( DP 1 = 100 : 1 , DP 2 = 800 : 1 and DP 3 = 400 , 000 : 1 ) to isolate differentially expressed genes was compared with the effectivity of conventional differential hybridizations . ^^^ In this situation , the intermediate RDA product DP 2 provided the best compromise . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The crystal structure of an E2F4 DP 2 DNA complex shows that the DNA binding domains of the E2F and DP proteins both have a fold related to the winged helix DNA binding motif . ^^^ E2F4 and DP 2 interact through an extensive protein protein interface , and structural features of this interface suggest it contributes to the preference for heterodimers over homodimers in DNA binding . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| A . niger PME is able to hydrolyse the methyl esters of fully methyl esterified oligogalacturonates with DP 2 , and preferentially hydrolyses the methyl esters located on the internal galacturonate residues , followed by hydrolysis of the methyl esters towards the reducing end . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Aminopeptidase P ( APP ) , dipeptidyl peptidase 2 ( DP 2 ) , dipeptidyl peptidase 4 ( DP 4 ) and prolyl oligopeptidase ( POP ) are proline specific peptidases . ^^^ As a result , the serine proteases DP 2 , DP 4 and POP were inhibited competitively , whereas metal dependent APP displayed a linear mixed type inhibition with inhibition constants up to 10 ( 4 ) M . ^^^ For the first time , Xaa Pyrr and Xaa Thia were characterized as inhibitors of DP 2 with inhibition constants in the micromolar range . ^^^ In contrast to DP 4 inhibition , the Xaa psi [ CS N ] Pyrr and Xaa psi [ CS N ] Thia have proven to be more potent inhibitors of DP 2 than the corresponding Xaa Pyrr and Xaa Thia . ^^^ Thus , these Xaa psi [ CS N ] Thia are new potent inhibitors especially suitable for DP 2 with K ( 1 ) values ranging in the upper nanomolar concentration . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Second , using the recently developed method that provides base line resolution of oligo / polySia from DP 2 to > 80 with detection thresholds of 1 . 4 fmol per resolved peak , we have determined the DP of polySia chains expressed in embryonic chicken brains at different developmental stages . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Native chicory inulin has an average degree of polymerization ( DP ) of 10 to 20 , whereas oligofructose contains chains of DP 2 to 10 , with an average DP of 4 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| These results indicate that in addition to the classic inhibitory DP 1 receptor , eosinophils possess a second , novel DP 2 receptor that is associated with PGD 2 induced cell activation . ^^^ These 2 receptors appear to interact to regulate eosinophil responses to PGD 2 , as blockade of DP 1 receptor mediated cAMP production by BWA868C resulted in enhanced DP 2 receptor mediated stimulation of CD11b expression . ^^^ The balance between DP 1 and DP 2 receptors could determine the degree to which prostaglandin D 2 can activate eosinophils and may play a role in eosinophil recruitment in asthma . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Heparin derived oligosaccharides from dp 2 to dp 24 were added together with HGF / SF to chlorate treated cells to determine the minimum size of oligosaccharides able to restore HGF / SF activity . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Xylose and xylooligosaccharides with a degree of polymerization ranging from DP 2 to 15 were separated under such conditions , and each xylooligosaccharide containing peak fraction afforded a single band on fluorophore assisted carbohydrate electrophoresis . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| However , the ratio of one to the other is the same in SCC and AC , but DP 2 is lost in ASC . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Xylanase , phenolic acid esterase and a combination of endoglucanase ( EG 2 ) with cellobiohydrolase ( CBH 1 ) resulted in the production of DP 1 after the addition of esterase , DP 2 and DP 3 after the addition of EG 2 and CBH 1 , from the dissolving pulp substrate . ^^^ Similar sequential enzyme addition to sugar cane bagasse resulted in DP 1 production after the addition of esterase and DP 1 , DP 2 and DP 3 production after the addition of the EG 2 and CBH 1 mixture . ^^^ The mass selectivity of MS revealed complementary information , including the co elution of saccharides as well as the presence of more than one type of DP 2 in the case of dissolving pulp and several types of DP 2 and DP 3 for sugar cane bagasse . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| It has been proposed that E2F 4 and E2F 5 , which lack defined nuclear localization signal ( NLS ) consensus sequences , enter the nucleus in association with NLS containing DP 2 or pRB family proteins . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Studies on the expression profiles of cell cycle regulators showed that the AhR or AhR ligand induces the expression of DP 2 , PCNA , and RFC 38 . ^^^ DP 2 is the transcription factor that forms the functional dimer with E2F and regulates the expression of several genes involved in DNA synthesis . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The inhibition of IL 12 production is mediated only in part by the cell surface G alpha s protein coupled D prostanoid receptor ( termed DP 1 ) but not by the G alpha 1 protein coupled DP receptor , DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Both bean samples had one type of DP 2 , but showed different types of DPs 3 , 4 and 5 . ^^^ Tandem MS of the hydrolysates showed that the DP 2 hydrolysates observed for the samples were of the same type , having a 1 , 6 linkage . ^^^ The data also showed the existence of 1 , 6 linkages for DP 3 , 4 , and 5 hydrolysates . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Non and partially methyl esterified OGAs with a dp of 3 and 4 were calculated semi quantitatively as dp 3 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Here we investigated the role of E2F1 and E2F4 expression , with or without co expression of DP 1 or DP 2 , on cell proliferation in transiently transfected primary rat MCs . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| DP 1 and DP 2 function as binding partners for E2F transcription factors . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Recent research described a major gene ( 6 SFT ) in crested wheatgrass that is involved in fructan biosynthesis . 1 kestotriose , the major DP 3 fructan in crested wheatgrass , serves as the substrate for the two major DP 4 fructans , 1 & 6 kestotetraose and 1 , 1 kestotetraose . ^^^ This paper provides structures of the various DP 3 , 4 , 5 and 6 fructan types produced by crested wheatgrass and provides suggested biosynthetic pathways for all major fructan linkage types present . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| PGD ( 2 ) is the major mediator released by mast cells during allergic responses , and it acts through two different receptors , the D prostanoid receptor 1 ( DP 1 ) and DP 2 , also known as CRTH 2 . ^^^ This process is mimicked by the DP 1 agonist BW245C , but not by the DP 2 agonist DK PGD ( 2 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| It produced beta ( 1 > 6 ) galacto oligomers ranging from DP 2 to at least 8 at the initial hydrolysis stage and galactose and beta ( 1 > 6 ) galactobiose as the major products at the final reaction stage . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| In contrast , hydrolysis of beta 1 , 3 linked oligosaccharides decreased from DP 2 to 3 , and polymers with a DP greater than 3 were not hydrolysed . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| TREATMENTS : PRIMUS 100 mL , PRIMUS 200 mL , PRIMSTAR 1 . 05 L / ha , PRIMSTAR 2 . 1 L / ha , BASAGRAN DP 3 L / ha , BASAGRAN DP 6 L / ha . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Expression of prostaglandin D 2 receptors DP 1 and DP 2 by human colorectal cancer cells . ^^^ Therefore , we studied expression of DP 1 and DP 2 receptors by reverse transcription polymerase chain reaction analysis of receptor mRNA levels in five human colorectal cancer cell lines ( HT 29 , HCA 7 , HCT 116 , SW 480 and SW 48 ) and VACO 235 human colorectal adenoma cells . ^^^ In addition , none of the human colorectal epithelial cell lines tested expressed DP 2 receptor mRNA . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Whereas the E2F family consists of seven members , the DP family contains only two ( Dp 1 and Dp 2 ) , Dp 1 being the more highly expressed member . ^^^ Importantly , the abundance of DP 2 protein does not increase and the expression of an array of cell cycle genes is virtually unchanged in Dp 1 deficient ES cells or chimeric E15 . 5 tissues with the absence of Dp 1 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The PVF in the forelimbs of Greyhounds was greatest in DP 3 , 4 , and 5 and DP 3 , DP 4 , and the MtP in the hind limbs . ^^^ The 6 in Greyhound forelimbs was greatest in DP 3 , 4 , and 5 but greatest in DP 4 in the hind limbs . ^^^ The 6 in Labrador Retriever forelimbs was greatest in DP 3 , DP 4 , and the McP but greatest in DP 3 and 4 in the hind limbs . ^^^ CONCLUSIONS AND CLINICAL RELEVANCE : This study confirms that DP 3 and DP 4 are major weight bearing pads in dogs . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Hop is composed of three tetratricopeptide repeat ( TPR ) domains ( TPR 1 , TPR2a , and TPR2b ) and two DP repeat domains ( DP 1 and DP 2 ) ; Hsp 70 interacts directly with TPR 1 and Hsp 90 with TPR2a , but the function of other domains is less clear . ^^^ Chimeric Hop constructs combining human and Drosophila domains demonstrate that the C terminal domain DP 2 is critical for this previously unrecognized role in steroid receptor function . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| PGD 2 binds to two membrane receptors , D prostanoid receptor ( DP ) 1 and DP 2 , endowed with antagonistic properties . ^^^ In humans , DP 2 is preferentially expressed on type 2 lymphocytes , eosinophils , and basophils and mediates chemotaxis in vitro . ^^^ Although not yet supported by in vivo studies , DP 2 is thought to be important in the promotion of Th 2 related inflammation . ^^^ Herein , we demonstrate that mouse eosinophils express both DP 1 and DP 2 and that PGD 2 exerts in vitro chemotactic effects on eosinophils through DP 2 activation . ^^^ Furthermore , 13 , 14 dihydro 15 keto PGD 2 , a specific DP 2 agonist not only increases eosinophil recruitment at inflammatory sites but also the pathology in two in vivo models of allergic inflammation : atopic dermatitis and allergic asthma . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Synthesis of 15R PGD 2 : a potential DP 2 receptor agonist . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Most of the herein described effects of PGD ( 2 ) on MDDC can be reproduced , usually with a higher efficacy , with a selective D prostanoid receptor ( DP ) 1 , but not DP 2 , agonist . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Two different DP subunits ( DP 1 and DP 2 ) exist in humans . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Chicory inulin is a linear beta ( 2 > 1 ) fructan ( degree of polymerisation ( DP ) 2 to 60 ; DPav=12 ) , its partial enzymatic hydrolysis product is oligofructose ( DP 2 to 8 ; DPav=4 ) , and by applying specific separation technologies a long chain inulin known as inulin HP ( DP 10 to 60 ; DPav=25 ) can be produced . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| METHODS : In a randomized , controlled , 3 arm trial conducted along the northwestern border of Thailand , the standard 4 dose course of DP ( DP 4 ) was compared to an equivalent dose given as a once daily regimen ( DP 3 ) and to the standard treatment of mefloquine artesunate ( MAS 3 ) . ^^^ The PCR genotyping adjusted cure rates at day 63 after treatment initiation were 95 . 7 % ( 95 % confidence interval [ 95 % CI ] , 92 . 2 % 98 . 9 % ) for MAS 3 , 100 % for DP 4 , and 99 . 4 % ( 95 % CI , 98 . 1 % 100 % ) for DP 3 . ^^^ The DP 4 and DP 3 cure rates were significantly higher than that for MAS 3 ( P= . 008 and P= . 03 , respectively ) . ^^^ There were 3 deaths ( 1 in the MAS 3 group and 2 in the DP 3 group ) , all of which were considered to be unrelated to treatment . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| While DP 1 is an essential and widespread component of E2F , much less is known about the DP 3 subunit , which exists as a number of distinct protein isoforms that differ in several respects including the presence of a nuclear localisation signal ( NLS ) . ^^^ We show here that the NLS region of DP 3 harbours a binding site for 14 3 3epsilon , and that binding of 14 3 3epsilon alters the cell cycle and apoptotic properties of E2F . ^^^ DP 3 responds to DNA damage , and the interaction between DP 3 and 14 3 3epsilon is under DNA damage responsive control . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| By IB , eight sera proved to have antibodies to both DP 1 ( 250 kDa ) and DP 2 ( 210 kDa ) , one serum had antibodies directed to DP 1 only , and two sera to DP 2 only . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Two PGD 2 receptors have been identified : PGD 2 receptor 1 ( DP 1 , also called DP ) and PGD 2 receptor 2 ( DP 2 , sometimes termed CRTH 2 ) . ^^^ DP 2 does not mediate NA induced vasodilation ; the DP 2 specific agonist DK PGD 2 ( 13 , 14 dihydro 15 keto PGD 2 ) did not induce cutaneous vasodilation , and DP 2 / mice had a normal vasodilatory response to NA . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| All the oligosaccharides observed belong to the neo carrabiose oligosaccharide series indicating that the lambda carrageenase cleaves the beta ( 1 > 4 ) glycosidic bonds . ( 1 ) H and ( 13 ) C NMR spectra recorded on oligomers from DP 2 to DP 8 were fully interpreted allowing unambiguous assignment of the lambda carrageenan spectra . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Discovery of potent CRTh 2 ( DP 2 ) receptor antagonists . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| This depigmentation is under the control of depigmentation genes Dp 1 and Dp 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The depigmentation character in the common goldfish is controlled by two dominant multiple genes , Dp 1 and Dp 2 , and only fish with double recessive alleles dp1dp1 dp2dp2 can retain larval melanophores throughout life . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Sections were stained using monoclonal antibodies to the desmosomal proteins dp 1 and dp 2 ( desmoplakins ) and the desmosomal glycoproteins dg 1 ( desmoglein ) , and dg 2 and dg 3 ( desmocollins ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Desmoplakins 1 and 2 ( DP 1 and DP 2 ) , major cytoskeletal structural proteins concentrated in desmosomes , have been purified in milligram quantities from keratomed pig tongue epithelium . ^^^ DP 1 and DP 2 extracted from purified desmosomes in 4 M urea were chromatographed on DEAE cellulose and remained soluble after removal of urea during subsequent chromatography . ^^^ The two proteins differed by only about 15 % in molecular weight ( Mr = 285 , 000 for DP 1 and 225 , 000 for DP 2 on sodium dodecyl sulfate polyacrylamide gels ) were found to have similar Svedberg constants , 6 . 7 S ( DP 1 ) and 6 . 4 S ( DP 2 ) ; nevertheless , separation was readily achieved by gel filtration , since DP 1 has a Stokes radius ( Rs ) of 164 nm , but DP 2 has a Rs = 90 nm . ^^^ Calculated molecular mass was 462 , 000 daltons for DP 1 and 242 , 000 daltons for DP 2 , suggesting that DP 1 may be a dimer in solution and DP 2 a monomer . ^^^ Cross linking by disuccinimidyl suberate of 125I labeled DP 1 or DP 2 at nanomolar concentrations confirmed that DP 1 is a dimer by doubling of its apparent Mr on sodium dodecyl sulfate gels and indicated that DP 2 , which failed to become cross linked , is a monomer . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Two major allergens , DP 1 ( Der p 1 ) and DP 2 ( Der p 2 ) , were isolated from the whole culture extract of Dermatophagoides pteronyssinus , and the physicochemical and immunochemical properties of these allergens were compared with those of the corresponding allergens from Dermatophagoides farinae , DF 1 ( Der fI ) and DF 2 ( Der fII ) . ^^^ On sodium dodecyl sulfate polyacrylamide gel electrophoresis , polyacrylamide gel isoelectric focusing and amino acid analysis , both DP 1 and DP 2 were demonstrated to have close physicochemical similarity with DF 1 and DF 2 , respectively . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Labelling for the high mol . wt proteins of Mr 250 , 000 and 215 , 000 ( dp 1 and dp 2 ) was largely excluded from the plaque , and was located distally , adjacent to the tonofilaments . ^^^ Hemidesmosomes could not be labelled with antibodies to dg 1 3 or dp 3 and 4 , but some labelling was obtained with antibody to dp 1 and 2 . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Segregation of diplopod embryos from chickens heterozygous for both dp 1 and dp 3 genes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Two human TFDP genes have been cloned , namely TFDP 1 and TFDP 2 ( or DP 1 and DP 2 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We have identified a novel DNA polymerase composed of two proteins , DP 1 and DP 2 , with molecular weights of 69294 Da and 143161 Da , respectively , in the hyperthermophilic archaeon , Pyrococcus furiosus , and have cloned the corresponding genes which are tandemly arranged on the Pyrococcus genome . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| However , it has no effect on the transcription of the E2F 3 , E2F 4 , E2F 5 , DP 1 , DP 2 , or p16 / Ink4 genes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Two regions , DP 1 ( 140 to 92 bp ) and DP 2 ( 353 to 304 bp ) of the promoter were essential for transcription in HeLa cells and human peripheral monocytes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The DNA polymerase is composed of two proteins , DP 1 and DP 2 . ^^^ Sequence analysis showed that considerable similarity exists between DP 1 and the second subunit of eukaryotic DNA polymerase delta , a protein essential for the propagation of Eukarya , and that DP 2 has conserved motifs found in proteins with nucleotide polymerizing activity . ^^^ These results , together with our previous biochemical analyses of one of the members , DNA polymerase 2 ( DP 1 + DP 2 ) from Pyrococcus furiosus , implicate the DNA polymerases of this family in the DNA replication process of Euryarchaeota . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The growth functions of 2F1 F 2 DPOAEs at F 2 frequencies of 1001 , 2002 and 4004 Hz ( DP 1 , DP 2 and DP 4 , respectively ) were measured with F 2 intensities ranging from 70 to 37 dBSPL in 3 dB steps . ^^^ The growth function was paired with the hearing threshold at the corresponding F 2 frequency , and the relationships between changes in DP 1 , DP 2 and DP 4 and those in hearing thresholds at 1 , 2 and 4 kHz , respectively , were also investigated . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The purpose of this study was to clarify the effects of low concentrations of fluoride on proliferation , differentiation and extracellular matrix synthesis in normal human dental pulp cells ( DP 1 and DP 2 ) in vitro . ^^^ Fluoride at micromolar concentrations significantly and dose dependently stimulated [ 3H ] thymidine incorporation into DNA in DP 1 , DP 2 and TE 85 cells , with optimal effects around 50 microM , by 127 + / 7 % , 124 + / 0 . 6 % and 152 + / 13 . 4 % , respectively . ^^^ Fluoride significantly increased that production by 150 + / 8 . 7 % in TE 85 , but not in either DP 1 or DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| This response was accompanied with down regulation in the protein expression of all five E2F ( 1 5 ) family transcription factors , and their heterodimeric partners DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Though the levels of DP 1 and 2 increase when cells progress from G 0 to S , the proportion of DP 1 to DP 2 remains relatively constant during the cell cycle . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Columnar luminal cells expressed cytokeratins 8 and 18 and rat prostatic secretory markers ( DP 1 and DP 2 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| In tumors , the protein expression of DP 1 did not show significant change whereas that of DP 2 showed a 2 . 2 fold increase . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The genes coding for DP 1 and DP 2 , the subunits of this DNA polymerase , are highly conserved in the Euryarchaeota . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| We have synthesized two water soluble dendritic porphyrins , termed DP 1 and DP 2 and have successfully radiolabeled them with 99mTc . ^^^ Tumor to muscle ratios of DP 1 and DP 2 were 8 . 0 and 9 . 7 , respectively . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| This response was accompanied by downregulation of protein expression of all five E2F ( 1 5 ) family members of transcription factors studied and their heterodimeric partners DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| No differences were observed between RA sensitive and RA resistant ovarian carcinoma cells in the levels of expression of many cell cycle genes including cyclin A , B and E , cdk 2 , 4 and 6 , E2F 1 , E2F 2 , E2F 3 , E2F 4 , E2F 5 , DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| This response was accompanied by downregulation in the protein expression of the E2F ( 1 through 5 ) family of transcription factors and their heterodimeric partners DP 1 and DP 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| We have studied the sural and peroneal nerves and the electromyographies of leg muscles in 50 healthy subjects ( average age 67 . 2 years , range 45 to 84 years ) , in 50 diabetic patients ( average age 66 . 34 years , range 44 to 82 years ) showing no symptoms and / or signs of polyneuropathy ( DP 1 ) , and in 50 diabetic patients ( average age 67 . 10 years , range 49 to 87 years ) showing symptoms and / or signs of polyneuropathy ( DP 2 ) . ^^^ DP 2 subjects showed AMP and CV values significantly lower than those in DP 1 subjects , and signs of acute and chronic denervation / reinervation were found in the leg muscles . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| To attempt to identify potent and selective DP 2 receptor agonists we compared the abilities of a series of PGD 2 analogs to activate eosinophils via the DP 2 receptor with their abilities to stimulate adenylyl cyclase in platelets via the DP 1 receptor . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The dipoles DP 1 and DP 2 , in which the configuration between the epoxide oxygen and the deuterium atoms is retained , are inferred for the direct photodenitrogenation reactions ( singlet state ) , whereas for the benzophenone sensitized photoreactions ( triplet state ) , after ISC , the ring opened dipole DP 3 is implied as the intermediate that is trapped by the alcohol . . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Thus , mRNA and protein levels of E2F 1 , 3 , and 4 and DP 1 and DP 2 were down regulated during development to undetectable levels in adult myocytes . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Rosiglitazone and ciglitazone , two other agonists of PPARgamma , did not synergize with PDB to induce DNA synthesis , suggesting that activation of PPARgamma is not involved in 15dPGJ ( 2 ) induced DNA synthesis . 15dPGJ ( 2 ) neither increased the levels of cAMP , nor changed the phosphorylation state of CREB , nor induced calcium mobilization , indicating that 15dPGJ ( 2 ) effects are independent of prostaglandin D ( 2 ) receptor ( DP 1 and DP 2 ) . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| RESULT : In vitro , TSDP was decomposed easily by rat intestinal bacteria , and metabolites DP 1 , DP 2 , DP 4 , DP 5 and diosgenin ( Dio ) were observed with prolongation of incubation time by ESI MS 2 . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| HAP 1 and a non tissue specific cationic protein transduction domain , PTD 5 , were fused to an antimicrobial peptide , ( KLAK ) ( 2 ) , to generate two proapoptotic peptides termed DP 2 and DP 1 , respectively . ^^^ Intra articular injection of DP 1 and DP 2 into arthritic rabbit joints with synovial hyperplasia induced extensive apoptosis of the hyperplastic synovium , while reducing the leukocytic infiltration and synovitis . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| We found that a 21 amino acid , subunit interacting peptide of the sequence from cysteine cluster 2 of the large subunit ( DP 2 ) stimulates the exonuclease activity of DP 1 and the internal deletion mutants of PolD lacking the 21 aa sequence . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| In L 5178 MDR cell line , the 11 dihydropyridines tested , but 3 , 5 diacetyl 4 ( 2 nitrophenyl ) 1 , 4 dihydro 2 , 6 dimethylpyridine ( DP 1 ) , 3 , 5 diacetyl 4 ( 3 phenoxyphenyl ) 1 , 4 dihydro 2 , 6 dimethylpyridine ( DP 2 ) and 3 , 5 diacetyl 4 ( 3 chlorophenyl ) 1 , 4 dihydro 2 , 6 dimethylpyridine ( DP 4 ) , exhibited an MDR reversing activity , with IC 50 values ranging between 3 . 02 10 10 ( 7 ) and 4 . 27 10 10 ( 5 ) , DP 7 being the most potent . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The order of the inhibitory activities of these prostaglandin D 2 metabolites depended on affinity of the prostanoid DP 1 receptor but not on the DP 2 receptor ( chemoattractant receptor homologous molecule expressed on T helper 2 cells , CRTH 2 ) and PPAR gamma receptors . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Effects of prostaglandin D 2 , 15 deoxy Delta 12 , 14 prostaglandin J 2 , and selective DP 1 and DP 2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats . ^^^ The objectives of the present study were to determine whether PGD 2 and 15 deoxy Delta 12 , 14 PGJ 2 can induce pulmonary eosinophilia , and , if so , to examine the abilities of selective DP 1 and DP 2 receptor agonists to induce this response . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The double potentials represent activation of the left atrial insertion of the AP ( DP 1 ) and later activation of the CS musculature ( DP 2 ) via connections between the paraseptal CS musculature and left atrium , respectively . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Instead , 15d PGJ 2 has been shown to act via PGD 2 receptors ( DP 1 and DP 2 ) and through interaction with intracellular targets . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the function of PGD ( 2 ) and its two receptors DP 1 and chemoattractant receptor homologous molecule expressed on Th 2 cells ( CRTH 2 ) ( DP 2 ) in neuronal survival . ^^^ It signals through two distinct G protein coupled receptors , DP 1 and DP 2 , that have opposing effects on cyclic AMP ( cAMP ) production . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| The second photoreaction process is photocyclization of cis BSF , which occurs to give DP 1 decaying with the half lifetime ( tau1 / 2 ) of 2 . 8 4 . 0 micros to produce another DHP type intermediate ( DP 2 ) with an absorption peak at 400 nm in the absence of O 2 , through [ 1 , 9 ] hydrogen shift . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| CB ( 13 ) and SC ( 1 ) were detected as changes in the activation times of the first and second components of DPs ( DP 1 , DP 2 ) during PS RA pacing and AS RA . ^^^ Similar changes in the activation times DP 1 and DP 2 during AS RA pacing as compared to PS RA reflected SC through the isthmus , whereas increased DP 1 activation time and decreased of DP 2 activation time reflected complete conduction block across the isthmus . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| Cultured astrocytes expressed two types of PGD 2 receptor , DP 1 and DP 2 , and showed enhanced GFAP production after stimulation of either receptor with its respective agonist . ^^^ |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P15924 and P14923 |
Pubmed |
SVM Score :0.0 |
| NA |
|