| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The primary sequences of the three individual glycoprotein ( GP ) chains , GPIb alpha , GPIb beta , and GPIX , comprising the normal platelet GPIb / IX receptor for von Willebrand factor ( vWF ) have recently been determined , opening the possibility for characterization of disorders of this receptor at the molecular level . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Anti PlE 1 antibody bound specifically to both the GPIb complex and glycocalicin . 3H labelled platelet membrane glycoproteins with apparent molecular weights of 130k , 25k , and 21k ( under reduced conditions ) corresponding to GPIb alpha , GPIb beta , and GPIX were immunoprecipitated by anti PlE 1 plasma . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Bernard Soulier syndrome Kagoshima : Ser 444 > stop mutation of glycoprotein ( GP ) Ib alpha resulting in circulating truncated GPIb alpha and surface expression of GPIb beta and GPIX . ^^^ The platelet membrane glycoprotein ( GP ) Ib / IX complex is composed of three polypeptides , GPIb alpha , GPIb beta , and GPIX , and functions as a platelet receptor for von Willebrand factor . ^^^ Her platelets completely lacked the surface expression of GPIb alpha , but expressed a residual amount of GPIb beta and GPIX . ^^^ Furthermore , the truncated GPIb alpha might be associated with the process of the surface expression of incomplete GPIb / IX complex , GPIb beta and GPIX . . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The complex is composed of four glycoprotein subunits , GPIb alpha , GPIb beta , GPIX and GPV , each with a variable number of leucine rich repeats . ^^^ GPIb alpha and GPIb beta are linked by a disulphide bridge while GPIX and GPV associate noncovalently with the complex . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Analysis of the genes for two other components of the platelet GPIb : 9 complex , namely GPIb beta and GPIX , showed two different missense mutations in the coding region of the GPIX gene : an A > G transition in codon 21 results in conversion of an aspartic acid to glycine and an A > G change in codon 45 converts an asparagine residue to serine . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Antibody binding assays with trypsin digested platelets ( ELISA , immunoprecipitation with biotin labelled platelets ) indicate that the antigen is not localized on the glycocalicin moiety of GP Ib alpha , but may be situated on the remnant moiety of GP Ib alpha , GP 9 or GPIb beta . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The platelet membrane glycoprotein ( Gp ) Ib complex consists of four polypeptides : the disulfide linked GpIb alpha and GpIb beta subunits ; GpIX , tightly , but noncovalently associated with GpIb alpha beta ; and the more weakly associated GpV . ^^^ It is not certain whether the association of GpIX to Gplb alpha beta is via GpIB alpha , GpIb beta , or both subunits , although recently published evidence implicates an interaction with GpIb beta . ^^^ We have investigated the interaction of GpIX with GpIb alpha beta using polyclonal rabbit antibodies to GpIb alpha and GpIb beta raised by immunization with purified glycocalicin and with synthetic peptide sequences from GpIb beta , respectively , as well as monoclonal antibodies directed against GpIX ( FMC 25 ) and against GpIb alpha ( AP 1 ) . ^^^ When wells were coated with polyclonal GpIb alpha or GpIb beta antibodies and then incubated with reduced GpIb complex , only wells coated with GpIb alpha antibodies captured GpIX reactivity . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| We amplified the coding regions of GPIb alpha , GPIb beta , GPV , and GPIX from the patients ' genomic DNA with the polymerase chain reaction ( PCR ) and sequenced the PCR products . in case 1 , we identified a point mutation in the GPIX coding region that changes the codon for tryptophan 126 ( TGG ) to a nonsense codon ( TGA ) . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Surface expression of GpIb alpha depends on the correct intracellular assembly with the GpIb beta and GpIX chains . ^^^ This study indicates that functional expression of the vWF binding domain of GpIb alpha on the surface of mammalian cells can be obtained in the absence of GpIb beta and GpIX . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Western blotting revealed normal levels of GPIX , decreased levels of GPIb beta and GPV , and < 1 % of GPIb alpha . ^^^ RT PCR studies showed the presence of mRNA coding for GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| In contrast , no detectable proteolytic modification of the two other subunits , GPIb beta and GPIX , was detected . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Like the genes encoding GPIb alpha , GPIX , and GPV , the GPIb beta gene appears simple in structure . ^^^ When we examined poly ( A ) + RNA from several human tissues for GPIb beta mRNA expression , we found that GPIb beta mRNA was expressed in a variety of tissues but was most abundant in heart and brain , while GPIb alpha and GPIX mRNA expression was found only in lung and placenta at very low levels . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The platelet membrane glycoprotein ( GP ) Ib 5 9 complex is the receptor for von Willebrand factor and is composed of four membrane spanning polypeptides : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The platelet glycoprotein Ib ( GpIb ) complex is composed of four polypeptides : the disulfide linked GpIb alpha and GpIb beta and the noncovalently associated GpIX and GpV . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Immunostaining of the CHO K 1 cells transfected with two plasmids for mutant GPIX and GPIb beta showed that mutant GPIX was weakly but certainly detected in the cytoplasm of the transfected cells . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The complex , which serves as a platelet receptor for von Willebrand factor , is composed of 4 subunits : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ Studies of transient coexpression of this mutant , W21stop GPIb beta , together with wild type GPIbalpha and GPIX , demonstrated a failure of GPIX expression on the surface of HEK 293T cells . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Lesions in the genes for GPIb alpha , GPIb beta or GPIX result in a bleeding diathesis , the Bernard Soulier syndrome ( BSS ) , which associates a platelet adhesion defect with thrombocytopenia , giant platelets and abnormal megakaryocytes ( MK ) . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| We analyzed all coding regions of GPIb alpha , GPIb beta , GPV and GPIX which were amplified from the patients ' genomic DNA by the polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The anti GPIb alpha antibody coprecipitated GPIb beta and GPIX , although the ratios of these polypeptides to GPIb alpha was greatly decreased compared with the ratio in normal platelets . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| It is composed of GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| After sequence analysis of the GPIb alpha , GPIb beta and GPIX genes , only a mutation in the GPIX gene at position 1826 ( A > G ) was identified , changing Asn 45 > Ser . ^^^ Our present observation of a decreased disulfide bridge formation between GPIb alpha and GPIb beta shows that GPIX is not only needed for the correct assembly of the complex but might also be needed for the disulfide bridge formation between GPIb alpha and GPIb beta . . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis showed normal electrophoretic mobility of GPIb alpha , GPIb beta , and GPIX . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The cysteine knot of platelet glycoprotein Ib beta ( GPIb beta ) is critical for the interaction of GPIb beta with GPIX . ^^^ The glycoprotein Ib ( GPIb ) complex is composed of GPIb alpha covalently attached to GPIb beta and noncovalently complexed with GPIX and GPV . ^^^ Patients with Bernard Soulier syndrome demonstrate that mutations in either GPIb beta or GPIX result in an absence of platelet GPIb alpha . ^^^ This occurs through the interaction of GPIX with GPIb beta . ^^^ The precise sites of interaction of GPIb beta with GPIX are not known . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Tests with GPV transfectants revealed that the antibodies reacted with GPV independent of GPIb alpha , GPIb beta , or GPIX . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| The complex consists of four polypeptides GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| Platelet glycoproteins Ib beta ( CD42c ) , 9 ( CD42a ) , and 5 ( CD42d ) , together with GP Ib alpha ( CD42b ) , form a receptor whose interaction with the von Willebrand factor is essential in the initial stages of haemostasis . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| We characterized the mutant GP1BB allele by expression in a cell line ( CHO alpha 9 ) that stably expresses two other components of the vWF receptor , GPIb alpha and GPIX . ^^^ |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13224 and P14770 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The primary sequences of the three individual glycoprotein ( GP ) chains , GPIb alpha , GPIb beta , and GPIX , comprising the normal platelet GPIb / IX receptor for von Willebrand factor ( vWF ) have recently been determined , opening the possibility for characterization of disorders of this receptor at the molecular level . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Anti PlE 1 antibody bound specifically to both the GPIb complex and glycocalicin . 3H labelled platelet membrane glycoproteins with apparent molecular weights of 130k , 25k , and 21k ( under reduced conditions ) corresponding to GPIb alpha , GPIb beta , and GPIX were immunoprecipitated by anti PlE 1 plasma . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Bernard Soulier syndrome Kagoshima : Ser 444 > stop mutation of glycoprotein ( GP ) Ib alpha resulting in circulating truncated GPIb alpha and surface expression of GPIb beta and GPIX . ^^^ The platelet membrane glycoprotein ( GP ) Ib / IX complex is composed of three polypeptides , GPIb alpha , GPIb beta , and GPIX , and functions as a platelet receptor for von Willebrand factor . ^^^ Her platelets completely lacked the surface expression of GPIb alpha , but expressed a residual amount of GPIb beta and GPIX . ^^^ Furthermore , the truncated GPIb alpha might be associated with the process of the surface expression of incomplete GPIb / IX complex , GPIb beta and GPIX . . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The complex is composed of four glycoprotein subunits , GPIb alpha , GPIb beta , GPIX and GPV , each with a variable number of leucine rich repeats . ^^^ GPIb alpha and GPIb beta are linked by a disulphide bridge while GPIX and GPV associate noncovalently with the complex . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Western blotting revealed normal levels of GPIX , decreased levels of GPIb beta and GPV , and < 1 % of GPIb alpha . ^^^ RT PCR studies showed the presence of mRNA coding for GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| In contrast , no detectable proteolytic modification of the two other subunits , GPIb beta and GPIX , was detected . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Like the genes encoding GPIb alpha , GPIX , and GPV , the GPIb beta gene appears simple in structure . ^^^ When we examined poly ( A ) + RNA from several human tissues for GPIb beta mRNA expression , we found that GPIb beta mRNA was expressed in a variety of tissues but was most abundant in heart and brain , while GPIb alpha and GPIX mRNA expression was found only in lung and placenta at very low levels . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Analysis of the genes for two other components of the platelet GPIb : 9 complex , namely GPIb beta and GPIX , showed two different missense mutations in the coding region of the GPIX gene : an A > G transition in codon 21 results in conversion of an aspartic acid to glycine and an A > G change in codon 45 converts an asparagine residue to serine . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The platelet membrane glycoprotein ( Gp ) Ib complex consists of four polypeptides : the disulfide linked GpIb alpha and GpIb beta subunits ; GpIX , tightly , but noncovalently associated with GpIb alpha beta ; and the more weakly associated GpV . ^^^ It is not certain whether the association of GpIX to Gplb alpha beta is via GpIB alpha , GpIb beta , or both subunits , although recently published evidence implicates an interaction with GpIb beta . ^^^ We have investigated the interaction of GpIX with GpIb alpha beta using polyclonal rabbit antibodies to GpIb alpha and GpIb beta raised by immunization with purified glycocalicin and with synthetic peptide sequences from GpIb beta , respectively , as well as monoclonal antibodies directed against GpIX ( FMC 25 ) and against GpIb alpha ( AP 1 ) . ^^^ When wells were coated with polyclonal GpIb alpha or GpIb beta antibodies and then incubated with reduced GpIb complex , only wells coated with GpIb alpha antibodies captured GpIX reactivity . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| We amplified the coding regions of GPIb alpha , GPIb beta , GPV , and GPIX from the patients ' genomic DNA with the polymerase chain reaction ( PCR ) and sequenced the PCR products . in case 1 , we identified a point mutation in the GPIX coding region that changes the codon for tryptophan 126 ( TGG ) to a nonsense codon ( TGA ) . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Surface expression of GpIb alpha depends on the correct intracellular assembly with the GpIb beta and GpIX chains . ^^^ This study indicates that functional expression of the vWF binding domain of GpIb alpha on the surface of mammalian cells can be obtained in the absence of GpIb beta and GpIX . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| We analyzed all coding regions of GPIb alpha , GPIb beta , GPV and GPIX which were amplified from the patients ' genomic DNA by the polymerase chain reaction ( PCR ) . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The anti GPIb alpha antibody coprecipitated GPIb beta and GPIX , although the ratios of these polypeptides to GPIb alpha was greatly decreased compared with the ratio in normal platelets . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| It is composed of GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The platelet membrane glycoprotein ( GP ) Ib 5 9 complex is the receptor for von Willebrand factor and is composed of four membrane spanning polypeptides : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The platelet glycoprotein Ib ( GpIb ) complex is composed of four polypeptides : the disulfide linked GpIb alpha and GpIb beta and the noncovalently associated GpIX and GpV . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Immunostaining of the CHO K 1 cells transfected with two plasmids for mutant GPIX and GPIb beta showed that mutant GPIX was weakly but certainly detected in the cytoplasm of the transfected cells . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The complex , which serves as a platelet receptor for von Willebrand factor , is composed of 4 subunits : GPIb alpha , GPIb beta , GPIX , and GPV . ^^^ Studies of transient coexpression of this mutant , W21stop GPIb beta , together with wild type GPIbalpha and GPIX , demonstrated a failure of GPIX expression on the surface of HEK 293T cells . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Lesions in the genes for GPIb alpha , GPIb beta or GPIX result in a bleeding diathesis , the Bernard Soulier syndrome ( BSS ) , which associates a platelet adhesion defect with thrombocytopenia , giant platelets and abnormal megakaryocytes ( MK ) . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| After sequence analysis of the GPIb alpha , GPIb beta and GPIX genes , only a mutation in the GPIX gene at position 1826 ( A > G ) was identified , changing Asn 45 > Ser . ^^^ Our present observation of a decreased disulfide bridge formation between GPIb alpha and GPIb beta shows that GPIX is not only needed for the correct assembly of the complex but might also be needed for the disulfide bridge formation between GPIb alpha and GPIb beta . . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis showed normal electrophoretic mobility of GPIb alpha , GPIb beta , and GPIX . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The cysteine knot of platelet glycoprotein Ib beta ( GPIb beta ) is critical for the interaction of GPIb beta with GPIX . ^^^ The glycoprotein Ib ( GPIb ) complex is composed of GPIb alpha covalently attached to GPIb beta and noncovalently complexed with GPIX and GPV . ^^^ Patients with Bernard Soulier syndrome demonstrate that mutations in either GPIb beta or GPIX result in an absence of platelet GPIb alpha . ^^^ This occurs through the interaction of GPIX with GPIb beta . ^^^ The precise sites of interaction of GPIb beta with GPIX are not known . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Tests with GPV transfectants revealed that the antibodies reacted with GPV independent of GPIb alpha , GPIb beta , or GPIX . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| The complex consists of four polypeptides GPIb alpha , GPIb beta , GPIX and GPV . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| We characterized the mutant GP1BB allele by expression in a cell line ( CHO alpha 9 ) that stably expresses two other components of the vWF receptor , GPIb alpha and GPIX . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Antibody binding assays with trypsin digested platelets ( ELISA , immunoprecipitation with biotin labelled platelets ) indicate that the antigen is not localized on the glycocalicin moiety of GP Ib alpha , but may be situated on the remnant moiety of GP Ib alpha , GP 9 or GPIb beta . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| Platelet glycoproteins Ib beta ( CD42c ) , 9 ( CD42a ) , and 5 ( CD42d ) , together with GP Ib alpha ( CD42b ) , form a receptor whose interaction with the von Willebrand factor is essential in the initial stages of haemostasis . ^^^ |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P14770 and P13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|