| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| CD 91 is a common receptor for heat shock proteins gp 96 , hsp 90 , hsp 70 , and calreticulin . ^^^ In order to explain the unusual efficiency of this process , the uptake of gp 96 had been postulated to occur through a receptor , identified recently as CD 91 . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| We recently have identified CD 91 as a receptor for the heat shock protein gp 96 . ^^^ Gp 96 and alpha ( 2 ) M are both ligands for CD 91 . ^^^ Furthermore , peptides chaperoned by alpha ( 2 ) M , like those chaperoned by gp 96 , can be re presented by CD 91 ( + ) APCs on their MHC 1 molecules . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| It has been found that , ( 1 ) gp 96 is one of the major peptide binding proteins in the ER , ( 2 ) gp 96 interacts specifically with receptors including CD 91 and possibly toll like receptors ( TLRs ) , on the surface of professional antigen presenting cells ( APCs ) , ( 3 ) interaction with APCs leads to re presentation of gp 96 chaperoned peptides to the major histocompatibility complex ( MHC ) molecules of APCs , ( 4 ) direct access of gp 96 to APCs triggers functional activation of APCs . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| On one hand , this phenomenon is based on the specific interaction with CD 91 that mediates endocytosis and results in major histocompatibility complex class 1 restricted representation of the Gp 96 associated peptides . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| GRP 94 ( gp 96 ) associated peptides can elicit cellular immune responses , an activity thought to reflect the presence of a cell surface receptor ( CD 91 ) on antigen presenting cells that mediates GRP 94 internalization and trafficking to an amenable site for peptide transfer to major histocompatibility complex class 1 molecules . ^^^ GRP 94 ( gp 96 ) associated peptides can elicit cellular immune responses , an activity thought to reflect the presence of a cell surface receptor ( CD 91 ) on antigen presenting cells that mediates GRP 94 internalization and trafficking to an amenable site for peptide transfer to major histocompatibility complex class 1 molecules . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| Recent data indicates , however , that inhibition of CD 91 ligand binding does not alter gp 96 recognition and uptake . ^^^ Furthermore , CD 91 expression is not itself sufficient for gp 96 binding and internalization . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| Essential role of CD 91 in re presentation of gp 96 chaperoned peptides . ^^^ The ability of cells to bind alpha ( 2 ) macroglobulin , a previously known CD 91 ligand , or HSP gp 96 , and their ability to process peptides chaperoned by alpha ( 2 ) macroglobulin , undergo identical variations . ^^^ In additional studies in vivo , protective tumor immunity elicited by tumor derived gp 96 peptide complexes is shown to be abrogated by anti CD 91 antisera . ^^^ These studies show that CD 91 is essential for re presentation of gp 96 chaperoned peptides by MHC molecules and have an important bearing on the mechanism of immunogenicity of necrotic cells . . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| However , the evidence for a CRT interaction with CD 91 is indirect , predicated on partial competition of cellular binding by gp 96 , of which CD 91 has been proposed as the unique endocytic receptor , and by the CD 91 ligand alpha 2 macroglobulin . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| The CD 91 molecule ( also called alpha 2 macroglobulin receptor or the low density lipoprotein related protein ) is shown here to be a cell surface receptor for the heat shock protein gp 96 . ^^^ CD 91 : a receptor for heat shock protein gp 96 . ^^^ CD 91 binds gp 96 directly , rather than through another ligand for CD 91 . ^^^ The previously known CD 91 ligand , alpha 2 macroglobulin , inhibits re presentation of gp 96 chaperoned antigenic peptides by macrophages , as do antibodies to CD 91 . ^^^ As gp 96 is exclusively intracellular and is released as a result of necrotic but not apoptotic cell death , we propose that CD 91 acts as a sensor for necrotic cell death . . ^^^ |
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| Interacting proteins: Q07954 and P14625 |
Pubmed |
SVM Score :0.0 |
| Cutting edge : CD 91 independent cross presentation of GRP 94 ( gp 96 ) associated peptides . ^^^ Entry into this pathway requires receptor mediated endocytosis , and CD 91 ( low density lipoprotein receptor related protein ) has been reported to be the receptor mediating GRP 94 uptake into APC . ^^^ We investigated the contribution of CD 91 to GRP 94 cell surface binding , internalization , and trafficking in APCs . ^^^ Whereas a clear role for CD 91 in alpha ( 2 ) macroglobulin binding and uptake was readily obtained , the addition of excess CD 91 ligand , activated alpha ( 2 ) macroglobulin , or receptor associated protein , an antagonist of all known CD 91 ligands , did not affect GRP 94 cell surface binding , receptor mediated endocytosis , or peptide re presentation . ^^^ These data identify a CD 91 independent , GRP 94 internalization pathway that functions in peptide Ag re presentation . . ^^^ |
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