| Interacting proteins: O60603 and P14625 |
Pubmed |
SVM Score :0.0 |
| Extensive work in the last 10 years has also suggested that HSPs such as Hsp 60 , Hsp 70 , Hsp 90 and gp 96 , may be potent activators of the innate immune system capable of inducing the production of pro inflammatory cytokines by the monocyte macrophage system , and the activation and maturation of dendritic cells via the Toll like receptor 2 and 4 signal transduction pathways . ^^^ |
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| Interacting proteins: O60603 and P14625 |
Pubmed |
SVM Score :0.0 |
| In this study , we have analyzed the consequences of Gp 96 interaction with cells expressing different Toll like receptors ( TLRs ) and with bone marrow derived dendritic cells from mice lacking functional TLR 2 and / or TLR 4 molecules . ^^^ |
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| Interacting proteins: O60603 and P14625 |
Pubmed |
SVM Score :0.0 |
| It has been reported that Hsp 60 , Hsp 70 , Hsp 90 , and gp 96 are capable of inducing the production of proinflammatory cytokines by the monocyte macrophage system and the activation and maturation of dendritic cells ( antigen presenting cells ) in a manner similar to the effects of lipopolysaccharide ( LPS ) and bacterial lipoprotein , e . g . , via CD14 / Toll like receptor 2 ( TLR 2 ) and CD14 / TLR4 receptor complex mediated signal transduction pathways . ^^^ |
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| Interacting proteins: O60603 and P14625 |
Pubmed |
SVM Score :0.0 |
| Interaction of TLR 2 and TLR 4 ligands with the N terminal domain of Gp 96 amplifies innate and adaptive immune responses . ^^^ However , preincubation of low amounts of Gp 96 with TLR 2 and TLR 4 ligands at concentrations unable to activate dendritic cells by themselves results in the production of high levels of proinflammatory cytokines , up regulation of activation markers , and amplification of T cell activation . ^^^ |
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| Interacting proteins: O60603 and P14625 |
Pubmed |
SVM Score :0.0 |
| NA |
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