| Interacting proteins: O00206 and P14625 |
Pubmed |
SVM Score :0.0 |
| In this study , we have analyzed the consequences of Gp 96 interaction with cells expressing different Toll like receptors ( TLRs ) and with bone marrow derived dendritic cells from mice lacking functional TLR 2 and / or TLR 4 molecules . ^^^ |
|
| Interacting proteins: O00206 and P14625 |
Pubmed |
SVM Score :0.0 |
| The localization of TLR 4 to the Golgi apparatus was abrogated by expression of a genetically modified form of the TLR 4 binding chaperone gp 96 . ^^^ |
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| Interacting proteins: O00206 and P14625 |
Pubmed |
SVM Score :0.0 |
| Interaction of TLR 2 and TLR 4 ligands with the N terminal domain of Gp 96 amplifies innate and adaptive immune responses . ^^^ However , preincubation of low amounts of Gp 96 with TLR 2 and TLR 4 ligands at concentrations unable to activate dendritic cells by themselves results in the production of high levels of proinflammatory cytokines , up regulation of activation markers , and amplification of T cell activation . ^^^ |
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| Interacting proteins: O00206 and P14625 |
Pubmed |
SVM Score :0.0 |
| NA |
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