| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| We immunohistochemically examined the expression of Schwann cell related markers , nerve growth factor ( NGF ) receptor , S 100 alpha and beta proteins , glial fibrillary acidic protein ( GFAP ) , and galactocerebroside ( gal C ) in 5 malignant schwannomas , 21 benign peripheral nerve sheath tumors , and 4 apparently normal sural nerves . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| Also the authors immunohistochemically examined the presence or absence of GFAP ( glial fibrillary acidic protein ) , NSE ( neuron specific enolase ) , S 100 alpha and beta subunits . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| A total of 14 cases of clear cell carcinoma of salivary glands were evaluated by immunohistochemical methods using monoclonal antibodies to cytokeratin ( K1 . 1 and K8 . 12 ) , vimentin , S 100 alpha and beta subunits , neuron specific enolase ( NSE ) , glial fibrillary acidic protein ( GFAP ) , MAM 3 and MAM 6 antigens and proliferating cell nuclear antigen ( PCNA ) , as well as polyclonal antibodies to lysozyme ( Ly ) , lactoferrin ( la ) and Alpha 1 antichymotrypsin ( alpha 1 Ach ) . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| Developing human fetal salivary glands of gestational age from 10 to 40 weeks ( n = 100 ) and normal adult glands ( n = 10 ) were examined for immunoreactivity to S 100 protein and its subunits S 100 alpha , S 100 beta , glial fibrillary acidic protein ( GFAP ) and neuron specific enolase ( NSE ) . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| CNTF induces GFAP in a S 100 alpha brain cell population : the pattern of CNTF alpha R suggests an indirect mode of action . ^^^ In contrast , when we utilized an S 100 alpha antibody recognizing a calcium binding protein in immature astrocytes , we found colocalization of S 100 alpha and GFAP mRNA . ^^^ These data suggest that CNTF induces an upregulation of GFAP in immature S 100 alpha + astrocytes . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| Expression of S 100 , detected with a polyclonal antibody , S 100 alpha , S 100 beta , alpha SMA , GFAP , and keratin 14 , was observed in 61 % , 83 % , 39 % , 33 % , 28 % , and 39 % of the IDCs with large central acellular zones , 17 % , 44 % , 6 % , 6 % , 0 % , and 6 % of the IDCs without such zones , and 80 % , 70 % , 50 % , 100 % , 80 % , and 50 % of the metaplastic carcinomas , respectively . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| Annexin 6 binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments . ^^^ Annexin 6 , a member of a family of Ca ( 2+ ) dependent phospholipid and membrane binding proteins , interacts with the Ca ( 2+ ) regulated EF hand proteins , S100A1 and S100B , and blocks the ability of these two proteins to inhibit the assembly of desmin and glial fibrillary acidic protein ( GFAP ) into intermediate filaments in a Ca ( 2+ ) and dose dependent manner . ^^^ We speculate that the annexin 6 site on S100A1 / B may only partially overlap to the desmin / GFAP site . ^^^ In contrast , no effects of annexin 5 on the ability of S100A1 or S100B to affect the desmin and GFAP assemblies could be documented , although binding of annexin 5 to S100A1 and S100B could be detected at relatively high Ca2+ concentrations . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| Role of the C terminal extension in the interaction of S100A1 with GFAP , tubulin , the S100A1 and S100B inhibitory peptide , TRTK 12 , and a peptide derived from p 53 , and the S100A1 inhibitory effect on GFAP polymerization . ^^^ Whereas native and recombinant S100A1 inhibited GFAP assembly , a truncated S100A1 lacking the last six C terminal residues ( Phe 88 Ser93 ) ( S100A1Delta88 93 ) proved unable to do so . ^^^ The inhibitory effects of native and recombinant S100A1 on GFAP assembly were blocked by both TRTK 12 , a synthetic peptide derived from the alpha subunit of the actin capping protein , CapZ , and a synthetic peptide derived from the tumor suppressor protein , p 53 , in a dose dependent manner . ^^^ By fluorescent spectroscopy , TRTK 12 and the p 53 peptide , like GFAP and tubulin , caused a dose and Ca2+ dependent blue shift of the fluorescence maximum of acrylodan S100A1 . ^^^ By chemical crosslinking , both TRTK 12 and the p 53 peptide strongly reduced or blocked the formation of GFAP S100A1 or tubulin S100A1 complexes , respectively , and S100A1Delta88 93 was unable to complex with tubulin , whereas a remarkably reduced complexation of GFAP with the truncated protein was observed . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| The Ca2+ modulated , dimeric proteins of the EF hand ( helix loop helix ) type , S100A1 and S100B , that have been shown to inhibit microtubule ( MT ) protein assembly and to promote MT disassembly , interact with the type 3 intermediate filament ( IF ) subunits , desmin and glial fibrillary acidic protein ( GFAP ) , with a stoichiometry of 2 mol of IF subunit / mol of S100A1 or S100B dimer and an affinity of 0 . 5 1 . 0 microM in the presence of a few micromolar concentrations of Ca2+ . ^^^ Binding of S100A1 and S100B results in inhibition of desmin and GFAP assemblies into IFs and stimulation of the disassembly of preformed desmin and GFAP IFs . ^^^ S100A1 and S100B interact with a stretch of residues in the N terminal ( head ) domain of desmin and GFAP , thereby blocking the head to tail process of IF elongation . ^^^ The C terminal extension of S100A1 ( and , likely , S100B ) represents a critical part of the site that recognizes desmin and GFAP . ^^^ |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P23297 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|