| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| HIV 1 Nef co localizes with the astrocyte specific cytoskeleton protein GFAP in persistently nef expressing human astrocytes . ^^^ Therefore , human astrocytic cell clones stably transfected with nef genes derived from HIV 1 Bru and its myristoylation defective TH variant were investigated by confocal laser scanning microscopy for expression of Nef and cytoskeleton proteins actin and GFAP , a marker for activated astrocytes . ^^^ Nef co localised with GFAP in the perinuclear region of astrocytes . ^^^ Nef / GFAP interaction could contribute to changes in morphology and activation state of astrocytes shown previously which are both critical for development of astrogliosis in HIV 1 infected brain . . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Relationship of Nef positive and GFAP reactive astrocytes to drug use in early and late HIV infection . ^^^ In this study of patients at different stages of the human immunodeficiency virus ( HIV ) infection , who had been treated at most with one antiretroviral drug , reactive astrocytes were identified by immunopositivity for glial fibrillary acidic protein ( GFAP ) and infected astrocytes by positivity for HIV Nef protein . ^^^ |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| A subpopulation of betaA treated astrocytes showed an increase in glial fibrillary acidic protein ( GFAP ) and Vimentin ( Vim ) immunostaining while other reactive astrocyte markers such as S100beta , MAP 2 , and ApoE remained unaltered or undetectable . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| GFAP and S100beta expression in the cortex and hippocampus in response to mild cortical contusion . ^^^ We studied the acute response of glial fibrillary acidic protein ( GFAP ) and S100beta gene expression in the cerebral cortex and hippocampus to mild unilateral cortical contusion . ^^^ We further analyzed the effect of contusion on GFAP and S100beta immunoreactive astrocyte density at 96 h postlesion or postsham by double label immunocytochemistry . ^^^ Furthermore , all S100beta immunoreactive astrocytes in the lesioned ipsilateral cortex were also GFAP immunoreactive , whereas only about 11 % of S100beta positive cells were also GFAP labeled in the contralateral lesioned or the ipsilateral sham cortex . ^^^ In the hippocampus , all S100beta immunoreactive cells were also GFAP immunoreactive under all conditions . ^^^ |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Its expression profile was well correlated with those of glial fibrillary acidic protein ( GFAP ) and S100B , which are known as glial differentiation markers . ^^^ It was , moreover , observed that the r gsp expression in brain increased considerably after birth , like those of S100B and GFAP . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| To investigate the developmental distribution of cochlear nucleus ( CN ) astrocytes , we used immunocytochemical localization of glial fibrillary acidic protein ( GFAP ) and S100beta in rats at 0 , 5 , 10 , 15 , 21 , 30 postnatal days plus the adult . ^^^ By contrast with GFAP , the apparition of S100beta immunoreactivity ( S100beta IR ) was abrupt ( between 0 and 5 days ) followed by a rapid stabilization of density and distribution of IR cells ( between 15 and 21 days ) . ^^^ With contrast to GFAP IR astrocytes , S100beta positive cells were mainly restricted to the central part of the CN , while only few IR astrocytes were observed in the granule cell domain of the ventral CN or in the molecular cell layer of the dorsal CN . ^^^ The gradual expression of GFAP and S100beta is interpreted as reflecting the time course of astrocytic maturation . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The S100B protein inhibits phosphorylation of GFAP and vimentin in a cytoskeletal fraction from immature rat hippocampus . ^^^ Analysis by two dimensional electrophoresis revealed a Ca2+ / calmodulin dependent and a Ca2+ / cAMP dependent inhibitory effect of S100B , ranging from 62 % to 67 % of control , on the phosphorylation of the intermediate filament proteins glial fibrillary acidic protein ( GFAP ) and vimentin . ^^^ The fact that S100B binds to the N terminal domain of GFAP and that the two proteins are co localized in astrocytes suggests a potential in vivo role for S100B in modulating the phosphorylation of intermediate filament proteins in glia . . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Annexin 6 binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments . ^^^ Annexin 6 , a member of a family of Ca ( 2+ ) dependent phospholipid and membrane binding proteins , interacts with the Ca ( 2+ ) regulated EF hand proteins , S100A1 and S100B , and blocks the ability of these two proteins to inhibit the assembly of desmin and glial fibrillary acidic protein ( GFAP ) into intermediate filaments in a Ca ( 2+ ) and dose dependent manner . ^^^ In contrast , no effects of annexin 5 on the ability of S100A1 or S100B to affect the desmin and GFAP assemblies could be documented , although binding of annexin 5 to S100A1 and S100B could be detected at relatively high Ca2+ concentrations . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| In cells treated with the MT depolymerizing agent , colchicine , S100B remained associated with the rearranged GFAP IFs throughout the cell and , at the cell periphery , vimentin IFs . ^^^ Also , a preferential association of S100B with GFAP vs . vimentin IFs could be observed near the nucleus where colocalization of S100B with MTs was also maximal . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| SCs were immunopositive for glutamine synthetase ( GS ) and S100beta and immunonegative for glial fibrillary acidic protein ( GFAP ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The Ca2+ modulated , dimeric proteins of the EF hand ( helix loop helix ) type , S100A1 and S100B , that have been shown to inhibit microtubule ( MT ) protein assembly and to promote MT disassembly , interact with the type 3 intermediate filament ( IF ) subunits , desmin and glial fibrillary acidic protein ( GFAP ) , with a stoichiometry of 2 mol of IF subunit / mol of S100A1 or S100B dimer and an affinity of 0 . 5 1 . 0 microM in the presence of a few micromolar concentrations of Ca2+ . ^^^ Binding of S100A1 and S100B results in inhibition of desmin and GFAP assemblies into IFs and stimulation of the disassembly of preformed desmin and GFAP IFs . ^^^ S100A1 and S100B interact with a stretch of residues in the N terminal ( head ) domain of desmin and GFAP , thereby blocking the head to tail process of IF elongation . ^^^ The C terminal extension of S100A1 ( and , likely , S100B ) represents a critical part of the site that recognizes desmin and GFAP . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The expression of S100beta and glial fibrillary acidic protein ( GFAP ) was analyzed following bilateral injection of kainic acid ( KA ) , a glutamate derivative , into the CA 3 region of the adult rat hippocampus . ^^^ A significant increase of GFAP and its mRNA was demonstrated at each time point , whereas S100beta mRNA levels were significantly enhanced only 30 days after the KA injection and the levels of S100beta protein remained unchanged at all time points . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Privileged anatomical relationships of the S100beta / vimentin network with the glial fibrillary acidic protein ( GFAP ) astrocytes further suggested that , together , they form the structural basis for a general meningeo glial network . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Serum anti S100b , anti GFAP and anti NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders . ^^^ Natural autoantibodies of IgG class to proteins S100b , glial fibrillar acidic protein ( GFAP ) , and nerve growth factor ( NGF ) are presented in serum of healthy adults and those levels / affinities are relatively constant and may vary among individuals within narrow limits . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The chronic healing responses after either technique appeared similar with : ( 1 ) a thin fibrous scar at the fenestration site , ( 2 ) cells uniformly distributed ( hematoxylin and eosin ) , and ( 3 ) up regulation of GFAP and S100beta in astrocytes adjacent to the fenestration site . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The levels of autoantibodies and their anti idiotypes to proteins of nervous tissue ( S100b , GFAP , MP 65 and nerve growth factor ) were studied in 85 women of 18 48 years of age with psychogenic neurotic depressions . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Most cells were GFAP ( ) / S100beta ( ) . ^^^ This finding suggests that DNA synthesis in GFAP ( ) / S100beta ( ) cells is tonically suppressed by endogenous opioids . ^^^ Assuming that S100beta and GFAP , respectively , distinguish among younger and older astroglia , this implies that astroglial replication becomes increasingly sensitive to morphine during maturation , and suggests that opioids differentially regulate the development of distinct subpopulations of glia and glial precursors . . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| S100beta ( glial ) immunoreactivity was similar in the post ischemic hippocampus of the GFAP ( + / + ) and GFAP ( / ) , indicating that reactive astrocytosis did not require GFAP . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Normal salivary glands had positive immunoreactivity for S 100A families , K8 . 12 and KL 1 in the ductal cells , while S100B , GFAP and NSE were observed in peripheral nerve fibers innervating the gland . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| S100B , ferritin and glial fibrillary acidic protein ( GFAP ) were quantified in CSF and brain tissue homogenate by ELISA ( enzyme linked immunosorbent assay ) techniques developed in house . ^^^ There was a correlation between GFAP levels and ambulation in SP multiple sclerosis ( r = 0 . 57 , P < 0 . 01 ) , and between S100B level and the 9HPT in PP multiple sclerosis patients ( r = 0 . 85 , P < 0 . 01 ) . ^^^ Both GFAP and S100B levels were significantly higher in the cortex of multiple sclerosis than in control brain homogenate ( P < 0 . 001 and P < 0 . 05 , respectively ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The immunocontent of the markers glial fibrillary acidic protein ( GFAP ) and S100B increased , while basal secretion of S100B decreased , in astrocytes from 10 to 40 days in vitro ( DIV ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| These OECs are the first glial cells encountered by the axons of developing ORNs as they exit the OE and display distinct and variable expression of p 75 , S100beta , GFAP , and O 4 , characteristic markers of bulb OECs . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Pancreatic islets of Langerhans are enveloped by peri islet Schwann cells ( pSC ) , which express glial fibrillary acidic protein ( GFAP ) and S100beta . pSC autoreactive T and B cell responses arise in 3 to 4 week old diabetes prone non obese diabetic ( NOD ) mice , followed by progressive pSC destruction before detectable beta cell death . ^^^ Moreover , GFAP specific NOD T cell lines transferred pathogenic peri insulitis to NOD / severe combined immunodeficient ( NOD / SCID ) mice , and immunotherapy with GFAP or S100beta prevented diabetes . pSC survived in rat insulin promoter Iymphocytic choriomeningitis virus ( rip LCMV ) glycoprotein / CD8+ T cell receptor ( gp ) double transgenic mice with virus induced diabetes , suggesting that pSC death is not an obligate consequence of local inflammation and beta cell destruction . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The temporal and spatial patterns of expression of the neuronal markers gamma aminobutyric acid ( GABA ) , choline acetyltransferase ( ChAT ) , dopamine beta hydroxylase ( DBH ) , dopamine receptor DR 1 and synaptophysin , as well as the glial cell markers glial fibrillary acidic protein ( GFAP ) , S100B and excitatory amino acid transporter protein GLT 1 are delineated in the fetal cortex using immunohistochemistry . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Neurofilament heavy chain ( NfH ( SM 135 ) ) , astrocytic glial fibrillary acidic protein ( GFAP ) , S100B and ferritin , markers of axonal loss , gliosis , astrocyte activation and microglial activation , respectively , were quantified in the spinal cord homogenates of mice with chronic relapsing experimental allergic encephalomyelitis ( CREAE , n=8 ) and controls ( n=7 ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| A few BrdU positive cells in postischemic monkeys were double stained for markers of neuronal progenitors ( class 3 beta tubulin , TUC 4 , doublecortin , or Hu ) , neurons ( NeuN ) , or glia ( S100beta or GFAP ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Morphologically , two subpopulations of nestin GFP positive cells were distinguishable ; one had an elaborate tree of processes in the granule cell layer and expression of GFAP ( but not of S100beta , another astrocytic marker ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The antibody used against S100beta marked the largest astrocytic pool in the gray matter of the cerebral cortex ; only approximately 5 % of astrocytes were glial fibrillary acidic protein ( GFAP ) ( + ) in control animals . ^^^ The first area , in contrast to focal traumatic injuries , consisted of a 196 microm thick boundary layer of S100beta ( + ) cells immediately surrounding the lesion that never expressed GFAP or VIM by day 6 . ^^^ A second unusual extended area around the base of the lesion reaching partly into the corpus callosum consisted of S100beta ( + ) / GFAP ( + ) / VIM ( + ) cells . ^^^ The proximal response at the base of the lesion developed over the first 3 days in the following sequence : S100beta ( + ) / GFAP ( ) / VIM ( ) to S100beta ( + ) / GFAP ( + ) / VIM ( ) to S100beta ( + ) / GFAP ( + ) / VIM ( + ) . ^^^ A third region , consistent with a remote or distal reactive gliotic response , demonstrated staining for S100beta and had increased GFAP contents throughout the neocortical hemisphere . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Neurone specific enolase ( NSE ) , protein S100B and glial fibrillary acidic protein ( GFAP ) are those proteins investigated most often as peripheral surrogate markers of brain damage after stroke in humans . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| MEASUREMENTS AND MAIN RESULTS : CSF and serum levels of S100B ( and its isoforms S100A1B and S100BB ) , neuronal specific enolase ( NSE ) , and the CSF levels of glial fibrillary acidic protein ( GFAp ) and lactate were determined . ^^^ One with a stroke showed a 540 fold increased GFAp , a 6 fold NSE , and S100B increase in CSF . ^^^ One with paraplegia had a 270 fold increase in GFAp , a 2 fold increase in NSE , and 5 fold increased S100B in CSF . ^^^ One patient without deficit increased GFAp 10 fold , NSE 4 fold , and S100B 23 fold in CSF . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Cells expressed a variety of neuroectodermal markers including GFAP , S100beta , and neurofilament . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Key indicators of this response are increased synthesis of glial fibrillary acidic protein ( GFAP ) and S100B , both astrocytic markers . ^^^ Like GFAP , S100B levels also were increased in all three brain areas of diabetic rats , an effect also reduced by melatonin treatment . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| We used immunoperoxidase and immunofluorescence techniques to determine whether these transporters co localized with markers for blood vessels ( CD 34 ) , neurons ( microtubule associated protein 2 [ MAP 2 ] , SMI 311 ) , radial glia ( vimentin ) , or astrocytes ( glial fibrillary acidic protein [ GFAP ] , S100beta protein ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical studies were performed to analyze GFAP and S100beta expression . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| S100B mediated inhibition of the phosphorylation of GFAP is prevented by TRTK 12 . ^^^ We observed an inhibitory effect of S100B on glial fibrillary acidic protein ( GFAP ) phosphorylation , when stimulated by cAMP or Ca2+ / calmodulin , in a cytoskeletal fraction from primary astrocyte cultures . ^^^ We found that S100B has no direct effect on CaM KII activity , the major kinase in this cytoskeletal fraction able to phosphorylate GFAP . ^^^ The inhibition of GFAP phosphorylation is most likely due to the binding of S100B to the phosphorylation sites on this protein and blocking the access of these sites to the protein kinases . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the ability of glial ( glial fibrillary acidic protein [ GFAP ] and S100b ) and neuronal ( neuron specific enolase [ NSE ] ) protein levels in peripheral blood to predict outcome after severe traumatic brain injury . ^^^ Blood samples taken at the time of hospital admission were analyzed for S100b , GFAP , and NSE . ^^^ RESULTS : The median serum levels of S100b , GFAP , and NSE were raised 18 . 3 fold ( S100b ) , 4 . 6 fold ( GFAP ) , and twofold ( NSE ) compared to normal reference values . ^^^ S100b , GFAP , and NSE serum levels correlated significantly with the injury severity score and CT findings but not with age , sex , or GCS . ^^^ S100b , GFAP , and NSE levels were significantly higher in patients who died or had a poor outcome 6 months post injury than in those who were alive or had good outcome . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Conversely , up regulation of astroglial markers [ glial fibrillary acidic protein ( GFAP ) and S100B ] was observed only at the subacute and chronic phases of inflammation . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| METHODS : Concentrations of the neurofilament light protein ( NFL ) , glial fibrillary acidic protein ( GFAP ) , S100B , and the neuron specific enolase protein ( NSE ) were determined in the CSF of 66 MS patients and 50 healthy control subjects with immunoassays . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Relationship between S100beta and GFAP expression in astrocytes during infarction and glial scar formation after mild transient ischemia . ^^^ The expression of astrocyte marker proteins ( S100beta and GFAP ) during infarction and glial scar formation after transient middle cerebral artery ( MCA ) occlusion was examined using double immunostaining . ^^^ Our results suggest that ( 1 ) higher concentration of S100beta in the extracellular space due to S100beta leakage from damaged astrocytes leads to up regulation of S100beta synthesis and induction of inducible nitric oxide synthase ( iNOS ) synthesis in astrocytes , contributing to infarct expansion that results in DNA damage or cell death via NO and ROS production , and ( 2 ) GFAP , but not S100beta , is a main contributor to glial scar formation . ^^^ |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| AIM AND METHODS : We investigated the immunohistochemical alterations of S100beta , S 100 , glial fibrillary acidic protein ( GFAP ) and isolectin B 4 positive cells in the hippocampus after 5 min of transient cerebral ischaemia in gerbils . ^^^ In our double labelled immunostainings , S 100 and S100beta immunoreactivity was found in GFAP positive astrocytes , but not in isolectin B 4 positive microglia . ^^^ This drug also prevented increases in the number of GFAP positive astrocytes , isolectin B 4 positive microglia , S 100 positive astrocytes and S100beta positive astrocytes after ischaemia . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Cell morphology was investigated by phase contrast microscopy and immunocytochemistry for actin , GFAP and S100B . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The expression of glial fibrillary acidic protein ( GFAP ) , S100B protein , and neuron specific enolase ( NSE ) was determined as well as lipid peroxidation ( LPO ) and glutathione ( GSH ) levels in some brain tissues . ^^^ Western blot analyses showed GFAP , S100B , and NSE levels significantly increased under STZ induced diabetes in brain , and LPO level increased as well . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Lower levels of S100B were observed in cerebrospinal fluid with no significant changes in S100B and GFAP content in brain tissue . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| At 3 , 7 or 14 days post lesion , animals were sacrificed and their brains processed for immunohistochemistry to detect GFAP , vimentin , MAP 2 , S100B and nuclear Hoechst staining . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| These S100A6 neocortex labelled astrocytes were also positive for the glial fibrillary acidic protein ( GFAP ) and S100B protein . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| GFAP versus S100B in serum after traumatic brain injury : relationship to brain damage and outcome . ^^^ Our goal was to analyze the relationship of GFAP / S100B to brain damage and outcome , and to compare the accuracy of GFAP / S100B for prediction of mortality after TBI . ^^^ GFAP / S100B were measured immunoluminometrically at admission and daily in the intensive care unit ( average 10 days , range 1 21 days ) . ^^^ We compared GFAP / S100B in non survivors versus survivors , accuracy for mortality prediction according to receiver operated characteristic curve analysis , correlation between GFAP and S100B , relationship of GFAP / S100B to computerized tomography , cerebral perfusion pressure ( CPP ) , mean arterial pressure ( MAP ) and 3 month Glasgow Outcome Score ( GOS ) . ^^^ GFAP ( p < 0 . 005 ) and S100B ( p < 0 . 0005 ) were higher in non survivors than survivors . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| AIM : To investigate the effect of gabapentin on neural [ neuron specific enolase ( NSE ) ] and glial markers [ glial fibrillary acidic protein ( GFAP ) and S100B ] in different brain regions of diabetic rats . ^^^ The levels of GFAP , S100B , and NSE were determined by immunoblotting in the hippocampus , cortex , and cerebellum . ^^^ RESULTS : Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats . ^^^ Pretreatment with gabapentin prevented the upregulation of GFAP , S100B , and NSE in all brain regions of diabetic rats . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| The effects of aging and chronic ethanol consumption on glial markers [ glial fibrillary acidic protein ( GFAP ) and S100B ] and oxidant and antioxidant status of rats were studied . ^^^ An age related increase in GFAP and S100B levels were found in the cortex and hippocampus . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Nestin GFP+ cells expressed the chondroitin sulfate proteoglycan NG 2 and nestin protein , but typically lacked mature astrocytic markers , that is , glial fibrillary acid protein ( GFAP ) or S100beta . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Administration of S100B before TMT treatment prevented TMT induced changes in morphology and GFAP expression . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| In monolayer culture with medium containing 10 % serum , FBD 104 cells expressed some markers of astrocytes , such as glial fibrillary acidic protein ( GFAP ) , S100beta , and glutamate aspartate transporter ( GLAST ) . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Amniotic fluid levels of neurofilament heavy chain ( NfH ) , glial acidic fibrillary protein ( GFAP ) and S100B were measured by standard ELISA techniques . ^^^ The rapid increase in GFAP , paralleled by a moderate increase in NfH and S100B , suggests that spinal cord damage starts to accelerate around E16 . 5 . ^^^ |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| We also found that GFAP , S100beta and AQP 4 protein elevation persisted for at least 9 months throughout contused spinal cords , consistent with the chronic nature of CNP . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| A majority of the proliferating cells express S100beta and astrocyte specific glutamate transporter ( GLAST ) and the subpopulation are also positive for glial fibrillary acidic protein ( GFAP ) and nestin . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine if levels of the glial derived proteins S100beta and glial acidic fibrillary protein ( GFAP ) and the pro and antiapoptotic proteins p 53 and Bcl 2 were altered in the cortex of subjects with schizophrenia or bipolar 1 disorder . ^^^ METHOD : Levels of S100beta , GFAP , p 53 and Bcl 2 were measured in cortex ( Brodmann ' s Areas ( BAs ) 9 , 10 , 46 and 40 ) of control subjects and subjects with schizophrenia , bipolar 1 disorder and in the cortex of rats treated with haloperidol or lithium using protein specific antibodies and western blot analysis . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| On postnatal day 90 , brains were processed for immunocytochemistry using primary antibodies to glial fibrillary acidic protein ( GFAP ; the main cytoskeletal astroglial protein ) , S100B protein ( an astroglial derived neurotrophic factor ) , MAP 2 ( a microtubule associated protein present almost exclusively in dendrites ) , and synaptophysin ( Syn ; one major integral protein of the synaptic vesicles membrane ) . ^^^ The results show a significant increase in the cell area of GFAP immunoreactive ( IR ) astrocytes , with high levels of S100B protein and a significant decrease in the relative area of MAP 2 IR neuronal processes in prenatally stressed adult rats . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Furthermore , aluminum caused marked elevation in the levels of the glial markers ( glial fibrillary acidic protein ( GFAP ) and S100B ) and proinflammatory cytokines ( TNF alpha and IL 1beta ) in both brain areas . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| In the three prosencephalic areas , astrocytes ' cell area ( GFAP ir cells ) increased after EtOH exposure and tended to return to normality after abstinence , while cytoplasmic astroglial S100b protein ir , relative area of MAP 2 ir and Nf 200 ir fibers decreased , and later partially recovered . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| In immunohistochemical and biochemical analyses , the expression of GABAA receptor beta subunit decreased , whereas expressions of glial fibrillary acidic protein ( GFAP ) and S100B , hallmarks of astrocytic activation , increased dramatically in the cultured astrocytes with in vitro aging . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated S100B secretion in rat cortical astrocytes acutely exposed to ammonia , as well astrocyte morphology , glial fibrillary acidic protein ( GFAP ) content and glutamine synthetase ( GS ) activity . ^^^ We found an increase in S100B secretion by astrocytes exposed to ammonia for 24h , accompanied by a decrease in GFAP content and GS activity . ^^^ Creatine addition did not prevent this increment in S100B secretion , but was able to prevent the decrease in GFAP content and GS activity induced by ammonia exposure . . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| Increased GFAP and S100beta but not NSE serum levels after subarachnoid haemorrhage are associated with clinical severity . ^^^ Hospital admission S100beta , glial fibrillary acidic protein ( GFAP ) and neuron specific enolase ( NSE ) serum levels were analysed in 67 patients with SAH . ^^^ Mean astroglial serum concentrations taken at hospital admission were increased ( S100beta 2 . 8 fold and GFAP 1 . 8 fold ) compared with the upper limit of normal laboratory reference values ( P 95 ) . ^^^ S100beta ( P < 0 . 001 ) and GFAP ( P =0 . 011 ) but not NSE levels were higher in patients who were in coma at the time of hospital admission compared with patients who were not . ^^^ Similarly S100beta and GFAP but not NSE serum levels increased with higher WFNS scores , raised intracranial pressure and higher CT Fisher grade scores . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| During the next days of culture immunoreactions for beta tubulin 3 , MAP 2 , GFAP , S100beta , Doublecortin , and GalC were induced with reciprocal lowering of stem cell gene and protein markers . ^^^ |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To assess levels of glial fibrillar acidic protein ( GFAP ) , myelin basic protein ( MBP ) , neurone specific enolase ( NSE ) and S100B in patients with first onset schizophrenia . ^^^ METHOD : We investigated CSF and serum samples from 12 patients with first onset schizophrenia and from 17 control subjects by ELISA ( GFAP , MBP ) or immunoluminometric sandwich assays ( NSE , S100B ) . ^^^ DISCUSSION : Our finding of increased levels of S100B in patients with schizophrenia without an indication for significant glial ( GFAP , MBP ) or neuronal ( NSE ) damage may be interpreted as indirect evidence for increased active secretion of S100B during acute psychosis . . ^^^ |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04271 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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