| Interacting proteins: O00255 and P14136 |
Pubmed |
SVM Score :0.0 |
| Here we report that menin interacts with the type 3 intermediate filament ( IF ) proteins glial fibrillary acidic protein ( GFAP ) and vimentin . ^^^ Deletion mutants of GFAP or vimentin involving the head domains of the molecules abolish the interaction with menin . ^^^ Endogenous menin is colocalized with GFAP and vimentin in glioma cells as determined by confocal microscopy . ^^^ Furthermore , a tailless GFAP deletion mutant , which disrupts the IF network , results in menin / GFAP / vimentin containing aggregates . ^^^ Triple immunofluorescence labeling studies with antibodies against menin , BrdU , and GFAP show that menin and GFAP colocalize in glioma cells at the S G 2 phase of the cell cycle , as measured by BrdU incorporation . ^^^ |
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| Interacting proteins: O00255 and P14136 |
Pubmed |
SVM Score :0.0 |
| The MEN 1 gene product interacts with glial fibrillary acidic protein ( GFAP ) in the brain . ^^^ This tumor represents a novel , non endocrine MEN 1 phenotype , compatible with a role of MEN 1 GFAP in glial oncogenesis . ^^^ |
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| Interacting proteins: O00255 and P14136 |
Pubmed |
SVM Score :0.0 |
| NA |
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