Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta is a dual specificity kinase differentially regulated by tyrosine and serine / threonine phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Localization and developmental changes of tau protein kinase I / glycogen synthase kinase 3 beta in rat brain . tau protein kinase 1 ( TPKI ) purified from bovine brain extract has been shown to phosphorylate tau and to form paired helical filament ( PHF ) epitopes and was found recently to be identical to glycogen synthase kinase 3 beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we have investigated which protein phosphatase activities can dephosphorylate recombinant tau phosphorylated with mitogen activated protein kinase , glycogen synthase kinase 3 beta , neuronal cdc 2 like kinase , or cyclic AMP dependent protein kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos . ^^^ To assess the role of a closely related kinase , glycogen synthase kinase 3 beta ( GSK 3 beta ) , in vertebrate embryogenesis , we cloned a cDNA encoding a Xenopus homolog of GSK 3 beta ( XGSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
These are the exclusive sites of phosphorylation in the N terminal third of the L myc protein , and can be phosphorylated in vitro by glycogen synthase kinase 3 beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Differential regulation of glycogen synthase kinase 3 beta by protein kinase C isotypes . ^^^ Here it is shown that glycogen synthase kinase 3 beta ( GSK 3 beta ) , a serine / threonine kinase that specifically targets the inhibitory c Jun phosphorylation sites , is phosphorylated in vitro by particular forms of PKC ( alpha , beta 1 , gamma greater than beta 2 ; not epsilon ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Baculovirus mediated expression and characterisation of rat glycogen synthase kinase 3 beta , the mammalian homologue of the Drosophila melanogaster zeste white 3sgg homeotic gene product . ^^^ Molecular cloning of glycogen synthase kinase 3 ( GSK 3 ) has demonstrated the existence of a novel form , termed GSK 3 beta , which is highly related to the well characterised GSK 3 alpha protein but derived from a distinct gene . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Mitogen inactivation of glycogen synthase kinase 3 beta in intact cells via serine 9 phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
PHF tau from Alzheimer ' s brain comprises four species on SDS PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inactivation of glycogen synthase kinase 3 beta by phosphorylation : new kinase connections in insulin and growth factor signalling . ^^^ The beta isoform of glycogen synthase kinase 3 ( GSK 3 beta ) isolated from rabbit skeletal muscle was inactivated 90 95 % following incubation with MgATP and either MAP kinase activated protein kinase 1 ( MAPKAP kinase 1 , also termed RSK 2 ) or p 70 S6 kinase ( p70S6K ) , and re activated with protein phosphatase 2A . ^^^ The inhibitory effect of Ser 9 phosphorylation on GSK 3 beta activity was observed with three substrates , ( inhibitor 2 , c jun and a synthetic peptide ) , and also with glycogen synthase provided that 0 . 15 M KCl was added to the assays . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta phosphorylates tau protein at multiple sites in intact cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta is identical to tau protein kinase 1 generating several epitopes of paired helical filaments . ^^^ We also present the amino acid sequence of TPKI , which is identical to glycogen synthase kinase 3 beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A number of kinases , including mitogen activated protein ( MAP ) kinase , glycogen synthase kinase ( GSK ) 3 alpha , GSK 3 beta and cyclin dependent kinase 5 , phosphorylate recombinant tau in vitro so that it resembles PHF tau as judged by its reactivity with a panel of antibodies capable of discriminating between normal tau and PHF tau , and by a reduced electrophoretic mobility that is characteristic of PHF tau . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of tau by glycogen synthase kinase 3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF tau from Alzheimer ' s disease brain . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we describe results that show that although MAP kinase can hyperphosphorylate tau in vitro , activation of MAP kinase in transformed fibroblasts does not result in hyperphosphorylation of transfected tau , whereas glycogen synthase kinase 3 beta ( GSK 3 beta ) when co transfected with tau does result in tau hyperphosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
ATP citrate lyase and glycogen synthase kinase 3 beta in 3T3 L 1 cells during differentiation into adipocytes . ^^^ ATP citrate lyase ( CL ) , acetyl CoA carboxylase ( ACC ) and glycogen synthase kinase 3 beta ( GSK 3 beta ) levels were measured in cytosol from 3T3 L 1 cells during differentiation from fibroblasts into fat cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To address the role of glycogen synthase kinase 3 beta ( GSK 3 beta ) , a mammalian homologue of Shaggy , in vertebrate embryogenesis , it was overexpressed in Xenopus embryos . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of protein phosphatase 1 isoforms and glycogen synthase kinase 3 beta in muscle from mdx mice . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To investigate the cellular mechanisms regulating neurofilament heavy subunit ( NF H ) side arm phosphorylation , we studied the ability of three putative neurofilament kinases , glycogen synthase kinase 3 ( GSK 3 ) alpha , GSK 3 beta , and cyclin dependent kinase 5 ( cdk 5 ) , to phosphorylate NF H in transfected cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Our results suggest that lithium acts through inhibition of glycogen synthase kinase 3 beta ( GSK 3 beta ) , which regulates cell fate determination in diverse organisms including Dictyostelium , Drosophila , and Xenopus . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Exposure of rat hippocampal neurons to amyloid beta peptide ( 25 35 ) induces the inactivation of phosphatidyl inositol 3 kinase and the activation of tau protein kinase I / glycogen synthase kinase 3 beta . ^^^ Exposure of rat hippocampal neurons to the peptide amyloid beta ( A beta ) ( 25 35 ) as well as A beta ( 1 40 ) peptides enhances phosphorylation of tau to a paired helical filament ( PHF ) state through activation of tau protein kinase 1 ( TPK 1 ) / glycogen synthase kinase 3 beta ( GSK 3 beta ) [ Busciglio , J . , Lorenzo , A . , Yeh , J . and Yankner , B . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using conditions in vitro under which two proline directed protein kinases , glycogen synthase kinase 3beta ( GSK 3beta ) and mitogen activated protein kinase ( MAPK ) , were able to hyperphosphorylate tau , GSK 3beta but not MAPK phosphorylated recombinant APPcyt . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of tau by glycogen synthase kinase 3 beta in intact mammalian cells : the effects on the organization and stability of microtubules . ^^^ This morphology is lost when tau is co expressed with glycogen synthase kinase 3 beta ; microtubules become less stable and are not bound by tau . ^^^ Independently of any direct or indirect effects on tau , glycogen synthase kinase 3 beta induces some but relatively slight changes in microtubule organization with the loss of a prominent centrosomal microtubular origin . ^^^ We have demonstrated , in intact cells , that tau highly phosphorylated in the presence of glycogen synthase kinase 3 beta loses the properties of microtubule binding and stabilization , suggesting that regulation of tau phosphorylation by this enzyme might be an important mechanism whereby cytoskeletal function is modulated during neurodevelopment and lost in neurodegeneration . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
XrelA also strongly reduces axis duplication caused by overexpression of a dominant negative mutant of Xenopus glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We report the cloning of the skp1+ gene , a Schizosaccharomyces pombe homolog of the glycogen synthase kinase 3 ( GSK 3 ) family whose members in higher eukaryotes are involved in cell fate determination , nuclear signalling , and hormonal regulation . skp 1 is 67 % identical to mammalian GSK 3 beta and displays similar biochemical properties in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
After cloning , TPKI was found to be identical with glycogen synthase kinase 3 beta ( GSK 3 beta ) , while TPKII consists of a novel 23 kDa protein activator and a catalytic subunit that is identical with cyclin dependent kinase 5 ( CDK 5 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The action of glycogen synthase kinase 3 beta ( GSK 3 beta ) on the maturation and phosphorylation of an amyloid precursor protein reporter construct ( APP REP ) was studied in transfected COS 7 cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Tau transfected into these cells is predominantly non phosphorylated at many PHF tau sites but co transfection with the tau kinase glycogen synthase kinase 3 beta ( GSK 3 beta ) induces phosphorylation that generates epitopes for several phosphorylation dependent antibodies . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta ( GSK 3 beta / zeste white 3 / shaggy ) is a negative regulator of the wnt signaling pathway which plays a central role in the development of invertebrates and vertebrates ; loss of function and dominant negative mutations in GSK 3 beta lead to activation of the wnt pathway in Drosophila and Xenopus . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To study the effects of phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) on the ability of the microtubule associated protein tau to promote microtubule self assembly , tau isoform 1 ( foetal tau ) and three mutant forms of this tau isoform were investigated . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Mutagenesis experiments demonstrate that substitution of the serine residues in the glycogen synthase kinase 3beta ( GSK3beta ) phosphorylation consensus motif of beta catenin inhibits ubiquitination and results in stabilization of the protein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In a search for genetic defects responsible for the decreased insulin stimulated glycogen synthesis seen in patients with non insulin dependent diabetes mellitus ( NIDDM ) and their glucose tolerant first degree relatives we have performed mutational analysis of the coding region of the 2 isoforms of GSK 3alpha and GSK 3beta in 72 NIDDM patients and 12 control subjects . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In order to investigate the effect on tau of manipulating glycogen synthase kinase ( GSK ) 3beta activity in the brain , we created transgenic mice harbouring wild type GSK 3beta genes or a mutant GSK 3beta that is predicted to be more active . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Further evidence that the inhibition of glycogen synthase kinase 3beta by IGF 1 is mediated by PDK1 / PKB induced phosphorylation of Ser 9 and not by dephosphorylation of Tyr 216 . 293 cells were transfected with wild type GSK3beta ( WT GSK3beta ) or a mutant in which the PKB phosphorylation site ( Ser 9 ) was altered to Ala ( A 9 GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The adenomatous polyposis coli gene product is a 300 , 000 mol . wt cytoplasmic protein that binds to at least three other proteins ; beta catenin , a cytoplasmic E cadherin associated protein ; hDLG , a human homologue of the Drosophila discs large tumour suppressor protein and glycogen synthase kinase 3 beta , a mammalian homologue of the Drosophila ZESTE WHITE 3 protein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The beta catenin , glycogen synthase kinase 3beta ( GSK 3beta ) , and adenomatous polyposis coli ( APC ) gene products interact to form a network that influences the rate of cell proliferation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Combined tau protein kinase 2 ( TPK 2 ) , which consists of CDK 5 and its activator ( p 23 ) , and glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylate tau to the PHF form in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using a yeast two hybrid method , we identified a novel protein which interacts with glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This suggests a possible link between Axin , the Wnt 1 signaling components beta catenin and glycogen synthase kinase 3 beta ( GSK 3 beta ) , and APC . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
PS 1 directly binds tau and a tau kinase , glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using human glycogen synthase kinase 3 beta ( Gsk 3 beta ) as bait in the yeast two hybrid system , we identified a novel human dynamin like protein 4 ( HdynIV ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
RESULTS : We found that Axin interacts with beta catenin and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We further present evidence that glycogen synthase kinase 3beta ( GSK 3beta ) and extracellular signal regulated kinase mitogen activated protein kinase ( ERK MAPK ) participate in the down regulation of HSF 1 transcriptional activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that MUC 1 associates with glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
By contrast , ventricular glycogen synthase kinase 3beta ( GSK3beta ) protein levels were maintained during postnatal development . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Now , we demonstrate that glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylates cyclin D 1 specifically on Thr 286 , thereby triggering rapid cyclin D 1 turnover . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the absence of a mitogenic signal from outside the cell , beta catenin is sequestered in complexes with the product of the adenomatous polyposis coli ( APC ) gene and a serine threonine glycogen kinase ( GSK 3 beta ) enabling degradation of free beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Taken together with our recent observations that Axin directly interacts with glycogen synthase kinase 3beta ( GSK 3beta ) and beta catenin and that it promotes GSK 3beta dependent phosphorylation of beta catenin , these results suggest that Axin , APC , GSK 3beta , and beta catenin make a tetrameric complex , resulting in the regulation of the stabilization of beta catenin . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The level of beta catenin is regulated by partner proteins , including glycogen synthase kinase 3beta ( GSK 3beta ) and the adenomatous polyposis coli ( APC ) tumor suppressor protein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Insulin treatment resulted in a transient increase in tau phosphorylation followed by a decrease in tau phosphorylation that correlated directly with a sequential activation and deactivation of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The adenomatous polyposis coli ( APC ) tumour suppressor protein controls the Wnt signalling pathway by forming a complex with glycogen synthase kinase 3beta ( GSK 3beta ) , axin / conductin and betacatenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
When Axin , a negative regulator of the Wnt signaling pathway , was expressed in COS cells , it coeluted with glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , and adenomatous polyposis coli protein ( APC ) in a high molecular weight fraction on gel filtration column chromatography . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
However , it is known that phosphorylation of c jun by glycogen synthase kinase ( GSK ) 3beta inhibits AP 1 DNA binding activity , and lithium has recently been demonstrated to inhibit GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Xenopus axin interacts with glycogen synthase kinase 3 beta and is expressed in the anterior midbrain . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Dysregulation of beta catenin can result from missense mutations that affect critical sites of phosphorylation by glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Axin forms a complex with glycogen synthase kinase 3beta ( GSK 3beta ) and beta catenin and promotes GSK 3beta dependent phosphorylation of beta catenin , thereby stimulating the degradation of beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
However , although Wnt signals are known to inhibit the activity of the negative regulatory protein kinase glycogen synthase kinase 3beta ( GSK 3beta ) , resulting in increased levels of beta catenin , we find no evidence for involvement of GSK 3beta in Tcf mediated transcription in T cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Deregulation of beta catenin accumulation as a result of mutations in adenomatous polyposis coli ( APC ) tumor suppressor protein is believed to initiate colorectal neoplasia . beta catenin levels are regulated by the ubiquitin dependent proteolysis system and beta catenin ubiquitination is preceded by phosphorylation of its N terminal region by the glycogen synthase kinase 3beta ( GSK 3beta ) / Axin kinase complex . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
From the binding experiments , we defined the domains of Axin that bind glycogen synthase kinase 3beta ( GSK 3beta ) and beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Based on analyses of the axonal cytoskeleton , a model is proposed in which Wnt 7a induces axonal remodelling by inhibiting glycogen synthase kinase 3 beta ( GSK 3 beta ) , a serine / threonine kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In parallel , glycogen synthase kinase 3beta ( GSK 3beta ) inactivation and eukaryotic translation initiation factor 4E binding protein 1 ( 4E BP 1 ) phosphorylation were monitored as markers of the rapamycin insensitive and sensitive branches of the PI3K signaling pathway , respectively . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Epistasis experiments in frog embryos indicated that Axin functioned downstream of glycogen synthase kinase 3beta ( GSK3beta ) and upstream of beta catenin , and subsequent studies showed that Axin is part of a complex including these two proteins and adenomatous polyposis coli ( APC ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inducible overexpression of PS 1 led to increased association of beta catenin with glycogen synthase kinase 3beta ( GSK 3beta ) , a negative regulator of beta catenin , and accelerated the turnover of endogenous beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Downregulation of glycogen synthase kinase 3beta ( GSK 3beta ) protein expression during neuroblastoma IMR 32 cell differentiation . ^^^ Glycogen synthase kinase 3gamma ( GSK 3beta ) is a multifunctional protein kinase that phosphorylates a variety of substrates including the neuronal specific microtubule associated protein tau . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To characterize the contribution of glycogen synthase kinase 3beta ( GSK3beta ) inactivation to insulin stimulated glucose metabolism , wild type ( WT GSK ) , catalytically inactive ( KM GSK ) , and uninhibitable ( S9A GSK ) forms of GSK3beta were expressed in insulin responsive 3T3 L 1 adipocytes using adenovirus technology . ^^^ Lithium stimulation of glycogen synthesis was insensitive to wortmannin , which is consistent with its acting directly on GSK3beta downstream of phosphatidylinositol 3 kinase . ^^^ These data support the hypothesis that GSK3beta contributes to insulin regulation of glycogen synthesis , but is not responsible for the increase in glucose transport . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
It was accompanied by the increased phosphorylation of glycogen synthase kinase 3 ( GSK 3 ) and the inhibition of the activity of GSK 3beta to catalyze phosphorylation of its substrate , translation initiation factor eIF2B . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The major nucleoporin p 62 can be phosphorylated in vitro by protein kinase A and glycogen synthase kinase ( GSK ) 3alpha but not by cyclin B / cdc2 or GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
However , the calcium induced increase in tau phosphorylation was inhibited by lithium , a noncompetitive inhibitor of glycogen synthase kinase 3beta ( GSK 3beta ) , and by the tyrosine kinase inhibitor , genistein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Current models predict that beta catenin ( beta cat ) functions in Wnt signaling via activation of Tcf / Lef target genes and that its abundance is regulated by the adenomatous polyposis coli ( APC ) and glycogen synthase kinase 3beta ( GSK3beta ) proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) has been described as a proline directed kinase which phosphorylates tau protein at several sites that are elevated in Alzheimer paired helical filaments . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To examine the mechanism ( s ) that contribute to this process , we studied Tat ' s effects on glycogen synthase kinase 3beta ( GSK 3beta ) , an enzyme that has been implicated in the regulation of apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In control rats , insulin caused a 40 50 % reduction of the phosphotransferase activity of the beta isoform of glycogen synthase kinase 3 ( GSK 3beta ) , which is a PKB target in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In addition , the interaction of beta catenin with the adenomatous polyposis coli protein is blocked in V12Ras and p110alpha transformants though no changes in glycogen synthase kinase 3 beta activity could be detected . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a proline directed kinase that forms part of the wingless signaling pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have defined a 25 amino acid sequence in axin that comprises the glycogen synthase kinase 3beta ( GSK 3beta ) interaction domain ( GID ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the present study , the role of CR 1 in the phosphatidylinositol 3 ' kinase ( PI3K ) / AKT ( protein kinase B ) / glycogen synthase kinase 3beta ( GSK 3beta ) dependent signaling pathway was evaluated in human SiHa cervical carcinoma cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Distribution of active glycogen synthase kinase 3beta ( GSK 3beta ) in brains staged for Alzheimer disease neurofibrillary changes . ^^^ Glycogen synthase kinase 3beta ( GSK 3beta ) is one of the candidate kinases involved in PHF tau formation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have recently shown that glycogen synthase kinase 3beta ( GSK3beta ) phosphorylates the microtubule associated protein ( MAP ) 1B in an in vitro kinase assay and in cultured cerebellar granule cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lithium has also been demonstrated to inhibit glycogen synthase kinase 3 beta ( GSK 3 beta ) , an enzyme known to regulate the levels of phosphorylated tau and beta catenin ( both of which may play a role in the neurodegeneration observed in Alzheimer ' s disease ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
RESULTS : Lithium ' s acute effects are mediated through inhibition of specific enzymes involved in two distinct but interacting signaling pathways the protein kinase C and glycogen synthase kinase 3 beta signaling cascades that converge at the level of gene transcriptional regulation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The product of the APC gene forms a complex with beta catenin , glycogen synthase kinase 3beta ( GSK 3beta ) and Axin / conductin , and induces the degradation of beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A contrasting pattern of expression was found in abnormal large neurons , which demonstrated elevated levels of Notch 1 , and glycogen synthase kinase 3beta ( GSK 3beta ) , and normal levels of APC . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
When the germline heterozygotes were crossed with mice expressing Cre recombinase in the intestines , the serines and threonine encoded by exon 3 and to be phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) were deleted in the offspring intestines , which caused adenomatous intestinal polyps resembling those in Apc ( Delta 716 ) knockout mice . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have investigated the ability of glycogen synthase kinase 3beta ( GSK 3beta ) to control tau induced processes outgrowth . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Other components of the Wnt signaling pathway , including Dvl , glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , and adenomatous polyposis coli ( APC ) , interact with Axin , and the phosphorylation and stability of beta catenin are regulated in the Axin complex . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In mammalian cells cytoplasmic accumulation of beta catenin follows reduction of the specific activity of glycogen synthase kinase 3 beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Among the proposed mechanisms , two lithium sensitive signal transduction pathways are active in the brain ; these are mediated by glycogen synthase kinase 3beta ( GSK 3beta ) and inositol ( 1 , 4 , 5 ) trisphosphate [ Ins ( 1 , 4 , 5 ) P 3 ] signalling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This region harbors several putative casein kinase 2 ( CKII ) and glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation sites and is highly phosphorylated . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We examined the interaction of these three rat brain dynamin like protein variants with glycogen synthase kinase 3beta ( Gsk 3beta ) using the yeast two hybrid screening , in vitro binding assay , and immunoprecipitation analysis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Axin forms a complex with adenomatous polyposis coli gene product ( APC ) , glycogen synthase kinase 3beta ( GSK 3beta ) , and beta catenin through different binding sites and downregulates beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Colon carcinoma and melanoma cells containing either a deletion of the adenomatous polyposis coli tumor suppressor protein ( APC ) or mutation of the site in beta catenin phosphorylated by glycogen synthase kinase 3beta ( GSK 3beta ) display elevated levels of detergent soluble beta catenin due to insensitivity of the cytosolic protein to proteasome dependent degradation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Terminal deoxynucleotidyl transferase mediated dUTP biotin in situ nick labeling ( TUNEL ) staining and immunoreactivity for glycogen synthase kinase 3beta ( GSK3beta ) were also markedly reduced in the brains with IGF 1 treatment . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) activity is negatively regulated by several signal transduction cascades that protect neurons against apoptosis , including the phosphatidylinositol 3 kinase ( PI 3 kinase ) pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using nanoelectrospray mass spectrometry , we have undertaken an extensive comparison of phosphorylation in vitro by several candidate tau kinases , namely , JNK , p 38 , ERK 2 , and glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Wnt signaling involves inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) and elevation of cytoplasmic beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase 3 beta . ^^^ The PSEN 1 binding protein glycogen synthase kinase 3 beta ( GSK 3 beta ) has been considered as a key protein in AD pathogenesis since GSK 3 beta phosphorylates tau and hyperphosphorylated tau is a main component of neurofibrillary tangles associated to AD . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Previous studies have demonstrated that cyclin D 1 ubiquitination is dependent on its phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) on threonine 286 and that this phosphorylation event is greatly enhanced by binding to CDK 4 ( Diehl , J . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lithium has also been demonstrated to inhibit glycogen synthase kinase 3beta ( GSK 3beta ) , an enzyme known to regulate the levels of phosphorylated tau and beta catenin ( both of which may play a role in the neurodegeneration observed in certain forms of Alzheimer ' s disease ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The effect of Wnt 1 in activating NF kappaB can be mimicked by inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) with lithium or with a dominant negative GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inhibition of alanyl aminopeptidase suppresses the activation dependent induction of glycogen synthase kinase 3beta ( GSK 3beta ) in human T cells . ^^^ Here , we analyzed by quantitative RT PCR and immunoblotting the expression in mitogen activated T cells of a major constituent of the Wnt 5a pathway , glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase 3 beta dependent phosphorylation of beta catenin and down regulates beta catenin . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 beta ) phosphorylated beta catenin slightly in the presence of either APC ( 1211 2075 ) or Axin ( delta ) ( beta ) ( catenin ) , in which the beta catenin binding site is deleted , and greatly in the presence of both proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The differential expression of glycosomes depends on the activity of glycogen synthase kinase 3 beta , a component of the wnt signaling pathway , and might in this spatiotemporal developmental window be involved in the commitment of presumptive cardiogenic and somatic cells . ^^^ Our results suggest that the target of LiCl action ( glycogen synthase kinase 3 beta ) might be involved in the specification of heart primordia and that WGA receptors mediate the migration of mesoderm to the anteriomedial direction . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recently , it has been shown that phosphorylation of cyclin D 1 by glycogen synthase kinase 3beta ( GSK 3beta ) on a single threonine residue ( Thr 286 ) positively regulates proteosomal degradation of cyclin D 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a key component in many biological processes including insulin and Wnt signaling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
ILK activation of the cyclin D 1 promoter was abolished by point mutation of a cAMP responsive element binding protein ( CREB ) / ATF 2 binding site at nucleotide 54 in the cyclin D 1 promoter , and by overexpression of either glycogen synthase kinase 3beta ( GSK 3beta ) or dominant negative mutants of CREB or ATF 2 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Axin forms a complex with adenomatous polyposis coli gene product , glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , Dvl , and protein phosphatase 2A and functions as a scaffold protein in the Wnt signaling pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the absence of Wnt signal , Axin and APC regulate cytoplasmic levels of the proto oncogene beta catenin through the formation of a large complex containing these three proteins , glycogen synthase kinase 3beta ( GSK3beta ) and several other proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Current hypotheses concerning presenilin function are based upon its cellular localization and its putative interaction as macromolecular complexes with the cell adhesion / signaling beta catenin molecule and the glycogen synthase kinase 3beta ( GSK 3beta ) enzyme . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inactivation of glycogen synthase kinase 3beta ( GSK3beta ) by S ( 9 ) phosphorylation is implicated in mechanisms of neuronal survival . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Pathogenic PSEN 1 mutations were demonstrated to have an effect on beta catenin and glycogen synthase kinase 3beta ( GSK 3beta ) , two members of the wingless Wnt pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We here report that paullones also act as very potent inhibitors of glycogen synthase kinase 3beta ( GSK 3beta ) ( IC 50 : 4 80 nM ) and the neuronal CDK5 / p25 ( IC 50 : 20 200 nM ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using human glycogen synthase kinase 3beta ( GSK 3beta ) as bait in the yeast two hybrid system , we identified a novel human centrosome associated protein , hNinein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we demonstrate that glycogen synthase kinase 3beta ( GSK 3beta ) is an effective kinase for protein tau in cerebral neurons in vivo in adult GSK 3beta and GSK 3beta 10 human tau 40 transgenic mice . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Indirubins inhibit glycogen synthase kinase 3 beta and CDK5 / p25 , two protein kinases involved in abnormal tau phosphorylation in Alzheimer ' s disease . ^^^ We report here that indirubins are also powerful inhibitors ( IC ( 50 ) : 5 50 nm ) of an evolutionarily related kinase , glycogen synthase kinase 3beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The microtubule stabilizing function of DVL 1 is mimicked by lithium mediated inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) and blocked by expression of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Herein , we report that glycogen synthase kinase 3beta ( GSK 3beta ) , a protein kinase previously implicated in processes as diverse as development and tumorigenesis , is inactivated by hypertrophic stimuli via a phosphoinositide 3 kinase dependent protein kinase that phosphorylates GSK 3beta on ser 9 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3 kinase or Akt but not for death caused by nerve growth factor withdrawal . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 beta ) , which is inhibited upon phosphorylation by Akt , was recently shown to function during cell death induced by PI 3 kinase inhibitors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
IGF 1 did , however , enhance transcriptional activity in combination with lithium chloride , an inhibitor of glycogen synthase kinase 3 beta , which also stabilizes beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Because the RGS domain is a major adenomatous polyposis coli gene product ( APC ) binding domain , APC association with glycogen synthase kinase 3beta ( GSK3beta ) on the Axin molecule may be important in inhibition of axis formation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Human tau protein kinase 1 ( TPK 1 ; also known as glycogen synthase kinase 3beta , GSK 3beta ) is a serine / threonine protein kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
These data suggest that stimulation of glycogen synthase by insulin in HepG 2 cells is mediated through the PI 3 kinase pathway by activating PKB and PP 1G and inactivating GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Because Akt inhibits glycogen synthase kinase 3beta ( GSK 3beta ) , an enzyme that facilitates cell death , we tested if GSK 3beta is a negative regulator of HSF 1 activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this report , we demonstrate that elevation of intracellular cAMP levels in rat cerebellar granule neurons leads to phosphorylation and inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase 3 beta identified by nano electrospray mass spectrometry . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we analyzed in forebrain homogenates from female Sprague Dawley rats the activities of extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) , c Jun NH ( 2 ) terminal kinase ( JNK ) , glycogen synthase kinase 3beta ( GSK 3beta ) , cyclin dependent kinase 5 ( Cdk 5 ) , cAMP dependent protein kinase A ( PKA ) , and Ca ( 2+ ) / calmodulin dependent protein kinase 2 ( CaMKII ) at 0 ( n = 5 ) , 3 ( n = 4 ) , 6 ( n = 5 ) , and 12 ( n = 5 ) h after heat shock and in non heat shocked controls ( n = 5 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 ( GSK 3beta ) phosphorylates tau and is inhibited via protein kinase C ( PKC ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have investigated the ability of four major neuronally active proline directed kinases , cyclin dependent protein kinase 5 , glycogen synthase kinase 3 beta , p 42 mitogen activated protein kinase and stress activated protein kinase 1b , to phosphorylate APPthr ( 668 ) and report here that SAPK1b induces robust phosphorylation of this site both in vitro and in vivo . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The cytoplasmic domain of MUC 1 interacts with glycogen synthase kinase 3 beta ( GSK 3 beta ) and thereby decreases binding of MUC 1 and beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To clarify how Abeta deposits induce secondary tauopathy , the presence of phosphorylated tau , glycogen synthase kinase 3alpha ( GSK3alpha ) , GSK3beta , cyclin dependent kinase 5 ( CDK 5 ) , mitogen activated protein kinase ( MAPK ) and fyn were examined in the Tg 2576 brain showing substantial brain Abeta amyloidosis and behavioral abnormalities . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A set of different protein kinases have been involved in tau phosphorylations , including glycogen synthase kinase 3beta ( GSK 3 beta ) , MARK kinase , MAP kinase , the cyclin dependent kinase 5 ( Cdk 5 ) system and others . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
LiCl , a potent inhibitor of Glycogen Synthase Kinase 3beta ( GSK3beta ) activity , abrogated the IL 6 induced inhibition of wild type beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In vitro phosphorylation of recombinant wild type 2N4R tau and FTDP 17 exonic mutant forms P301L , V337M and R406W by glycogen synthase kinase 3beta ( GSK3beta ) was examined by two dimensional phosphopeptide mapping analysis on thin layer cellulose plates . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inactivation of glycogen synthase kinase 3beta ( GSK3beta ) and the resulting stabilization of free beta catenin are critical steps in the activation of Wnt target genes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Axin , a negative regulator of the Wnt signaling pathway , forms a complex with glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , adenomatous polyposis coli ( APC ) gene product , and Dvl , and it regulates GSK 3beta dependent phosphorylation in the complex and the stability of beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer ' s disease . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 beta ) phosphorylates the microtubule associated protein tau at sites that are aberrantly phosphorylated in AD . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Two cellular targets of ILK 1 , glycogen synthase kinase 3 beta ( GSK3beta ) and protein kinase B ( PKB ) / AKT , were differentially affected by ILKAP mediated inhibition of ILK 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Provocatively , the enhanced glucose metabolism in GLUT 1 overexpressing VSMC as well as neointimal tissue correlated with the inactivation of the proapoptotic kinase , glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the presence of 10 microM TBB ( and 100 microM ATP ) only CK 2 was drastically inhibited ( > 85 % ) whereas three kinases ( phosphorylase kinase , glycogen synthase kinase 3 beta and cyclin dependent kinase 2 / cyclin A ) underwent moderate inhibition , with IC ( 50 ) values one two orders of magnitude higher than CK 2 ( IC ( 50 ) =0 . 9 microM ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inactivation of glycogen synthase kinase 3beta ( GSK3beta ) is critical for transcription of atrial natriuretic factor ( ANF ) by beta adrenergic receptors in cardiac myocytes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a Ser / Thr kinase that is involved in numerous cellular activities . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This residue is part of a highly conserved glycogen synthase kinase 3beta ( GSK 3beta ) consensus phosphorylation site within the loop domain of PS 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of glycogen synthase kinase 3 beta ( GSK 3beta ) by platelet activating factor mediates migration and cell death in cerebellar granule neurons . ^^^ PAF , produced from human immunodeficiency virus type 1 ( HIV 1 ) infected brain resident macrophages , induces neuronal apoptosis in cultured cerebellar granule neurons ( CGNs ) in part by activating glycogen synthase kinase 3 beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that both wild type glycogen synthase kinase 3 beta ( GSK 3 beta ) and kinase dead GSK 3 beta Y216F ( capable of binding to Axin ) , but not GSK 3 beta K85M ( incapable of binding to Axin in mammalian cells ) , prevented MEKK 1 binding to the Axin complex , thereby inhibiting JNK activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
GSK3beta was identified as the kinase that phosphorylates glycogen synthase but is now known to be involved in multiple signaling pathways . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The glycogen synthase kinase 3 beta ( GSK 3 beta ) generates many phosphorylated sites on tau . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The impairment of GS activation was paralleled by a similarly sized inhibition of glycogen synthase kinase 3 alpha ( GSK 3 alpha ) and GSK 3 beta inactivation by insulin with no change in protein phosphatase 1 activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta phosphorylates serine 33 of p 53 and activates p 53 ' s transcriptional activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
It is shown here that engagement of CCR 9 with TECK leads to phosphorylation of Akt ( protein kinase B ) , mitogen activated protein kinases ( MAPKs ) , glycogen synthase kinase 3 beta ( GSK 3 beta ) , and a forkhead transcription factor , FKHR , in a human T cell line , MOLT 4 , that naturally expresses CCR 9 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase 3 beta . ^^^ The goal of this study was to determine whether the intracellular distribution of the proapoptotic enzyme glycogen synthase kinase 3 beta ( GSK 3 beta ) is dynamically regulated by conditions that activate apoptotic signaling cascades . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
IGF 2 also caused the rapid and sustained deactivation of glycogen synthase kinase 3 beta ( Gsk3beta ) , reaching maximal at 1 3 min , shortly preceding , therefore , maximal activation of Akt . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To examine whether regulation of beta catenin by PS 1 requires phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) , we examined whether inhibiting GSK 3beta activity overcomes the inhibition of beta catenin transcription induced by mutant PS 1 constructs . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthesis in the normal and insulin resistant adipocytes was stimulated by lithium , an inhibitor of glycogen synthase kinase 3 beta , suggesting the involvement of phosphorylation events in dexamethasone induced insulin resistance . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a fascinating enzyme with an astoundingly diverse number of actions in intracellular signaling systems . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To examine the differences of the response to cerebral ischemia between young and old rat brains , distributions of glycogen synthase kinase 3beta ( GSK3beta ) and tau proteins were analyzed after 90 min of transient middle cerebral artery occlusion ( MCAO ) in young ( 10 11 weeks ) and old ( 15 months ) rats by immunohistochemical analyses . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Li ( + ) , an inhibitor of glycogen synthase kinase 3 beta , had no effect on osmotic stress induced caspase activation , but reduced phosphorylation at the Tau 1 epitope . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The inhibitory effect of p 53 on beta catenin is apparently mediated by the ubiquitin proteasome system and requires an active glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Two main protein kinases have been shown to be involved in anomalous tau phosphorylations : the cyclin dependent kinase Cdk 5 and glycogen synthase kinase GSK3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
CREB DNA binding activity is inhibited by glycogen synthase kinase 3 beta and facilitated by lithium . ^^^ The regulatory influences of glycogen synthase kinase 3 beta ( GSK 3 beta ) and lithium on the activity of cyclic AMP response element binding protein ( CREB ) were examined in human neuroblastoma SH SY5Y cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Abnormal degradation of beta catenin caused by alteration of the glycogen synthase kinase 3beta ( GSK 3beta ) consensus motif is an important step for carcinogenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To understand the different effects between tau and glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylated tau on the organization and stability of microtubules , we performed transfection studies on 3T3 cells using EGFP tau ( Enhanced Green Fluorescence Protein tau ) and GSK 3beta to quantify the stability of microtubules . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To test if glycogen synthase kinase 3beta ( GSK3beta ) , a pro apoptotic kinase that is inhibited by Akt , is involved in regulating MPP induced apoptosis , overexpression of GSK3beta and lithium , a selective inhibitor of GSK3beta , were used to directly alter GSK3beta activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
GSK 3 beta located downstream of Akt is an important molecule to further transmit insulin signal for glycogen synthesis in skeletal muscles . ^^^ In accordance with the results of Akt , insulin induced phosphorylation and inactivation of GSK 3 beta , subsequent activation of glycogen synthase and glycogen synthesis were decreased by expression of WT SHIP 2 , whereas these events were increased by expression of Delta IP SHIP 2 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In recent studies we have demonstrated that glycogen synthase kinase 3beta ( GSK3beta ) and its substrate microtubule associated protein 1B ( MAP1B ) regulate the microtubule cytoskeleton during axon outgrowth . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In addition , glycogen synthase kinase 3 beta , a potent inhibitor for both Dvl and Wnt , also failed to inhibit LRPC 2 or Dkk 2C2 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Dvl proteins participate as key intermediates in signal transmission from the seven membrane spanning Frizzled receptors leading to inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) , stabilization of beta catenin , and activation of the lymphoid enhancer factor ( LEF ) transcription factor . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A variety of targets of the Akt protein kinase have been implicated in cell survival , including the protein kinase glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of the Wnt cascade leads to inactivation of glycogen synthase kinase 3beta ( GSK 3beta ) , accumulation and activation of beta catenin and expression of genes involved in neuronal development . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is able to phosphorylate tau in a cellular context which could play a role in the formation of these NFT . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , PTH failed to induce transcriptional activity of GAL 4 CREB in cells treated with genistein , a general tyrosine kinase inhibitor known to inhibit glycogen synthase kinase 3 ( GSK 3 ) activity , or LiCl , the most specific GSK 3 inhibiting agent known , strongly implicating GSK 3beta in this process . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Several kinases , such as glycogen synthase kinase 3 beta ( GSK3beta ) and c Jun N terminal kinase ( JNK ) , phosphorylate tau at sites that are phosphorylated in PHF . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Testosterone prevents the heat shock induced overactivation of glycogen synthase kinase 3 beta but not of cyclin dependent kinase 5 and c Jun NH 2 terminal kinase and concomitantly abolishes hyperphosphorylation of tau : implications for Alzheimer ' s disease . ^^^ We have shown previously that glycogen synthase kinase 3 beta ( GSK 3 beta ) , cyclin dependent kinase 5 , and c Jun NH ( 2 ) terminal kinase become overactivated and hyperphosphorylate tau in heat shocked female rats . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a physiological kinase for tau and is a candidate protein kinase involved in the hyperphosphorylation of tau present in paired helical filament ( PHF ) tau of neurofibrillary tangles ( NFT ) in Alzheimer ' s disease ( AD ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) has been implicated in the phosphorylation of tau in normal and Alzheimer ' s disease brain . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the wing , the canoe mutants develop extra veins when they are heterozygous for shaggy , a mutation in the locus encoding the glycogen synthase kinase 3 beta ( Gsk 3 beta ) , which has been known to phosphorylate the Armadillo protein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Fas receptor signaling inhibits glycogen synthase kinase 3 beta and induces cardiac hypertrophy following pressure overload . ^^^ Fas activation by Fas ligand induced a hypertrophic response in cultured cardiomyocytes , which was dependent on the inactivation of glycogen synthase kinase 3 beta ( GSK 3 beta ) by phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To assess the functional involvement of Wnt signaling in BMP 2 induced chondrogenesis , cultures were treated with lithium chloride , a Wnt 7A mimetic that acts by inhibiting the serine / threonine phosphorylation activity of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta . ^^^ Here , we found that , in contrast what was found for cells adherent to fibronectin , alpha 2 beta 1 mediated cell adhesion to collagen leads to dephosphorylation of Akt and glycogen synthase kinase 3 beta ( GSK 3 beta ) and concomitantly to the induction of protein serine / threonine phosphatase 2A ( PP2A ) activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta mutagenesis identifies a common binding domain for GBP and Axin . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 ) is a key downstream target of Wnt signaling and is regulated by its interactions with activating and inhibitory proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
First non ATP competitive glycogen synthase kinase 3 beta ( GSK 3beta ) inhibitors : thiadiazolidinones ( TDZD ) as potential drugs for the treatment of Alzheimer ' s disease . ^^^ Glycogen synthase kinase 3 beta ( GSK 3beta ) has a central role in Alzheimer ' s disease ( AD ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In perfused rat hearts , PC ( 4 cycles of 5 minutes of ischemia and 5 minutes of reflow ) increased phosphorylation of glycogen synthase kinase 3beta ( GSK 3beta ) , a downstream target of PI 3 kinase and protein kinase B ( PKB ) , an effect that was blocked by wortmannin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The roles of glycogen synthase kinase 3beta ( GSK 3beta ) and tau phosphorylation were examined in seven day old rats injected with the NMDA receptor antagonist ( MK 801 ) that is known to induce neuronal apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Protein kinase A enhances , whereas glycogen synthase kinase 3 beta inhibits , the activity of the exon 2 encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion . ^^^ In kinase assays PKA phosphorylated Ser 87 of hnRNP D , whereas glycogen synthase kinase 3 beta ( GSK 3 beta ) phosphorylated Ser 83 , but only if Ser 87 had been pre phosphorylated by PKA . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Direct sequencing was performed to look for mutations in key genes involved in the Wnt signaling pathway : Exon 3 of beta catenin encompassing the glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation region and the mutational cluster region of the adenomatosis polyposis coli protein ( APC ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Mutations in the glycogen synthase kinase 3beta ( GSK3beta ) phosphorylation sites of the beta catenin gene exon 3 are found in 20 30 % of human primary hepatocellular carcinoma ( HCC ) , whereas mutations in the APC or AXIN genes are found in other HCC populations . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The level of beta catenin in cells is tightly controlled in a multiprotein complex , and mutations in the glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation sites of the beta catenin gene ( CTNNB 1 ) result in nuclear and / or cytoplasmic accumulation of beta catenin and constitutive transactivation of T cell factor and lymphoid enhancer factor target genes , a mechanism occurring in many cancers . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
As shown in in vitro experiments , glycogen synthase kinase 3 beta ( GSK3beta ) and protein kinase A ( PKA ) may be key kinases in these phosphorylation events . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Whereas insulin receptor autophosphorylation and insulin receptor substrate 2 tyrosine phosphorylation were not affected by PUGNAc inhibition of O GlcNAcase , downstream phosphorylation of Akt at Thr 308 and glycogen synthase kinase 3 beta at Ser 9 was inhibited . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Specifically , XNeuroD function in the retina can be inhibited by glycogen synthase kinase 3beta ( GSK3beta ) , while Xath 5 function can be inhibited by Notch . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
GLP 2 inhibited activation of glycogen synthase kinase 3 ( GSK 3 ) through phosphorylation at Ser ( 21 ) in GSK 3alpha and at Ser ( 9 ) in GSK 3beta in a PI3K independent , PKA dependent manner . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , lithium has been shown to regulate circadian cycles in diverse species , including humans , possibly through inhibition of glycogen synthase kinase 3 beta ( GSK 3beta ) , a known target of lithium . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Examination of glycogen synthase kinase 3beta , GSK 3beta , whose phosphorylation is controlled by protein kinase A and B , showed a substantial decrease in the levels of its phosphorylated form and an increase in total GSK 3beta levels in IB MECA treated melanoma cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a ubiquitously expressed constitutively active serine / threonine kinase that phosphorylates cellular substrates and thereby regulates a wide variety of cellular functions , including development , metabolism , gene transcription , protein translation , cytoskeletal organization , cell cycle regulation , and apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a central figure in Wnt signaling , in which its activity is controlled by regulatory binding proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we identified human glycogen synthase kinase 3 beta ( GSK 3beta ) as a specific interacting partner with SGKL in a yeast two hybrid screening of human brain cDNA library . ^^^ Human serum and glucocorticoid inducible kinase like kinase ( SGKL ) phosphorylates glycogen syntheses kinase 3 beta ( GSK 3beta ) at serine 9 through direct interaction . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , the activity of glycogen synthase kinase 3beta ( GSK 3beta ) increased transiently , as demonstrated by the kinase activity assay and by immunoblottings of serine 9 and tyrosine 216 phosphorylated of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a central component in many critical intracellular signaling mechanisms . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To assess the contribution of Wnt 3A to BMP 2 mediated chondrogenesis , we have generated C3H10T1 / 2 cell lines overexpressing Wnt 3A and various forms of glycogen synthase kinase 3beta ( GSK 3beta ) , an immediate cytosolic component of the Wnt signaling pathway , and examined their response to BMP 2 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The insulin like effect of zinc cations raises the possibility that they inhibit glycogen synthase kinase 3beta ( GSK 3beta ) , a serine / threonine protein kinase linked with insulin resistance and type 2 diabetes . ^^^ Treatment of HEK 293 cells with zinc enhanced glycogen synthase activity and increased the intracellular levels of beta catenin , providing evidence for inhibition of endogenous GSK 3beta by zinc . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we report that DeltaNp 63 associates with the B56alpha regulatory subunit of protein phosphatase 2A ( PP2A ) and glycogen synthase kinase 3beta ( GSK3beta ) , leading to a dramatic inhibition of PP2A mediated GSK3beta reactivation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Pharmacological inhibitor studies demonstrated each pathway to be intimately involved in HGF induced increases in TER , cortical actin thickening , and phosphorylation of the Ser / Thr glycogen synthase kinase 3beta ( GSK 3beta ) , a potential target for the HGF barrier promoting response . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the present study , we examined if alterations in the activity of glycogen synthase kinase 3 beta ( GSK3beta ) or treatment with mood stabilizers modulated BDNF mediated signal transduction pathways in differentiated human neuroblastoma SH SY5Y cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Consistent with the role of AKT in the regulation of glycogen synthase kinase 3beta ( GSK3beta ) , cAMP decreased the phosphorylation of GSK3beta and stimulated its activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We hypothesize that in neurodegenerative disorders such as Alzheimer ' s disease and human immunodeficiency virus encephalitis the neuroprotective activity of fibroblast growth factor 1 ( FGF 1 ) against several neurotoxic agents might involve regulation of glycogen synthase kinase 3beta ( GSK3beta ) , a pathway important in determining cell fate . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Insulin inhibited glycogen synthase kinase 3alpha ( GSK 3alpha ) activity by 30 % and GSK 3beta activity by approximately 65 % and increased protein phosphatase 1 activity by 40 47 % in both glycerol and lipid infused rats . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To determine whether changes in glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation contribute to muscle hypertrophy , we delineated the effects of GSK 3beta activity on C ( 2 ) C ( 12 ) myotube size . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Genetic studies have suggested that the Drosophila homolog of glycogen synthase kinase 3beta ( GSK3beta ) , Shaggy , may act as a positive modulator of the Notch signaling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A kinase anchoring protein AKAP 220 binds to glycogen synthase kinase 3beta ( GSK 3beta ) and mediates protein kinase A dependent inhibition of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , although protein kinase A ( PKA ) is responsible for phosphorylation at S 133 , glycogen synthase kinase 3beta ( GSK 3beta ) activity is required and may be responsible for phosphorylation of CREB at S 129 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) plays important roles in metabolism , embryonic development , and tumorigenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Neonatal neuronal overexpression of glycogen synthase kinase 3 beta reduces brain size in transgenic mice . ^^^ Glycogen synthase kinase 3beta ( GSK 3beta ) is important in neurogenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Several modes of action might be relevant for the biological activity of VPA : ( 1 ) VPA increases the DNA binding of activating protein 1 ( AP 1 ) transcription factor , and the expression of genes regulated by the extracellular regulated kinase ( ERK ) AP 1 pathway ; ( 2 ) VPA downregulates protein kinase C ( PKC ) activity ; ( 3 ) VPA inhibits glycogen synthase kinase 3beta ( GSK 3beta ) , a negative regulator of the Wnt signaling pathway ; ( 4 ) VPA activates the peroxisome proliferator activated receptors PPARgamma and delta ; ( 5 ) VPA blocks HDAC ( histone deacetylase ) , causing hyperacetylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To study phenotype genotype correlations , ErbB / Ras pathway tumors ( transgenic for ErbB 2 , c Neu , mutants of c Neu , polyomavirus middle T antigene ( PyV mT ) , Ras , and bi transgenic for ErbB2 / Neu with ErbB 3 and with progesterone receptor ) from four different institutions were histopathologically compared with Wnt pathway tumors [ transgenes Wnt 1 , Wnt10b , dominant negative glycogen synthase kinase 3 beta , beta Catenin , and spontaneous mutants of adenomatous polyposis coli gene ( Apc ) ] . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
TRH withdrawal was found to enhance the activity of glycogen synthetase kinase 3 ( GSK 3beta ) , a critical enzyme necessary for the phosphorylation of tau , as well as the phosphorylation of the tau protein itself . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Thapsigargin , which causes ER stress by inhibiting the ER Ca ( 2+ ) ATPase , was found to not only activate the apoptosis effector caspase 3 but also to cause a large and prolonged increase in the activity of glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Moreover , studies on signaling pathway activation from myocardial extracts demonstrated that glycogen synthase kinase 3 beta is phosphorylated , whereas p42 / 44 mitogen activated protein kinases is not , indicating that Akt induces hypertrophy in vivo by activating the glycogen synthase kinase 3 beta / GATA 4 pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A : involvement of the wnt / glycogen synthase kinase 3 beta pathway . ^^^ Glycogen synthase kinase 3beta ( GSK 3beta ) , which rephosphorylates NFAT and promotes nuclear export , is inhibited by EC costimulation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have previously demonstrated a reduction in glycogen synthase kinase 3beta ( GSK 3beta ) levels in the prefrontal cortex in schizophrenia and aimed to further elucidate the abnormalities of the Wnt signalling pathway in this and other psychiatric disorders . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The status of cyclin D 1 and glycogen synthase kinase 3beta ( GSK 3beta ) was investigated in 41 patients with T 1 and T 2 squamous cell carcinomas ( SCCs ) of the tongue . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
All of the mutations occurred at the serine / threonine phosphorylation sites of glycogen synthase kinase 3beta ( GSK 3beta ) or their neighboring residues . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we investigated the effect of glycosylation on phosphorylation of tau catalyzed by cyclin dependent kinase 5 ( cdk 5 ) and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inhibition of glycogen synthase kinase 3beta ( GSK3beta ) is one of the mechanisms by which phosphatidylinositol 3 kinase ( PI3K ) activation protects neurons from apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This effect was accomplished by inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) activity , which led to the accumulation of cytoplasmic beta catenin and transcriptional activation via beta catenin / T cell factor / lymphoid enhancer factor 1 ( TCF / LEF 1 ) of Wnt target genes , which in the present study were engrailed 1 ( en 1 ) and cyclin D 1 ( cycD 1 , ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) phosphorylates substrates , including the microtubule associated protein tau , at both primed and unprimed epitopes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Tau phosphorylation was examined in Alzheimer ' s disease ( AD ) , Pick ' s disease ( PiD ) , progressive supranuclear palsy ( PSP ) and corticobasal degeneration ( CBD ) using phospho specific tau antibodies recognizing the phosphorylated form of Ser 202 , Ser 214 and Ser 396 , and antibodies to non phosphorylated glycogen synthase kinase 3alpha / beta ( GSK 3alpha / beta ) , which regulates phosphorylation at these specific sites on tau and phosphorylated GSK 3betaSer9 ( GSK 3beta P ) ; this antibody is directed to the inactive form of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Tau phosphorylation and rephosphorylation after stress was mediated by glycogen synthase kinase 3beta ( GSK 3beta ) , and not by ERK 1 , 2 and could be suppressed by lithium chloride , a specific inhibitor of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is an essential protein kinase that regulates numerous functions within the cell . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we examined whether glycogen synthase kinase 3beta ( GSK 3beta ) could be a target in human hepatoma cell lines and transgenic ASV mice with hepatic expression of the SV 40 large T antigen . ^^^ The blockage of GSK 3beta phosphorylation markedly inhibited glycogen synthesis and decreased beta catenin expression . ^^^ Persistent phosphorylation of GSK 3beta could be critical for regulation of glycogen metabolism and cell growth in hepatoma cells . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Genetic analysis of beta catenin induced oncogenic transformation in chicken embryo fibroblasts ( CEF ) revealed the following prerequisites for oncogenicity : ( 1 ) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta ( GSK3beta ) , ( 2 ) retention of the N terminal transactivation domain , and ( 3 ) retention of the armadillo repeats . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The main function of APC is thought to be the regulation of free beta catenin in concert with the glycogen synthase kinase 3beta ( GSK 3beta ) and Axin proteins . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent structural and biochemical work has revealed the basis of phosphorylation regulation of three consecutive protein kinases phosphoinositide dependent kinase 1 ( PDK 1 ) , protein kinase B ( PKB ) / Akt and glycogen synthase kinase 3beta ( GSK3beta ) which transduce signals generated by insulin and / or growth factors binding to cell surface receptors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Regulation of Akt and glycogen synthase kinase 3 beta phosphorylation by sodium valproate and lithium . ^^^ This study tested if sodium valproate or lithium , two agents used to treat bipolar mood disorder , altered the regulatory phosphorylations of Akt or glycogen synthase kinase 3beta ( GSK3beta ) in human neuroblastoma SH SY5Y cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Indeed , hamartin and tuberin co immunoprecipitated with glycogen synthase kinase 3 beta and Axin , components of this complex in a Wnt 1 dependent manner . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Analysis of intracellular signaling events induced by pressure overload indicated that phosphorylation of glycogen synthase kinase 3beta ( GSK 3beta ) was specifically blunted in melusin null hearts . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
DIF 3 induced degradation of cyclin D 1 was also prevented by treatment with lithium chloride , an inhibitor of glycogen synthase kinase 3beta ( GSK 3beta ) , suggesting that DIF 3 induced cyclin D 1 proteolysis through the activation of GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that overexpression of PLCgamma 1 highly phosphorylated glycogen synthase kinase 3beta ( GSK 3beta ) at serine 9 in 3Y1 fibroblasts . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Gene structure and alternative splicing of glycogen synthase kinase 3 beta ( GSK 3beta ) in neural and non neural tissues . ^^^ Glycogen synthase kinase 3 beta ( GSK 3beta ) is a multifaceted serine threonine kinase that is of interest both because of its role in the canonical Wnt signaling pathway , which is involved in mammalian brain regionalization , and its role in phosphorylating the microtubule associated protein Tau . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Heat shock also resulted in a rapid and sustained Akt / glycogen synthase kinase 3 beta ( GSK 3 beta ) phosphorylation . ^^^ Wortmannin blocked heat shock induced Akt / GSK 3 beta phosphorylation , prevented 2 deoxyglucose uptake and abolished the heat shock induced glycogen synthesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
BACKGROUND : Glycogen synthase kinase 3beta ( GSK 3beta ) plays important roles in intracellular signaling pathways . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a serine / threonine kinase involved in insulin , growth factor and Wnt signalling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a kinase that plays a pivotal role in numerous cellular functions from modulation of microtubule dynamics and cell death . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta is a natural activator of mitogen activated protein kinase / extracellular signal regulated kinase kinase kinase 1 ( MEKK 1 ) . ^^^ Glycogen synthase kinase 3beta ( GSK 3 beta ) is implicated in many biological events , including embryonic development , cell differentiation , apoptosis , and insulin response . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have targeted glycogen synthase kinase 3alpha ( GSK 3alpha ) and GSK 3beta , two related kinases involved in the regulation of a variety of cellular processes and also implicated in the pathogenesis of several human diseases . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta mediated tau phosphorylation in cultured cell lines . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Wnt signaling in hepatocellular carcinoma : analysis of mutation and expression of beta catenin , T cell factor 4 and glycogen synthase kinase 3 beta genes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show , through the use of primary rat astrocytes in a cell migration assay , that Par 6 PKCzeta interacts directly with and regulates glycogen synthase kinase 3beta ( GSK 3beta ) to promote polarization of the centrosome and to control the direction of cell protrusion . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we found that sodium arsenite ( NaAsO ( 2 ) ) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
By use of this system , an inducible expression of an abundant contractile protein , the atrial isoform of essential myosin light chain 1 , and a powerful biological effector , glycogen synthase kinase 3beta ( GSK 3beta ) , were obtained . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Molecular studies showed that the spectrum of beta catenin mutations was markedly different in chlorophyllin promoted colon tumors many of the mutations led to direct substitutions of critical Ser / Thr residues within the glycogen synthase kinase 3beta ( GSK 3beta ) region , whereas in all other groups , including DMH and IQ controls , the mutations typically affected amino acids adjacent to Ser ( 33 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we investigated beta catenin activation and mutations , cyclin D 1 expression , H ras mutations and phosphorylation of extracellular signal regulated protein kinases 1 / 2 ( ERK1 / 2 ) , Akt and glycogen synthetase kinase 3beta ( GSK 3 beta ) in mouse hepatic carcinogenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Ilk binds the cytoplasmic domain of beta 1 , beta 2 and beta 3 integrins and recruits adaptors and kinases , and is thought to stimulate downstream signalling events through phosphorylation of protein kinase B / Akt ( Pkb / Akt ) and glycogen synthase kinase 3 beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , we examined the effect of L PGDS incubation on insulin stimulated Akt , glycogen synthase kinase 3beta ( GSK 3beta ) , and ERK phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In fact , we found that beta catenin was up regulated , escaping the glycogen synthase kinase 3 beta ( GSK 3 beta ) control , through unclear mechanisms . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We show that ceramide treatment initiates a cascade of biochemical alterations associated with cell death : earliest signal transduction changes involve Akt dephosphorylation and inactivation followed by dephosphorylation of proapoptotic regulators such as BAD ( proapoptotic Bcl 2 family member ) , Forkhead family transcription factors , glycogen synthase kinase 3 beta , mitochondrial depolarization and permeabilization , release of cytochrome c into the cytosol , and caspase 3 activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Moreover , early stage embryos lacking maternal Axin show significant delay of initial glycogen decomposition , and RNAi of Axin in S 2 cells revealed quite increase of endogenous glycogen level as well as GSK3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase 3beta ( GSK 3beta ) activity in N1E 115 cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Evidence for a role of glycogen synthase kinase 3 beta in rodent spermatogenesis . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 beta ) regulates cell metabolism , cell cycle , and cell fate through the phosphorylation of a diverse array of substrates . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We performed a PKB / Akt kinase assay and studied several of its substrates using phosphorylation specific antibodies to show reduced phosphorylation in PKB / Akt itself , as well as in glycogen synthetase kinase 3beta ( GSK 3beta ) , BAD , and Forkhead . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Previous in vitro studies suggested that its inhibitory activity towards PP 1 is regulated by phosphorylation at Thr 72 by glycogen synthase kinase 3beta ( GSK 3beta ) , and at Ser 86 , Ser 120 , and Ser 121 by casein kinase 2 ( CK 2 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Presenilins also interact with alpha catenin , beta catenin and glycogen synthase kinase 3beta ( GSK 3beta ) , but a functional role for these proteins in gamma secretase activity has not been established . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Free beta catenin is eliminated by two adenomatous polyposis coli ( APC ) dependent proteasomal degradation pathways regulated by glycogen synthase kinase 3beta ( GSK 3 beta ) or p 53 inducible Siah 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Cell adhesion to the extracellular matrix protein fibronectin modulates radiation dependent G 2 phase arrest involving integrin linked kinase ( ILK ) and glycogen synthase kinase 3beta ( GSK 3beta ) in vitro . ^^^ The dependence of cell survival on beta 1 integrin linked kinase ( ILK ) , protein kinase Balpha / Akt ( PKBalpha / Akt ) and glycogen synthase kinase 3beta ( GSK 3beta ) activity , which participate in beta 1 integrin signalling and cell cycle progression was investigated as a function of radiation exposure . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Axin acts as a scaffold in this complex , to assemble beta catenin substrate and kinases ( casein kinase 1 [ CKI ] and glycogen synthase kinase 3 beta [ GSK 3 ] ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The serine / threonine kinase , glycogen synthase kinase 3 beta ( GSK 3 beta ) , plays a pro apoptotic role in granule neurons . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation by glycogen synthase kinase 3 beta down regulates Notch activity , a link for Notch and Wnt pathways . ^^^ There is evidence that the Wnt signaling pathway , which results in glycogen synthase kinase 3 beta ( GSK 3 beta ) inhibition , cross talks with the Notch pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The target of TWS 119 was shown to be glycogen synthase kinase 3beta ( GSK 3beta ) by both affinity based and biochemical methods . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Finally , we examined the kinase activity of 1 kappa B kinase alpha and found that this kinase , unlike glycogen synthase kinase 3 beta , appears to preferentially phosphorylate Ser 45 and Thr 41 , independent of priming by casein kinase 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent work indicates that presenilin 1 ( PS 1 ) interacts with glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a molecular regulator of cell fate in the central nervous system and a target of the phosphatidylinositol 3 kinase ( PI 3K ) pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In unstimulated cells , beta catenin is continuously targeted for ubiquitin dependent degradation , which depends on its NH ( 2 ) terminal phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) in association with a multiprotein complex . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Decreased glycogen synthase kinase 3 beta levels and related physiological changes in Bacillus anthracis lethal toxin treated macrophages . ^^^ Expression of genes regulated by MAPKK activity did not change significantly , yet a series of genes under glycogen synthase kinase 3 beta ( GSK 3beta ) regulation changed expression following LeTx treatment . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta regulates NF kappa B1 / p105 stability . ^^^ Here we investigated the molecular cross talk between glycogen synthase kinase 3 beta ( GSK 3 beta ) and the p 105 precursor of the NF kappa B p 50 subunit . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of Akt and its downstream molecules [ FKHR ; Forkhead ( Drosophila ) homologue 1 ; and GSK 3beta ; glycogen synthase kinase 3 beta ] was significantly associated with pPTEN ( P < 0 . 001 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) activity is suppressed when it becomes phosphorylated on serine 9 by protein kinase B ( Akt ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent findings suggest that glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation of MAP1B may act as a molecular switch to regulate microtubule stability during axonogenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In cell based functional assays , several compounds effectively blocked interleukin 8 release induced by PKC betaII and increased glycogen synthase activity by inhibiting GSK 3beta . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
BP 75 , bromodomain containing M ( r ) 75 , 000 protein , binds dishevelled 1 and enhances Wnt signaling by inactivating glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Prenatal cocaine exposure alters glycogen synthase kinase 3beta ( GSK3beta ) pathway in select rabbit brain areas . ^^^ Glycogen synthase kinase 3beta ( GSK3beta ) plays an important role in neuronal development and survival . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Attempts to design the macrocyclic maleimides as selective protein kinase C gamma inhibitors led to the unexpected discovery of a novel series of potent and highly selective glycogen synthase kinase 3beta ( GSK 3beta ) inhibitors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The aim of this study is to investigate the potential correlation between the expression of phosphorylated glycogen synthase kinase 3beta ( phospho GSK 3beta ) and beta catenin , and the mutations of beta catenin gene at the consensus GSK 3beta phosphorylation site . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
One potential mechanism underlying this phenomenon is activation of the protein kinase B ( PKB ) / Akt / glycogen synthase kinase 3beta ( GSK 3beta ) survival pathway . ^^^ In addition , we measured the relative activity of PKB / Akt and GSK 3beta , and assayed for molecular and histological indices of PKB / Akt activation ( cyclooxygenase mRNA levels and glycogen levels ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Further , compound SB 216763 inhibited Tau phosphorylation at Ser 396 and stabilized cytosolic beta catenin , consistent with the inhibition of glycogen synthase kinase 3 beta ( GSK 3 beta ) , but failed to reproduce lithium effects on MEK and ERK phosphorylation and cell cycle arrest . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of the Wnt cascade leads to inactivation of glycogen synthase kinase 3 beta ( GSK 3 beta ) , accumulation and activation of beta catenin and expression of genes involved in neuronal development . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The present study investigated , by immunohistochemistry and immunoblotting , the protein expression and localisation of beta catenin , adenomatous polyposis coli ( APC ) , glycogen synthase kinase 3beta ( GSK3beta ) and lymphocyte enhancer factor 1 ( Lef 1 ) in normal human ovaries and in epithelial ovarian tumours in vivo and in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) binds to and promotes the actions of p 53 . ^^^ The recent discovery of direct interactions between two important regulators of cell fate , the tumor suppressor p 53 and glycogen synthase kinase 3beta ( GSK3beta ) , led us to examine the mechanism and outcomes of this interaction . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
LKB1 / XEEK1 regulates glycogen synthase kinase ( GSK ) 3beta phosphorylation and it is physically associated in vivo with GSK3beta and protein kinase C ( PKC ) zeta , a known GSK 3 kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Treatment of NPCs with lithium , a specific inhibitor of glycogen synthase kinase 3beta ( GSK3beta ) , significantly suppressed apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study we show that both glycogen synthase kinase 3 ( GSK 3 ) isoforms , GSK3alpha and GSK3beta , are present in human platelets and are phosphorylated on Ser ( 21 ) and Ser ( 9 ) , respectively , in platelets stimulated with collagen , convulxin and thrombin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Thienyl and phenyl alpha halomethyl ketones : new inhibitors of glycogen synthase kinase ( GSK 3beta ) from a library of compound searching . ^^^ Glycogen synthase kinase ( GSK 3beta ) plays a crucial role in Alzheimer ' s disease ( AD ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Expression of the constitutively active Galphaq mutant Galphaq ( Q209L ) promoted an increase in glycogen synthase kinase 3beta ( GSK 3beta ) activity that was associated with increased phosphorylation of Tyr 216 on GSK 3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
On the protein level , histamine treatment increases phosphorylation of glycogen synthase kinase 3 beta in HeLa cells , murine macrophages , and DLD 1 , HT 29 , and SW 480 colon cell lines . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of the endogenous GSK3alpha ( glycogen synthase kinase 3alpha ) at Tyr 279 and GSK3beta at Tyr 216 was suppressed in HEK 293 or SH SY5Y cells by incubation with pharmacological inhibitors of GSK 3 , but not by an Src family inhibitor , 4 amino 5 ( 4 chlorophenyl ) 7 ( t butyl ) pyrazolo [ 3 , 4 d ] pyrimidine ( PP 2 ) , or a general protein tyrosine kinase inhibitor ( genistein ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Western blot revealed that H 2693 propagated the phosphorylation of Akt ( activation ) and its downstream substrate glycogen synthase kinase 3beta ( GSK 3beta , inactivation ) compared to untreated IR . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recently , LiCl has been shown to inhibit amyloid beta peptide secretion in association with diminished glycogen synthase kinase beta ( GSK3beta ) activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
LMP2A activated Akt in a PI3K dependent manner , and the downstream Akt targets glycogen synthase kinase 3beta ( GSK3beta ) and the Forkhead transcription factor FKHR were phosphorylated and inactivated in LMP2A expressing HFK cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In addition , DNA was extracted from formalin fixed , paraffin wax blocks , and a 226 bp fragment of exon 3 of the beta catenin gene was amplified , sequenced , and screened for activating mutations in the glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation targets . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The present studies find that these adaptive mechanisms are dampened by the simultaneous activation of an apoptotic pathway linked to a glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
HO 3073 enhanced the ischaemia reperfusion triggered phosphorylation of Akt 1 ( activation ) and glycogen synthase kinase 3 beta ( inactivation ) as evidenced by Western blot analysis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The accumulation of beta catenin is post translationally regulated by an increased Wnt expression , a simultaneous decrease in glycogen synthase kinase 3beta ( GSK3beta ) expression and a different expression pattern of adenomatous polyposis coli ( APC ) isoforms . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we evaluated the effect of glycogen synthase kinase 3beta ( GSK 3beta ) suppression on tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) induced apoptosis in human prostate cancer cell lines . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is implicated in regulating apoptosis and tau protein hyperphosphorylation in Alzheimer ' s disease ( AD ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have recently shown that nerve growth factor ( NGF ) induces the phosphorylation of the microtubule associated protein 1B ( MAP1B ) by activating the serine / threonine kinase glycogen synthase kinase 3beta ( GSK3beta ) in a spatio temporal pattern in PC 12 cells that correlates tightly with neurite growth . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Evidence for increased glycogen synthase kinase 3beta ( GSK3beta ) activity in p 35 / mice suggests that GSK3beta may be one such kinase regulated by cdk 5 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We show that Gadd45a not only directly associates with two components of the APC complex , namely protein phosphatase 2A ( PP2A ) and glycogen synthase kinase 3beta ( GSK3beta ) but also promotes GSK3beta dephosphorylation at Ser 9 , which is essential for GSK3beta activation , and resultant activation of the APC destruction complex . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) phosphorylated Rap1GAP immunoprecipitated from thyroid cells , and GSK3beta inhibitors prevented phosphorylation and degradation of endogenous Rap1GAP . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
AM gene transfer increased phosphorylation of Akt and glycogen synthase kinase ( GSK 3beta ) but reduced GSK 3beta and caspase 3 activities in the heart . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta is highly activated in nuclei and mitochondria . ^^^ Glycogen synthase kinase 3 beta ( GSK 3 beta ) is located predominantly in the cytosol , but also is in nuclei and mitochondria . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Sprague Dawley adult male rats were exposed during sleep to IH or to normoxia ( RA ) for periods ranging from 0 to 30 days , and expression of total and phosphorylated AKT , of forkhead family members FKHR and FKHRL 1 , and of glycogen synthase kinase 3beta ( GSK3beta ) was assessed . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Binding Wnt to its receptor , frizzled ) , leads to the inactivation of the glycogen synthase kinase 3 beta in a cytoplasmic complex with APC , beta catenin , axin and components of the ubiquitin ligation machinery . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Metabolic labeling and phospho amino acid analysis demonstrated phosphorylation of NTP on Serine residues , 30 60 min after insulin or IGF 1 stimulation , when glycogen synthase kinase 3beta ( GSK 3beta ) activity would no longer have been suppressed . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
METHODS : We analyzed the alterations of three key components of Wnt pathway , beta catenin , glycogen synthase kinase 3beta ( GSK 3beta ) and T cell factor 4 ( Tcf 4 ) , in 34 samples of hepatocellular carcinoma ( HCC ) and paracancerous normal liver by immunohistochemistry , polymerase chain reaction single strand conformation polymorphism ( PCR SSCP ) , direct sequencing , semi quantitative reverse transcription polymerase chain reaction ( RT PCR ) and in situ hybridization . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The phosphorylation of downstream molecules of Akt , forkhead transcription factors ( FKHR ) , endothelial nitric oxide synthase ( eNOS ) , and glycogen synthase kinase 3beta ( GSK 3beta ) was also increased . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Primed phosphorylation of tau at Thr 231 by glycogen synthase kinase 3beta ( GSK3beta ) plays a critical role in regulating tau ' s ability to bind and stabilize microtubules . ^^^ Although tau is a substrate of glycogen synthase kinase 3beta ( GSK3beta ) , the exact sites on tau that are phosphorylated by this kinase in situ have not yet been established , and the effect of these phosphorylation events on tau microtubule interactions have not been fully elucidated . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A mouse line was produced in which proteins encoded by the endogenous glycogen synthase kinase 3 beta ( GSK 3beta ) gene are fused to an 89 amino acid tag , FRB * . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Azakenpaullone is a selective inhibitor of glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Adenomatous polyposis coli ( APC ) tumor suppressor protein , together with Axin and glycogen synthase kinase 3beta ( GSK 3beta ) , forms a Wnt regulated signaling complex that mediates phosphorylation dependent degradation of cytoplasmic beta catenin by ubiquitin dependent proteolysis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A single nucleotide polymorphism in glycogen synthase kinase 3 beta promoter gene influences onset of illness in patients affected by bipolar disorder . ^^^ A single nucleotide polymorphism ( SNP ) ( 50 T / C ) falling into the effective promoter region ( nt 171 to +29 ) of the gene coding for glycogen synthase kinase 3 beta ( GSK 3 beta ) has been identified . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Dishevelled ( DVL ) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine / threonine kinase , glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The double cassette expression vector strategy enabled us to clarify the roles of protein kinase A ( PKA ) and glycogen synthase kinase 3beta ( GSK 3beta ) in the development of olfactory sensory neurons and RGCs . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
As a function of radiation , the impact of fibronectin ( FN ) and phosphatidylinositol 3 kinase ( PI3K ) related signaling on survival , the cell cycle , and the beta 1 integrin signaling kinases integrin linked kinase ( ILK ) , protein kinase Balpha / Akt ( PKBalpha / Akt ) , and glycogen synthase kinase 3beta ( GSK 3beta ) was examined in normal lung fibroblasts in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
These abnormalities were associated with activation of kinases that phosphorylate tau , including glycogen synthase kinase 3beta ( GSK 3beta ) , mitogen activated protein kinase ( MAPK ) , and cyclin dependent kinase 5 ( Cdk 5 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The mechanism of inhibition involves the increased cytoplasmic localization of p 53 due to phosphorylation at serine 315 and serine 376 , which is mediated by glycogen synthase kinase 3 beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Synthesis and biological evaluation of novel macrocyclic bis 7 azaindolylmaleimides as potent and highly selective glycogen synthase kinase 3 beta ( GSK 3 beta ) inhibitors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Structural insight into nucleotide recognition in tau protein kinase I / glycogen synthase kinase 3 beta . ^^^ Human tau protein kinase 1 ( TPK 1 ; also known as glycogen synthase kinase 3 beta ; GSK 3 beta ) is a serine / threonine protein kinase that participates in Alzheimer ' s disease . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have shown that the ubiquitous kinase glycogen synthase kinase 3beta ( GSK3beta ) directly phosphorylated alphaNAC in vitro and in vivo . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inhibition of glycogen synthase kinase 3 beta is involved in the resistance to oxidative stress in neuronal HT 22 cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
PUGNAc did not significantly alter insulin stimulated phosphorylation of Akt ( serine and threonine ) or its substrates glycogen synthase kinase ( GSK ) 3 alpha and GSK 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In mammalian brain , tau , glycogen synthase kinase 3beta ( GSK3beta ) , and 14 3 3 , a phosphoserine binding protein , are parts of a multiprotein tau phosphorylation complex . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The phosphorylation of cyclin D 1 at threonine 286 by glycogen synthase kinase 3beta ( GSK3beta ) has been shown to be required for the ubiquitination and nuclear export of cyclin D 1 and its subsequent degradation in the proteasome . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The lithium treated flies also show reduced activity of one of the previously reported targets of lithium action , Glycogen Synthase Kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta ( GSK3beta ) responds to ER stress , and its activity is regulated by phosphorylation . 6 OHDA significantly inhibited phosphorylation of GSK3beta at Ser 9 , whereas it induced hyperphosphorylation of Tyr 216 with little effect on GSK3beta expression in SH SY5Y cells and PC 12 cells ( a rat dopamine cell line ) , as well as CGNs . ^^^ Glycogen synthase kinase 3beta ( GSK3beta ) mediates 6 hydroxydopamine induced neuronal death . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The potential role of 4 hydroxynonenal ( HNE ) , a major product of membrane lipid peroxidation , in regulating glycogen synthase kinase 3beta ( GSK3beta ) activity was examined in human neuroblastoma IMR 32 cells . ^^^ The inhibition of GSK3beta activity by HNE was observed by in vitro kinase assays with two substrates , the synthetic glycogen synthase peptide 2 and the human recombinant tau . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Suppression of androgen receptor mediated transactivation and cell growth by the glycogen synthase kinase 3 beta in prostate cells . ^^^ Here we report a new kinase signaling pathway by showing that AR transactivation was repressed by wild type glycogen synthase kinase 3beta ( GSK 3 beta ) or constitutively active S9A GSK 3 beta in a dose dependent manner . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Protein kinases including glycogen synthase kinase 3 beta ( GSK3beta ) , cyclin dependent kinase 5 ( Cdk 5 ) , and c Jun N terminal kinase ( JNK ) have been implicated in NFT formation making the use of selective kinase inhibitors an attractive treatment possibility in AD . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Two adenomatous polyposis coli ( APC ) dependent proteasomal degradation pathways , one involving glycogen synthase kinase 3beta ( GSK3beta ) and the other involving p 53 Siah 1 , degrade excess beta catenin in normal cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We demonstrate that elevation of intracellular levels of cAMP promotes degradation of cyclin D 3 in proteasomes , and that this occurs via glycogen synthase kinase 3beta ( GSK 3beta ) mediated phosphorylation of cyclin D 3 at Thr 283 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Rac GTPases ) , which then activate a range of downstream targets including glycogen synthase kinase 3beta ( GSK 3beta ) , mammalian target of rapamycin ( mTOR ) , p70S6 kinase , endothelial nitric oxide synthase ( eNOS ) and several anti apoptotic effectors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , lithium chloride , a modulator of glycogen synthase kinase 3beta ( GSK 3beta ) promoted Schwann cell differentiation , suggesting the involvement of GSK 3beta as a downstream molecule of PI3K Akt pathways . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Remarkably , these lithium sensitive behaviors are also observed in mice lacking one copy of the gene encoding glycogen synthase kinase 3beta ( Gsk 3beta ) , a well established direct target of lithium . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The in vivo activity of Ime 1 , the key transcriptional activator of meiosis specific genes in Saccharomyces cerevisiae , is inhibited by the cyclic AMP / protein kinase A signal pathway through the glycogen synthase kinase 3 beta homolog Rim 11 . ^^^ Ser 302 and Ser 306 are part of a consensus site for the mammalian homolog of Rim 11 , glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We also established that Akt phosphorylates tau separately at T 212 and S 214 , two sites previously shown to be phosphorylated by glycogen synthase kinase 3beta ( GSK3beta ) and protein kinase A ( PKA ) , respectively . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , the status of Akt activation and its targets , glycogen synthase kinase 3beta ( GSK 3beta ) and beta catenin , was investigated in NPC and HL clinical specimens . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In other cell types , Akt dependent phosphorylation of glycogen synthase kinase 3 beta ( GSK 3 beta ) inhibits its activity and its ability to stimulate apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Concordant phosphorylation of downstream targets of Akt , glycogen synthase kinase 3beta ( GSK 3beta ) and p 70 ribosomal S 6 kinase ( p 70 ( S6K ) ) , in response to Akt activation was observed at 15 min after pressure overload . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Integrin linked kinase ( ILK ) , bound to the cytoplasmic tails of integrin beta 1 , beta 2 , and beta 3 , is thought to signal through AKT and glycogen synthase kinase 3beta ( GSK 3beta ) for survival and proliferation regulation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of glycogen synthase kinase 3beta ( GSK 3beta ) was evident after 7 days of cage wheel exposure in both sexes and remained elevated in females only by 21 days of exercise . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
IGF 1 stimulation of the PI3K / Akt pathway phosphorylates three known Akt effectors : the survival transcription factor cyclic AMP response element binding protein ( CREB ) and the pro apoptotic effector proteins glycogen synthase kinase 3beta ( GSK 3beta ) and forkhead ( FKHR ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the absence of a Wnt signal , casein kinase 1 ( CK 1 ) and glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylate cytosolic beta catenin , thereby flagging it for recognition and destruction by the ubiquitin / proteosome machinery . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we report that indirubin 3 ' oxime , a known effective inhibitor of cyclin dependent kinases ( CDKs ) and glycogen synthase kinase 3 beta ( GSK 3beta ) , has a significant inhibitory effect on JNK . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Reporter and DNA pull down assays indicated that NeuroAB functions as a transcriptional repressor by binding to the E box sequence , and its activity is modulated by phosphorylation at a specific serine residue that fits the consensus phosphorylation site for glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Previously we reported that inhibition of glycogen synthase kinase 3beta ( GSK3beta ) , a key regulator in many intracellular signaling pathways , enhances the survival and migration of vascular endothelial cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Wnts bind to Frizzled ( Fz ) receptors and subsequent canonical signaling inhibits glycogen synthase kinase 3beta ( GSK 3beta ) , causing beta catenin translocation into the nucleus to induce target gene expression . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Downstream targeting genes such as sterol regulatory element binding protein 1c ( SREBP 1c ) , glucokinase ( GKC ) , and fatty acid synthase ( FAS ) genes , as well as phospho glycogen synthase kinase 3beta ( GSK 3beta ) were activated and they showed the similar expression profiles during cold preservation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We tested whether statins inhibit cardiomyocyte apoptosis through glycogen synthase kinase 3beta ( GSK3beta ) inactivation and evaluated activation of downstream transcription factors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A downstream target of Akt , glycogen synthase kinase 3beta ( GSK 3beta ) , was slightly phosphorylated , indicating that the level of activation of Akt was very low . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A glycogen synthase kinase 3 beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression . ^^^ A single nucleotide polymorphism ( SNP ) ( 50T / C ) falling into the effective promoter region ( nt 171 to +29 ) of the gene coding for glycogen synthase kinase 3 beta ( GSK 3 beta ) has been linked with different age at onset of bipolar illness . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The capacity of nicotinamide to govern not only intrinsic cellular integrity , but also extrinsic cellular inflammation rests with the modulation of a host of cellular targets that involve protein kinase B , glycogen synthase kinase 3 beta ( GSK 3 beta ) , Forkhead transcription factors , mitochondrial dysfunction , poly ( ADP ribose ) polymerase , cysteine proteases , and microglial activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
At 29 weeks of age , GSK 3beta protein levels were 5 fold higher , and glycogen synthase activation ( 27 % ) , glycogen levels ( 58 % ) and insulin receptor substrate 1 ( IRS 1 ) protein levels ( 67 % ) were significantly reduced in skeletal muscle . ^^^ Female GSK 3beta transgenic mice did not develop glucose intolerance despite 7 fold overexpression of GSK 3beta protein and a 20 % reduction in glycogen synthase activation in skeletal muscle . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lithium , a known mood stabilizer frequently used in treatment of bipolar disorders , is an effective glycogen synthase kinase 3beta ( GSK 3beta ) inhibitor . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Restoration of SHIP expression in Jurkat cells with an inducible expression system caused a 69 % reduction of phosphatidylinositol 3 , 4 , 5 trisphosphate ( PtdIns ( 3 , 4 , 5 ) P ( 3 ) ) and a 65 % reduction of Akt kinase activity , which was associated with reduced phosphorylation of glycogen synthase kinase 3beta ( GSK 3beta ) ( Ser 9 ) without changing the phosphorylation of Bad ( Ser 136 ) , FKHR ( Ser 256 ) or MAPK ( Thr 202 / Tyr 204 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the present study , we demonstrated that homozygous disruption of glycogen synthase kinase 3beta ( GSK 3beta ) dramatically sensitized mouse embryonic fibroblasts ( MEFs ) to JNK activation induced by lysophosphatidic acid ( LPA ) and sphingosine 1 phosphate , two prototype ligands for G protein coupled receptors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lithium exerts neuroprotective actions that involve the inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation and hence inactivation of glycogen synthase kinase 3beta ( GSK 3beta ) , a general survival factor , is often a downstream consequence of mitogen activated protein kinase pathway activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The beta catenin regulating kinase , glycogen synthase kinase 3beta ( GSK3beta ) , was shown to be phosphorylated and inactivated in EBV infected lymphocytes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Cdk 5 phosphorylates CRMP 2 at serine 522 , possibly facilitating phosphorylation of serine 518 and threonine 514 by glycogen synthase kinase 3beta ( GSK3beta ) , a kinase previously implicated in Sema 3A signaling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta induces caspase cleaved tau aggregation in situ . ^^^ The effects of glycogen synthase kinase 3 beta ( GSK 3 beta ) , a well established tau kinase , on these processes also were examined . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we show that two activators of the canonical Wnt / beta catenin transcription pathway , namely Dvl 2 , the Axin 501 560 fragment binding glycogen synthase kinase 3beta ( GSK 3beta ) , and the negative Wnt regulator wt Axin did not alter cell invasion into type 1 collagen . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
FRAT 2 preferentially increases glycogen synthase kinase 3 beta mediated phosphorylation of primed sites , which results in enhanced tau phosphorylation . ^^^ Although it is well established that tau is phosphorylated at both primed and unprimed epitopes by glycogen synthase kinase 3 beta ( GSK 3 beta ) , how specific proteins that interact with GSK 3 beta regulate tau phosphorylation has not been thoroughly examined . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a critical activator of neuronal apoptosis induced by a diverse array of neurotoxic insults . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The present study shows that the IFN gamma mediated upregulation of secretory phospholipase A 2 of group IIA ( sPLA 2 IIA ) in HASMC and HepG 2 cells is synergistically increased after simultaneous inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) by indirubin 3 ' monoxime , 5 iodo or AR A 014418 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
RGS 2 also inhibited Flt 3 ITD induced phosphorylation of Akt and glycogen synthase kinase beta ( Gsk 3 beta ) without influencing signal transducer and activator of transcription 5 ( STAT 5 ) activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Insulin stimulated Akt / PKB kinase activity , as judged by immune complex kinase assay and phosphorylation status of the endogenous substrate of Akt / PKB , glycogen synthase kinase 3beta ( GSK 3beta ) , was significantly impaired in burned rats . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In MC3T3 E 1 osteoblast like cultures , dexamethasone ( DEX ) activates glycogen synthase kinase 3beta ( GSK3beta ) and inhibits a differentiation related cell cycle that occurs at a commitment stage immediately after confluence . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Dishevelled ( Dvl ) is a cytoplasmic protein involved in the Wnt Frizzled signaling cascade , which has also been shown to interact with the cytoskeleton in part through inhibition of glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Three closely related forms of glycogen synthase kinase 3 ( GSK 3alpha , GSK 3beta and GSK 3beta2 ) have a major role in Wnt and Hedgehog signaling pathways and regulate the cell division cycle , stem cell renewal and differentiation , apoptosis , circadian rhythm , transcription and insulin action . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , the neuroprotective effects of minocycline were blocked by phosphatidylinositol 3 kinase ( PI 3 K ) inhibitors LY 294002 and wortmannin , while pharmacologic inhibition of glycogen synthase kinase 3beta ( GSK3beta ) attenuated glutamate induced apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
At the neuronal level , several AD related proteins interact with transducers of the Wnt / beta catenin signaling pathway , including beta catenin and glycogen synthase kinase 3 beta ( GSK 3 beta ) and both in vitro and in vivo studies suggest that Wnt / beta catenin signaling is a target for A beta toxicity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The present study examines the hypothesis that lithium ( Li ( + ) ) and ( 2 ' Z , 3 ' E ) 6 bromoindirubin 3 ' oxime ( BIO ) , two glycogen synthase kinase 3beta ( GSK3beta ) inhibitors , promote survival of growth factor deprived renal epithelial cells by activating the Wnt pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Valproic acid ( VPA ) has long been used as an antiepileptic drug and recently as a mood stabilizer , and evidence is increasing that VPA exerts neuroprotective effects through changes in a variety of intracellular signalling pathways including upregulation of Bcl 2 protein with an antiapoptotic property and inhibiting glycogen synthase kinase 3 beta , which is considered to promote cell survival . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In vitro studies indicate that lithium can induce renal medullary interstitial cell cyclooxygenase 2 ( COX 2 ) protein expression via inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
First , FSS induced a transient , but significant , increase in the phosphorylation of both glycogen synthase kinase 3beta ( GSK 3beta ) and Akt . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We present for consideration several critical cellular pathways modulated by EPO that involve Janus kinase 2 ( Jak 2 ) , the serine threonine kinase Akt , forkhead transcription factors , glycogen synthase kinase 3beta ( GSK 3beta ) , cellular calcium , protein kinase C , caspases , as well as the control of inflammatory microglial activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
HIV 1 neurotoxins have the unique ability to up regulate glycogen synthase kinase 3beta ( GSK 3beta ) activity that in turn elicits neuronal apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We investigated how PI3K / Akt and glycogen synthase kinase 3beta ( GSK3beta ) affect HIF 1alpha in human RKO cells under prolonged periods of severe hypoxia / anoxia . 16 to 32 h lasting incubations attenuated Akt activity and decreased HIF 1alpha protein . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we showed that glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylated CRMP 2 at Thr 514 and inactivated it . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The phosphorylation level of glycogen synthase kinase 3 beta , a kinase important for beta catenin protein destabilization , correlated with beta catenin protein level . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In turn , the enhanced motility of JAM A negative cells was abrogated either on transfection of exogenous JAM A or on treatment with inhibitors of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Application of graph theory : prediction of glycogen synthase kinase 3 beta inhibitory activity of thiadiazolidinones as potential drugs for the treatment of Alzheimer ' s disease . ^^^ The relationship of Wiener ' s index , a distance based topological descriptor ; Zagreb group parameter , M ( 1 ) , an adjacency based topological descriptor and eccentric connectivity index , an adjacency cum distance based topological descriptor with the glycogen synthase kinase 3 beta inhibitory activity of thiadiazolidinones has been investigated . ^^^ Subsequently , biological activity was predicted for each analogue involved in the data set using these models , which was then compared with the reported glycogen synthase kinase 3 beta inhibitory activities . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study , we demonstrate that cyclin dependent kinase 5 ( Cdk 5 ) and glycogen synthase kinase 3beta ( GSK3beta ) plays a critical role in Sema3A signalling . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) was found to be one of the downstream targets of Akt . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This interaction is regulated by the phosphorylation of Tau at selected sites , by glycogen synthase kinase 3beta ( GSK3beta ) and cyclin dependent kinase 5 ( Cdk 5 ) , and requires an intact microtubule network . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
It is not currently known whether the effect of VPA on InsP 3 depletion is related to the deleterious effects of teratogenicity or elevated viral replication , or if it occurs via putative inhibitory effects on glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Treatment of HUVEC with FGF 2 resulted in dose and time dependent activation of the extracellular regulated kinase ( ERK ) , with moderate effects on phosphoinositol 3 kinase ( PI3K ) and protein kinase B ( PKB ) , also known as AKT , but no effects on glycogen synthase kinase 3 ( GSK3beta ) activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Long term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3 beta 50 T / C SNP . ^^^ A single nucleotide polymorphism ( SNP ) ( 50 T / C ) falling into the effective promoter region ( nt 171 to +29 ) of the gene coding for glycogen synthase kinase 3 beta ( GSK 3 beta ) has been linked with different age at onset of bipolar illness and with different antidepressant effects of total sleep deprivation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have found that a PPAR target gene , glycogen synthase kinase 3beta ( GSK 3beta ) , was down regulated and EGR 1 was up regulated in the mouse samples of Chattanooga Creek . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Several lines of evidence indicate that glycogen synthase kinase 3beta ( GSK3beta ) is one of the candidates for schizophrenia susceptibility factor . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We studied in vitro effects of glycogen synthase kinase 3beta ( GSK3beta ) inhibitor lithium on the growth of hepatocellular carcinoma ( HCC ) cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent experiments show that the microtubule associated protein ( MAP ) 1B is a major phosphorylation substrate for the serine / threonine kinase glycogen synthase kinase 3beta ( GSK 3beta ) in differentiating neurons . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In pheochromocytoma 12 ( PC 12 ) cells and sympathetic neurons , nerve growth factor ( NGF ) engagement with the tropomyosin related tyrosine kinase ( TrkA ) receptor activates the serine / threonine kinase glycogen synthase kinase 3beta ( GSK3beta ) , enabling it to phosphorylate the microtubule associated protein 1B ( MAP1B ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Rapamycin treatment leads to an increase in the kinase activity of glycogen synthase kinase 3beta ( GSK3beta ) , a known regulator of cyclin D 1 proteolysis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This surprising mechanism is supported by local inactivation of glycogen synthase kinase 3beta ( GSK 3beta ) by nerve growth factor through the integrin linked kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent studies using glycogen synthase kinase 3beta ( GSK 3beta ) deficient mouse embryonic fibroblasts suggest that GSK 3beta positively regulates nuclear factor kappaB ( NFkappaB ) mediated gene transcription . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using these mice we show that inactivation of GSK3beta rather than GSK3alpha is the major route by which insulin activates muscle glycogen synthase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Stable cell lines were created by small interfering RNA ( siRNA ) with graded reduction of insulin receptor expression , and these cells had enhanced susceptibility to ER stress induced apoptosis and reduced levels of phospho glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
When the Wnt pathway was regulated at the lower level of glycogen synthase kinase 3 beta ( GSK 3 beta ) or adenomatous polyposis coli ( APC ) , we detected discrepant expression trends . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We further show that this results in the inhibition of the Akt substrate Forkhead transcription factor and the stimulation of phosphorylation of a second key Akt substrate , glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
However , the role of glycogen synthase kinase 3beta ( GSK 3beta ) in this process has not been elucidated . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this study we tested the roles of mammalian target of rapamycin and glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation as well as MAPK and calcineurin dependent signaling pathways in the anticatabolic effects of IGF 1 by incubating extensor digitorum longus muscles from burned rats in the presence of IGF 1 and specific signaling pathway inhibitors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Consistent with a role of PI3K in the R 18 effect , R 18 induced phosphorylation of a protein cloned from the vakt oncogene of retrovirus AKT 8 ( Akt also called protein kinase B , PKB ) at Ser 473 and glycogen synthase 3beta ( GSK3beta ) at Ser 9 , but not extracellular signal regulated kinase 1 / 2 ( ERK1 / 2 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Induction of Akt activation and ERK1 / 2 activationunder hypoxic condition was detected at 12 hours and correlated with inactivation of glycogen synthase kinase 3beta ( GSK 3beta ) , an effector protein involved in regulation of apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have previously shown that MAPK and glycogen synthase kinase 3beta ( GSK 3beta ) are involved in the cell death / cell survival induced by kainic acid . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Moreover , LPA activates the main signaling events in the beta catenin pathway : phosphorylation of glycogen synthase kinase 3beta ( GSK3beta ) , nuclear translocation of beta catenin , transcriptional activation of T cell factor ( Tcf ) / lymphoid enhancer factor ( Lef ) , and expression of target genes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We also wanted to study effects of HI and / or IGF 1 on the serine / threonine kinases Akt and glycogen synthase kinase 3beta ( GSK3beta ) in the phophatidylinositol 3 kinase ( PI3K ) pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that E 2 stimulates phosphoinositide 3 kinase to activate phosphokinase B / AKT to effect an inhibitory phosphorylation of glycogen synthase kinase ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Kallikrein gene delivery also increased Akt and glycogen synthase kinase ( GSK ) 3beta phosphorylation , resulting in decreased GSK 3beta activity in the heart . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Analysis of the human gal 3 sequence reveled a structural similarity to beta catenin as it also contains the consensus sequence ( S92XXXS96 ) for glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation and can serve as its substrate . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Downstream target proteins , glycogen synthase kinase 3beta ( GSK 3beta ) and caspase 9 , were inactivated . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To elucidate the mechanisms that contribute to these processes , we studied the role of glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NT 3 significantly inhibited FGF 2 induced phosphorylation of Akt and glycogen synthase kinase 3beta ( GSK3beta ) , a downstream kinase of Akt , whereas phosphorylation of ERK1 / 2 was unaffected . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
METHODS : The effects of K ras ( Val 12 ) on VEGF and T cell factor 4 ( TCF 4 ) promoter activity , nuclear levels of beta catenin and beta catenin / TCF 4 complexes , glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylation , and GSK 3beta kinase activity were measured . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In Hep3B cells , LY 294002 led to the reactivation of glycogen synthase kinase 3beta ( GSK 3beta ) by promoting its dephosphorylation on the serine 9 residue independently from Akt inhibition . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
METHODS : Western blotting and immunocytochemical staining were used to detect tau phosphorylation level , total tau and glycogen synthase kinase 3beta ( GSK 3beta ) in cortical neurons . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A pivotal signaling network in colorectal cancer cells involves glycogen synthase kinase 3beta ( GSK3beta ) , a multifunctional kinase whose role in tumor cell survival is not defined . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In order to investigate the importance of the PDK 1 PKB GSK 3 signalling network in regulating glycogen synthase ( GS ) in the heart , we have employed tissue specific conditional knockout mice lacking PDK 1 in muscle ( mPDK 1 / ) , as well as knockin mice in which the protein kinase B ( PKB ) phosphorylation site on glycogen synthase kinase 3alpha ( GSK3alpha ) ( Ser 21 ) and GSK3beta ( Ser 9 ) is changed to Ala . ^^^ Despite the inability of insulin to stimulate glycogen synthesis in hearts from the mPDK 1 / or double GSK3alpha / GSK3beta knockin mice , these animals possessed normal levels of cardiac glycogen , demonstrating that total glycogen levels are regulated independently of insulin ' s ability to stimulate GS in the heart and that mechanisms such as allosteric activation of GS by glucose 6 phosphate and / or activation of GS by muscle contraction , could operate to maintain normal glycogen levels in these mice . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Paudel , 14 3 3 connects glycogen synthase kinase 3 beta to tau within a brain microtubule associated tau phosphorylation complex , J . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Specific inhibitors of glycogen synthetase kinase 3beta ( GSK3beta ) , which mimic Wnt signaling , may also have a therapeutic benefit by enhancing in vitro osteogenesis despite the presence of Dkk 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The Drosophila shaggy gene product is a mammalian glycogen synthase kinase 3beta ( GSK 3beta ) homologue that contributes to the circadian clock of the Drosophila through TIMELESS phosphorylation , and it regulates nuclear translocation of the PERIOD / TIMELESS heterodimer . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
GSK 3 ( glycogen synthase kinase 3 ) inhibitors decreased S 1 phosphorylation , and siRNA ( short interfering RNA ) silencing indicated further the involvement of GSK3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lu gp is phosphorylated by glycogen synthase kinase 3 beta , casein kinase 2 , and PKA at serines 596 , 598 , and 621 , respectively . ^^^ Alanine substitutions of serines 596 and 598 abolished phosphorylation by glycogen synthase kinase 3 beta and casein kinase 2 , respectively , but had no effect on adhesion of K 562 cells to laminin under flow conditions . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Ser 557 phosphorylated mCRY 2 is degraded upon synergistic phosphorylation by glycogen synthase kinase 3 beta . ^^^ Importantly , phosphorylation of mCRY 2 at Ser 557 allows subsequent phosphorylation at Ser 553 by glycogen synthase kinase 3beta ( GSK 3beta ) , resulting in efficient degradation of mCRY 2 by a proteasome pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Inhibition of the PI3K / Akt pathway suppressed the Wnt / beta catenin pathway by activation of glycogen synthase kinase 3beta ( GSK 3beta ) and degradation of beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) phosphorylation of the NH 2 terminal domain of beta catenin targets it for ubiquitination and proteosomal degradation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Effects of d 5 HT1B are synergistic with a mutation in the circadian photoreceptor cryptochrome ( CRY ) and are mediated by SHAGGY ( SGG ) , Drosophila glycogen synthase kinase 3beta ( GSK3beta ) , which phosphorylates TIM . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The involvement of PI 3 K / Akt pathway in the imipramine action was confirmed by Western blot study , which showed that this drug increased phospho Ser 473 Akt level , but had no effect on total Akt and glycogen synthase kinase ( GSK 3beta ) levels . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
LPA was shown to stimulate nuclear accumulation of beta catenin in a manner that depended on activation of Galpha ( q ) by LPA ( 2 , 3 ' ) , activation of phospholipase Cbeta , activation of a conventional protein kinase C , and phosphorylation and inhibition of glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In addition , we showed hyperphosphorylation of c Jun N terminal kinase ( JNK ) and glycogen synthase kinase 3 beta ( GSK 3 beta ) at serine 9 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Western blotting demonstrated that calcineurin ( CnA ) , the 70 kDa ribosomal S 6 kinase ( p 70 ( S6k ) ) , glycogen synthase kinase 3beta ( GSK 3beta ) , and the phosphorylated forms of GSK 3beta and p 70 ( S6k ) ( p GSK 3beta ( Ser 9 ) and p p 70 ( S6kThr389 ) ) were regulated differently with aging and between muscle types . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) reportedly has opposing roles , repressing Wnt / beta catenin signaling on the one hand but maintaining cell survival and proliferation through the NF kappaB pathway on the other . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In many human lung adenocarcinoma cell lines , a pathway involving epidermal growth factor receptor ( EGFR ) , ErbB 2 and ErbB 3 receptors , phosphatidyl inositol 3 kinase ( PI3K ) , Akt , glycogen synthase kinase 3 beta ( GSK 3 beta ) , and cyclin D 1 controls cell growth , survival , and invasiveness . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In the present work , we show that cGMP / cGMP dependent protein kinase ( PKG ) induced dephosphorylation and activation of C / EBPbeta by inhibiting glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we showed that CK 2 does not phosphorylate all sites in PTEN and that glycogen synthase kinase 3beta ( GSK3beta ) also participates in PTEN phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Cardiomyocyte hypertrophy is transcriptionally controlled and inhibited by glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Immunoblot analysis revealed that phosphorylation signals , including protein kinase B ( Akt / PKB ) , glycogen synthase kinase 3beta ( GSK 3beta ) , and cyclic adenosine monophosphate response element binding protein ( CREB ) were reduced immediately after ECS treatment . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
DIF 1 induced cyclin D 1 degradation , but this effect was prevented by treatment with lithium chloride and SB 216763 , the inhibitors of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we report that stimulation of NMDARs in cultured rat hippocampal or cortical neurons and in the adult mouse brain in vivo disinhibited glycogen synthase kinase 3beta ( GSK3beta ) by protein phosphatase 1 ( PP 1 ) mediated dephosphorylation of GSK3beta at the serine 9 residue . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
INTRODUCTION : The serine / threonine kinase glycogen synthase kinase 3beta ( GSK3beta ) is abundant in the central nervous system and is neuron specific . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
A concurrent decrease in the glycogen synthase kinase 3beta ( GSK3beta ) , axin , and ser45 / thr41 phosphorylated beta catenin proteins was observed in matrigel treated cultures , implying decreased degradation of beta catenin . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To elucidate the IGF 1 signal transduction responsible for muscle formation ( myogenesis ) during muscle growth and regeneration , we applied IGF 1 to differentiating C ( 2 ) C ( 12 ) myoblasts and evaluated the effects on phosphatidylinositol 3 kinase ( PI3K ) / Akt / glycogen synthase kinase 3beta ( GSK 3beta ) signaling and myogenesis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Both ILK and Akt can phosphorylate glycogen synthetase kinase 3beta ( GSK3beta ) , rendering it inactive . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Its neuroprotective activities occur as a consequence of glycogen synthase kinase 3beta ( GSK 3beta ) inhibition leading to downstream blockade of beta catenin and Tau phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Loss of glycogen synthase kinase 3beta ( GSK 3beta ) in mice results in embryonic lethality via hepatocyte apoptosis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
These changes include decreased levels of the antiapoptotic proteins , survivin , phosphorylated Bad , and phosphorylated glycogen synthetase kinase 3beta ( GSK 3beta ) , and increased levels of the proapoptotic BH 3 only protein , Bim . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
T 3 increased cell viability as measured by MTT assays , prevented DNA laddering , and reduced TUNEL positive cells , which was associated with increased phosphorylated Akt and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Insulin inhibits GSK 3 by promoting phosphorylation of a serine residue ( Ser 21 in GSK3alpha , Ser 9 in GSK3beta ) , thereby relieving GSK 3 inhibition of glycogen synthesis in muscle . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a multifunctional enzyme involved in a variety of biological events including development , glucose metabolism and cell death . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Consistent with the previously proposed role for glycogen synthase kinase 3beta ( GSK3beta ) in modulating the assembly and activity of the beta catenin targeting complex , formation of the fully assembled complex was reduced by inhibitors of GSK3beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we showed that glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylated CRMP 2 at Thr 514 and inactivated it . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we investigated possible contributions of a phosphatidylinositol 3 kinase cascade [ PI3K , Akt , glycogen synthase kinase 3beta ( GSK 3beta ) ] that is linked to apoptosis and various degenerative conditions . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Although PKA did not affect the formation of a complex between glycogen synthase kinase 3beta ( GSK 3beta ) , beta catenin , and Axin , phosphorylation of beta catenin by PKA inhibited ubiquitination of beta catenin in intact cells and in vitro . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
N ( 4 Methoxybenzyl ) N ' ( 5 nitro 1 , 3 thiazol 2 yl ) urea ( AR A 014418 ) , a highly selective inhibitor of glycogen synthase kinase 3beta ( GSK 3beta ) , was radiolabelled with carbon 11 ( half life=20 . 4min ) for cerebral positron emission tomography ( PET ) studies . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we report a unique role for glycogen synthesis kinase 3beta ( GSK 3beta ) in regulating p 53 functions in human colorectal cancer cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , by screening a kinase directed library of small inhibitory RNAs , we identify glycogen synthase kinase 3beta ( GSK3beta ) as a gene whose inactivation potentiates TNF related apoptosis inducing ligand death receptor mediated apoptosis specifically in MYC overexpressing cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The increased glycogen synthase activity occurs in spite of decreased signaling through the insulin receptor substrate 1 ( IRS 1 ) phosphoinositide ( PI ) 3 kinase Akt pathway and increased glycogen synthase kinase 3beta ( GSK3beta ) activity in the basal state . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
AICD transgenic mice show activation of glycogen synthase kinase 3beta ( GSK 3beta ) and phosphorylation of CRMP 2 protein , a GSK 3beta substrate that plays a crucial role in Semaphorin3a mediated axonal guidance . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Akt kinase blocks apoptosis by phosphorylating the substrates forkhead transcription factor ( FKHR ) and glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
DIF 1 activated glycogen synthase kinase 3beta ( GSK 3beta ) and inhibition of GSK 3beta attenuated the DIF 1 induced beta catenin degradation , indicating the involvement of GSK 3beta in this effect . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In this paper 1 discuss the role of the Wnt Dvl ( Dishevelled protein ) GSK 3beta ( glycogen synthase kinase 3beta ) signalling pathway in axon remodelling during synapse formation in the central nervous system . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In addition , 4R did not enhance total phospho ERK 1 / 2 but increased the amount of total Akt / PKB phosphorylated on the activation site and of glycogen synthase kinase 3 beta phosphorylated on the inhibitory site . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that nitric oxide produced by sodium nitroprusside ( SNP ) , a recognized donor of nitric oxide , induces tau hyperphosphorylation at Ser396 / 404 and Ser 262 in HEK293 / tau441 cells with a simultaneous activation of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Our first finding that treatment of cells with LiCl , a selective inhibitor of another major tau kinase , glycogen synthase kinase 3beta ( GSK 3beta ) , inhibits phosphorylation of Ser 262 of tau led us to investigate the possible involvement of GSK 3beta in MARK 2 activation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Pharmacological inhibitors of nuclear factor kappaB ( NF kappaB ) , JNK , ERK , glycogen synthase kinase 3beta ( GSK 3beta ) , and dsRNA activated protein kinase ( PKR ) inhibit the expression of IL 8 and IP 10 in astrocytes , indicating that the activation of these signaling molecules is required for the TLR 3 mediated chemokine gene induction . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This potentiation was presumably due to the increased inactivated glycogen synthase kinase 3 beta by Ser 9 phosphorylation and nuclear factor of activated T cell nuclear accumulation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of glycogen synthase kinase 3beta ( Gsk3beta ) has been shown to be a key component in signaling pathways that underlie neurodegeneration and neurodegenerative disease . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Previous studies have shown that glycogen synthase kinase 3beta ( GSK3beta ) phosphorylates beta catenin and thereby targets it for proteosomal degradation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
To investigate the mechanism of resistance to EGFR inhibition in bladder cancer , we compared EGFR tyrosine kinase inhibitor ( Gefitinib , Iressa , ZD 1839 ) with respect to its inhibitory effects on three kinases situated downstream of EGFR : MAPK , Akt , and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The present report shows that Akt mediates the binding of HXK 2 to the mitochondria by negatively regulating the activity of glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is a target of lithium as well as sodium valproate , both of which are effective mood stabilizing prophylatics / treatments for bipolar disorder , a highly heritable psychiatric disorder . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Recent studies have suggested the involvement of Glycogen synthase kinase 3 beta ( GSK 3 beta ) in pathogenesis and treatment target of schizophrenia and bipolar disorder , which led to consider GSK 3 beta as one of the candidate genes for those disorders . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Thyrotropin releasing hormone ( TRH ) is an endogenous antidepressant that reduces the expression of glycogen synthase kinase 3beta ( GSK 3beta ) , an enzyme that hyperphosphorylates tau and is implicated in bipolar depression , diabetes and Alzheimer ' s disease . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NMDA at 10 microm suppressed LY 294002 induced activation of a pro apoptotic kinase , glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The effects of the inhibitors of glycogen synthase kinase 3beta ( GSK 3beta ) , TDZD 8 and SB 415286 , which can substantially reduce the systemic inflammation associated with endotoxic shock in vivo , have now been investigated on the acute colitis provoked by trinitrobenzene sulphonic acid ( TNBS ) in the rat . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We identified two functional single nucleotide polymorphisms in the glycogen synthase kinase 3beta gene ( GSK3B ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Crystallographic and modelling data , in conjunction with a medicinal chemistry template hopping approach , led to the identification of a series of novel and potent inhibitors of human cyclin dependent kinase 2 ( CDK 2 ) , with selectivity over glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We have previously shown that both basal and cAMP induced degradation of cyclin D 3 in Reh cells is dependent on Thr 283 phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a serine / threonine kinase that has recently emerged as a key target for neurodegenerative diseases and diabetes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Moreover , PARP inhibitors facilitated Akt phosphorylation and activation , as well as the phosphorylation of its downstream target glycogen synthase kinase 3beta ( GSK 3beta ) in normoxia and , more robustly , during IR . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We assessed glucose metabolism by measuring the incorporation of D [ U ( 14 ) C ] glucose into glycogen , ( 14 ) CO ( 2 ) and lactate production , as well as the phosphorylation level and total protein content of insulin signalling proteins , including insulin receptor beta subunit ( IRbeta ) , insulin receptor substrate ( IRS ) , Akt and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^ Resistin also decreased glycogen synthesis and GSK 3beta phosphorylation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We previously showed that glycogen synthase kinase 3beta ( GSK 3beta ) is critical for specifying axon / dendrite fate by the regulation of the phosphorylation of collapsin response mediator protein 2 ( CRMP 2 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Activation of ET ( A ) R by ET 1 triggers an integrin linked kinase ( ILK ) mediated signaling pathway leading to glycogen synthase kinase 3beta ( GSK 3beta ) inhibition , Snail and beta catenin stabilization , and regulation of transcriptional programs that control EMT . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
With the shortcomings of traditional assays in mind , the aim of this study was to develop a high throughput , non radioactive kinase assay for screening Glycogen Synthase Kinase 3beta ( GSK 3beta ) activity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) by SB 415286 induced expression of COX 2 mRNA and protein as well as the enzyme activity in the gastric cancer cells . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Hepatic insulin receptors were functional in all the mice , but insulin signaling via the Akt FoxO 1 pathway was reduced in Irs 1 / and LKO liver , and undetected in LKO : : Irs 1 / liver ; however , Gsk3beta phosphorylation ( Ser 9 ) and hepatic glycogen stores were nearly normal in all of the mice . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Interestingly , the reduction of soluble Abeta oligomers , but not insoluble Abeta , significantly correlated with reduced tau phosphorylation by glycogen synthase kinase 3beta ( GSK 3beta ) , a major tau kinase implicated previously in mediating Abeta toxicity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Further , this diet prevents a number of pathologic indicators in males , including fibrosis , induction of beta myosin heavy chain , inactivation of glycogen synthase kinase 3beta ( GSK3beta ) , and caspase 3 activation . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) has been implicated in the pathogenesis of major psychoses . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Tungstate treatment increases the phosphorylation of glycogen synthase kinase 3beta ( GSK3beta ) at serine 9 , which triggers its inactivation both in cultured neural cells and in vivo . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Additionally , changes associated with symptom age of onset have been recently reported in the brain derived neurotrophic factor ( BDNF ) and glycogen synthase kinase 3 beta ( GSK 3 beta ) genes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Using pharmacological inhibitors and siRNA , we showed that both resistance pathways required the activity of the glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
One of the main candidate to hyperphosphorylate Tau in AD is glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Silencing of phosphatase and tensin homologue deleted on chromosome 10 ( PTEN ) and glycogen synthase kinase beta ( GSK3beta ) are frequently associated with advanced PrCa systems and likely serve critical roles in promoting AR and PI3K / Akt gain of function . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Pin 1 is a peptidyl prolyl cis / trans isomerase that stabilizes beta catenin by inhibiting its binding to the adenomatous polyposis coli gene product and subsequent glycogen synthase kinase 3beta ( GSK 3beta ) dependent degradation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) phosphorylates tau protein , and increased GSK 3beta expression has been associated with neurofibrillary tangles . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) phosphorylation ( at serine 9 ) was greatly reduced in MPTP mice ; this was completely prevented by PPT , whereas 17beta estradiol and Delta 5 diol treatments were less effective . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we show that R406W mutation primarily disrupts tau phosphorylation at Ser 404 , a priming phosphorylation site of glycogen synthase kinase 3beta ( GSK 3beta ) , thereby reducing subsequent GSK 3beta mediated phosphorylation at the PHF 1 site ( mostly Ser 396 ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Regulation of dishevelled and beta catenin in rat skeletal muscle : an alternative exercise induced GSK 3beta signaling pathway . beta catenin is a multifunctional protein involved in cell cell adhesion and the Wnt signaling pathway . beta Catenin is activated upon its dephosphorylation , an event triggered by Dishevelled ( Dvl ) mediated phosphorylation and deactivation of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^ Treadmill running exercise in vivo significantly decreased beta catenin phosphorylation in both muscle types , with complete dephosphorylation being elicited by maximal exercise . beta Catenin dephosphorylation was intensity dependent , as dephosphorylation was highly correlated with muscle glycogen depletion during exercise ( r ( 2 ) = 0 . 84 , P < 0 . 001 ) . beta Catenin dephosphorylation was accompanied by increases in GSK 3beta Ser ( 9 ) phosphorylation and Dvl GSK 3beta association . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here , we show that phosphorylation of the Akt downstream target glycogen synthase kinase 3beta ( GSK 3beta ) at Ser 9 also occurred within minutes of exposure to ionizing radiation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In contrast , levels of active cyclin dependent kinase 5 ( CDK 5 ) and glycogen synthase kinase 3beta [ GSK 3beta ; but not stress activated protein kinase 1 ( SAPK 1 ) ] , kinases that phosphorylate APP , were reduced . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we aimed to determine whether bradykinin protects the heart at reperfusion by modulating the mitochondrial permeability transition pore ( mPTP ) opening through glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We examined the role for the JAK / STAT signaling pathway in acute opioid induced cardioprotection ( OIC ) and whether opioid induced glycogen synthase kinase 3beta ( GSK 3 beta ) inhibition is mediated by the JAK / STAT pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Moreover , leptin elicited the phosphorylation of the phosphatidylinositol 3 kinase effector Akt and evoked Ser 9 phosphorylation of glycogen synthase kinase 3beta ( GSK3beta ) , an event inactivating this kinase . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Further , increases in mitochondrial phosphorylated glycogen synthase kinase 3beta ( pGSK 3beta ) levels were hastened in aged and adult hearts following KID 1 1 ( p < 0 . 05 ) , increasing the pGSK 3beta / GSK 3beta ratio . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Here we identify glycogen synthase kinase 3beta ( GSK 3beta ) , which is inhibited by Akt mediated phosphorylation , as the link between both processes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Erythropoietin affords additional cardioprotection to preconditioned hearts by enhanced phosphorylation of glycogen synthase kinase 3 beta . ^^^ The aim of this study was to determine whether erythropoietin ( EPO ) affords additional cardioprotection to the preconditioned myocardium by enhanced phosphorylation of Akt , STAT 3 , or glycogen synthase kinase 3beta ( GSK 3 beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Several studies have implicated molecular and cellular signaling cascades involving the serine threonine kinase , glycogen synthase kinase beta ( GSK 3beta ) in the pathogenesis of AD . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
By this method we identified Shaggy , the Drosophila homologue of glycogen synthase kinase 3beta ( GSK 3beta ) , as a component of centrosomes . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The inhibition of IRbeta signaling was accompanied by an elevated content of glycogen synthase kinase ( GSK ) 3 alpha and GSK 3beta without significant changes in phospho Ser ( 21 / 9 ) GSK 3 alpha / beta levels . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a serine / threonine kinase with a broad array of cellular targets , such as cytoskeletal proteins and transcription factors . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3 beta inhibition reduces secondary damage in experimental spinal cord trauma . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
N 6 ( 3 iodobenzyl ) adenosine 5 ' N methylcarboxamide confers cardioprotection at reperfusion by inhibiting mitochondrial permeability transition pore opening via glycogen synthase kinase 3 beta . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We report that the direction of PCP in blood vessels is age and vessel specific ; nonetheless , it is caused by shear related regulation of glycogen synthase kinase 3beta ( GSK 3beta ) , a profound regulator of endothelial microtubule stability . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Key mediators of synaptic NMDA receptor dependent neuroprotection , phosphatidylinositol 3 kinase Akt ( PI 3 kinase Akt ) signaling to Forkhead box subgroup O ( FOXO ) export and glycogen synthase kinase 3beta ( GSK3beta ) inhibition and cAMP response element binding protein dependent ( CREB dependent ) activation of brain derived neurotrophic factor ( BDNF ) , can be induced only by low doses of NMDA via this action potential dependent route . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The methylation of the genes Ade nomatous polyposis coli ( APC ) , glycogen synthase kinase beta 3 ( GSK3beta ) and eyes absent 4 ( EYA 4 ) was analyzed in 12 colon cancer and 12 normal tissues . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
PDTC reduced the HI induced dephosphorylation of Akt and glycogen synthase kinase 3beta ( GSK 3beta ) , expression of cleaved caspase 3 , and nuclear translocation of NF kappaB in the neonatal brain . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This is concomitant with the activation of the integrin linked kinase ( ILK ) pathway , leading to the activation and nuclear translocation of Akt and the inactivation of glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a serine / threonine protein kinase that has recently emerged as a key regulatory switch in the modulation of the inflammatory response . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Phosphorylation of mCRY 2 at Ser 557 allows subsequent phosphorylation at Ser 553 by glycogen synthase kinase 3beta ( GSK 3beta ) , resulting in efficient degradation of mCRY 2 by a proteasome pathway . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
PKCiota / lambda also closely associated with the inactivated form of glycogen synthase kinase 3beta , GSK 3beta [ ser 9 ] . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We show here that multisite glycogen synthase kinase 3beta ( GSK3beta ) phosphorylation and ubiquitination by SCFbetaTrCP are required for Gli 3 processing . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The inhibition of glycogen synthase kinase 3beta ( GSK 3beta ) via phosphorylation by Akt or protein kinase C ( PKC ) , or the activation of mitogen activated protein kinase ( MAPK ) cascades can play a pivotal role in left ventricular remodeling following myocardial infarction . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , the level of active glycogen synthase kinase 3beta ( GSK 3beta [ pTyr ] ) was increased ( +55 % ) after amyloid beta peptide ( 25 35 ) exposure . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Higher activation of Akt was associated with increased phosphorylation of its downstream targets glycogen synthase kinase 3beta ( GSK3beta ) , FKHR , and mammalian target of rapamycin ( mTOR ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Under certain conditions , glycogen synthase kinase 3beta ( GSK 3beta ) , a protein serine / threonine kinase that regulates beta catenin degradation within the Wnt signaling pathway , can also phosphorylate AR and suppress its ability to activate transcription . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase 3 beta and a caspase 9 dependent apoptosis in cerebellar granule neurons . ^^^ Despite these apparent differences , both brefeldin A and TFW induced dephosphorylation ( activation ) of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Striata from mice that are not dopamine supersensitive did not reveal elevated D2High states ; these include mice with knockouts of adenosine A2A receptors , glycogen synthase kinase GSK3beta , metabotropic glutamate receptor 5 , dopamine D 1 or D 3 receptors , histamine H 1 , H 2 , or H 3 receptors , and rats treated with ketanserin or aD 1 antagonist . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The canonical Wnt signaling step mimicked by lithium involves inactivation of glycogen synthase kinase 3beta ( GSK 3beta ; Klein and Melton [ 1996 ] Proc . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
In cultured bovine adrenal chromaffin cells treated with nicotine ( 10 microm for 24 h ) , phosphorylation of Akt , glycogen synthase kinase 3beta ( GSK 3beta ) and extracellular signal regulated kinase ( ERK ) 1 / 2 induced by insulin ( 100 nm for 10 min ) was enhanced by approximately 62 % , without altering levels of these protein kinases . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
This study investigated whether estradiol modulates the anti apoptotic signal through the phosphorylation of Akt and its downstream target , glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Concomitantly , we detected a significant activation in glycogen synthase kinase 3beta ( GSK 3beta ) and p 38 MAPKs , including p38alpha , p38beta , and p38delta , but no obvious change was measured in the activity of p38gamma , ERK , and c Jun amino terminal kinase ( JNK ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Src homology 2 domain containing phosphatase 2 ( SHP 2 ) association with beta catenin was diminished in PECAM 1 null ECs , suggesting that lack of PECAM 1 inhibits the ability of this adherens junction component to become dephosphorylated , promoting a sustained increase in permeability . beta Catenin / Glycogen synthase kinase 3 ( GSK 3beta ) association and beta catenin serine phosphorylation levels were increased and beta catenin expression levels were reduced in PECAM 1 null ECs . ^^^ Glycogen synthase kinase 3 ( GSK 3beta ) serine phosphorylation ( inactivation ) was blunted in PECAM 1 null ECs after histamine treatment or shear stress . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Suppression of PTEN expression during the aggregation was accompanied by increased phosphorylation of serine / threonine kinase Akt and glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The involvement of PI 3 K / protein kinase B ( PKB , Akt ) pathway was confirmed by the results of the Western blot study , which showed that both drugs increased the level of active phospho Ser 473 Akt , without changing the total Akt level , and decreased the level of active , nonphosphorylated glycogen synthase kinase 3 ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The glycogen synthase kinase 3beta ( GSK 3beta ) , one of the main enzymes of the Wnt signaling , has been associated to Alzheimer ; s and schizophrenia diseases etiology . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Consistent with increased activation of the PI3K cascade , sEH null mice exhibit increased cardiac expression of glycogen synthase kinase 3beta ( GSK 3beta ) phospho protein after ischemia . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Immunoblotting revealed that resveratrol 50 microM induced the phosphorylation / activation of Akt and extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) and the phosphorylation / inactivation of glycogen synthase kinase 3beta ( GSK 3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Asymmetric distributions of activities of the protein kinases Akt and glycogen synthase kinase 3beta ( GSK 3beta ) are critical for the formation of neuronal polarity . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The purpose of this study was to examine the in vivo effect of melatonin ( MEL ) on peroxynitrite induced tau hyperphosphorylation and the involvement of glycogen synthase kinase 3beta ( GSK 3beta ) and mitogen activated protein kinase ( MAPK ) families . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Interfering with O GlcNAc cycling with either oga 1 ( ok 1207 ) or the O GlcNAc transferase null ogt 1 ( ok 430 ) altered Ser and Thr phosphoprotein profiles and increased glycogen synthase kinase 3beta ( GSK 3beta ) levels . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK 3beta ) is a serine / threonine kinase that plays a role in glycogen synthesis by inhibiting glycogen synthase ( GS ) through phosphorylation . ^^^ We hypothesized that GSK 3beta by virtue of its role in glycogen synthesis through the inhibition of GS will play a role in the preparation of the endometrium for blastocyst implantation . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Furthermore , the activity of MAP1A and MAP1B is controlled by upstream signaling mechanisms , including the MAP kinase and glycogen synthase kinase 3 beta pathways . . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Lithium inhibits glycogen synthase kinase 3beta ( GSK 3beta ) directly or indirectly via stimulation of the kinase Akt 1 . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is one of the key elements of the Wnt pathway involved in the regulation of beta catenin homeostasis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
Glycogen synthase kinase 3beta ( GSK3beta ) is one of the key elements of the Wnt pathway , governing beta catenin homeostasis . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
The protein kinase 5 akt murine thymoma viral oncogene homolog ( AKT ) gene family comprises three human homologs that phosphorylate and inactivate glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
We also show that Abeta inhibited mitochondrial transport by acting through glycogen synthase kinase 3beta ( GSK3beta ) . ^^^
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
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Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA
Interacting proteins: P13807 and P49841	Pubmed	SVM Score :0.0
NA