| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Here we show that , in addition to the decreased levels of expression of the MHC class 1 heavy chain and the peptide transporter Tap 2 , the expression levels of the chaperone Tapasin and the immunoproteasome components MECL 1 , PA 28 alpha , and PA 28 beta also are much lower in Ad 12 than in Ad 5 transformed BRK cells . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| This close functional relationship of the transporter and class 1 heavy chain genes and their linkage within the MHC raise the question of whether PSF 1 and PSF 2 , like most class 1 genes , are polymorphic . ^^^ A possible involvement of the PSF 1 and PSF 2 genes in susceptibility to MHC associated diseases was examined in a preliminary assessment in patients with ankylosing spondylitis , insulin dependent diabetes mellitus , or celiac disease . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Comparative analysis with both human and zebrafish MHC maps indicates two blocks of genes ( KNSL 2 , ZNF 297 , DAXX , TAPBP , FLOTILLIN ; and PSMB 8 , PSMB 10 , PSMB 9 , ABCB 3 , FABGL , BRD 2 , COL11A2 , RXRB ) which have remained linked over 400 million years and may represent an ancestral arrangement of the vertebrate MHC . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Two genes have been identified in the MHC class 2 region , RING 4 and RING 11 in humans , which are believed to encode the peptide transport proteins . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The participation of TAP 1 and TAP 2 genes , located in the MHC region and coding for antigenic peptide transporters , was investigated in 116 IDDM patients and 98 normal controls using oligotyping after DNA amplification . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Transport is mediated by a heterodimer of the MHC encoded proteins , transporter associated with Ag presentation ( TAP ) 1 and TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Short peptides produced by the proteasome are transported into the ER by the product of another set of MHC class 2 genes , TAP 1 and TAP 2 , where they bind and stabilise HLA class 1 molecules . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We have already shown that in species with highly polymorphic major histocompatibility complex ( MHC ) class 1 molecules ( human , mouse ) no functional polymorphism of the peptide transporters TAP 1 and TAP 2 is detectable ( Lobigs and Mllbacher 1993 ) . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Effects of MHC encoded TAP 1 and TAP 2 gene polymorphism and matching on kidney graft rejection . ^^^ The products of TAP 1 and TAP 2 genes , recently mapped within the MHC class 2 region , are involved in antigen presentation by MHC class 1 molecules , especially in the transport of endogenous peptides . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Assembled class 1 MHC and antigen was measured by flow cytometry ; mRNA levels of assembly components ( class 1 MHC heavy chain , beta 2 microglobulin , and the antigen transporter gene product TAP 2 ) were determined ; and antigen processing was measured with a chimeric reconstituted system using vaccinia vectors . ^^^ PPC 1 cells underexpressed TAP 2 mRNA despite abundant class 1 MHC and beta 2 microglobulin message . ^^^ The specific underexpression of TAP 2 gene product in PPC 1 cells contrasts with prior studies of TAP gene underexpression in lung cancer ( which concurrently underexpressed class 1 MHC heavy chain ) and provides evidence for a regulatory pathway controlling TAP 2 gene expression in human cancers that may not affect class 1 MHC heavy chain expression . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The class 2 region of the MHC contains a cluster of genes encoding proteins involved in antigen processing , including genes for two proteasome subunits ( LMP 2 and LMP 7 ) , the peptide transporter heterodimer ( TAP 1 and TAP 2 ) , and the H 2M / HLA DM molecule ( Ma and Mb , or DMA and DMB ) . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| However , here we show that unlike most other MHC class 1 molecules , TL is expressed efficiently in the absence of functional transporter associated with antigen processing subunit 2 ( TAP 2 ) . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Recognition of tumour cells depends on the gamma delta TCR but is independent of major histocompatibility complex ( MHC ) class 1 , MHC class 2 , or TAP 2 peptide transporter expression . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| TAP 1 and TAP 2 , two genes encoded within the MHC class 2 region between HLA DP and DQ loci , display genetic variability and are involved in the transport of antigenic peptides from the cytoplasm to the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| It displays a high level of similarity with the MHC linked transporters TAP 1 and TAP 2 which are involved in the delivery of immunogenic peptides across the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Recombinant expression of vaccinia virus encoded TAP 1 and TAP 2 promotes MHC class 1 restricted antigen presentation in a Syrian hamster cell line . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Polymorphism of the TAP 2 gene locus , situated approximately 150 kb centromeric to the MHC class 2 loci HLA DR , DQ was examined in 100 Australian patients with relapsing / remitting multiple sclerosis ( MS ) , in 100 random controls and in 37 selected HLA DRB1 * 1501 positive controls . ^^^ TAP 2 encodes a protein involved in the transport and presentation of antigenic peptides by MHC class 1 molecules and hence is a candidate locus for a putative MS susceptibility gene either through functional interactions with class 1 alleles or as an explanation , via linkage disequilibrium ( LD ) , for the known association between MS and the alleles DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 . ^^^ The results of this study exclude TAP 2 as a locus for a necessary MS / MHC gene but indicate that an MS gene carried by the DRB1 * 1501 , DQA1 * 0102 , DQB1 * 0602 haplotype could reside centromeric of DQ . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Using probes for the recently discovered Tap 1 and Tap 2 genes and the different MHC class 2 genes , we found the gene order in the rat MHC ( RT 1 ) region to be RT1 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| MHC class I / beta 2m dimers were shown to associate with individual TAP 1 chains but were not detectable with individual TAP 2 chains . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Because new genes have recently been mapped within the MHC class 2 region , we typed TAP 1 and TAP 2 gene polymorphisms by ARMS PCR in order to characterize more effectively MHC genes involved in this alloimmunization . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We propose that MHC class 1 presentation of self peptides may represent a normal pathway for tolerance induction and interruption of this important class 1 function from any cause , including the MHC class 2 linked Tap 1 and Tap 2 genes , which may result in autoreactivity . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| This phenotype results from a homozygous deletion in the MHC that includes the peptide transporter genes TAP 1 and TAP 2 , and the proteasome subunits LMP 2 and LMP 7 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Two proteasomal polymorphic genes , LMP 2 and LMP 7 , are localized within the MHC class 2 region , closely linked to the TAP 1 and TAP 2 genes that are responsible for the ATP dependent , size and sequence selective transport of antigenic peptides generated in the cytoplasm into the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Presentation of self antigens by major histocompatibility complex ( MHC ) class 1 molecules requires the function of the MHC class 2 linked genes Tap 1 and Tap 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| While TAP 1 and TAP 2 have been shown to transport antigenic peptides from the cytosol into the endoplasmic reticulum , where the peptides associate with MHC class 1 molecules , the role of LMP2 / 7 in antigen presentation is less clear . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These antigenic peptides derived from the cytoplasmic protein pool are transported by the recently described MHC encoded transporters ( TAP 1 and TAP 2 ) into a pre Golgi region where they take part in the assembly of MHC class 1 molecules . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These peptides are translocated in an ATP dependent fashion into the lumen of the endoplasmic reticulum ( ER ) for binding to class 1 molecules by means of the MHC encoded transporters associated with antigen processing , TAP 1 and TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The human Ag processing defective cell line 721 . 174 , and its derivative T 2 , have a large homozygous deletion in the MHC class 2 region encompassing the TAP 1 and TAP 2 as well as the LMP 2 and LMP 7 genes . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Stable cell surface presentation of MHC class 1 molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes , TAP 1 and TAP 2 , which are maped in the MHC class 2 region . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The gene products of tap 1 and tap 2 encoded in the major histocompatibility complex ( MHC ) class 2 region belong to the ATP binding cassette superfamily of transporters . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The antigen processing defective cell line RMA S ( H 2b ) has a premature stop in the Tap 2 gene and probably therefore fails to deliver peptides into the ER , which leads to a low level of cell surface MHC class 1 molecules . ^^^ Transfection of a Tap 2 gene restores to RMA S both MHC class 1 molecule expression and the ability to present influenza viral antigens . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The efficient presentation of such peptides requires the functioning of two MHC gene products [ TAP 1 and TAP 2 ( transporter associated with Ag processing 1 and 2 ) ] that form a complex that facilitates transmembrane movement of peptides from the cytosol to the endoplasmic reticulum , the site of peptide association with class 1 molecules . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Transport of the resulting cytosolic peptides into the endoplasmic reticulum for association with class 1 molecules is essential and probably involves a heterodimer of the MHC encoded proteins , Tap 1 and Tap 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Two MHC encoded putative transporter proteins , TAP 1 and TAP 2 , are required for efficient assembly of class 1 molecules and presentation of endogenous peptides . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Northern blot analysis of these cells revealed low to nondetectable levels of mRNAs for MHC encoded proteasome components LMP 7 and LMP 2 , as well as the putative peptide transporters TAP 1 and TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Alleles and haplotypes of the MHC encoded ABC transporters TAP 1 and TAP 2 . ^^^ TAP 1 and TAP 2 are two major histocompatibility complex ( MHC ) genes , located between HLA DP and DQ , whose products form a transporter molecule involved in endogenous antigen processing . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| For the stable assembly of MHC class 1 complex it is necessary that the antigenic peptide is transported by the MHC encoded transporters TAP 1 and TAP 2 into a pre Golgi region . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In some human tumors , reduced or defective MHC class 1 surface expression has been attributed to functional deficiencies of the genes of the antigen processing machinery , the proteasome subunits low molecular weight ( LMP ) 2 and LMP 7 , as well as the peptide transporters associated with antigen processing ( TAP ) 1 and TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| This resistance to immune surveillance is not due to an obvious CTL dysfunction but has been partly attributed to the down regulation of the peptide transporters , TAP 1 and TAP 2 , thus restricting the endogenous loading of MHC class 1 molecules with peptides derived from viral nuclear antigens . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Peptides produced by proteasomes are transported into the endoplasmic reticulum by transporter proteins TAP 1 and TAP 2 , where they bind and stabilize MHC class 1 molecules required for antigenic presentation on the cell surface . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| To investigate whether the class 1 antigen processing genes , encoded within the MHC class 2 region between the HLA DP and DQ loci , are involved in determining the susceptibility to sarcoidosis , TAP 1 , TAP 2 , and LMP 2 alleles were analyzed by the PCR RFLP method in 85 Japanese patients with sarcoidosis and 91 healthy controls . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Presentation of endogenous peptides by major histocompatibility complex class 1 ( MHC ) molecules is controlled , in part , by the Tap 1 and Tap 2 genes in the MHC class 2 region that encode a heterodimeric peptide transporter . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The major histocompatibility complex ( Mhc ) regions of mice , rats , and humans all contain a pair of related genes , TAP 1 and TAP 2 , which encode members of a large superfamily of proteins of similar structure and function . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The transporter associated with antigen processing ( TAP ) complex is a heterodimeric transmembrane pump consisting of the TAP 1 and TAP 2 subunits ; these subunits translocate peptides from the cytoplasm into the lumen of the endoplasmic reticulum , where they bind nascent major histocompatibility complex ( MHC ) class 1 molecules . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Assessment of intracellular TAP 1 and TAP 2 in conjunction with surface MHC class 1 in plasma cells from patients with multiple myeloma . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The polymorphic TAP ( TAP 1 and TAP 2 ) genes code for a heteromeric complex that translocates cytosolic peptides across the membrane of the endoplasmic reticulum where they associate with MHC class 1 molecules . ^^^ In the rat , extensive TAP 2 polymorphism modifies the spectrum of peptides presented by MHC class 1 molecules on the cell surface . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The peptides are delivered to the secretory pathway by TAP , which is formed by the association of MHC encoded TAP 1 and TAP 2 gene products . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In contrast , as described here , in the TAP deficient human cell line T 2 , MHC class 1 molecules interact with a transfected rat TAP 2 polypeptide in addition to rat TAP 1 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In a number of human and murine tumours , defects in the expression of the different components of the MHC class 1 antigen processing machinery , such as the proteasomal subunits LMP 2 and LMP 7 and the peptide transporters TAP 1 and TAP 2 , account for impaired MHC class 1 surface expression . ^^^ IFN gamma treatment of 577LM resulted in a significant increase of MHC class 1 surface expression which was preceded by an upregulation of TAP , LMP and MHC class 1 transcripts as well as of TAP 1 and TAP 2 , but not of LMP 2 and LMP 7 , protein expression . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Analysis of NPC cells in fresh tumor biopsies and long term , established NPC tumors in nude mice revealed normal expression of the MHC encoded putative peptide transporters TAP 1 and TAP 2 , as well as the proteasome components LMP 2 and LMP 7 , which have been shown previously to be essential components of the class 1 processing pathway . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The antimetastatic effect of peptide pulsed APC could be further enhanced by pretreating the cells with antisense oligonucleotides directed against the TAP 2 gene to increase the density of specific peptide major histocompatibility complex ( MHC ) class 1 complexes and thereby improve the APC function of the treated cells ( Nair SK et al . , J Immunol 1996 ; 156 : 1772 ) . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We here investigate whether the suppressed MHC class 1 surface expression of ras transformed fibroblasts is due to dysregulation of the genes of the antigen processing machinery , the peptide transporters TAP 1 and TAP 2 and the proteasome subunits LMP 2 and LMP 7 , and whether it can be restored by gene transfer . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Some of the peptides generated by the proteasome in the cytosol are transported by the products of the TAP 1 and TAP 2 genes into the lumen of the endoplasmic reticulum and are loaded onto the assembling MHC class 1 molecules . ^^^ In mammals , the LMP 2 , LMP 7 , TAP 1 , and TAP 2 genes reside in the class 2 region of the Mhc , closely linked to the RING 3 gene . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| ERp 57 co purified with the rat TAP complex ( comprising TAP 1 and TAP 2 ) , and associated with MHC class 1 molecules at an early stage in their biosynthesis . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To study the influence MHC class 2 and TAP 2 alleles exert on systemic lupus erythematosus ( SLE ) susceptibility and on the clinical and serological manifestations of the disease , in a cohort of Spanish patients . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In some cases , virtually complete deficiencies were observed in the expression of the four genes encoded within the MHC ( TAP 1 , TAP 2 , LMP 2 , and LMP 7 ) , as well as LMP 10 , which is encoded outside the MHC . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Stable MHC class 1 cell surface expression requires delivery of cytosolic peptides into the endoplasmic reticulum by the peptide transporter molecules TAP 1 and TAP 2 , with peptides subsequently transported to the cell surface in complexes containing MHC class 1 heavy chain and beta 2 microglobulin . ^^^ The melanoma cell line Mz 18 exhibits a global down regulation of MHC class 1 heavy chain transcripts ; beta 2 microglobulin ; the proteasome subunits LMP2 / 7 , involved in generating cytosolic peptide fragments ; and the peptide transporter molecules TAP 1 and TAP 2 , involved in peptide transport from the cytosol into the endoplasmic reticulum . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to analyse prospectively MHC region involvement in the genetic susceptibility to SS by studying DRB 1 , DQB 1 , DPB 1 , TAP 1 , TAP 2 genes and TNF microsatellites in a population of 45 primary SS patients . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| This presentation requires the coordinated expression of several genes contained in the MHC , including those encoding the MHC class 1 heavy chain , the proteins LMP 2 and LMP 7 , which are involved in the proteasomal degradation of cytosolic antigens into peptide fragments that are destined for association with MHC class 1 molecules , and TAP 1 and TAP 2 , which transport these fragments across the membrane of the endoplasmic reticulum at the start of their journey to the cell surface . ^^^ Here we report that the proto oncogene product PML induces expression of LMP 2 , LMP 7 , TAP 1 and TAP 2 in an MHC class 1 negative , recurrent tumour , leading to the re expression of cell surface MHC in tumours and to rejection of the tumours . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Here , we report the isolation of a transporter associated with antigen processing ( TAP ) gene , TAP 2 , and demonstrate its linkage to the MHC . ^^^ Segregation analysis of 34 individuals from two families showed exact restriction fragment length polymorphism matching between the MHC class Ia gene and the one TAP 2 gene demonstrating linkage conservation since the mammalian / amphibian divergence approximately 350 million years ago . ^^^ In addition , one non MHC linked TAP 2 hybridizing fragment was detected in approximately half of the individuals tested . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Such peptides are delivered to the ER by an MHC encoded transporter composed of TAP 1 and TAP 2 protein delivery . ^^^ The common coexpression of an alternative splice product of the Tap 2 gene may contribute to broaden immune diversity , a mechanism previously described to occur predominantly at the level of the TCR and MHC class 1 gene products . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In TAP 2 mutated RMA S cells , both TAP 1 and MHC class 1 were coprecipitated by anti tapasin antiserum indicative of association of tapasin with TAP 1 but not TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Restriction fragment length polymorphism ( RFLP ) analysis was conducted by using three MHC related cDNA probes : chicken MHC class 4 ( B G ) , chicken MHC class 1 ( B F ) , and human MHC linked Tap 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| However , analysis of NPC cells has revealed normal expression of the major histocompatibility complex ( MHC ) encoded peptide transporters TAP 1 and TAP 2 , together with high levels of human leukocyte antigen ( HLA ) class 1 alleles on the cell surface . ^^^ Burkitt ' s lymphoma ( BL ) displays downregulated expression of MHC class 1 and TAP 1 and TAP 2 proteins , whereas viral antigen expression is limited to a protein incapable of processing class 1 CTL epitopes . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Six of the nine genes reside in the zebrafish MHC ( Mhc ) class 1 region , four of them reside in a single cluster closely associated with TAP 2 on a 26 kb long genomic fragment , and two reside at some distance from the fragment . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Analysis of MHC encoded antigen processing genes TAP 1 and TAP 2 polymorphisms in sarcoidosis . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In addition to the differential expression of MHC class 1 pathway genes , two cell lines representing competent ( FF ) and defective ( BHK ) antigen presentation phenotypes for mouse class 1 MHC restriction elements demonstrated substantial sequence polymorphism in Tap 1 but not Tap 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In spite of significant up regulation of TAP 1 and TAP 2 , and increased expression of MHC class 1 , the BL cells remained unable to present endogenously expressed viral antigens to EBV specific CTL . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These include the two subunits of the transporter associated with antigen presentation ( TAP 1 and TAP 2 ) , which are essential for introducing peptides into the ER from the cytosol , and tapasin , an MHC encoded membrane protein . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We have therefore used both haplotype analysis and direct detection of crossovers in sperm to characterize a putative recombination hotspot in the TAP 2 gene within the class 2 region of the MHC . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Differential resistance to cytolysis in metastatic versus primary prostate cancer cells was not attributable to the differential expression of molecules such as transporter associated with antigen processing ( TAP ) 1 , TAP 2 , low molecular weight protein of the proteasome complex ( LMP ) 2 , and LMP 7 that contribute to antigen presentation by class 1 MHC . ^^^ IFN gamma induced surface class 1 MHC expression , as well as gene expression of TAP 1 , TAP 2 , LMP 2 , and LMP 7 in the metastatic cells , yet the cells remained resistant to cell lysis induced by CTLs . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| This inhibition in chronic hepatitis occurs despite augmented ( as in acute infection ) expression of hepatic genes for class 1 MHC heavy chain , beta ( 2 ) microglobulin , and transporters associated with antigen processing ( TAP 1 and TAP 2 ) . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These data suggest that the expression level of MHC class 1 molecules is associated , in most cases , with the loss of the LMP 7 gene but without the loss of the TAP 1 , TAP 2 or LMP 2 genes . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These results suggest that the level of MHC class 1 surface expression is associated , in most cases , with the expression of the LMP 7 gene regardless of the LMP 2 , TAP 1 , TAP 2 , or MHC class 1 genes . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| On the other hand , in situ hybridization with probes for MHC class 1 heavy chain , beta 2 microglobulin , and TAP 1 and TAP 2 mRNAs revealed increased expression in a majority of neurons , as well as in inflammatory cells , endothelial cells , and ependymal cells in the central nervous system of infected mice . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Rats transgenic for the human MHC molecule HLA B 27 were used to study the effect of two alleles , cima and cimb , which are associated with peptide transport by the MHC encoded Tap 2 transporter , on the function of HLA B 27 as a restriction element for CTL recognition of the male H Y minor H Ag and on the multisystem inflammatory disease characteristic of B 27 transgenic rats . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The gene for human TAPL is assigned to chromosome 12q24 . 31 q24 . 32 , while those for TAP 1 and TAP 2 are located at the MHC locus of chromosome 6p21 . ! 3 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In many cases , such as in renal cell carcinoma ( RCC ) , the lack of MHC class 1 antigen presentation can be attributed to the down regulation of genes needed for antigen processing , such as the transporters associated with antigen processing ( TAP ) 1 and TAP 2 , and the proteasomal components low molecular weight proteins ( LMP ) 2 and LMP 7 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Also TAP 1 and TAP 2 genes expression were investigated in order to confirm or exclude involvement of the MHC class 1 molecules assembling machinery . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The impaired TAP 1 protein expression was associated with deficient TAP 2 protein expression , peptide binding , translocation , and MHC class 1 surface expression . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Previous studies have shown that Epstein Barr virus encoded latent membrane protein 1 ( LMP 1 ) is uniquely able to up regulate the expression of the peptide transporters ( referred to as TAP 1 and TAP 2 ) and major histocompatibility complex ( MHC ) class 1 in Burkitt ' s lymphoma ( BL ) cell lines . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Expression of cell surface MHC class 1 : peptide complex requires coordinated expression of multiple genes such as MHC class 1 heavy chain , beta ( 2 ) microglobulin ( beta ( 2 ) m ) , transporters associated with antigen processing ( TAP ) 1 and TAP 2 , and proteosomal components low molecular weight polypeptide ( LMP ) 2 and LMP 7 . ^^^ While the cis elements involved in transcription of the MHC class 1 heavy chain , beta ( 2 ) m , TAP 1 and LMP 2 have been analyzed extensively , those for TAP 2 and LMP 7 have not been well studied . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Thus , TAP 1 and TAP 2 do not appear to differ in their ability to interact with MHC class 1 alleles . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Among the differential expressed genes identified we focussed on the expression of the transporters associated with antigen processing , TAP 1 and TAP 2 , which are involved in the antigen presentation via MHC class 1 . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Cysteine less TAP 1 and TAP 2 restore maturation and intracellular trafficking of MHC class 1 molecules to the cell surface . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| When the expression of some components of the antigen processing machinery ( APM ; LMP 2 , TAP 1 , and TAP 2 ) was tested , a reduced TAP 1 production was detected in cell lines with downregulated MHC class 1 expression . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In physiological conditions , the central nervous system expresses neither MHC class 1 molecules nor TAP 1 and TAP 2 transporters but besides being constitutive , it is unknown whether immuno proteasomes are also present in this tissue . ^^^ We present evidence that in human brain , the two types of proteasome exist suggesting that under physiological conditions , the mechanisms regulating expression of IFN gamma inducible subunits as well as of MHC class 1 molecules and TAP 1 and TAP 2 transporters in nervous tissue , are not entirely coordinated . . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The sequence is closely related to the mammalian ABCB 9 protein and the TAP 1 and TAP 2 proteins that transport peptides for loading onto nascent Mhc class 1 molecules . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| B78H1 , unlike B16F1 and B16F10 sublines , is also selectively devoid of TAP 2 and low molecular weight protein 7 as well as classical class 1 MHC K ( b ) and D ( b ) transcripts . ^^^ Cotransfection of B78H1 with TAP 2 and class 1 H chain genes is sufficient to reconstitute surface expression of exogenously delivered class 1 MHC without concomitant re expression of endogenous beta ( 2 ) microglobulin associated class 1 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| In the frog Xenopus , MHC class 1 antigen presentation and processing genes ( the immunoproteasome LMP 2 and LMP 7 and the transporter TAP 1 and TAP 2 ) seem to be closely linked in a primordial organization . ^^^ We now show that the Xenopus MHC ' class 1 region ' lies between class 2 and class 3 genes and we have isolated two distinct alleles at both the TAP 1 and TAP 2 loci . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Genes involved in MHC class 1 antigen presentation , such as beta ( 2 ) microglobulin , subunits of an immunoproteasome and ATP binding cassette transporter TAP 2 were expressed at higher levels in the AD patients than in the healthy controls . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| These results indicate that NK cells in TAP 2 deficient patients have developed unique mechanisms to reduce NK killing activity and to compensate for the lack of class 1 MHC mediated inhibition . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Here , we propose that human scalp hair follicles , which are abundantly available and easily studied , are ideally suited for this purpose : interferon gamma induces ectopic MHC class 1 expression in the constitutively MHC class 1 negative hair matrix epithelium of organ cultured anagen hair bulbs , likely via interferon regulatory factor 1 , along with up regulation of the MHC class 1 pathway molecules beta ( 2 ) microglobulin and transporter associated with antigen processing ( TAP 2 ) . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We isolated the medaka counterparts of human MHC genes , class 1 A , class 2 B , LMP 2 , LMP 7 , TAP 2 , complement Bf and C 4 , and subjected them to linkage analysis . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| To determine the influence of this natural mutated TAP on peptides loaded onto MHC class 1 , we analyzed the repertoire of peptides loaded onto MHC class 1 on transfectants with TAP 1 and TAP 2 or mutated TAP 2 by electrospray ionization tandem mass spectrometry ( ESI MS / MS ) . ^^^ To our knowledge this is the first report to show that the natural mutation of TAP 2 changes the peptide profile loaded onto MHC class 1 molecules . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The dominant MHC class 1 gene is adjacent to the polymorphic TAP 2 gene in the duck , Anas platyrhynchos . ^^^ In chickens , the dominantly expressed MHC class 1 gene lies adjacent to the transporter of antigen processing ( TAP 2 ) gene . ^^^ PCR amplification from genomic DNA allowed us to determine that the dominantly expressed MHC class 1 gene was adjacent to TAP 2 . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| As MHC class 1 protein expression increases with age , we have explored the effect of age on the transcription of MHC class 1 genes ( Kb ) and TAP 1 and TAP 2 genes in C57BL / 6 mice . ^^^ While MHC class 1 and Tap genes underwent very similar age related changes , MHC class 1 mRNA was about 50 times more abundant than either TAP 1 or TAP 2 mRNA . . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Critical role for the tapasin docking site of TAP 2 in the functional integrity of the MHC class 1 peptide loading complex . ^^^ Tapasin organizes a peptide loading complex ( PLC ) by recruiting MHC 1 and accessory chaperones to the N terminal regions ( N domains ) of the TAP subunits TAP 1 and TAP 2 . ^^^ To investigate the function of the tapasin docking sites of TAP in MHC 1 processing , we expressed N terminally truncated variants of TAP 1 and TAP 2 in combination with wild type chains , as fusion proteins or as single subunits . ^^^ Strikingly , TAP variants lacking the N domain in TAP 2 , but not in TAP 1 , build PLCs that fail to generate stable MHC 1 peptide complexes . ^^^ |
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| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| Our present study provides evidence that re expression of an H 2K MHC class 1 encoding gene in these cells also augments the expression of the Tap 2 peptide transporter and the inducible proteasome subunits , i . e . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| The clone carried five MHC class 1 genes and the TAP genes in the following gene order : TAP 1 , TAP 2 , UAA , UBA , UCA , UDA , and UEA . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We hypothesize that over expression of transporters associated with antigen processing ( TAP 1 and TAP 2 ) , components of the major histocompatibility complex ( MHC ) class 1 antigen processing pathway , enhances antigen specific cytotoxic activity in response to viral infection . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| We show in this report that JEV infection of mouse brain astrocytes results in induction of the nonclassical MHC Class Ib genes , H 2T23 , H 2Q4 and H 2T10 in addition to MHC 1 , Type 1 ( alpha / beta ) IFNs , TAP 1 , TAP 2 , Tapasin , LMP 2 , LMP 7 and LMP 10 but not IFNgamma , CD 80 , CD 86 and MHC 2 genes . ^^^ |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q03519 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|