| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| CD94 / NKG2C , an activating NK cell receptor of the C type lectin superfamily that binds to HLA E , noncovalently associates with DAP 12 , a membrane receptor containing an immunoreceptor tyrosine based activating motif . ^^^ |
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| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| Expression of the activating CD94 / NKG2C killer lectin like receptor ( KLR ) specific for HLA E was analyzed in peripheral blood lymphocytes ( PBLs ) from healthy adult blood donors ; the expression of other natural killer ( NK ) cell receptors ( ie , CD94 / NKG2A , KIR , CD85j , CD 161 , NKp 46 , NKp 30 , and NKG2D ) was also studied . ^^^ Human cytomegalovirus ( HCMV ) infection as well as the HLA E and killer immunoglobulin like receptor ( KIR ) genotypes were considered as potentially relevant variables associated with CD94 / NKG2C expression . ^^^ The HLA E genotype and the number of activating KIR genes of the donors were not significantly related to the percentage of NKG2C ( + ) lymphocytes . ^^^ |
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| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| In this study , we determine the affinities and interaction thermodynamics between three NKG2x / CD94 receptors ( NKG2A , NKG2C , and NKG2E ) and complexes of HLA E with four representative peptides . ^^^ Inhibitory NKG2A / CD94 and activating NKG2E / CD94 receptors bind HLA E with indistinguishable affinities , but with significantly higher affinities than the activating NKG2C / CD94 receptor . ^^^ |
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| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| The CD94 / NKG2C killer lectin like receptor ( KLR ) specific for HLA E is coupled to the KARAP / DAP12 adapter in a subset of NK cells , triggering their effector functions . ^^^ Coculture with the 721 . 221 HLA class 1 deficient lymphoma cell line transfected with HLA E ( . 221 AEH ) induced IL 2Ralpha expression in CD94 / NKG2C+ NK cells and a minor subset of CD94 / NKG2C ( + ) T cells , promoting their proliferation ; moreover , a similar response was triggered upon selective engagement of CD94 / NKG2C with a specific mAb . ^^^ |
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| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26717 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|