| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| RESULTS : When the interaction between NK cell inhibitory receptors ( i . e . , CD158a , CD158b , and CD159a ) and MHC class 1 molecules ( i . e . , HLA C and HLA E ) on HIV infected autologous T cells was blocked , a drastic increase in killing of anti gp 120 coated HIV infected cells by NK cells was observed . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Human natural killer cell receptors involved in MHC class 1 recognition are disulfide linked heterodimers of CD 94 and NKG 2 subunits . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| In mice , the latter category is represented by the Ly 49 family of receptors , whereas in humans , NK cells express the distantly related CD 94 , which forms MHC class 1 specific heterodimers with NKG 2 family members . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Ly 49 genes have previously been identified in the rat , and the existence of rat NKG 2 genes in addition to a CD 94 orthologue suggests that NK cell populations utilize different C type lectin receptors for MHC class 1 molecules in parallel . . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| The formation of this dimer reveals a putative ligand binding region for HLA E and suggests how NKG 2 interacts with CD94 . . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| One of the most important of these mechanisms of regulation is the recognition of the non classical class 1 MHC molecule HLA E , in complex with nonamer peptides derived from the signal sequences of certain class 1 MHC molecules , by heterodimers of the C type lectin like proteins CD 94 and NKG 2 . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Like its human counterpart , the mouse CD 94 protein associates with different NKG 2 isoforms and recognizes the atypical MHC class 1 molecule Qa 1b . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| In this review the structure and function of a number of molecules found on the NK cell surface are discussed , particular emphasis being placed on the molecular details of the recognition of target cell classical class 1 HLA molecules by Killer cell Immunoglobulin like Receptors ( KIR ) and the binding of the non classical class 1 molecule HLA E to the heterodimer formed by the association of CD 94 with various members of the NKG 2 proteins . . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Thus , the data obtained reveal a substantial variability in the NKG 2 repertoire among NK cell subpopulations , which is likely to affect the sensitivity and reactivity towards the ligand HLA E . . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Specific engagement of the CD94 / NKG2 A killer inhibitory receptor by the HLA E class Ib molecule induces SHP 1 phosphatase recruitment to tyrosine phosphorylated NKG 2 A : evidence for receptor function in heterologous transfectants . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Specific HLA class 1 leader sequence derived nonapeptides bind to endogenous HLA E molecules in the HLA defective cell line 721 . 221 , inducing HLA E surface expression , and promote CD94 / NKG2A mediated recognition . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Mouse CD94 / NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex ( MHC ) class 1 molecule Qa 1 ( b ) . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| They also express various MHC class 1 specific inhibitory receptors ( IR ) , in particular CD94 / NKG 2 A heterodimers , which participate in the fine tuning of their TCR mediated activation threshold . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Over 75 % of them expressed Ly49C , 1 , or NKG2A , which are thought to recognize self class 1 MHC ( H 2b ) . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| CD 94 / NKG 2 A complex is the inhibitory receptor for the non classical MHC class 1 molecule HLA E on human NK cells . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| CD94 / NKG2A recognizes the non classical MHC class 1 ( class Ib ) molecule Qa 1 ( b ) and inhibits NK cytotoxicity . ^^^ Co expression of Qa 1 ( b ) and D ( k ) on target cells significantly inhibited cytotoxicity of D ( k ) specific cytotoxic T lymphocytes generated by mixed lymphocyte reaction , indicating that Qa 1 ( b ) on antigen presenting cells interacts with CD94 / NKG2A on CD 8 T cells and regulates classical MHC class 1 restricted cytotoxic T cells . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| In comparison to N NK , HCV NK showed higher expression of CD94 / NKG2A and produced IL 10 and TGFbeta when cultured with hepatic cells , most of which express HLA E , a ligand for CD94 / NKG2A . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Blockading CD94 / NKG2A restored lysis against the AML blasts , which all expressed HLA E , the ligand for CD94 / NKG2A . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| CD94 / NKG2A is an inhibitory receptor expressed by most human NK cells and a subset of T cells that recognizes HLA E on potential target cells . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| In this study , we determine the affinities and interaction thermodynamics between three NKG2x / CD94 receptors ( NKG2A , NKG2C , and NKG2E ) and complexes of HLA E with four representative peptides . ^^^ Inhibitory NKG2A / CD94 and activating NKG2E / CD94 receptors bind HLA E with indistinguishable affinities , but with significantly higher affinities than the activating NKG2C / CD94 receptor . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| The distinct roles of CD94 / NKG2A and KIR receptors suggest that shifting MHC class 1 receptor expression patterns reflect age related changes in NK cell and CD 56 ( + ) T cell turnover and function in vivo . . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| The CD94 / NKG2A heterodimer is a natural killer receptor ( NKR ) , which inhibits cell mediated cytotoxicity upon interaction with MHC class 1 gene products . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| HLA E , a ligand for NKG2A , was expressed in all human hepatoma cell lines tested as well as in nontransformed hepatocytes , but not in K 562 cells , a classic NK sensitive target . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we found a significantly increased proportion of NKG2A expressing NK cells and CD8+ T cells in HCV positive patients , resulting in a reduced cytolytic activity against cells incubated with the HLA E stabilising peptide HCV core 35 44 . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| By studying liver derived NK cells , we show that only a subpopulation of NK cells expressing high levels of the inhibitory receptor NKG2A are able to lyse autologous vaccinia infected targets , and that this is due to selective down regulation of HLA E . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| We report that natural killer receptors ( NKR ) for major histocompatibility complex ( MHC ) class 1 molecules ( MHC NKR ) , the inhibitory killer immunoglobulin like receptors ( KIR ) , and the CD94 / NKG2A receptor are present on a small proportion of CD 8 T cells in cord blood . ^^^ |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P26715 and P13747 |
Pubmed |
SVM Score :0.0 |
| NA |
|