Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The role of the CD 66 antigens in neutrophil effector function was examined using non cross reacting and cross reacting domain mapped CD 66 monoclonal antibody ( mAb ) , which recognize epitopes on biliary glycoprotein ( BGP ; CD66a ) , CEA gene family member 6 ( CGM 6 ; CD66b ) , nonspecific cross reacting antigen 90 ( NCA 90 ; CD66c ) or CGM 1 ( CD66d ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Gonococci and recombinant Escherichia coli strains synthesizing Opa 52 showed specific binding and internalization by transfected HeLa cell lines expressing the CD 66 family members BGP ( CD66a ) , NCA ( CD66c ) , CGM 1 ( CD66d ) and CEA ( CD66e ) , but not that expressing CGM 6 ( CD66b ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Four members of the carcinoembryonic antigen family , CEACAM 1 , CEACAM 8 , CEACAM 6 and CEACAM 3 , recognized by CD66a , CD66b , CD66c and CD66d monoclonal antibodies ( mAb ) , respectively , are expressed on human neutrophils . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Three species of carcinoembryonic antigen ( CEA ) like macromolecules , called the biliary glycoprotein 1 , 2 and 3 ( BGP 1 , 2 and 3 ) were identified in human bile . ^^^ BGP 1 differed immunologically from CEA in that it lacked the tumor associated determinants of CEA . ^^^ It was different from NGP ( and CEA ) in that it contained BGP 1 specific determinants as revealed by anti BGP 1 antibodies . ^^^ Immunologically and physicochemically , BGP 2 and BGP 3 appeared to be closely similar to NGP and CEA , respectively . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Immunofluorescence studies on the occurrence and localization of the CEA related biliary glycoprotein 1 ( BGP 1 ) in normal human gastrointestinal tissues . ^^^ Biliary glycoprotein , 1 ( BGP 1 ) is a carcinoembryonic antigen ( CEA ) cross reactive glycoprotein of normal human bile . ^^^ Its occurrence and localization was studied in normal human gastrointestinal tissues by means of direct immunofluorescence using immunadsorbent purified BGP 1 antibodies with high selectivity for BGP 1 , as compared to CEA and ' non specific cross reacting antigen ' ( NCA ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Human hepatic bile contains a glycoprotein ( biliary glycoprotein 1 , BGP 1 ) which cross reacts with the carcinoembryonic antigen ( CEA ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Antibody dependent lymphocyte ( K cell ) mediated lysis of tumor cells in vitro was used to assay for cell surface associated carcinoembryonic antigen ( CEA ) and two CEA related normal tissue components , `` normal glycoprotein ' ' ( NGP ) and biliary glycoprotein 1 ( BGP 1 ) . ^^^ To induce lysis we used the IgG fraction of specific rabbit and monkey anti CEA sera and of specific rabbit anti NGP and anti BGP 1 sera , respectively . ^^^ T 24 and Mel 1 were not lysed by anti CEA , HT 29 and T 24 were lysed by low concentrations of anti BGP 1 . ^^^ Anti CEA and anti BGP 1 gave 30 40 % corrected lysis of HT 29 . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen ( CEA ) , a tumor marker for lung cancers of small cell ( SCLC ) and non small cell ( NSCLC ) types , belongs in a multigene family which includes non specific cross reacting antigen ( NCA ) and biliary glycoprotein 1 ( BGP ) . ^^^ In both lung and colorectal cell lines expression of NCA RNA was relatively high , while BGP RNA was relatively low , and the median concentrations of CEA were greater than in corresponding non malignant tissues . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Biliary glycoprotein ( BGP ) , a cell adhesion molecule related to carcinoembryonic antigen ( CEA ) , has been shown to exist as several alternatively spliced isoforms . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Using carcinoembryonic antigen ( CEA ) subgroup specific degenerate PCR primers , we have identified three new CEA gene family member L / N exons ( CGM 9 , CGM 10 , and CGM 11 ) and all previously reported L / N exons of the CEA subgroup ( CEA , BGP , NCA , CGM 1 , CGM 2 , CGM 6 , CGM 7 , and CGM 8 ) . ^^^ CEA , BGP , NCA , and CGM 1 form a fairly well supported group within the CEA subgroup . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The CEA family consists of two structurally and functionally distinct sub groups ; the group including CEA , NCA and CGM 6 which are cell surface bound by phosphatidyl inositol ( PI ) linkages , and the group of BGP splice variants which have trans membrane and cytoplasmic domains . ^^^ Although all CEA family members mediate intercellular adhesion in vitro , the PI linked group show Ca++ and temperature independent adhesion whereas the BGP group show rapidly reversible Ca++ and temperature dependent adhesion . ^^^ From the close alignment in cDNA nucleotide sequences between family members and between repeated domains in one family member , it is apparent that the CEA family is now rapidly evolving ; in fact , analogs of only the trans membrane BGP group have been found so far in the mouse . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Two epitopes were CEA specific ( D 14 and B7 . 1 ) , one was shared with nonspecific cross reacting antigen ( NCA ) ( B7 . 8 ) , and the fourth ( B 18 ) was common to CEA , NCA , and biliary glycoprotein antigen ( BGP ) . ^^^ The authors conclude that CEA immunostaining may assist in identifying the histogenesis of epithelial tumors in several morphologic categories ; that differential reactivities of the CEA monoclonal antibody panel exceed those of the polyclonal antibody ; and that the discriminating power of the monoclonal panel is related to whether ( 1 ) CEA is or is not produced or ( 2 ) NCA or BGP is produced without concomitant CEA production . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Immobilized purified CEA ( carcinoembryonic antigen ) , NCA ( non specific crossreacting antigen ) and BGP 1 ( biliary glycoprotein 1 ) bind strains of E . coli ( including EPEC ) and some Salmonella species ( including S . typhi , S . paratyphi A + B and S . java ) while Shigella , Yersinia and Bacteroides strains showed no adhesion . ^^^ The putative role of members of the CEA gene family ( CEA , NCA an BGP ) as ligands for the bacterial colonization of different human epithelial tissues . ^^^ From inhibition studies with aromatic mannose compounds , it was suggested that in contrast to Salmonella strains E . coli strains exhibit a higher hydrophobicity in the binding region adjacent to the CEA , NCA and BGP binding site . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
In contrast , we show here that transfectants of a third member of the CEA family , biliary glycoprotein ( BGP ) , also aggregate homotypically in suspension but require Ca2+ for aggregation . ^^^ In addition , like the cadherins and unlike CEA or NCA or other adhesion molecules of the immunoglobulin supergene family , BGP transfectant aggregation requires physiological temperatures . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Each CEA and NCA has hydrophobic domain in the C terminus consisting of 26 amino acids which is eliminated when it binds with membrane and is reconstituted by combining with phosphatidylinositol glycan , whereas BGPI contains transmembrane and cytoplasmic domains . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Biliary glycoprotein 1 ( BGP 1 ) is a member of carcinoembryonic antigen ( CEA ) gene family consisting of at least 11 related genes . ^^^ Biliary glycoprotein 1 ( BGP 1 ) is a member of carcinoembryonic antigen ( CEA ) gene family consisting of at least 11 related genes . ^^^ When the malignant tissues were compared to the non malignant ones for the intensity of the band , no significant difference was observed . mRNAs of CEA and non specific cross reacting antigen ( NCA ) were not detected in 5 samples which were shown to have the message of the BGP 1 gene . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Four carcinoembryonic antigen ( CEA ) reactive monoclonal antibodies Parlam 1 , 4 , 5 and 6 were studied in respect to reactivity with CEA and its cross reacting antigens ( NCA 1 , NCA 2 , BGP ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The diagnostic contribution of the demonstration of alpha fetoprotein , alpha antitrypsin , hepatitis B surface antigen , carcinoembryonic antigen ( CEA ) , and biliary glycoprotein 1 ( BGPI ) , compared with routine hematoxylin eosin and reticulin stains was evaluated . ^^^ Immunohistochemistry of CEA and BGPI , however , appeared to be of help in differentiating between primary and secondary liver tumors as follows : CEA is consistently absent in liver cell tumors , while a bile canalicular staining pattern was seen in 80 % of HCC due to the presence of BGPI reactivity . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Three Carcinoembryonic Antigen ( CEA ) gene family members : CEA , Non specific cross reactive antigen 50 / 90 ( NCA ) and biliary glycoprotein ( BGP ) were expressed in the colon carcinoma cell lines LS174T and HT 29 . ^^^ The CEA , NCA50 / 90 and four alternatively spliced BGP transcripts ( BGP a d ) were identified . ^^^ The molecular weights of the mature glycoproteins were : CEA , 180kD ; NCA50 / 90 , 70 100 kD ; BGP , 85 , 120 and 140 kD . ^^^ CEA and NCA50 / 90 , but not BGP , were linked to the cell membrane via glycosyl phosphatidyl inositol and could be released from the intact tumor cells by glycosyl phosphatidyl inositol specific phospholipase C . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The gene coding for ' biliary glycoprotein ( BGP ) ' is a member of the carcinoembryonic antigen ( CEA ) gene family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
BGP 1 is a member of the carcinoembryonic antigen ( CEA ) gene family , which is a subfamily in the immunoglobulin gene superfamily . ^^^ The nucleotide sequence of BGP 1 exhibited greater than 80 % identity with CEA and nonspecific crossreacting antigen ( NCA ) in the leader peptide , N terminal domain , and immunoglobulin like domain . ^^^ The BGP 1 specific domain , designated A ' , was 56 . 7 % and 55 . 8 % identical at the nucleotide level and 42 . 6 % and 39 . 6 % identical at the amino acid level to the immunoglobulin like domain of NCA and the first immunoglobulin like domain of CEA , respectively . ^^^ We propose that BGP 1 diverged from NCA by acquiring an immunoglobulin like domain substantially different from the domains found in NCA or CEA and also a new cytoplasmic domain . ^^^ The latter feature should result in a substantially different membrane anchorage mechanism of BGP 1 compared to CEA , which lacks the cytoplasmic domain and is anchored via a phosphatidylinositol glycan structure . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
B 9 , JA 4 , and AH 3 were suggested to react with CEA related antigens , such as NCA and BGPI , whereas KM 10 and A 10 were suggested to recognize the distinctive part of CEA . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Expression studies showed that the cDNA codes for a 72 kDa glycoprotein that reacts immunologically with antisera to CEA , biliary glycoprotein 1 , and PS beta G . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
It is conceivable that this elevated CEA observed in the cystic fluid might be correlated with CEA like antigens such as NCA , NFA and BGP . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Therefore , antigen for CEA , NCA and BGP were prepared , and biliary CEA , NCA and BGP levels were measured by the ELISA method . ^^^ In malignant disease , both biliary NCA and biliary BGP increased , though not so remarkable compared with CEA . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
At cut off points of 3 ng / ml , 10 U / ml , and 30 U / ml , respectively , carcinoembryonic antigen ( CEA ) , biliary glycoprotein 1 ( BGP 1 ) , and CA 19 9 discriminated between benign and malignant serous effusions with a sensitivity of between 24 % and 67 % . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The anti CEA antibody has a high affinity ( 2 . 6 10 10 ( 10 ) M 1 ) for CEA and does not cross react with normal cross reacting antigen , biliary glycoprotein 1 , or tumor extracted , CEA related antigen . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
In these nine cases the reactivity was further studied in tests using anti CEA serum absorbed with normal human bile or with biliary glycoprotein 1 ( BGP 1 ) . ^^^ The result was negative in five of the nine cases regarding immunoreactivity to anti CEA serum absorbed with normal human bile , but in none of the tests using anti CEA serum absorbed with BGP 1 . ^^^ The observations suggest that the gallbladder epithelium may produce CEA and / or some CEA related antigens , except to NCA and BGP 1 , and that the CEA level in bile may be raised in the inflammatory process of cholecystolithiasis . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
It was highly specific inasmuch as none of three known CEA related substances , `` nonspecific crossreacting antigens 1 and 2 ' ' ( NCA 1 and NCA 2 ) and biliary glycoprotein 1 ( BGP 1 ) , reacted in the assay . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
There are several CEA related normal antigens ; nonspecific cross reacting antigen ( NCA ) from normal lung or spleen , NCA 2 from meconium , normal fecal antigen ( NFA ) from normal adult feces , which consists of 3 molecular species ; NFA 1 , NFA 2 and NFCA , and biliary glycoprotein 1 ( BGP 1 ) from bile . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
They did not react with non specific cross reacting antigen ( NCA ) , biliary glycoprotein 1 ( BGP 1 ) or orosomucoid . 10 20 muCi ( 1 2 micrograms ) of 131I labelled mab was injected intraperitoneally into mice bearing heterografts of the CEA containing human tumor cell lines LS 174T , Detroit 562 or HT 29 or into mice bearing grafts of the non CEA containing human tumor cell line RD . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
AIM : the ability of the breast cancer associated placental acid isoform of ferritin ( p 43 PLF ) to modulate cell surface expression of HLA , CD 59 ( protectin ) and CD 66 antigen ( adhesion antigen related to CEA ) was examined . ^^^ Furthermore , PLF down regulated cell surface expression of CEA related CD 66 antigen on both these cell lines . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
In contrast to CEA , whose overexpression has been correlated with cancer progression , the human and mouse Bgp proteins are generally down regulated upon tumor formation . ^^^ RNase protection assays and primer extension analyses indicated that the mouse bgp 1 transcriptional start site is positioned 240 nucleotides upstream of the ATG translational initiation codon , which is 140 nucleotides further upstream than in any other CEA family member . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Members of the carcinoembryonic antigen ( CEA ) family include CEA , non specific cross reacting antigen ( NCA ) , and biliary glycoprotein ( BGP ) , and appear to function as cell adhesion molecules . ^^^ The ability to detect this phosphoprotein did not correlate with CEA production , and immunoprecipitation studies suggested that the phosphoprotein is BGP . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA belongs to a large protein family , which includes cross reacting antigens , e . g . , non specific cross reacting antigens ( NCAs ) and biliary glycoprotein ( BGP ) as well as pregnancy specific glycoproteins ( PSGs ) . ^^^ MAb 4 / 3 / 17 recognizes CEA and BGP on the surface of transfectants and NCA 160 from granulocytes . ^^^ On granulocytes , which do not express CEA , MAb 4 / 3 / 17 is specific for NCA 160 ( BGP ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Specific primer sets were designed for CEA , non specific cross reacting antigen ( NCA ) , biliary glycoprotein ( BGP ) , carcinoembryonic antigen gene family members 1 , 6 and 7 ( CGM 1 , CGM 6 and CGM 7 ) , and one set for all pregnancy specific glycoprotein ( PSG ) transcripts . ^^^ In ovarian mucinous adenocarcinomas , we always found co expression of CEA and NCA transcripts , and occasionally BGP mRNA . ^^^ CEA , NCA and BGP transcripts were present in endometrial carcinomas of the uterus and cervical carcinomas , whereas uterine leiomyomas were completely negative . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Sequences of the promoter and the first exon showed remarkably high similarity to the corresponding regions of bgp 1 and bgp 2 , two other members of the murine CEA subgroup . ^^^ Consensus sequences for two transcription factors ( USF and an AP 2 like factor ) that bind to the human BGP gene promoter were also present in the cea 10 promoter and possibly convey expression of these genes in epithelial cells . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Even the mechanism of intermolecular adhesion appears to differ fundamentally in that GPI linked CEA CEA binding involves a double reciprocal bonding between two domains , whereas transmembrane linked biliary glycoprotein ( BGP ) BGP binding requires only one domain . ^^^ Finally , the ectopic expression of CEA in myoblasts can block myogenic differentiation leaving the cells with the ability to divide , while expression of BGP does not affect or may even accelerate myogenic differentiation . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen ( CEA ) positivity of bile canaliculi by cross reaction with biliary glycoprotein 1 ( BGP 1 ) made possible the differentiation of HCC from metastases . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
BGP is a member of the carcinoembryonic antigen ( CEA ) gene family , which belongs to the immunoglobulin supergene family , yet it displays restricted expression patterns and unique functions . ^^^ Unlike the CEA gene , BGP gene transcription was not modulated by a silencer region ; repetitive elements in the BGP upstream region were not involved in activation or repression . ^^^ The Sp 1 transcription factor , shown to be involved in CEA gene transcriptional regulation , does not bind to the BGP gene promoter . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
All samples of bile from the patients with biliary cancer showed three bands that corresponded to CEA , nonspecific crossreacting antigen , and biliary glycoprotein 1 , respectively . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Both chimeric Fab fragments exhibited strong immunohistochemical reactivity with various gastrointestinal carcinomas and no reactivity with CEA related antigens , such as NCA ( nonspecific cross reacting antigen ) or BGPI ( biliary glycoprotein 1 ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Mouse hepatitis virus A 59 ( MHV A 59 ) , a murine coronavirus , can utilize as a cellular receptor MHVR , a murine glycoprotein in the biliary glycoprotein ( BGP ) subfamily of the carcinoembryonic antigen ( CEA ) family in the immunoglobulin superfamily ( G . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Mouse cell lines transfected with carcinoembryonic antigen ( CEA ) and with 2 other members of the human CEA gene family , non specific cross reacting antigen ( NCA ) and biliary glycoprotein ( BGP ) , were used to analyze the specificity of several monoclonal antibodies ( MAbs ) . ^^^ The MAb B6 . 2 reacted with cells expressing the NCA gene product but not with those expressing CEA or BGP . ^^^ The MAb B1 . 1 reacted strongly with the transfected CEA and BGP gene products but only weakly with the NCA gene product . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen ( CEA ) , biliary glycoprotein ( BGP ) , and non specific cross reacting antigen ( NCA ) are three closely related cell surface glycoproteins induced by gamma interferon ( IFN gamma ) in colonic epithelial cells . ^^^ Northern blot analysis of HT 29 cells treated with IFN gamma and probed with specific probes for BGP , CEA , and NCA showed a 2 fold increase in mRNA level for BGP , and a greater than 10 fold induction for CEA and NCA . ^^^ Similar results were obtained for the SW 403 cell line , but in the case of the LS174T cell line , CEA mRNA levels remained constant before and after IFN gamma treatment , while BGP and NCA mRNA levels increased by 2 5 fold . ^^^ A comparison of the kinetics of induction of the mRNA levels for BGP and CEA by IFN gamma in the HT 29 cell line revealed a half time of < 6 h for BGP and 48 h for CEA . ^^^ The induction of CEA mRNA was completely inhibited with either cycloheximide ( protein synthesis inhibitor ) or actinomycin D ( RNA synthesis inhibitor ) , but the induction of BGP mRNA was superinduced by cycloheximide . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The other two groups are homologous to the nonspecific cross reacting antigen ( NCA ) and biliary glycoprotein ( BGP ) , both of which are members of the carcinoembryonic antigen ( CEA ) family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
According to recent data , this Ag may be a product of the biliary glycoprotein ( BGP ) gene that belongs to the CEA gene family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The biliary glycoprotein ( BGP ) encoding gene is a member of the human carcinoembryonic antigen ( CEA ) gene family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CD66a , also called biliary glycoprotein ( BGP ) , is a member of the carcinoembryonic antigen ( CEA ) family and of the immunoglobulin superfamily . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The carcinoembryonic antigen ( CEA ) family comprises a group of glycoproteins including the classical CEA , nonspecific cross reacting antigens ( NCA ) , and biliary glycoprotein ( BGP ) . ^^^ The secretory parts of eccrine sweat glands expressed CEA , NCA 90 , and BGP , whereas apocrine glands remained unreactive for CEA glycoproteins . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
OBJECTIVE : The aim of this study was to examine the expression of glycoproteins of the CEA family , that is , CEA 180 , nonspecific cross reacting antigens ( NCAs ) , and biliary glycoprotein ( BGP ) , in sebaceous glands and in neoplasms with sebaceous differentiation . ^^^ METHODS : Normal adult and fetal skin , hyperplasias , hamartomas , and neoplasms with sebaceous or follicular differentiation were stained immunohistochemically with a panel of polyclonal and monoclonal antibodies highly specific for CEA 180 , NCAs , and BGP . ^^^ RESULTS : Whereas sweat glands coexpressed CEA , NCAs , BGP , and EMA , sebaceous glands were exclusively labeled with the antibodies recognizing BGP or EMA . ^^^ CONCLUSION : The expression of BGP , a CEA glycoprotein , in differentiating sebocytes accounts for the reactivity of many anti CEA antibodies with sebaceous glands and thus disqualifies the CEA family as a monospecific marker for sweat gland differentiation . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
In contrast to previous assumptions , CEA does not represent a single oncofetal antigen but comprises a family of homologous glycoproteins , i . e . the classical CEA 180 , biliary glycoprotein ( BGP ) , and non specific crossreacting antigens ( NCA ) . ^^^ Co expression of CEA 180 , NCA 90 , and BGP was consistent with differentiation towards the secretory part of eccrine glands or the transitional portion of proximal ducts . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA , NCA , and BGP have all been shown to function in vitro as intercellular adhesion molecules . ^^^ We show here that the properties of adhesion are radically different , in that BGP mediated adhesion is reversibly Ca2+ and Mg2+ dependent , temperature dependent , and ATP inhibitable , whereas CEA and NCA mediated adhesion is the opposite in all aspects . ^^^ Also , the novel double reciprocal , antiparallel binding observed for CEA CEA interactions is not seen for BGP . ^^^ Finally , the myogenic differentiation block demonstrated for the ectopic expression of CEA in myoblasts was also observed for NCA but not for BGP , which is consistent with the changes in expression seen in cancer . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Using soluble chimeric receptor molecules , we have demonstrated that meningococcal Opa proteins bind to the N terminal domain of biliary glycoproteins ( classified as BGP or CD66a ) that belong to the CEA ( CD 66 ) family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CD66a ( BGP ) is a member of carcinoembryonic antigen ( CEA , CD 66 ) family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Cell surface levels of CEA and the CEA family member nonspecific crossreacting antigen ( NCA ) , both overexpressed in colon cancer , were higher in LS 174T than in SW 1222 cells , whereas family member biliary glycoprotein ( BGP ) , downregulated in colon carcinoma was higher in the SW 1222 cells . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
We have earlier demonstrated that BGP mRNA is expressed in hepatocellular carcinomas ( HCCs ) and the adjacent non cancerous regions , neither of which express CEA and NCA mRNA . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Two other CEA family members , biliary glycoprotein ( BGP ) and nonspecific cross reacting antigen ( NCA ) , are similarly expressed , whereas CEA transcripts were found down to the base of the crypts but were less predominant in the upper region . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
However , other Opa proteins interact with CEA gene family member 1 ( CGM 1 ) or biliary glycoprotein ( BGP ) , members of the CD 66 antigen family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA was recognized by at least 9 of 11 Opa variants , and the BGP transfectants specifically bound and internalized 10 of 11 Opa variants and also bound Opa negative gonococci . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CD66a , also known as biliary glycoprotein ( BGP ) , is a member of the carcinoembryonic antigen ( CEA ) family and the human homologue of the rat cell CAM . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The primary cellular receptor for mouse hepatitis virus ( MHV ) , a murine coronavirus , is MHVR ( also referred to as Bgp1a or C CAM ) , a transmembrane glycoprotein with four immunoglobulin like domains in the murine biliary glycoprotein ( Bgp ) subfamily of the carcinoembryonic antigen ( CEA ) family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Expression of four CEA family antigens ( CEA , NCA , BGP and CGM 2 ) in normal and cancerous gastric epithelial cells : up regulation of BGP and CGM 2 in carcinomas . ^^^ Four human carcinoembryonic antigen ( CEA ) family members , CEA ( CD66e ) , non specific cross reacting antigen ( NCA , CD66c ) , biliary glycoprotein ( BGP , CD66a ) and CEA gene family member 2 ( CGM 2 ) , are expressed in normal mucosal epithelia of the colon . ^^^ The transcripts of the CEA , NCA and BGP genes evaluated by reverse transcription polymerase chain reaction were detectable at various levels in all the gastric adenocarcinoma cell lines tested , while CGM 2 mRNA was detectable in the cell lines of poorly differentiated but not of well differentiated carcinomas . ^^^ Our findings indicate that expression of the CEA family antigens , particularly that of BGP and CGM 2 , is differently regulated in epithelial cells of the colon and the stomach . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Dysregulated expression of CD66a ( BGP , C CAM ) , an adhesion molecule of the CEA family , in endometrial cancer . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Pretreatment of HepG 2 cells with a polyclonal antiserum directed against all CEA family members , or with a monoclonal antibody , Kat4c ( cd66abde ) , directed against Bgp 1 , CGM 6 , CGM1a , NCA and CEA , significantly reduced virus replication and the capacity of MHV H 2 to infect HepG 2 cells . ^^^ Monoclonal antibodies Col 4 , Col 14 , and Kat4c ( cd66abde ) all reacted strongly with human Bgp and CEA , but displayed variable binding patterns with other CEA genes . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Consistent with this , T 84 cells were shown by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunoblotting to co express CD66a ( BGP ) , CD66c ( NCA ) and CD66e ( CEA ) . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
To test this hypothesis , the human biliary glycoprotein ( Bgp ) and CEA genes were cloned and expressed in normally nonpermissive BHK cell lines by using noncytopathic Sindbis virus replicons ( pSinRep 19 ) . ^^^ By growth curves and FA staining , human CEA and to a much lesser extent human Bgp functioned as receptors for V51B entry . ^^^ Furthermore , V51B replication was blocked with polyclonal antiserum directed against human CEA and Bgp . ^^^ Under identical conditions , the parental MHV strain A 59 failed to replicate in BHK cells expressing human Bgp or CEA . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Four carcinoembryonic antigen subfamily members , CEA , NCA , BGP and CGM 2 , selectively expressed in the normal human colonic epithelium , are integral components of the fuzzy coat . ^^^ The result showed the CEA , nonspecific crossreacting antigen 50 / 90 ( NCA ) , biliary glycoprotein ( BGP ) , and carcinoembryonic antigen gene family member 2 ( CGM 2 ) mRNAs were expressed in the colon . ^^^ Colon epithelium expression of CEA , NCA , BGP and CGM 2 coincided with that of corresponding mRNAs . ^^^ Ultrastructurally , CEA , NCA , BGP and CGM 2 were localized mainly to the apical surface glycocalyx , the fuzzy coat , of columnar cells . ^^^ As integral components of the fuzzy coat , CEA , NCA , BGP and CGM 2 can hardly function as intercellular adhesion molecules ; they possibly play an important role in epithelial microbial interactions . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
This suggests that the Bgp 2 protein represents a distinctive member of the CEA family ; its unusual expression patterns in mouse tissues and the unique functions it may be fulfilling may provide novel clues about the multiple functions mediated by a common BGP protein in humans and rats . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 1 , also known as C CAM , BGP and CD66a , is a member of the carcinoembryonic antigen ( CEA ) family which is itself part of the immunoglobulin supergene family . ^^^ CEACAM 1 , also known as C CAM , BGP and CD66a , is a member of the carcinoembryonic antigen ( CEA ) family which is itself part of the immunoglobulin supergene family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
When MCF10F m cells are treated with IFNgamma , they express CEA ( carcinoembryonic antigen ) but not BGP . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The carcinoembryonic antigen ( CEA ) family member CEACAM 1 ( previously called biliary glycoprotein or CD66a ) was previously shown to function as a receptor that can mediate the binding of Opa protein expressing Neisseria meningitidis to both neutrophils and epithelial cells . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Four members of the carcinoembryonic antigen ( CEA ) family , CEA , CEACAM 1 ( BGP ) , CEACAM 6 ( NCA 50 / 90 ) , and CEACAM 7 ( CGM 2 ) , are coexpressed in normal colorectal epithelia but are deregulated in colorectal cancers , where they could play a role in tumorigenesis . ^^^ This is well documented for CEACAM 1 and CEA but not for CEACAM 6 or CEACAM 7 . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 1 ( biliary glycoprotein or CD66a ) is a member of the carcinoembryonic antigen ( CEA ) subgroup of the CEA family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The carcinoembryonic antigen ( CEA ) gene family members , CEACAM 1 , CEACAM 3 , CEACAM 5 and CEACAM 6 , are bound by the Opa outer membrane proteins of pathogenic Neisseria spp . , whereas CEACAM 8 is not . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 1 ( CD66a , BGP , C CAM ) is an adhesion molecule of the carcinoembryonic antigen ( CEA ) family which has been shown to be normally expressed at the apical pole of epithelial cells and to show a dysregulated expression pattern in tumors derived from the latter . ^^^ CEACAM 1 ( CD66a , BGP , C CAM ) is an adhesion molecule of the carcinoembryonic antigen ( CEA ) family which has been shown to be normally expressed at the apical pole of epithelial cells and to show a dysregulated expression pattern in tumors derived from the latter . ^^^ For this purpose , we performed immunohistochemistry using the 4D1 / C2 monoclonal antibody which specifically recognizes CEACAM 1 and does not interact with other members of the CEA family . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Human carcinoembryonic antigen ( CEA ) , a widely used tumor marker , and CEACAM 6 [ formerly nonspecific cross reacting antigen ( NCA ) ] are up regulated in many types of human cancers , whereas family member CEACAM 1 [ formerly biliary glycoprotein ( BGP ) ] is usually down regulated . ^^^ Deregulated overexpression of CEA / CEACAM6 but not CEACAM 1 can inhibit the differentiation and disrupt the polarization and tissue architecture of many different types of cells . ^^^ In this report , we show that CEA and CEACAM 6 , but not CEACAM 1 , markedly inhibit the apoptosis of cells when deprived of their anchorage to the extracellular matrix , a process known as anoikis . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Ectopic expression of various members of the human carcinoembryonic antigen ( CEA ) family of intercellular adhesion molecules in murine myoblasts either blocks ( CEA , CEACAM 6 ) or allows ( CEACAM 1 ) myogenic differentiation . ^^^ CEA and CEACAM 6 are glycophosphatidyl inositol ( GPI ) anchored , whereas CEACAM 1 is transmembrane ( TM ) anchored . ^^^ The molecular requirements for the myogenic differentiation block were investigated using chimeric constructs in which the COOH terminal hydrophobic domains of CEA , CEACAM 1 , and NCAM p 125 were exchanged . ^^^ The presence of the GPI signal sequence specifically from CEA in the chimeras was sufficient to convert both CEACAM 1 and NCAM into differentiation blocking proteins . ^^^ Conversely , CEA could be converted into a neutral protein by exchanging its GPI anchor for the TM anchor of CEACAM 1 . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Immunoaffinity isolation of CEACAM 1 on hydrazide derivatized cellulose with immobilized monoclonal anti CEA antibody . ^^^ Carcinoembryonic cell adhesion molecule 1 ( CEACAM 1 ) is a human membrane glycoprotein belonging to the carcinoembryonic antigen ( CEA ) family and to the immunoglobulin superfamily . ^^^ Affinity chromatography of CEACAM 1 on hydrazide activated cellulose with immobilized monoclonal anti CEA F 34 187 antibody is described . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 6 reveals homophilic adhesion and heterophilic adhesion to other CEACAM family antigens including CEACAM 8 , CEACAM 1 , and CEA , whereas CEACAM 8 exhibits only heterophilic adhesion to CEACAM 6 . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA cell adhesion molecule 1 ( CEACAM 1 ) , a type 1 transmembrane and homotypic cell adhesion protein belonging to the carcinoembryonic antigen ( CEA ) gene family and expressed on epithelial cells , is alternatively spliced to produce four major isoforms with three or four Ig like ectodomains and either long ( CEACAM 1 L ) or short ( CEACAM 1 S ) cytoplasmic domains . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Proteins were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis ( SDS PAGE ) , blotting and immunochemical staining with anti carcinoembryonic antigen , CEA related adhesion molecule 1 ( CEACAM 1 ) cross reacting antibodies . ^^^ Two isoforms of CEACAM 1 ( 85 and 115 kd bands ) , CEA and 2 CEA cross reacting protein bands of 40 and 50 kd were found in human bile . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
PURPOSE : Biliary glycoprotein ( BGP ) , a member of the carcinoembryonic antigen ( CEA ) gene family , is produced by hepatocytes , and is suggested to function as a cell adhesion molecule , mouse hepatitis virus receptor , and tumor suppressor . ^^^ METHODS : For enzyme immunoassay , a monoclonal antibody ( mAb ) , TS 135 , which recognizes BGP was used as a catcher , and biotin labeled polyclonal anti CEA antibodies were used as a tracer . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Biliary glycoprotein ( BGP , CD66a , CEACAM 1 ) is a member of the carcinoembryonic antigen family ( CEA , CD 66 ) , a group of transmembrane proteins belonging to the immunoglobulin superfamily . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The widely expressed adhesion receptor CEACAM 1 is a member of the carcinoembryonic antigen ( CEA ) family within the immunoglobulin ( Ig ) superfamily of glycoproteins . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 1 ( carcinoembryonic antigen related cell adhesion molecule 1 ) is a transmembrane glycoprotein belonging to the carcinoembryonic antigen ( CEA ) family and immunoglobulin superfamily . ^^^ CEACAM 1 ( carcinoembryonic antigen related cell adhesion molecule 1 ) is a transmembrane glycoprotein belonging to the carcinoembryonic antigen ( CEA ) family and immunoglobulin superfamily . ^^^ Whereas CEA is highly expressed in adenocarcinomas , CEACAM 1 expression is down regulated in many tumors and its tumor supressive function was confirmed . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
PURPOSE : CEACAM 6 , CEACAM 1 , and human carcinoembryonic antigen ( CEA ) are coexpressed in normal colorectal epithelia , but show deregulated expression in colorectal cancers ( CRC ) . ^^^ The aim of our study was to evaluate the prognostic relevance of CEACAM 6 , CEACAM 1 , and CEA tissue expression in patients with CRC . ^^^ RESULTS : Tissue expression of CEACAM 6 , CEACAM 1 , and CEA was enhanced in 55 % , 58 % , and 94 % of patients , respectively . ^^^ Multivariate Cox analysis including sex , age , tumor site , stage , differentiation grade , treatment , and nodal status as covariates showed that CEACAM 6 overexpression independently predicted poor OS ( HR , 1 . 86 ; P = . 0100 ) and DFS ( HR , 2 . 00 ; P = . 0028 ) , whereas CEACAM 1 or CEA were not significantly related to these outcomes . ^^^ Whether CEACAM 6 or CEA and CEACAM 1 might be useful as predictive markers of chemotherapy benefit remains unclear . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Mapping the binding domains on meningococcal Opa proteins for CEACAM 1 and CEA receptors . ^^^ Neisseria meningitidis strain H44 / 76 possesses four different Opa proteins , of which OpaA and OpaJ bind to CEACAM 1 , while OpaB and OpaD bind to CEACAM 1 and CEA . ^^^ Hybrid Opa variants with different combinations of HV 1 and HV 2 derived from OpaB and OpaJ showed a reduced binding to CEACAM 1 and CEA , indicating that particular combinations of HV 1 and HV 2 are required for the Opa binding capacity . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA , CEACAM 1 , CEACAM 6 and CEACAM 7 , are localized to the apical glycocalyx of normal colonic epithelium and have been suggested to play a role in innate immunity . ^^^ IFN gamma , but not the other agents , modified expression of CEA , CEACAM 1 and CEACAM 6 . ^^^ Additionally , IFN gamma induced increased cell surface expression of CEA , CEACAM 1 and CECAM 6 . ^^^ IFN gamma has two important effects on the expression levels of the CEA family molecules in colon epithelial cells : direct upregulation of CEACAM 1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM 6 and decreased expression of CEACAM7 . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Among them , 22 clones produced HmAbs that reacted with CEA but not with 3 other CEA related cell adhesion molecule ( CEACAM ) family members , CEACAM 1 , CEACAM 6 and CEACAM 8 . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA family GPI anchorage appears to have evolved twice independently during the primate radiation , in a manner suggestive of evolution from more primitive TM anchored CEACAM 1 . ^^^ We show here that very few mutations in the TM exon of present day human CEACAM 1 are required to give efficient GPI anchorage and the biological specificity of CEA GPI anchors , i . e . , to give the differentiation blocking function of GPI anchored CEA . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
The results demonstrate that only E . coli expressing a subfamily of Afa / Dr adhesins , named here Afa / Dr 1 , including Dr , F 1845 and AfaE 3 adhesins , bound onto CHO cells expressing CEACAM 1 , CEA or CEACAM 6 . ^^^ Whereas all the Afa / Dr adhesins elicit recruitment of CD 55 around adhering bacteria , only the Afa / Dr 1 subfamily elicits the recruitment of CEACAM 1 , CEA and CEACAM 6 . ^^^ The recruited CEACAM 1 , CEA and CEACAM 6 around adhering bacteria resist totally or in part a detergent extraction , whereas the recruited CEACAM 3 does not . ^^^ Finally , the results show that recognition of CEA and CEACAM 6 , but not CEACAM 1 , is accompanied by tight attachment to bacteria of cell surface microvilli like extensions , which are elongated . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEA cell adhesion molecule 1 ( CEACAM 1 ) is a cell cell adhesion molecule that , paradoxically , is expressed in an apical location in normal breast epithelium . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen related cell adhesion molecule ( CEACAM 1 ) , the primordial member of the carcinoembryonic antigen ( CEA ) family , functions as a MHC independent natural killer ( NK ) cell inhibitory receptor , regulates T and B cell proliferation , and induces dendritic cell ( DC ) maturation . ^^^ Despite these fundamental functions , CEACAM 1 and most of the CEA family members differ significantly in primates and rodents . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Following the recognition of membrane bound receptors , including type 4 collagen , DAF , CEACAM 1 , CEA , and CEACAM 6 , by Afa / Dr adhesins , activation of signal transduction pathways leads to structural and functional injuries at brush border and junctional domains and to proinflammatory responses in polarized intestinal cells . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen ( CEA ) and CEA related cell adhesion molecule 1 ( CEACAM 1 ) , apically expressed on human colonic M cells , are potential receptors for microbial adhesion . ^^^ We have demonstrated previously that in the human colonic epithelium , carcinoembryonic antigen ( CEA ) and CEA related cell adhesion molecule 1 ( CEACAM 1 ) are integral components of the apical glycocalyx which participate in epithelial microbial interactions . ^^^ In this study , based on the reactivity of specific monoclonal antibodies and on immunoelectron microscopy , we show that M cells of human colonic solitary lymphoid follicles express CEA and CEACAM 1 on the apical surface . ^^^ This leads us to propose a role for CEA and CEACAM 1 in the adherence of enteric bacteria to the apical membrane of colonic M cells . ^^^ We also hypothesize that , unlike colonic enterocytes , M cells lack the defense mechanism that eliminates CEA and CEACAM 1 upon microbial binding and which is based on vesiculation of microvillus plasma membrane . . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Carcinoembryonic antigen ( CEA ) related cell adhesion molecule 1 ( CEACAM 1 ) is a member of the CEA family of immunoglobulin like adhesion molecules with two major splice variants , CEACAM 1 ( a ) 4L and CEACAM 1 ( b ) 4S , differing in the length of their COOH terminal cytoplasmic tail . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
RESULTS : The scFv MA 39 antibody was affinity maturated by in vitro mutagenesis and the new scFv clone , E 8 , was isolated , typed for CEA family member recognition and its CEACAM 1 , 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
We demonstrate here that epithelial carcinoembryonic antigen ( CEA ) related cell adhesion molecule 1 ( CEACAM 1 ) downregulation in prostate intraepithelial neoplasia ( PIN ) is inversely correlated with its upregulation in adjacent blood vessels . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
In the present study , utilizing differentially ( serine / threonine or tyrosine ) phosphorylated cytoplasmic domains of CEACAM 1 and CEACAM 3 as bait to isolate associated proteins from granulocyte extracts , we have identified human paxillin as a binding partner of the tyrosine phosphorylated cytoplasmic CEACAM 1 domain . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
We have previously demonstrated the existence of a novel inhibitory mechanism of NK cell cytotoxicity mediated by the homophilic carcinoembryonic Ag ( CEA ) related cell adhesion molecule 1 ( CEACAM 1 ) interactions . ^^^ In this study , we demonstrate that CEACAM 1 also interacts heterophilically with the CEA protein . ^^^ Importantly , we show that these heterophilic interactions of CEA and CEACAM 1 inhibit the killing by NK cells . ^^^ We further characterize , for the first time , the CEACAM 1 CEA interactions . ^^^ Using functional and binding assays , we demonstrate that the N domains of CEACAM 1 and CEA are crucial but not sufficient for both the CEACAM 1 CEACAM1 homophilic and CEACAM 1 CEA heterophilic interactions . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Among the 22 murine Cea related genes , only for Ceacam 1 has an ortholog been assigned . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
We examined the role of phosphatidylinositol 3 kinases ( PI3Ks ) in gonococcal invasion of epithelial cell lines expressing either CEACAM 1 or CEACAM 3 . ^^^ CEACAM 3 mediated internalization , but not that mediated by CEACAM 1 , was accompanied by localized and transient accumulation of the class 1 PI3K product phosphatidylinositol 3 , 4 , 5 trisphosphate at sites of bacterial engulfment . ^^^ Inhibition of phosphatidylinositol 3 kinases reduced CEACAM 3 mediated uptake but , paradoxically , led to an increase in intracellular survival of bacteria internalized via either CEACAM 1 or CEACAM 3 , suggesting additional roles for PI3K products . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Interestingly , human granulocytes express a specific isoform , CEACAM 3 , that participates together with CEACAM 1 and CEACAM 6 in the recognition of CEACAM binding microorganisms . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
CEACAM 1 and CEACAM 3 each contain proteinaceous transmembrane and cytoplasmic domains ; however , the processes of neisserial uptake mediated by these receptors differ with respect to their susceptibilities to both tyrosine kinase inhibitors and the actin microfilament disrupting agent cytochalasin D . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
Sequence alignment reveals a dichotomy among the CEACAM family members : both CEACAM 1 and CEACAM 5 contain the R and Q residues in positions 43 and 44 , respectively , whereas CEACAM 3 and CEACAM 6 contain the S and L residues , respectively . ^^^
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
NA
Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
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Interacting proteins: P40198 and P13688	Pubmed	SVM Score :0.0
NA