| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.64517476 |
| CEACAM 1 bound by gonococcal Opa 52 associated with the tyrosine phosphatases SHP 1 and SHP 2 , which implicates the receptor ' s ITIM ( immunoreceptor tyrosine based inhibitory motif ) in this effect . . 0.64517476^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| In addition , our results indicate that residues +4 , +5 , and +6 relative to Tyr 515 in the Bgp 1 cytoplasmic domain play a significant role in these interactions , as their deletion reduced Bgp 1 Tyr phosphorylation and association with SHP 1 and SHP 2 by as much as 80 % . ^^^ Together , these results indicate that both SHP 1 and SHP 2 interact with the Bgp 1 cytoplasmic domain via ITIM like sequences . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| We showed that tyrosine phosphorylated Bgp , expressed in mouse colon carcinoma CT 51 cells , could reversibly associate with protein tyrosine phosphatase SHP 1 . ^^^ Mutation of either of two tyrosine residues present in the cytoplasmic domain of Bgp abrogated SHP 1 binding , suggesting that this association was mediated by both tyrosine residues . ^^^ Similarly , we noted that either of the two SH 2 domains of SHP 1 could bind tyrosine phosphorylated Bgp in vitro . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| The structural features surrounding the tyrosine residues in the cytoplasmic domain of BGP share similarity with the consensus sequence of the immunoreceptor tyrosine based inhibition motif ( ITIM ) , the docking site for SHIP , SHP 1 , and SHP 2 molecules . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| This result is in agreement with our previous studies demonstrating the C terminal region of the cytoplasmic domain influences the levels of CEACAM 1 Tyr phosphorylation and its association with the protein Tyr phosphatases SHP 1 and SHP 2 . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of CEACAM 1 L , its association with SHP 1 , the activation of Erk1 / 2 and caspase 3 appeared to be crucial for the CEACAM 1 mediated anti apoptotic effect . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| This CEACAM 1 promoted cell death pathway does not involve the inhibitory signals or the tyrosine phosphatases SHP 1 and SHP 2 but depends on Bruton ' s tyrosine kinase in DT 40 cells . ^^^ |
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| Interacting proteins: P13688 and P29350 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of CEACAM 1 , a modulator of hepatic insulin clearance , and clearance of serum [ 125I ] insulin were markedly increased in SHP 1 deficient mice or SHP 1 deficient hepatic cells in vitro . ^^^ |
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