| Interacting proteins: P13688 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using a GST CEACAM 1 cytoplasmic tail fusion protein , it was shown that the cytoplasmic tail of CEACAM 1 bound the src homology domain containing phosphatase 1 and adaptor protein 1 complex in its phosphorylated and nonphosphorylated states , respectively . ^^^ |
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| Interacting proteins: P13688 and P12931 |
Pubmed |
SVM Score :0.0 |
| This suggests that CEACAM 1 can exert its signal regulating activities by discriminating between binding of Src kinases and SHP phosphatases , respectively . ^^^ |
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| Interacting proteins: P13688 and P12931 |
Pubmed |
SVM Score :0.0 |
| We thus cotransfected Jurkat T cells with CEACAM 1 isoform encoding constructs and an IL 2 promoter bearing plasmid or a small interference RNA targeting src homology domain 2 containing phosphatase 1 . ^^^ The inhibitory function of CEACAM 1 , was dependent upon src homology domain 2 containing phosphatase 1 activity , required both tyrosine residues within the immunoreceptor tyrosine based inhibitory motif domains of the cyt tail and was mediated through the mitogen activated protein kinase pathway . ^^^ |
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| Interacting proteins: P13688 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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