| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.57096821 |
| Association of NCAM with GFRalpha 1 , a GPI anchored receptor for GDNF , downregulates NCAM mediated cell adhesion and promotes high affinity binding of GDNF to p 140 ( NCAM ) , resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET , a known GDNF signaling receptor . 0.57096821^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| In cells lacking RET , GDNF binds with high affinity to the NCAM and GFRalpha 1 complex , which activates Fyn and FAK . . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| Using double immunostaining for either of them and NCAM , PGP 9 . 5 , or alpha gustducin , we additionally sought to determine what type of taste bud cells expressed GDNF or GFR alpha 1 , because NCAM is reported to be expressed in type 3 cells , PGP 9 . 5 , in type 3 and some type 2 cells , and alpha gustducin , in some type 2 cells . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| Thus RET independent GFRalpha 1 is dispensable for organogenesis and nerve regeneration in vivo , indicating that trans signaling and GFRalpha dependent NCAM signaling play a minor role physiologically . . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| These effects required GFRalpha 1 but neither RET nor NCAM , the two transmembrane signaling receptors known for GDNF . ^^^ Mutant mice lacking GDNF or GFRalpha 1 , but neither RET nor NCAM , showed reduced numbers of GABAergic cells in the cerebral cortex and hippocampus . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| Tissue expression of alternatively spliced GFRalpha 1 , NCAM and RET isoforms and the distinct functional consequence of ligand induced activation of GFRalpha 1 isoforms . ^^^ Glial cell line derived neurotrophic factor ( GDNF ) exerts its effect through a multi component receptor system consisting of GFRalpha 1 , RET and NCAM . ^^^ In this study , isoform specific real time PCR assays were used to quantify the expression levels of GFRalpha 1 , RET and NCAM isoforms in murine embryonic and adult tissues . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| We confirmed that GDNF , GFRalpha 1 and NCAM are expressed in neonatal rat SCs . ^^^ |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P56159 and P13591 |
Pubmed |
SVM Score :0.0 |
| NA |
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