| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.69435232 |
| The structure of the NCAM F 3 module 2 was determined by NMR and the module was shown by NMR to interact with the FGFR 1 Ig module 3 and ATP . 0.69435232^^^ We here demonstrate for the first time a direct interaction between NCAM ( fibronectin type 3 [ F 3 ] modules 1 and 2 ) and FGFR 1 ( Ig modules 2 and 3 ) by surface plasmon resonance ( SPR ) analysis . 0.68764512^^^ Structural basis for a direct interaction between FGFR 1 and NCAM and evidence for a regulatory role of ATP . 0.68353202^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| FGFR 1 and CAMLG were more frequently significantly overexpressed in patients with CD 56 immunophenoytpe . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| The binding of FGFR 1 beta / Fc protein to CD 56 molecules was verified by immunoprecipitation of CD 56 with anti CD 56 mAb followed by Western blotting with FGFR 1 beta / Fc . ^^^ These findings suggest that ligation of FGFR 1 by CD 56 may contribute to the interaction between NK cells and T cells that we have postulated in our previous studies . . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| Although no significant differences in the expression of adhesion molecules ( NCAM ) , selected morphogens ( TGFbeta 2 , HGF / SF , FGF 2 , KGF ) , or their receptors ( TGFbetaR 2 , m met , FGFR 1 ) were seen between DP of p75NTR knockout and wild type mice , p75NTR mutants showed a prominent upregulation of FGFR 2 , a high affinity receptor for KGF , in both follicular DP and epithelium . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| The following antibodies were used as the first antibody ; FGF 2 and FGF 7 for FGFs , FGFR 1 and FGFR 2 for FGFRs , NCAM , L1CAM , and N cadherin for CAMs . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| Here , we show that intracerebroventricular administration of the FG loop ( FGL ) , a synthetic 15 amino acid peptide corresponding to the binding site of NCAM for the fibroblast growth factor receptor 1 ( FGFR 1 ) , immediately after training rats in fear conditioning or water maze learning , induced a long lasting improvement of memory . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| This signature corresponded to relative overexpression of transcripts associated with neuroglial differentiation ( NCAM , MBP , L1CAM , P1P ) and relative down regulation of proliferation and growth factor associated transcripts ( IGF 2 , FGFR 1 , MDK , Ki 67 ) . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| The angiogenic effect of NCAM peptide was , at least in part , mediated by the association of NCAM and FGFR 1 . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| The neural cell adhesion molecule ( NCAM ) can bind to and activate fibroblast growth factor receptor 1 ( FGFR 1 ) . ^^^ However , there are four major FGFR isoforms ( FGFR 1 FGFR4 ) , and it is not known whether NCAM also interacts directly with the other three FGFR isoforms . ^^^ In this study , we show by surface plasmon resonance analysis that NCAM can bind to FGFR 2 with an affinity similar to that for the NCAM FGFR 1 interaction . ^^^ However , the kinetic parameters for the NCAM FGFR 2 binding are different from those of the NCAM FGFR 1 binding . ^^^ Both receptors were shown to cycle relatively fast between the NCAM bound and unbound states , although FGFR 2 cycling was clearly faster ( 13 times ) than the FGFR 1 cycling . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| A 15 amino acid long peptide , the FG loop ( FGL ) peptide , that is derived from the second F 3 module of NCAM has been found to activate FGFR 1 . ^^^ |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13591 and P11362 |
Pubmed |
SVM Score :0.0 |
| NA |
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