| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.94181197 |
| Whereas p 59 ( fyn ) was constitutively associated with NCAM 140 , the focal adhesion kinase p 125 ( fak ) , a nonreceptor tyrosine kinase known to mediate integrin dependent signaling , became recruited to the NCAM 140 p59 ( fyn ) complex when cells were reacted with antibodies against the extracellular region of NCAM . 0.94181197^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| DRMs enriched in cholesterol , caveolin , NCAM 140 , GPI linked NCAM 120 , fyn , and GAP 43 , all conventional markers of microdomains or rafts , were located in areas 2 and 3 of the gradient . ^^^ A detergent resistant membrane fraction recovered from area 4 was enriched in NCAM 140 , phosphorylated GAP 43 , and actin , but not cholesterol , caveolin , or fyn . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of the cytoplasmic part of NCAM 140 also inhibited cell motility , presumably via the non receptor tyrosine kinase p 59 ( fyn ) with which NCAM 140 interacts . ^^^ |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| We have analyzed the expression of the intracellular marker protein neuron specific enolase ( NSE ) , synaptophysin ( SYN ) and of the cell surface marker NCAM ( neural cell adhesion molecule ) in both normal hypophysis and in pituitary adenomas in order to explore their potential use as diagnostic tools . ^^^ A combined analysis of NCAM , SYN and NSE could be useful to characterize inactive adenomas which are not immunoreactive for pituitary hormones and which may contain no or only low levels of the alpha chain of the glycoprotein hormones . . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| Synaptophysin ( SYN ) staining was unaffected by heating and immunoreactivity of the low affinity nerve growth factor ( p75NGFR ) and the neural cell adhesion molecule ( NCAM ) were lost . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NCAM dependent neurite outgrowth is inhibited in neurons from Fyn minus mice . ^^^ To determine whether src related tyrosine kinases mediate NCAM dependent neurite outgrowth , cultures of cerebellar and sensory neurons from fyn , src , and yes minus mice were analyzed for neurite outgrowth on monolayers of NCAM 140 transfected L fibroblasts . ^^^ NCAM dependent neurite outgrowth was selectively inhibited in cultures of cerebellar and dorsal root ganglion neurons from fyn , but not src or yes mice . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| In this study , seven paraffin embedded PPNAD tumors , one skin myxoma , and two cell lines ( one myxoma and one PPNAD ) established from patients with CNC were stained with antisera for synaptophysin ( SYN ) , neuron specific enolase , chromogranin A , tyrosine hydroxylase , and the neural cell adhesion molecule ( NCAM ) . ^^^ SYN , neuron specific enolase , and NCAM also stained the medulla . ^^^ The myxoma cell line , but not normal fibroblasts , stained for SYN and NCAM . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the rafts , Fyn kinase is tightly associated with NCAM 120 and F 3 . ^^^ |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| We here demonstrate that NCAM induced neurite outgrowth depends on activation of p 59 ( fyn ) , focal adhesion kinase ( FAK ) , phospholipase Cgamma ( PLCgamma ) , protein kinase C ( PKC ) , and the Ras mitogen activated protein ( MAP ) kinase pathway . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| In the present report , we investigate the expression of neural cell adhesion molecule ( NCAM ) , nerve growth factor receptor ( NGFR ) , neurofilament ( NF ) , synaptophysin ( SYN ) , glial fibrillary acidic protein ( GFAP ) , S 100 , Bcl 2 , and Ki 67 by using the immunohistochemistry against specific antibodies . ^^^ All 17 tumors were reactive for NCAM , SYN and Bcl 2 . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| Association of NCAM with GFRalpha 1 , a GPI anchored receptor for GDNF , downregulates NCAM mediated cell adhesion and promotes high affinity binding of GDNF to p 140 ( NCAM ) , resulting in rapid activation of cytoplasmic protein tyrosine kinases Fyn and FAK in cells lacking RET , a known GDNF signaling receptor . ^^^ GDNF stimulates Schwann cell migration and axonal growth in hippocampal and cortical neurons via binding to NCAM and activation of Fyn , but independently of RET . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| In cells lacking RET , GDNF binds with high affinity to the NCAM and GFRalpha 1 complex , which activates Fyn and FAK . . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NCAM mediates neurite extension in PC 12 cells by two principal routes of signaling : NCAM / Fyn and NCAM / fibroblast growth factor receptor ( FGFR ) , respectively . ^^^ This activation was blocked by inhibitors of both FGFR and Fyn , indicating that NCAM activates FGFR signaling in a manner distinct from FGF 2 stimulation , and regulates ShcA phosphorylation by the concerted efforts of the NCAM / FGFR as well as the NCAM / Fyn signaling pathway . . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| Animals doubly deficient in MAG and the neural cell adhesion molecule ( NCAM ) show defects similar to those present in MAG single mutants while mice deficient in MAG and the nonreceptor type tyrosine kinase Fyn are severely hypomyelinated , in addition to the MAG specific myelin abnormalities . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : Four hundred and thirty nine cases of NSCLC were examined , immunohistochemically , using antibodies to chromogranin A ( CGA ) , synaptophysin ( SYN ) and CD56 / neural cell adhesion molecule ( NCAM ) . ^^^ CGA was positive in 5 . 5 % of cases , SYN in 16 . 5 % and NCAM in 28 % . ^^^ |
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| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| Both cis and trans interactions between NCAM at the neuronal surface and PrP promote recruitment of NCAM to lipid rafts and thereby regulate activation of fyn kinase , an enzyme involved in NCAM mediated signaling . ^^^ |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| In Ret negative cells , the alternative transmembrane coreceptor is the 140 kDa isoform of neural cell adhesion molecule ( NCAM ) associated with a non receptor tyrosine kinase Fyn . ^^^ |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13591 and P06241 |
Pubmed |
SVM Score :0.0 |
| NA |
|