| Interacting proteins: P13591 and P04156 |
Pubmed |
SVM Score :0.76986736 |
| We show that PrP interacts directly with the neural cell adhesion molecule ( NCAM ) and associates with NCAM at the neuronal cell surface . 0.76986736^^^ Cis and trans interactions between NCAM and PrP promote neurite outgrowth . 0.52226167^^^ |
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| Interacting proteins: P13591 and P04156 |
Pubmed |
SVM Score :0.0 |
| Similarly , CD3+ cells co expressing the activation marker CD 56 ( N CAM ) exhibited significantly higher PrPC expression levels than their CD 56 counterparts . ^^^ |
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| Interacting proteins: P13591 and P04156 |
Pubmed |
SVM Score :0.0 |
| Enzymatic removal of N linked sugar moieties did not disrupt the complexes , arguing that the interaction of PrP with N CAM occurs through amino acid side chains . ^^^ Additionally , similar levels of PrP / N CAM complexes were found in N2a and prion infected N2a ( ScN2a ) cells . ^^^ With the use of an N CAM specific peptide library , the PrP binding site was determined to comprise beta strands C and C ' within the two consecutive fibronectin type 3 ( FNIII ) modules found in proximity of the membrane attachment site of N CAM . ^^^ N CAM deficient ( N CAM ( / ) ) mice that were intracerebrally challenged with scrapie prions succumbed to disease with a mean incubation period of 122 ( + / 4 . 1 , SEM ) days , arguing that N CAM is not involved in PrP ( Sc ) replication . ^^^ Our findings raise the possibility that N CAM may join with PrP ( C ) in carrying out some as yet unidentified physiologic cellular function . . ^^^ |
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| Interacting proteins: P13591 and P04156 |
Pubmed |
SVM Score :0.0 |
| NA |
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