| Here we show , for the first time , that type 2 LPA receptors ( LPA 2 ) are expressed at the apical surface of intestinal epithelial cells , where they form a macromolecular complex with Na+ / H+ exchanger regulatory factor 2 and CFTR through a PSD95 / Dlg / ZO 1 based interaction . ^^^ LPA inhibited CFTR dependent iodide efflux through LPA 2 mediated Gi pathway , and LPA inhibited CFTR mediated short circuit currents in a compartmentalized fashion . ^^^ CFTR dependent intestinal fluid secretion induced by CTX in mice was reduced substantially by LPA administration ; disruption of this complex using a cell permeant LPA 2 specific peptide reversed LPA 2 mediated inhibition . ^^^ |