| Interacting proteins: Q9H3Z4 and P13569 |
Pubmed |
SVM Score :0.50772281 |
| The documented role of Csp in regulated exocytosis , its interaction with mature CFTR , and its coexpression with CFTR at the apical membrane domain of epithelial cells may reflect also a role for Csp in regulated CFTR trafficking at the plasma membrane . . 0.50772281^^^ |
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| Interacting proteins: Q9H3Z4 and P13569 |
Pubmed |
SVM Score :0.0 |
| We examined the role of the cysteine string protein ( Csp ) in cystic fibrosis transmembrane conductance regulator ( CFTR ) biogenesis in relation to another J domain protein , Hdj 2 , a recognized CFTR cochaperone . ^^^ Increased expression of Csp produced a dose dependent reduction in mature ( band C ) CFTR and an increase in immature ( band B ) CFTR . ^^^ Exogenous expression of Hdj 2 also increased CFTR band B , but unlike Csp , Hdj 2 increased band C as well . ^^^ The Csp induced block of CFTR maturation required Hsp 70 , because a J domain mutant ( H43Q ) that interferes with the ability of Csp to stimulate Hsp 70 ATPase activity relieved the Csp induced block of CFTR maturation . ^^^ Nevertheless , Csp H43Q still increased immature CFTR . ^^^ |
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