| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.54292879 |
| Although calnexin binds nascent CFTR via its oligosaccharide chains in the ER lumen and Hsp 70 binds CFTR cytoplasmic domains , perturbation of these interactions alone is without major influence on maturation or degradation . 0.54292879^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.75368423 |
| Csp induced band B CFTR was found adjacent to the nucleus , co localizing with calnexin , and it remained detergent soluble . 0.75368423^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Synthesis of a molecular mimic of the Glc1Man9 oligoside as potential inhibitor of calnexin binding to DeltaF 508 CFTR protein . ^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Although the bulk of wild type and delta F 508 CFTRs were present initially in complexes containing calnexin , only wild type CFTR was able to escape from this association and exit the ER . ^^^ Calnexin retains misfolded or incompletely assembled proteins in the ER and thus is likely to contribute to the mislocalization of mutant CFTR . . ^^^ Participation of the endoplasmic reticulum chaperone calnexin ( p 88 , IP 90 ) in the biogenesis of the cystic fibrosis transmembrane conductance regulator . ^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Conversely , calnexin and binding protein ( BiP ) , which are required for the proteolysis of ER lumenal proteins in both yeast and mammals , are dispensable for the degradation of CFTR , suggesting unique mechanisms for the disposal of at least some soluble and integral membrane ERAD substrates in yeast . . ^^^ |
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| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| In Calu 3 airway cells , immunofluorescence colocalized Csp with calnexin in the endoplasmic reticulum and with CFTR at the apical membrane domain . ^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| In immortalized human CF cell lines expressing Delta F 508 CFTR , a halide efflux assay showed that calnexin Delta 185 520 partially restored CFTR function . ^^^ We show that calnexin Delta 185 520 but not calnexin can partially reverse the mislocalization of Delta F 508 CFTR . ^^^ Calnexin Delta 185 520 interacted with CFTR directly , and was secreted into the extracellular compartment over time . ^^^ Forty eight hours after transfection into CHO cells , calnexin Delta 185 520 increased the conversion of immature Delta F 508 CFTR into mature Delta F 508 CFTR . ^^^ These data indicate that calnexin Delta 185 520 may give a clue to develop the therapeutic way of cystic fibrosis with Delta F 508 CFTR . . ^^^ |
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| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Delta F 508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression . ^^^ Because the prolonged interaction of Delta F 508 CFTR with calnexin , an ER chaperone , results in the ERAD of Delta F 508 CFTR , calnexin seems to lead it to the ERAD pathway . ^^^ In this study , we found that calnexin overexpression partially attenuated the ERAD of Delta F 508 CFTR . ^^^ We observed the formation of concentric membranous bodies in the ER upon calnexin overexpression and that the Delta F 508 CFTR but not the wild type CFTR was retained in the concentric membranous bodies . ^^^ Furthermore , we observed that calnexin overexpression moderately inhibited the formation of aggresomes accumulating the ubiquitinated Delta F 508 CFTR . ^^^ |
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| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Some knowledge is emerging on CFTR membrane folding and on the role of this process of molecular chaperones , such as Hsp70 / Hdj 1 and calnexin . ^^^ |
|
| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| Most F508del CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin . ^^^ Our data show that the major degradation pathway of the cystic fibrosis transmembrane conductance regulator ( CFTR ) with F508del ( the most frequent mutation found in patients with the genetic disease cystic fibrosis ) from the ER is independent of calnexin . ^^^ Together , our data support a novel model by which wt and F508del CFTR undergo ERAD from two distinct checkpoints , the mutant being disposed of independently of N glycosidic residues and calnexin , probably by the Hsc70 / Hsp70 machinery , and wt CFTR undergoing glycan mediated ERAD . . ^^^ |
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| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| We also used Baby Hamster Kidney cells , heterologously expressing deltaF 508 CFTR , to determine if SERCA inhibitors could interfere with the interaction between calnexin and CFTR and thereby correct the deltaF 508 CFTR misfolding defect . ^^^ |
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| Interacting proteins: P27824 and P13569 |
Pubmed |
SVM Score :0.0 |
| The isocyanide ligand forms complexes with ruthenium ( 2 ) bis bipyridine of the type [ Ru ( bpy ) ( 2 ) ( CNx ) Cl ] ( CF ( 3 ) SO ( 3 ) ) ( 1 ) , [ Ru ( bpy ) ( 2 ) ( CNx ) ( py ) ] ( PF ( 6 ) ) ( 2 ) ( 2 ) , and [ Ru ( bpy ) ( 2 ) ( CNx ) ( 2 ) ] ( PF ( 6 ) ) ( 2 ) ( 3 ) ( bpy = 2 , 2 ' bipyridine , py = pyridine , and CNx = 2 , 6 dimethylphenylisocyanide ) . ^^^ |
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