| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| All types of fibroblasts spontaneously released abundant amounts of CXCL 12 , CCL 2 , IL 6 and tissue inhibitor of metalloproteinase 1 , while the production of IL 11 , TGF beta 1 , matrix metalloproteinase 1 ( MMP 1 ) and MMP 9 was detected at moderate levels . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| We here show that recombinant human MCP 1 affects gene expression of interstitial collagenase ( matrix metalloproteinase 1 ( MMP 1 ) ) in primary human skin fibroblasts and a stable fibroblast cell line . ^^^ MMP 1 mRNA was induced by MCP 1 ( 10 ng / ml ) as early as 6 h and reached a maximal expression at 24 h . ^^^ MCP 1 also caused an increase of MMP 2 mRNA expression in both types of fibroblasts at 48 h . ^^^ Immunoblot analysis demonstrated increased levels of MMP 1 and TIMP 1 protein in the culture supernatants of primary fibroblasts stimulated with MCP 1 . ^^^ In addition , MCP 1 strongly induced IL 1 alpha mRNA expression in dermal fibroblasts in parallel with the induction of MMP 1 . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| RESULTS : CD68+ macrophage infiltration and the expression of MIP 1alpha , MCP 1 , MMP 1 , MMP 3 , TIMP 1 , and TIMP 2 were observed in synovial tissue of patients with early RA . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| The effects on markers of pathophysiologically different problems were studied in a comparable manner : Markers of endothelial function such as prostacyclin , endothelin and plasminogen activator inhibitor 1 ( PAI 1 ) , markers of plaque initiation such as the adhesion molecules E Selectin , ICAM 1 and the monocyte attraction protein 1 ( MCP 1 ) and markers of plaque stability such as the precursor of the matrix metalloproteinase 1 ( pro MMP 1 ) . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| Unstimulated subepithelial myofibroblasts secreted a large amount of MMP 2 , but a small amount of IL 8 , MCP 1 and MMP 1 . ^^^ IL 1beta and TNF alpha both induced a dose and time dependent increase in IL 8 , MCP 1 and MMP 1 secretion , and weakly stimulated MMP 2 secretion . ^^^ The inhibition of NF kappaB activation markedly blocked both IL 1beta and TNF alpha induced IL 8 and MCP 1 mRNA expression , but did not affect MMP 1 mRNA expression . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| DESIGN : Endothelial cell cultures from human female coronary arteries were used to evaluate the effect of progestin addition to E ( 2 ) on the production of the following endothelial markers : prostacyclin , endothelin , plasminogen activator inhibitor 1 , E selectin , intercellular adhesion molecule 1 , monocyte chemoattractant protein 1 ( MCP 1 ) , and the precursor of matrix metalloproteinase 1 ( pro MMP 1 ) . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| The closely related chemokines MCP 1 , MCP 2 , and MCP 4 were not cleaved by MMP 2 or MT 1 MMP , but were cleaved by MMP 1 and MMP 3 with varying efficiency . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| Atherosclerotic changes ( plaque formation , lipid and macrophage rich intimal thickening , the increase in MCP 1 , IL 8 , TNF alpha , IL 1beta , M CSF , MMP 1 , MMP 9 , MMP 12 , and ACE mRNA expression , and the increase in plasma MCP 1 levels ) were observed in the high cholesterol diet group ( HC ) . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| The objective of this study was to compare the individual and combined effect of CRP and ox LDL on human monocyte MMP 1 and the role of MCP 1 in this effect . ^^^ Enhancement of MMP 1 by CRP and ox LDL was attributable to a differential increase in MCP 1 and prostaglandin E 2 ( PGE 2 ) . ^^^ Accordingly , CRP and ox LDL induced MMP 1 production by monocytes was inhibited by anti MCP 1 antibodies and indomethacin , respectively . ^^^ Moreover , addition of exogenous MCP 1 or PGE 2 enhanced MMP 1 production by TNF alpha and GM CSF stimulated monocytes . ^^^ These results show that the combination of CRP and ox LDL can cause a synergistic enhancement of the role of monocytes in inflammation , first , by increasing MCP 1 , which attracts more monocytes and directly enhances MMP 1 production by activated monocytes , and second , by elevating PGE 2 production , which also leads to higher levels of MMP 1 . . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| High sensitivity C reactive protein ( CRP ) , soluble intercellular adhesion molecule type 1 ( sICAM 1 ) , soluble vascular cell adhesion molecule type 1 ( sVCAM 1 ) , e selectin , p selectin , interleukin 6 ( IL 6 ) , monocyte chemotactic protein type 1 ( MCP 1 ) , matrix metalloproteinases types 1 , 2 , and 9 ( MMP 1 , MMP 2 , and MMP 9 ) , and the tissue inhibitor of metalloproteinases type 1 ( TIMP 1 ) were measured in serum on the last day of both low salt and high salt intakes . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| Oncostatin M stimulates monocyte chemoattractant protein 1 and interleukin 1 induced matrix metalloproteinase 1 production by human synovial fibroblasts in vitro . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| Furthermore , considerable levels of IFN gamma inducible protein 10 and matrix metalloproteinase 1 were measured in stimulated HCF cultures , while the constitutive secretion of monocyte chemotactic protein 1 remained unaffected . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| The aim of this study is to investigate whether the functional polymorphisms in the promoter of matrix metalloproteinase 1 ( MMP 1 ) and in the regulatory region of the monocyte chemoattractant protein 1 ( MCP 1 ) gene are associated with susceptibility to rheumatoid arthritis ( RA ) and its clinical features . ^^^ The MMP 1 1G / 2G polymorphism and the MCP 1 promoter A / G polymorphism were determined by polymerase chain reaction restriction fragment length polymorphism in 117 RA patients and 97 healthy controls . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| TNF like weak inducer of apoptosis ( TWEAK ) , a recently identified member of the TNF ligand family , induces PGE 2 , MMP 1 , IL 6 , IL 8 , RANTES , and IP 10 in fibroblasts and synoviocytes , and upregulates ICAM 1 , E selectin , IL 8 , and MCP 1 in endothelial cells . ^^^ |
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| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13500 and P03956 |
Pubmed |
SVM Score :0.0 |
| NA |
|