| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| Physical properties of Tld , Sog , Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of the Drosophila embryo . ^^^ Previous genetic and biochemical studies have revealed that the Sog , Tsg and Tld proteins modify Dpp activity at the post transcriptional level . ^^^ The predominant view is that Sog and Tsg form a strong ternary complex with Dpp that prevents it from binding to its cognate receptors in lateral regions of the embryo , while in the dorsal most cells Tld is proposed to process Sog and thereby liberate Dpp for signaling . ^^^ In this study , additional genetic and biochemical assays were developed to further probe the relationships between the Sog , Tsg , Tld and Dpp proteins . ^^^ We propose that the strong Dpp concentration dependence exhibited by the processing reaction , together with movement of Dpp by Sog and Tsg protein can help explain how Tld activity is confined to the dorsal most region of the embryo through formation of a spatially dependent positive and negative reinforcement loop . ^^^ |
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| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| The ternary complex of Tsg / Chd / Bmp is cleaved by the metalloprotease Tolloid ( Tld ) / Xolloid ( Xld ) . ^^^ |
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| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| BMP signaling is modulated by a number of extracellular proteins , including the inhibitor Chordin , Tolloid related enzymes ( Tld ) , and the interacting protein Twisted Gastrulation ( Tsg ) . ^^^ |
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| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| This in vivo processing of Sog can be duplicated in vitro by treating Sog with a combination of the metalloprotease Tolloid ( Tld ) plus Twisted Gastrulation ( Tsg ) , another extracellular factor involved in Dpp signaling . ^^^ |
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| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| This refinement suggests that cells respond to the local transient morphogen distribution that results from interactions between bone morphogenetic proteins ( BMPs ) , their receptors , the BMP binding proteins Sog and Tsg , the metalloprotease Tld , and a putative , positively regulated component that locally enhances surface binding of BMPs within the region of high signaling . ^^^ |
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| Interacting proteins: Q9GZX9 and P13497 |
Pubmed |
SVM Score :0.0 |
| NA |
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