| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| We have isolated a chimpanzee processed pseudogene for subunit 4 of cytochrome c oxidase ( COX ; EC 1 . 9 . 3 . 1 ) by screening a chimpanzee genomic library in lambda Charon 32 with a bovine liver cDNA encoding COX subunit 4 ( COX 4 ) , and localized it to a 1 . 9 kb HindIII fragment . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| A comparison of the steady state levels of Cox1p through Cox4p in the COX 1 , COX 2 , COX 3 and COX 4 mutants shows the interdependance of the accumulation of these four subunits in the mitochondrial membranes . . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| We measured protein levels of CO subunits encoded by mitochondrial ( COX 1 , COX 2 ) and nuclear ( COX 4 , COX VIc ) DNA in autopsied brain of patients with AD whom we previously reported had decreased cerebral cortical CO activity . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| In this study we used immunohistochemistry and quantitative autoradiographic methods to study the expression pattern of two cytochrome oxidase subunit proteins ( nuclear encoded COX 4 and mitochondrial encoded COX 1 ) in the hippocampus in relation to the development of AD type pathology . ^^^ Levels of COX 4 but not of COX 1 were related to the amount of hyperphosphorylated tau accumulated in the same hippocampal region but not to the amount of amyloid deposited in sporadic AD . ^^^ In Down ' s syndrome COX 1 and COX 4 were similarly increased in the presence of AD pathology in non tangle bearing neurones . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| No differences were observed in the mRNA abundances of COX 1 , a mitochondrially encoded subunit of cytochrome c oxidase or of nuclearly encoded subunits of various electron transport components ( SD , COX 4 , and ND 51 ) . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| Reduced mitochondrial heme aa 3 with both treatments was accompanied by approximately 50 % reduced , mitochondrial genome encoded COX 1 and 2 mRNAs and nuclear genome encoded COX Vb mRNAs , but no change in COX 4 mRNA level . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| Protein levels of mitochondrial transcription factor A ( Tfam ) and nuclear and mitochondrial encoded subunits of respiratory chain complex 4 ( COX 1 and COX 4 ) as well as citrate synthase activity were analysed in muscle biopsy samples of vastus lateralis in six healthy male subjects before and after 4 weeks of one legged cycle training . ^^^ Tfam , COX 1 and COX 4 levels all increased with training , with no differences observed between the legs . ^^^ The increases of COX 1 and COX 4 indicate a concurrent increase of nuclear and mitochondrial encoded subunits of respiratory enzyme complex 4 at the protein level in skeletal muscle in response to increased muscle activity . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| This finding is similar to earlier observations of an accelerated non synonymous substitution rate for some lineages of primates for COX 1 , COX 2 , COX 4 , and COX7AH . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| We quantified mitochondrial DNA ( mtDNA ) , expression of nuclear ( COX 4 ) and mitochondrial ( COX 1 ) encoded cytochrome c oxidase subunits as well as nuclear factors involved in mitochondrial biogenesis and in the necessary coordinated interplay between nuclear and mitochondrial genomes in health and CHF . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| Transcript levels for factors involved in mitochondrial biogenesis ( PGC 1alpha , Tfam ) , mitochondrial function ( COX 1 , COX 4 ) , control of contractile phenotype ( MyHC 1 , IIa , IIx ) as well as mechanical stress marker ( IGF 1 ) were quantified using an reverse transcriptase polymerase chain reaction approach . ^^^ The PGC 1alpha significantly correlated with Tfam , and both PGC 1alpha and Tfam significantly correlated with COX 1 and COX 4 mRNAs . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| In addition , the blots revealed the presence of five subassemblies : three subassemblies involving the core subunit MTCO 1 but apparently no other subunits ; a subassembly containing subunits MTCO 1 , COX 4 , and COX5A ; and a subassembly containing at least subunits MTCO 1 , MTCO 2 , MTCO 3 , COX 4 , and COX5A . ^^^ COX5A subassembly was not detected in COX 10 deficient cells , which suggests that heme A incorporation into MTCO 1 occurs prior to association of MTCO 1 with COX 4 and COX5A . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| This inhibitory effect of cyclosporin occurred at the posttranscriptional level , as evidenced by normal increases in COX 1 and COX 4 mRNAs in response to exercise in the cyclosporin treated rats . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| In addition , immunoblot analysis indicated that the CCO subunit ( Cox 1 ) was reduced on postnatal Days 10 and 21 , and that Cox 4 was reduced on PND 21 in heart mitochondria of the neonates from copper deficient dams . ^^^ Furthermore , the concurrent reductions in Cox 1 and Cox 4 suggest that the impaired CCO activity reflects a CCO deficiency in heart mitochondria . ^^^ |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00395 and P13073 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| We have isolated a chimpanzee processed pseudogene for subunit 4 of cytochrome c oxidase ( COX ; EC 1 . 9 . 3 . 1 ) by screening a chimpanzee genomic library in lambda Charon 32 with a bovine liver cDNA encoding COX subunit 4 ( COX 4 ) , and localized it to a 1 . 9 kb HindIII fragment . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| A comparison of the steady state levels of Cox1p through Cox4p in the COX 1 , COX 2 , COX 3 and COX 4 mutants shows the interdependance of the accumulation of these four subunits in the mitochondrial membranes . . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| We measured protein levels of CO subunits encoded by mitochondrial ( COX 1 , COX 2 ) and nuclear ( COX 4 , COX VIc ) DNA in autopsied brain of patients with AD whom we previously reported had decreased cerebral cortical CO activity . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| In this study we used immunohistochemistry and quantitative autoradiographic methods to study the expression pattern of two cytochrome oxidase subunit proteins ( nuclear encoded COX 4 and mitochondrial encoded COX 1 ) in the hippocampus in relation to the development of AD type pathology . ^^^ Levels of COX 4 but not of COX 1 were related to the amount of hyperphosphorylated tau accumulated in the same hippocampal region but not to the amount of amyloid deposited in sporadic AD . ^^^ In Down ' s syndrome COX 1 and COX 4 were similarly increased in the presence of AD pathology in non tangle bearing neurones . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| No differences were observed in the mRNA abundances of COX 1 , a mitochondrially encoded subunit of cytochrome c oxidase or of nuclearly encoded subunits of various electron transport components ( SD , COX 4 , and ND 51 ) . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| Reduced mitochondrial heme aa 3 with both treatments was accompanied by approximately 50 % reduced , mitochondrial genome encoded COX 1 and 2 mRNAs and nuclear genome encoded COX Vb mRNAs , but no change in COX 4 mRNA level . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| We quantified mitochondrial DNA ( mtDNA ) , expression of nuclear ( COX 4 ) and mitochondrial ( COX 1 ) encoded cytochrome c oxidase subunits as well as nuclear factors involved in mitochondrial biogenesis and in the necessary coordinated interplay between nuclear and mitochondrial genomes in health and CHF . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| In addition , the blots revealed the presence of five subassemblies : three subassemblies involving the core subunit MTCO 1 but apparently no other subunits ; a subassembly containing subunits MTCO 1 , COX 4 , and COX5A ; and a subassembly containing at least subunits MTCO 1 , MTCO 2 , MTCO 3 , COX 4 , and COX5A . ^^^ COX5A subassembly was not detected in COX 10 deficient cells , which suggests that heme A incorporation into MTCO 1 occurs prior to association of MTCO 1 with COX 4 and COX5A . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| Transcript levels for factors involved in mitochondrial biogenesis ( PGC 1alpha , Tfam ) , mitochondrial function ( COX 1 , COX 4 ) , control of contractile phenotype ( MyHC 1 , IIa , IIx ) as well as mechanical stress marker ( IGF 1 ) were quantified using an reverse transcriptase polymerase chain reaction approach . ^^^ The PGC 1alpha significantly correlated with Tfam , and both PGC 1alpha and Tfam significantly correlated with COX 1 and COX 4 mRNAs . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| This inhibitory effect of cyclosporin occurred at the posttranscriptional level , as evidenced by normal increases in COX 1 and COX 4 mRNAs in response to exercise in the cyclosporin treated rats . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| In addition , immunoblot analysis indicated that the CCO subunit ( Cox 1 ) was reduced on postnatal Days 10 and 21 , and that Cox 4 was reduced on PND 21 in heart mitochondria of the neonates from copper deficient dams . ^^^ Furthermore , the concurrent reductions in Cox 1 and Cox 4 suggest that the impaired CCO activity reflects a CCO deficiency in heart mitochondria . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| Protein levels of mitochondrial transcription factor A ( Tfam ) and nuclear and mitochondrial encoded subunits of respiratory chain complex 4 ( COX 1 and COX 4 ) as well as citrate synthase activity were analysed in muscle biopsy samples of vastus lateralis in six healthy male subjects before and after 4 weeks of one legged cycle training . ^^^ Tfam , COX 1 and COX 4 levels all increased with training , with no differences observed between the legs . ^^^ The increases of COX 1 and COX 4 indicate a concurrent increase of nuclear and mitochondrial encoded subunits of respiratory enzyme complex 4 at the protein level in skeletal muscle in response to increased muscle activity . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| This finding is similar to earlier observations of an accelerated non synonymous substitution rate for some lineages of primates for COX 1 , COX 2 , COX 4 , and COX7AH . ^^^ |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P13073 and P00395 |
Pubmed |
SVM Score :0.0 |
| NA |
|