| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| Surprisingly perhaps , given the role of Mre 11 in yeast NHEJ , disruption of NHEJ by deletion of KU 70 greatly exacerbates the effects of MRE 11 deficiency , revealing a significant Mre 11 independent component of metazoan NHEJ . . ^^^ |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| Intra and inter pathway interactions were quantified by co localisation , FRET imaging and by co immunoprecipitation ( Co IP ) of XRCC 4 , DNA PK and Ku 70 as representatives of NHEJ , Rad 51 and Rad 52 for HRR and gamma H2AX , Mre 11 and Rad 50 as representatives of both pathways . ^^^ |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| LOH was recurrently observed for 8 of the 9 studied genes ( KU 70 , KU 80 , XRCC 4 , LIG 4 , Artemis , MRE 11 , RAD 50 , NBS 1 ) but not for DNA PKcs . ^^^ |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| Mre 11 and Ku 70 interact in somatic cells , but are differentially expressed in early meiosis . ^^^ We demonstrate here a physical interaction between mammalian Ku 70 , which is essential for NHEJ ( ref . 5 ) , and Mre 11 , which functions both in NHEJ and meiotic HR ( Refs 2 , 6 ) . ^^^ Moreover , we show that irradiated cells deficient for Ku 70 are incapable of targeting Mre 11 to subnuclear foci that may represent DNA repair complexes . ^^^ Nevertheless , Ku 70 and Mre 11 were differentially expressed during meiosis . ^^^ In the mouse testis , Mre 11 and Ku 70 co localized in nuclei of somatic cells and in the XY bivalent . ^^^ |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| Here we describe two PCR based methods to monitor telomere length and examine the fate of dysfunctional telomeres in Arabidopsis lacking the catalytic subunit of telomerase ( TERT ) and the DNA repair proteins Ku 70 and Mre 11 . ^^^ In triple ku 70 tert mre 11 mutants , chromosome fusions were still detected , but microhomology at the junction was no longer favored . ^^^ These data indicate that both Ku 70 and Mre 11 contribute to fusion of critically shortened telomeres in higher eucaryotes . ^^^ |
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| Interacting proteins: P49959 and P12956 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Using both supershift and Western analysis , the following proteins were identified in the DNA end binding complex : Ku 70 , Ku 80 , DNA dependent protein kinase catalytic subunit , DNA ligase 4 , 10 ray cross complementing protein 4 , meiotic recombination protein 11 ( Mre 11 ) , Werner ' s syndrome protein , Bloom ' s syndrome protein , p 53 , poly ( ADP ribose ) polymerase , replication protein A ( RPA ) 14 , and RPA 32 , ataxia telangiectasia mutant , c Abl , Rad 50 , Nijmegen breakage syndrome protein 1 ( NBS 1 ) , and DNA ligase 3 were not detected in the binding complex by any assay . ^^^ |
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