| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.86158685 |
| In addition , c Src interacts with TRAF 6 in response to IL 1 and this interaction is required for c Src activity . 0.86158685^^^ |
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| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| TRANCE , a TNF family member , activates Akt / PKB through a signaling complex involving TRAF 6 and c Src . ^^^ Here , we demonstrate that TRANCE activates the antiapoptotic serine / threonine kinase Akt / PKB through a signaling complex involving c Src and TRAF 6 . ^^^ A deficiency in c Src or addition of Src family kinase inhibitors blocks TRANCE mediated PKB activation in osteoclasts . c Src and TRAF 6 interact with each other and with TRANCE R upon receptor engagement . ^^^ TRAF 6 , in turn , enhances the kinase activity of c Src leading to tyrosine phosphorylation of downstream signaling molecules such as c Cbl . ^^^ |
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| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^ |
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| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| We recently demonstrated that TRANCE activates Akt via a mechanism involving TRANCE receptor ( TRANCE R ) / RANK , TRAF 6 , and c Src . ^^^ |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| GST pull down experiments indicated that the association of SHP 1 with TRAF 6 is mediated by SHP 1 lacking the two Src homology 2 domains . ^^^ |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that TRAF 6 acts as a critical adapter of both the Src / ERK1 / 2 and IKK / NF kappaB proinflammatory signaling pathways in monocytes and macrophages . . ^^^ |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| Key regulatory intermediates include TRAF 6 , src , Smad 3 , phosphatidylinositol 3 kinase , Jak / Stat , and the cGMP dependent protein kinase 1 . ^^^ |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| TRAF 6 activation of PI 3 kinase dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src . ^^^ It was observed that PI 3 kinase was activated either by treatment with IL 1 or by expression of either TRAF 6 , Src , MyD 88 or dominant positive PI 3 kinase , and resulted in the formation of long filopodia like cellular protrusions that appeared to branch at membrane sites consisting of clusters of phosphoinositide . ^^^ This depended upon a TRAF 6 polyproline motif and Src catalytic activity , and was blocked by inhibitors of PI 3 kinase , Src and Ras . ^^^ Using both conventional and split fluorescent protein probes fused to expressed TRAF 6 and Src in living cells , the polyproline sequence of TRAF 6 and the Src homology 3 ( SH 3 ) domain of Src were shown to be required for interaction between these two proteins . ^^^ Although a key factor in TRAF 6 dependent activation of PI 3 kinase , ectopic expression of Src was insufficient for NF kappaB activation and , in contrast to NF kappaB , was not inhibited by IRAK2 . . ^^^ |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9Y4K3 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|