| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.53710782 |
| As in other cells , Gab 2 was found to associate with several signaling molecules including Src homology 2 containing protein tyrosine phosphatase 2 , Grb 2 , Lyn , and phospholipase C gamma ( PLC gamma ) . 0.53710782^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Gab 2 ( Grb 2 associated binder 2 ) , a member of the IRS ( insulin receptor substrate ) / Gab family of adapter proteins , undergoes tyrosine phosphorylation in response to cytokine or growth factor stimulation and serves as a docking platform for many signal transduction effectors , including the tyrosine phosphatase SHP 2 [ SH 2 ( Src homology 2 ) domain containing tyrosine phosphatase ] . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ligation of CD 28 stimulates the formation of a multimeric signaling complex involving grb 2 associated binder 2 ( gab 2 ) , SRC homology phosphatase 2 , and phosphatidylinositol 3 kinase : evidence that negative regulation of CD 28 signaling requires the gab 2 pleckstrin homology domain . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of Gab 2 in response to M CSF requires the kinase activity of Fms , but not that of Src . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Preincubation of cells with the Src family kinase inhibitor , PP 1 , surprisingly increased the IL 2 and IL 15 induced tyrosine phosphorylation of Gab 2 , indicating that an Src family kinase member negatively regulates IL 2 receptor signaling in MF T cells . ^^^ Thus , although Gab 2 seems to function normally in MF T cells compared to normal T cells , Gab 2 itself might be abnormally regulated by an Src family kinase . . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , Gab 2 was also constitutively associated with SHP 1 phosphatase via its C terminal Src homology 2 domain . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Among these LAT , SLP 76 and Gab 2 are critically important as adapters that facilitate events initiated by IgE receptor dependent activation of Src family protein tyrosine kinases , Lyn and Fyn . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Key role for Src phosphorylation of the docking protein Gab 2 . ^^^ Here , we demonstrate that PP 1 , a selective inhibitor of Src family kinases , blocks the EGF induced Gab 2 tyrosine phosphorylation without inhibiting EGF induced phosphorylation of the EGF receptor , ErbB 3 , or Shc . ^^^ We also show that Gab 2 phosphorylation is increased in Csk knockout cells in which Src family kinases are constitutively activated . ^^^ We demonstrate that Gab 2 and Src are constitutively associated . ^^^ Since this association involves the proline rich sequences of Gab 2 , it probably involves the Src homology 3 domain of Src kinase . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Gab 2 functions as a signal branch for activation vs . inhibition , as phosphorylation of either Src homology 2 ( SH 2 ) domain containing leukocyte phosphoprotein of 76 kDa ( SLP 76 ) or Gab 2 by zeta associated protein of 70 kDa ( ZAP 70 ) determines the fate of the response . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Specific inhibitors of Src kinase ( PD 173 and PP 1 ) but not Jak 2 kinase ( AG 490 ) blocked Gab 2 phosphorylation . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Inhibitors of phosphatidylinositide 3 kinase and Src kinases suppressed EPO dependent phosphorylation of Gab 2 . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| Gab 2 is persistently tyrosine phosphorylated in Ba / F3 cells expressing caSTAT 5 ( constitutively activated STAT 5 ) , independent of JAK 2 ( Janus kinase 2 ) activation where it interacts with STAT 5 , p 85 and Grb 2 , but not with Shp 2 [ SH 2 ( Src homology 2 ) domain containing tyrosine phosphatase ] proteins . ^^^ |
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| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| The E76K mutation in the N terminal Src homology 2 domain increased interactions of mutant SHP 2 with Grb 2 , Gab 2 , and p 85 , leading to hyperactivation of IL 3 induced Erk and phosphatidylinositol 3 kinase ( PI3K ) pathways . ^^^ |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UQC2 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|