| Interacting proteins: Q9HBA0 and P12931 |
Pubmed |
SVM Score :0.0 |
| SRC family kinase dependent tyrosine phosphorylation of TRPV 4 on TYR 253 mediates its response to hypotonic stress . ^^^ TRPV 4 associated with Src family kinases by co immunoprecipitation studies and confocal immunofluorescence microscopy , and this interaction required an intact Src family kinase SH 2 domain . ^^^ In aggregate , these data indicate that hypotonic stress results in Src family tyrosine kinase dependent tyrosine phosphorylation of the tonicity sensor TRPV 4 at residue Tyr 253 and that this residue is essential for channel function in this context . ^^^ |
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| Interacting proteins: Q9HBA0 and P12931 |
Pubmed |
SVM Score :0.0 |
| Two distinct mechanisms have been described through which TRPV 4 may be activated by hypotonicity : one involves the Src family of nonreceptor protein tyrosine kinases , whereas a second is mediated via arachidonic acid metabolites . ^^^ |
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| Interacting proteins: Q9HBA0 and P12931 |
Pubmed |
SVM Score :0.0 |
| The TRPV 4 mediated nociceptive behaviors induced by hyper and hypotonic stimuli were dependent on Src tyrosine kinase . ^^^ |
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| Interacting proteins: Q9HBA0 and P12931 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis shows that the interaction of the two proteins requires both a TRPV 4 specific proline rich domain upstream of the ankyrin repeats of the channel and the carboxyl terminal Src homology 3 domain of PACSIN 3 . ^^^ |
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