| Interacting proteins: Q8WUM4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Hp 95 promotes anoikis and inhibits tumorigenicity of HeLa cells . p 95 is a putative signal transduction protein of approximately 95 kDa that contains multiple tyrosine residues that are conserved from yeast to human , a Src phosphorylation consensus sequence and a proline rich C terminus that binds SH 3 domains . ^^^ |
|
| Interacting proteins: Q8WUM4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although there was no evidence for direct molecular interactions between SETA and cytoskeletal proteins , the SETA interacting protein AIP 1 , which is a rat ortholog of the Xenopus src substrate Xp 95 , strongly interacted with structural proteins of the cytoskeleton , including actin and tubulins . ^^^ |
|
| Interacting proteins: Q8WUM4 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src phosphorylation of Alix / AIP1 modulates its interaction with binding partners and antagonizes its activities . ^^^ Tyr 319 of Alix bound the isolated Src homology 2 ( SH 2 ) domain and was necessary for interaction with intact Src . ^^^ A proline rich region in the C terminus of Alix bound the Src SH 3 domain , but this interaction was dependent on the release of the Src SH 2 domain from its Src internal ligand either by interaction with Alix Tyr 319 or by mutation of Src Tyr 527 . ^^^ Src phosphorylated Alix at a C terminal region rich in tyrosines , an activity that was stimulated by the presence of the Alix binding partner SETA / CIN85 . ^^^ Phosphorylation of Alix by Src caused it to translocate from the membrane and cytoskeleton to the cytoplasm and reduced its interaction with binding partners SETA / CIN85 , epidermal growth factor receptor , and Pyk 2 . ^^^ |
|
| Interacting proteins: Q8WUM4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WUM4 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|