| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that although both Src and Laloo physically interact with the substrate protein SNT 1 / FRS2alpha only Laloo phosphorylates SNT 1 , an event previously shown to be required for the activity of the latter and for mesoderm induction in vivo . ^^^ We show that Src is enzymatically capable of stimulating mesoderm formation , as an activated Src construct both phosphorylates SNT 1 and induces mesoderm in explant cultures . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| Consistent with this model , FRS 2 binds Grb 2 , Crk , the SH 2 domain containing tyrosine phosphatase SH PTP 2 , the cyclin dependent kinase substrate p 13 ( suc 1 ) , and the Src homology 3 ( SH 3 ) domain of Src , providing a functional link between TrkA , cell cycle , and multiple NGF signaling effectors . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| Consistent with the mitogenic response to FGF 1 , the lack of Src does not affect the tyrosine phosphorylation of Snt ( or Frs 2 ) , a FGF 1 early signaling protein that links to Ras . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| Xenopus FRS 2 is involved in early embryogenesis in cooperation with the Src family kinase Laloo . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that Grb 2 bound to tyrosine phosphorylated FRS 2 alpha forms a ternary complex with Cbl by means of its Src homology 3 domains resulting in the ubiquitination of fibroblast growth factor ( FGF ) receptor and FRS 2 alpha in response to FGF stimulation . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that activation of protein kinase C , Src family kinases , and MEK1 / 2 are involved in regulating serine threonine phosphorylation of FRS 2 , which can indirectly affect FRS 2 phosphotyrosine levels . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| FRS 2 dependent SRC activation is required for fibroblast growth factor receptor induced phosphorylation of Sprouty and suppression of ERK activity . ^^^ Activation of SRC via fibroblast growth factor signalling is dependent upon FRS 2 and fibroblast growth factor receptor kinase activity . ^^^ These results show that recruitment of SRC to FRS 2 leads to activation of signal attenuation pathways . . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the slices from sciatic nerve transection ( SNT ) rats , genistein ( 50 microM ) , a broad spectrum PTKs inhibitor , or PP 2 ( 20 microM ) , a selective Src family tyrosine kinase inhibitor , significantly reduced the amplitude of Abeta fiber EPSCs . ^^^ |
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| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q8WU20 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|