| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| Now , Wong et al . have identified MNAR ( modulator of nongenomic activity of estrogen receptor ) as an adaptor protein that allows the ER to bridge the signaling pathways of tyrosine kinases ( i . e . , Src ) and the mitogen activated protein kinase ( MAPK ) cascade . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| PELP 1 ( proline , glutamic acid , and leucine rich protein 1 ) ( also known as the modulator of nongenomic activity of estrogen receptor ) plays a role in genomic functions of the estrogen receptor via histone interactions and in nongenomic functions via its influence on the MAPK Src pathway . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here we show that MNAR modulates estrogen receptor ( ER ) interaction with members of the Src family of tyrosine kinases , which leads to a stimulation of Src enzymatic activity and activation of Erk 1 and Erk 2 kinases . ^^^ We also show that MNAR , through activation of the Src / Erk phosphorylation cascade , affects ER transcriptional activity and ultimately ER mediated gene expression . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc . ^^^ Mutational analysis and functional evaluation of MNAR and the use of ERalpha and cSrc mutants revealed that MNAR interacts with Src ' s SH 3 domain via its N terminal PXXP motif . ^^^ In this study , we have evaluated the molecular mechanism of Src activation after its interaction with estrogen receptor alpha ( ERalpha ) and a newly identified scaffold protein , called MNAR ( modulator of nongenomic activity of ER ) . ^^^ Mutation of this motif abolished both the MNAR induced activation of Src and the stimulation of ER transcriptional activity . ^^^ ER interacts with Src ' s SH 2 domain using phosphotyrosine 537 , and this complex was further stabilized by MNAR ER interaction . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| Additional experiments showed that Src and the scaffold protein MNAR coimmunoprecipitated with AR , indicating a role for Src as an apical molecule in the Src MEK 1 / 2 ERK 1 / 2 CREB pathway . ^^^ Interestingly , differences between the two cell lines were that in LNCaP HP cells presence of an AI phenotype and lack of response to DHT were associated with constitutive activation of the protein kinase Src and interaction among Src , AR , and MNAR . ^^^ In contrast , in LNCaP ( nan ) cells , presence of an AD phenotype and ability to respond to DHT were associated with DHT dependent activation of Src kinase activity and interaction among Src , AR , and MNAR . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| Estrogen triggered activation of Src can be regulated by the modulator of nongenomic actions of the estrogen receptor ( MNAR ) , which binds to estrogen receptors and Src to create a signaling complex . ^^^ Additionally , Xenopus MNAR augmented androgen receptor ( AR ) mediated transcription in CV 1 cells through activation of Src . ^^^ |
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| Interacting proteins: Q8IZL8 and P12931 |
Pubmed |
SVM Score :0.0 |
| In addition , PELP 1 cyto cells exhibited increased association of PELP 1 with Src , enhanced mitogen activated protein kinase ( MAPK ) activation , and constitutive activation of AKT . ^^^ |
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