| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we have identified pp 55 and pp 130 as the adaptor molecules SKAP55hom / R ( Src kinase associated protein of 55 kDa homologue ) and FYB / SLAP 130 ( Fyn binding protein / SLP 76 associated protein of 130 kDa ) , respectively , and the tyrosine kinase activity as PYK 2 . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have recently cloned the 55 kDa protein that was termed Src kinase associated phosphoprotein of 55 kDa ( SKAP 55 ) . ^^^ By co transfection of truncated mutants of SKAP 55 and SLAP 130 as well as by using the two hybrid selection system , we further demonstrate that the association between SLAP 130 and SKAP 55 is direct and involves the Src homology 3 domain of SKAP 55 and the proline rich sequence of SLAP 130 . . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| RA 70 , which is expressed during neuronal differentiation of P 19 EC , is highly homologous to human src kinase associated phosphoprotein ( SKAP 55 ) . ^^^ Thus , like SKAP 55 , RA 70 is an adaptor protein of the src family kinases . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| Among the individual members of the Fyn complex pp 85 , SKAP 55 and pp 43 are constitutively phosphorylated on tyrosine residue ( s ) in vivo and likely interact with Fyn via its src homology 2 ( SH 2 ) domain . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| In human T lymphocytes the Src family protein tyrosine kinase p 59 ( fyn ) associates with three phosphoproteins of 43 , 55 , and 85 kDa ( pp 43 , pp 55 , and pp 85 ) . ^^^ Employing a GST Fyn Src homology 2 ( SH 2 ) domain fusion protein pp 55 was purified from lysates of Jurkat T cells . ^^^ Molecular cloning of the pp 55 cDNA reveals that the pp 55 gene codes for a so far nondescribed polypeptide of 359 amino acids that comprises a pleckstrin homology domain , a C terminal SH 3 domain , as well as several potential tyrosine phosphorylation sites , among which one fulfills the criteria to bind Src like SH 2 domains with high affinity . ^^^ Consistent with this observation , pp 55 selectively binds to isolated SH 2 domains of Lck , Lyn , Src , and Fyn but not to the SH 2 domains of ZAP 70 , Syk , Shc , SLP 76 , Grb 2 , phosphatidylinositol 3 kinase , and c abl in vitro . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| In a yeast two hybrid screen , SKAP 55 , the Src kinase associated phosphoprotein of unknown function , was found as a substrate which associated with CD 45 in vivo . ^^^ Thus , SKAP 55 is an essential adapter to couple CD 45 with the Src family kinases for dephosphorylation and , thus , positively regulates TCR signaling . . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| We observed that adapter protein SKAP 55 , the Src kinase associated phosphoprotein , formed homodimers through its SH 3 domain and SK region . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src kinase associated phosphoprotein of 55 kDa ( SKAP 55 ; encoded by SCAP 1 ) is a T cell adaptor protein of unknown function that contains a pleckstrin homology and an SH 3 domain . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| ADAP ( adhesion and degranulation promoting adaptor protein ) and SKAP 55 ( Src kinase associated phosphoprotein of 55 kDa ) are T cell adaptors that mediate inside out signaling from the T cell antigen receptor to integrins , giving rise to increased integrin affinity / avidity and formation of the immunological synapse between the T cell and the antigen presenting cell . ^^^ Inactivation of the Src homology 3 domain of SKAP 55 , which mediates the association between SKAP 55 with ADAP , blocks the protective effect of ADAP . ^^^ |
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| Interacting proteins: Q86WV1 and P12931 |
Pubmed |
SVM Score :0.0 |
| The immune cell adaptor adhesion and degranulation promoting adaptor protein ( ADAP ) and its binding to T cell adaptor Src kinase associated protein of 55 kDa ( SKAP 55 ) play a key role in the modulation of T cell adhesion . ^^^ |
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