| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| C3G , a guanine nucleotide releasing protein expressed ubiquitously , binds to the Src homology 3 domains of CRK and GRB2 / ASH proteins . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Proline rich segments in the guanine nucleotide exchange factor C3G bind much more strongly to the N terminal Src homology 3 domain ( SH 3 N ) of the proto oncogene product c Crk than to other SH 3 domains . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Four proline rich sequences of the guanine nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| While Sos binds to both Grb 2 Src homology 3 ( SH 3 ) domains , Vav was found to associate selectively with the carboxyl terminal SH 3 domain , while C3G bound selectively to the amino terminal SH 3 domain of bacterially expressed Grb 2 . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Because the Src homology 3 domain of 5 Crk is capable of binding the Ras family guanine nucleotide exchange factors Sos and C3G , the contribution of cellular Ras to signaling by 5 Crk was evaluated . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| C3G is a guanine nucleotide releasing protein that binds to the Src homology 3 ( SH 3 ) domain of the adapter protein Crk . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| CrkL then regulates activation of the guanine exchange factor C3G , with which it interacts constitutively via its N terminus src homology 3 domain . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that PKA ' s activation of Rap 1 was mediated by the Rap 1 guanine nucleotide exchange factor C3G , the adaptor Crk L , the scaffold protein Cbl , and the tyrosine kinase Src . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Activated Src ( SrcY529F ) as well as activation of putative Src signaling mediators ( Fak , Cas , Crk / CrkL , C3G , and Rap 1 ) blocked the effect of FA Csk in a manner dependent on Rap 1 . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| GH stimulated the tyrosine phosphorylation of C3G , which again required the combined activity of JAK 2 and c Src . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Responses to 5HT1E , but not D 1 , were sensitive to inhibition by a dominant negative C3G fragment , by the Src like kinase inhibitors PP 1 and PP 2 , and by a dominant negative mutant of Src . ^^^ These data indicate that GPCRs coupled to pertussis toxin sensitive G proteins activate Rap through a Galpha subunit , C3G , and Src dependent pathway . . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylated guanine nucleotide exchange factor C3G , induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton . ^^^ RESULTS : C3G is phosphorylated in vivo on Y 504 upon coexpression with Src or Hck , two members of the Src family tyrosine kinases . ^^^ While exogenously expressed C3G was present mostly in the cytosol , pY 504 C3G formed upon Hck or Src coexpression localized predominantly at the cell membrane and the Golgi complex . ^^^ Tyrosine 504 phosphorylated C3G showed colocalization with Hck and Src . ^^^ Expression of Src family kinases or treatment of cells with pervanadate resulted in an increase in endogenous pY 504 C3G , which was localized predominantly at the Golgi and the cell periphery . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Involvement of the c Src Crk C3G Rap 1 signaling in the nectin induced activation of Cdc 42 and formation of adherens junctions . ^^^ Rap 1 was recruited to the nectin based cell cell contact sites and locally activated through the c Src Crk C3G signaling there . ^^^ These results indicate that Rap 1 is activated by nectins through the c Src Crk C3G signaling and involved in the nectin induced , c Src and FRG mediated activation of Cdc 42 and formation of AJs . . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| Trans interacting cadherin induced activation of c Src locally at the cadherin based cell cell adhesion sites . c Src then tyrosine phosphorylated Vav 2 , one of the Rac GDP / GTP exchange factors ( GEFs ) , and induced activation of C3G , one of the Rap 1 GEFs , through Crk adaptor protein , resulting in the activation of Rap 1 locally at the cadherin based cell cell adhesion sites . ^^^ |
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| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , EGF induced tyrosine phosphorylation of the Rap GEF C3G occurred regardless of whether e3B1 was overexpressed or not , and this did not involve Src tyrosine kinases . ^^^ |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13905 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|