| Interacting proteins: Q13444 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation dependent interactions between ADAM 15 cytoplasmic domain and Src family protein tyrosine kinases . ^^^ We show here that the cytoplasmic domain of ADAM 15 , metargidin , can interact specifically with Src family protein tyrosine kinases ( PTKs ) and the adaptor protein Grb 2 in hematopoietic cells ( Jurkat , THP 1 , U 937 , and K 562 cell lines ) . ^^^ Src homology 3 domains from several Src family PTKs including Lck , Fyn , Abl , and Src associate with ADAM 15 in vitro . ^^^ Dephosphorylation of cell extracts resulted in decreased association of ADAM 15 with Src family PTK SH 3 domains , indicating that phosphorylation influences ADAM 15 interactions with its binding partners . ^^^ These data demonstrate selective , phosphorylation dependent interactions of ADAM 15 with Src family PTKs and Grb 2 , which highlight the potential for integration of ADAM functions and cellular signaling . . ^^^ |
|
| Interacting proteins: Q13444 and P12931 |
Pubmed |
SVM Score :0.0 |
| Structure and expression of the murine ADAM 15 gene and its splice variants , and difference of interaction between their cytoplasmic domains and Src family proteins . ^^^ ADAM15v2 protein interacted more strongly with the Src family proteins Lck and Src than ADAM 15 protein , when examined by pull down and immunoprecipitation followed by immunoblot analysis using a T lymphocyte line . ^^^ |
|
| Interacting proteins: Q13444 and P12931 |
Pubmed |
SVM Score :0.0 |
| ADAM 15 might be linked to AD via interaction with integrin and / or src protein tyrosine kinases . . ^^^ |
|
| Interacting proteins: Q13444 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|