| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Using the cytoplasmic domain of Ret as bait in a yeast two hybrid screen of a mouse embryonic library , it was discovered that the src homology 2 ( SH 2 ) domain containing protein Grb 10 bound Ret . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 10 protein was reported to bind to the insulin receptor and / or the insulin like growth factor ( IGF ) 1 receptor via its src homology 2 domain and to inhibit the associated tyrosine kinase activity that is involved in the growth promoting activities of insulin and IGFs ( IGF 1 and 2 ) . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 10 interacts differentially with the insulin receptor , insulin like growth factor 1 receptor , and epidermal growth factor receptor via the Grb 10 Src homology 2 ( SH 2 ) domain and a second novel domain located between the pleckstrin homology and SH 2 domains . ^^^ The interaction of this protein with the IR has been shown to be mediated in part by the Src homology 2 ( SH 2 ) domain of Grb 10 . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 10 and its close homologues Grb 7 and Grb 14 , belong to a family of adapter proteins characterized by a proline rich region , a central PH domain , and a carboxyl terminal Src homology 2 ( SH 2 ) domain . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recently , the Src homology 2 ( SH 2 ) domain containing protein Grb 10 has been shown to interact with RET in vitro and in vivo , early in development . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Identification of Grb 10 as a direct substrate for members of the Src tyrosine kinase family . ^^^ Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb 10 , a Src homology 2 ( SH 2 ) and pleckstrin homology domain containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin receptor ( IR ) . ^^^ Consistent with this finding , Grb 10 tyrosine phosphorylation in cells was inhibited by herbimycin A , a relatively specific inhibitor for members of the Src tyrosine kinase family , and by the expression of dominant negative Src or Fyn . ^^^ In addition , Grb 10 tyrosine phosphorylation was stimulated by expression of constitutively active Src or Fyn in cells and by incubation with purified Src or Fyn in vitro . ^^^ The insulin stimulated or Src / Fyn mediated tyrosine phosphorylation in vivo was significantly reduced when Grb 10 tyrosine 67 was changed to glycine . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| An intact SH 2 domain is required for Grb 10 tyrosine phosphorylation in response to VEGF , and this phosphorylation is mediated in part through the activation of Src . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| In HEK 293 cells , co expression of Kv1 . 3 plus 5 Src with Grb 10 causes a decrease in 5 Src induced Kv1 . 3 tyrosine phosphorylation and a reversal of 5 Src induced Kv1 . 3 current suppression , increase in inactivation time constant ( tau ( inact ) ) , and disruption of cumulative inactivation properties . ^^^ Collectively these data indicate that Grb 10 and n Shc adaptor molecules differentially modulate the degree of Kv1 . 3 tyrosine phosphorylation , the channel ' s biophysical properties , and the physical complexes associated with Kv1 . 3 in the presence of Src kinase . . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 7 is the prototype of a family of adaptor molecules that also include Grb 10 and Grb 14 that share a conserved molecular architecture including Src homology 2 ( SH 2 ) and pleckstrin homology ( PH ) domains . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Structural basis for dimerization of the Grb 10 Src homology 2 domain . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Likewise , overexpression of a Grb 10 mutant lacking the Src homology 2 ( SH 2 ) domain impaired ubiquitination of the IGF IR in parental p 6 and p6 / Grb10 cells , indicating that Grb 10 binding to Nedd 4 is critical for ubiquitination of the receptor . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| This occurs through the interaction of two C terminal Grb 10 motifs ( BPS and Src homology domains ) with receptor phosphotyrosine residues . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Grb 10 is a Pleckstrin homology and Src homology 2 ( SH 2 ) domain containing protein that binds to the tyrosine phosphorylated insulin receptor in response to insulin stimulation . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cloning , chromosome localization , expression , and characterization of an Src homology 2 and pleckstrin homology domain containing insulin receptor binding protein hGrb10gamma . hGrb10alpha ( previously named Grb IR ) is a Src homology 2 domain containing protein that binds with high affinity to the tyrosine phosphorylated insulin receptor and insulin like growth factor 1 receptor . ^^^ |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13322 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|