| Interacting proteins: Q13009 and P12931 |
Pubmed |
SVM Score :0.0 |
| This NH 2 terminal PH domain of Tiam 1 can be functionally replaced by the myristoylated membrane localization domain of c Src , indicating that the primary function of this PH domain is to localize the protein at the membrane . ^^^ |
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| Interacting proteins: Q13009 and P12931 |
Pubmed |
SVM Score :0.0 |
| Evidence of a role for Tiam 1 and Vav 2 in Rac activation by Src . ^^^ We further show that Vav 2 and the ubiquitously expressed Rac 1 guanine nucleotide exchange factor Tiam 1 are phosphorylated in tyrosine residues in cells transfected with active and oncogenic Src . ^^^ Moreover , phosphorylation of Tiam 1 in cells treated with pervanadate , a potent inhibitor of tyrosine phosphatases , was partially inhibited by the Src inhibitor SU 6656 . ^^^ Using truncated mutants of Tiam 1 , we demonstrate that multiple sites can be tyrosine phosphorylated by Src . ^^^ Furthermore , Tiam 1 cooperated with Src to induce activation of Rac 1 in vivo and the formation of membrane ruffles . ^^^ |
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| Interacting proteins: Q13009 and P12931 |
Pubmed |
SVM Score :0.0 |
| SRC induced disintegration of adherens junctions of madin darby canine kidney cells is dependent on endocytosis of cadherin and antagonized by Tiam 1 . ^^^ Expression of an RacGEF , Tiam 1 ( T lymphoma invasion and metastasis gene 1 ) , prevented flattening of Src transformed MDCK cells at 35 degrees C and resulted in accumulation of cadherin to lateral membranes . ^^^ At nonpermissive temperature , both Src MDCK and Tiam 1 transfected Src MDCK cells exhibited nonpolarized morphology in collagen 1 , a loose cluster in the mixture of collagen 1 and laminin , and a differentiated cyst in Matrigel . ^^^ In growth factor depleted Matrigel , the Src MDCK cells grew in nondifferentiated clusters , whereas Tiam 1 transfected cells went to apoptosis . ^^^ |
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| Interacting proteins: Q13009 and P12931 |
Pubmed |
SVM Score :0.0 |
| Taken together , these studies identify G protein betagamma subunits , Src kinase and the GEF Tiam 1 as upstream modulators of S1P mediated Rac 1 activation , and establish a central role for Rac 1 in S1P mediated activation of PI 3 kinase / Akt / endothelial nitric oxide synthase signaling in vascular endothelial cells . . ^^^ |
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| Interacting proteins: Q13009 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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