| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.65252709 |
| In addition , c Src kinase associates with Met following stimulation with HGF . 0.65252709^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| The GDNF induced branching of MDCK cells requires Src activation , whereas the HGF induced branching does not . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of paxillin was reduced by HGF and was sensitive to the Src kinase inhibitor PP 2 . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Both the c Src and c Fyn tyrosine kinases are tyrosine phosphorylated and activated by cellular hGH stimulation and form part of the multiprotein signaling complex as does tensin , paxillin , IRS 1 , the p 85 subunit of phosphatidylinositol 3 kinase , C3G , SHC , Grb 2 , and Sos 1 . c Cbl and Nck are also tyrosine phosphorylated by cellular stimulation with hGH and associate with the p 130 ( Cas ) CrkII complex . c Jun N terminal kinase / stress activated protein kinase ( JNK / SAPK ) is activated in response to hGH in accordance with the formation of the abovementioned signaling complex , and hGH stimulated JNK / SAPK activity is increased in CrkII overexpressing NIH3T3 cells compared with vector transfected NIH3T3 cells . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| AVP induces extracellular signal related kinase ( ERK ) 1 ( p 44 ( mapk ) ) and ERK 2 ( p 42 ( mapk ) ) activation , a response prevented by treatment with mitogen activated protein kinase kinase ( MEK ) inhibitors ( PD 98059 and U 0126 ) , specific PKC inhibitors ( GF 1 and Ro 31 8220 ) , depletion of Ca ( 2+ ) ( EGTA and thapsigargin ) , selective epidermal growth factor receptor ( EGFR ) tyrosine kinase inhibitors ( tyrphostin AG 1478 , compound 56 ) , or the selective Src family kinase inhibitor PP 2 . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| In osteoclasts , HGF receptor activation is followed by increase in intracellular Ca2+ concentration and by activation of the pp60c Src kinase . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have also shown that several signaling molecules including phosphatidylinositol 3 kinase , Src , focal adhesion kinase , and phospholipase C gamma in SP 1 cells are constitutively tyrosine phosphorylated , suggesting that coexpression of HGF and HGF receptor / Met may in part contribute to sustained tyrosine phosphorylation of these cytoplasmic proteins in SP 1 cells . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Progression of familial adenomatous polyposis ( FAP ) colonic cells after transfer of the src or polyoma middle T oncogenes : cooperation between src and HGF / Met in invasion . ^^^ Taken together , the data indicate that : ( 1 ) experimental activation of src and PyMT pathways directly induces tumorigenicity and Met upregulation in a colon adenoma cell line ; ( 2 ) HGF activated Met and src cooperate in inducing invasion ; ( 3 ) in view of the molecular associations between catenins and cadherin or the tumour suppressor gene product APC , the cell adhesion molecule E cadherin may constitute a downstream effector of src and Met . . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| The HGF receptor tyrosine kinase works through a Src homology ( SH 2 ) docking site that can activate several signalling pathways . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| In human colonic PCmsrc cells transformed by c src oncogene , the hepatocyte growth factor ( HGF ) dependent invasiveness of collagen gels was abolished by 0 . 1 microM PAF and restored by the PAF R antagonists WEB 2086 and SR 27417 . ^^^ Similar effects were observed in ts srcMDCK kidney epithelial cells transformed by a 5 Src temperature sensitive mutant : ( 1 ) PAF and wortmannin exerted additive inhibitory effects on Src induced invasion and ( 2 ) activated and dominant negative forms of p110alpha PI3 ' K , respectively , amplified and abrogated the Src and HGF dependent invasiveness of parental and ts srcMDCK cells . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| We suggest that pp 60 ( c src ) plays a key role in mediating the mitogenic and motogenic action of HGF , whereas tubulogenic cell differentiation induced by HGF is transduced by a pp 60 ( c src ) independent signalling pathway . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| The transducers involved in HGF triggered gene inductions were investigated using different protein kinase inhibitors : genistein for the receptor tyrosine kinase , herbimycin A for the nonreceptor tyrosine kinase ( pp 60 ( c src ) ) , wortmannin for phosphatidylinositol 3 kinase ( PI3K ) and H 7 for protein kinase C ( PKC ) . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| These data underline the importance of pp 60 ( c src ) in mediating mitogenic and motogenic effects of HGF , whereas stimulation of tubulogenic cell differentiation may be transduced by a pp 60 ( c src ) independent pathway . . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results also suggest that the activation of Src upon HGF stimulation is likely to be one , if not the only , of the mechanisms responsible for the HGF induced tyrosine phosphorylation of FAK . ^^^ |
|
| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| We show that endothelial proliferation induced by HGF required the activation of the MAPK cascade , while HGF induced endothelial migration was dependent on the tyrosine phosphorylation of Src . ^^^ Indeed , TGF beta 2 inhibited HGF effects because it prevented HGF induced MAP kinase activation and tyrosine phosphorylation of Src . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Herein we demonstrate that : ( 1 ) the enzymatic activity of alpha diacylglycerol kinase ( alphaDgk ) is stimulated by HGF in epithelial , endothelial and alphaDgk transfected COS cells ; ( 2 ) cellular expression of an alphaDgk kinase defective mutant inhibits activation of endogenous alphaDgk acting as dominant negative ; ( 3 ) specific inhibition of alphaDgk prevents HGF induced cell movement of endothelial cells ; ( 4 ) HGF induces the association of alphaDgk in a complex with Src , whose tyrosine kinase activity is required for alphaDgk activation by HGF ; ( 5 ) Src wild type stimulates alphaDgk activity in vitro ; and ( 6 ) alphaDgk can be tyrosine phosphorylated in intact cells . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| However , in the presence of the specific phosphatidylinositol 3 kinase inhibitor LY 294002 or the selective Src family kinase inhibitor PP 1 , although cells retained their response to HGF for increasing integrin alpha ( 2 ) expression , they failed to scatter , indicating that increased expression of integrin alpha ( 2 ) alone is not sufficient for cell scattering . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| We recently reported that thrombin inhibits cellular invasion induced by src , hepatocyte growth factor ( HGF ) , and leptin in kidney and colonic epithelial cells via predominant activation of the pertussis toxin ( PTx ) sensitive G proteins Galphao / Galphai . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that sustained activation or hyper activation of c Src and Stat 3 , which occurs in invasive breast cancer , can stimulate strong expression of HGF in carcinoma cells . ^^^ We hypothesize that increased autocrine HGF Met signaling is a critical downstream function of c Src Stat 3 activation in mammary tumorigenesis . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| IL 4 enhancement of HGF signaling was partially blocked in 32D / c Met cells treated with inhibitors of MEK 1 or c Src kinases , completely blocked by expression of a catalytically inactive mutant of Janus kinase 3 ( Jak 3 ) , and increased in 32D / c Met cells overexpressing STAT 6 . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| HGF induced iNOS expression was partially abrogated in the presence of the phosphatidylinositol 3 kinase ( PI 3 kinase ) inhibitor LY 294002 , but not the Src kinase inhibitor , PP 1 . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , we demonstrate that HGF induces strong tyrosine phosphorylation of the proto oncogene product c Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn , as well as with phosphatidylinositol 3 kinase and CrkL . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Expression of FAK related nonkinase , kinase deficient Src , or the Src homology 3 domain of p 130 ( cas ) , which respectively serve as dominant negative versions of FAK , Src , and p 130 ( cas ) , apparently reversed the transformed phenotypes of FAK overexpressed cells upon HGF stimulation . ^^^ Moreover , FAK overexpression was able to enhance HGF elicited signals , leading to sustained activation of ERK , JNK , and AKT , which could be prevented by the expression of the Src homology 3 domain of p 130 ( cas ) . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the present study we investigated the role of Src family kinases and nitric oxide ( NO ) in HGF stimulated EC growth . ^^^ A Src family kinases inhibitor PP 1 inhibited HGF stimulated NO production by 71 % . ^^^ These findings demonstrated that Src family kinases regulate HGF stimulated NO production in HUVEC and that HGF stimulates HUVEC growth through NO dependent and NO independent pathways . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the stimulation of Stat 3 DNA binding activity by EGF requires the activity of EGF R tyrosine kinase as well as Src kinase , while the upregulation of Stat 3 activity by IL 6 or HGF requires only Src kinase activity . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| In this study , we found that the tyrosine phosphorylation of Gab 1 in the cells derived from Src / Yes / Fyn null mouse embryos was approximately 40 % lower than that in their wild type counterparts upon HGF stimulation . ^^^ Increased expression of wild type Src enhanced HGF induced phosphorylation of Gab 1 , and , in contrast , expression of the Src kinase deficient mutant or treatment of the specific Src inhibitor PP 1 suppressed it . ^^^ Expression of a constitutively active Src mutant ( Y527F ) or oncogenic 5 Src led to a prominent increase in Gab 1 phosphorylation independent of HGF stimulation . ^^^ Finally , the increased phosphorylation of Gab 1 by Src selectively potentiated HGF induced activation of ERK and AKT . ^^^ Taken together , our results establish a new role for Src in HGF induced Gab 1 phosphorylation . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Focal adhesion kinase and Src phosphorylations in HGF induced proliferation and invasion of human cholangiocarcinoma cell line , HuCCA 1 . ^^^ AIM : To study the role of focal adhesion kinase ( FAK ) and its association with Src in hepatocyte growth factor ( HGF ) induced cell signaling in cholangiocarcinoma progression . ^^^ RESULTS : HGF enhanced HuCCA 1 cell proliferation and invasion by mediating FAK and Src phosphorylations . ^^^ Autophosphorylated Src , induced by HGF , mediates Src kinase activation , which subsequently phosphorylates its substrate , FAK , and signals to cell proliferation and invasion . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Hepatocyte Growth Factor ( HGF ) and its protooncogene receptor c Met regulate osteoclast function by activating pp 60 ( c Src ) kinase and alpha ( 5 ) beta 3 integrin . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| A novel activating function of c Src and Stat 3 on HGF transcription in mammary carcinoma cells . ^^^ We previously demonstrated a cooperative effect between c Src and Stat 3 in the activation of HGF transcription in mammary carcinoma cells . ^^^ The present report defines a novel Stat 3 consensus site at nt 95 in the HGF promoter that is highly conserved in human and mouse , and is required for c Src and Stat 3 to activate HGF transcription in breast epithelial cells . ^^^ In addition , coexpression of Stat 3 and activated c Src caused increased expression of endogenous HGF mRNA and protein and marked cell scattering in breast epithelial cells . ^^^ Our results delineate a novel c Src / Stat3 dependent mechanism that regulates HGF promoter activity , and is linked to transformation of mammary epithelial cells . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| HGF induced capillary morphogenesis of endothelial cells is regulated by Src . ^^^ HGF induced capillary morphogenesis of the murine spleen endothelial cell line MSS 31 was inhibited by a Src family kinase inhibitor , PP 2 . ^^^ Stable expression of kinase inactive Src in MSS 31 cells inhibited HGF induced activation of Src as well as capillary morphogenesis . ^^^ The HGF induced capillary morphogenesis of human umbilical vein endothelial cells was also inhibited by PP 2 and was reduced by the downregulation of Src by small interfering RNA . ^^^ These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src . . ^^^ |
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| Interacting proteins: Q07889 and P12931 |
Pubmed |
SVM Score :0.0 |
| Our results indicate a functional role of Met E cadherin interaction in MCF 7 cells through the amplification of the signaling downstream of HGF Met triggering that involved c Src and phosphoinositide 3 kinase activities . . ^^^ |
|