| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase . `` Sky ' ' is a putative receptor tyrosine kinase predominantly expressed in the brain . ^^^ Using the anti Src antibody , which is reactive to Src , Fyn and Yes , we obtained evidence for an association between the Src family tyrosine kinase and the tyrosine phosphorylated Sky receptor . ^^^ These results suggest that the Src family kinase may play an important role in signal transduction of the Sky receptor . . ^^^ |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| Several candidate proteins have been identified , including receptor interacting protein ( RIP ) 140 , RIP 160 , transcription intermediary factor ( TIF ) 1 , suppressor of gal4D lesions ( SUG ) 1 and steroid receptor co activator ( SRC ) 1 . ^^^ |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC 1 and TIF 2 coactivators : evidence for haploinsufficiency . ^^^ Steroid receptor coactivator ( SRC ) 1 and transcriptional intermediary factor ( TIF ) 2 are homologous nuclear receptor coactivators . ^^^ We have investigated their possible redundancy as thyroid hormone ( TH ) coactivators by measuring thyroid function in compound SRC 1 and TIF 2 knock out ( KO ) mice . ^^^ Whereas SRC 1 KO ( SRC 1 ( / ) ) mice are resistant to TH and SRC 1 ( + / ) are not , we now demonstrate that TIF 2 KO ( TIF 2 ( / ) ) mice have normal thyroid function . ^^^ Yet double heterozygous , SRC 1 ( + / ) / TIF 2 ( + / ) mice manifested resistance to TH of a similar degree as that in mice completely deficient in SRC 1 . ^^^ |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to examine the expression of four steroid receptor co activators ( steroid receptor co activator 1 ( SRC 1 ) , transcription intermediary factor 2 ( TIF 2 ) , protein 300 kDa / CREB binding protein ( p300 / CBP ) , amplified in breast cancer 1 ( AIB 1 ) ) , and of the co repressor nuclear receptor co repressor ( NCoR ) , in malignant breast tissues and in matching normal breast biopsies of the same individuals . ^^^ The tumoral ER alpha protein expression was significantly correlated with that of PgR ( r = 0 . 61 , p = 0 . 001 ) and NCoR ( r = 0 . 4 , p = 0 . 043 ) , whereas ER beta expression was associated with SRC 1 ( r = 0 . 68 , p < or = . 001 ) , TIF 2 ( r = 0 . 64 , p = 0 . 001 ) and NCoR ( r = 0 . 48 , p = 0 . 014 ) protein levels in malignant specimens . ^^^ |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| Roles of steroid receptor coactivator ( SRC ) 1 and transcriptional intermediary factor ( TIF ) 2 in androgen receptor activity in mice . ^^^ Genetic disruption of the steroid receptor coactivator ( SRC ) 1 and transcriptional intermediary factor ( TIF ) 2 / SRC 2 in mouse resulted in distinctive mutant phenotypes . ^^^ To quantify their roles in the function of androgen receptor ( AR ) transcriptional activity in vivo , we generated a unique transgenic AR reporter mouse and analyzed the cell specific contributions of SRC 1 and TIF 2 to the activity of AR in mouse testis . ^^^ Analyses of the resultant bigenic mice by in vivo imaging and luciferase assays showed that testicular AR activity was decreased significantly in those with the TIF2+ / mutation but not in the SRC 1+ / background , suggesting that TIF 2 serves as the preferential coactivator for AR in testis . ^^^ Although SRC 1 concentrates in Sertoli cell nuclei in the absence of TIF 2 , nuclear SRC 1 is not able to rescue AR activity in the TIF 2 mutant background . ^^^ |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06418 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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