| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| Integrin mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c Src . ^^^ Adhesion of RON expressing epithelial cells to ECM caused phosphorylation of RON , which depended on the kinase activity of both RON itself and c Src . ^^^ This conclusion is based on these observations : 1 ) ECM induced RON phosphorylation was inhibited in cells expressing kinase inactive c Src ; 2 ) active c Src could phosphorylate immunoprecipitated RON from ECM stimulated cells but not from unstimulated cells ; and 3 ) ECM did not cause RON phosphorylation in cells expressing kinase dead RON , nor could active c Src phosphorylate RON immunoprecipitated from these cells . ^^^ The data fit a pathway in which ECM induced integrin aggregation causes both c Src activation and RON oligomerization followed by RON kinase dependent autophosphorylation ; this results in RON becoming a target for activated c Src , which phosphorylates additional tyrosines on RON . ^^^ |
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| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| We find that expression of mouse RON , but not human RON , results in constitutive receptor autophosphorylation , ligand independent activation of the mitogen activated protein kinase pathway , and association of the receptor with c Src . ^^^ However , deletion of this region in the context of human RON enhanced receptor phosphorylation , activation of mitogen activated protein kinase , and association of c Src at levels comparable with those observed with mouse RON . ^^^ |
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| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| In the first presentation , Dorit Ron presented data showing how activation of Fyn or Src tyrosine kinases differentially regulated the cell surface expression and activity of NR2A and NR2B containing NMDA receptors . ^^^ |
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| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q04912 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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