| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| Neuron specific Cdk 5 kinase is responsible for mitosis independent phosphorylation of c Src at Ser 75 in human Y 79 retinoblastoma cells . c Src is phosphorylated at specific serine and threonine residues during mitosis in fibroblastic and epithelial cells . ^^^ |
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| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| Production of mouse ES cells homozygous for Cdk 5 phosphorylated site mutation in c Src alleles . c Src null mutants have not provided a full understanding of the cellular functions of c Src , reflecting the functional redundancy among Src family members . c Src is phosphorylated by cyclin dependent kinase 1 ( Cdk 1 ) and Cdk 5 at Ser 75 in the unique amino terminal c Src specific domain . ^^^ |
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| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| Cdk 5 regulates activation and localization of Src during corneal epithelial wound closure . ^^^ Conversely , the Cdk 5 inhibitor , olomoucine , accelerated debridement wound healing in organ cultured eyes of normal mice , caused migrating cells to separate from the epithelial cell sheet , and increased the level of activated Src ( pY 416 ) along the wound edge . ^^^ To explore the relationship between Cdk 5 and Src in greater detail , we examined scratch wounded cultures of corneal epithelial cells . ^^^ Inhibiting Cdk 5 activity with olomoucine or a dominant negative construct , Cdk5T33 , increased the concentration of Src ( pY 416 ) , shifted its subcellular localization to the cell periphery and enhanced wound closure . ^^^ Inhibiting Src activity with PP 1 blocked the appearance of Cdk 5 ( pY 15 ) , suggesting that Cdk 5 phosphorylation is Src dependent . ^^^ |
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| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q00535 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|