| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Etk / Bmx is the newest member of Btk tyrosine kinase family that contains a pleckstrin homology domain , an src homology 3 domain , an src homology 2 domain , and a catalytic domain . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| In NIH3T3 cells , although Etk did not itself induce transformation , it effectively enhanced the transforming ability of a partially active c Src mutant ( c Src378G ) . ^^^ Etk , a Btk family tyrosine kinase , mediates cellular transformation by linking Src to STAT 3 activation . ^^^ Coexpression of 5 Src and Etk led to a transphosphorylation on tyrosine 566 of Etk and subsequent autophosphorylation . ^^^ To investigate whether Etk could mediate 5 Src induced activation of STAT 3 and cell transformation , we overexpressed a dominant negative mutant of Etk in an immortalized , untransformed rat liver epithelial cell line , WB , which contains endogenous Etk . ^^^ Dominant negative inactivation of Etk not only blocked 5 Src induced tyrosine phosphorylation and activation of STAT 3 but also caused a great reduction in the transforming activity of 5 Src . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Etk / Bmx is a member of the Btk / Tec family of kinases , which are characterized by having a pleckstrin homology domain at the N terminus , in addition to the Src homology 3 ( SH 3 ) , SH 2 , and the catalytic domains , shared with the Src family kinases . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Neuropeptide induced androgen independence in prostate cancer cells : roles of nonreceptor tyrosine kinases Etk / Bmx , Src , and focal adhesion kinase . ^^^ We found that three nonreceptor tyrosine kinases , focal adhesion kinase ( FAK ) , Src , and Etk / BMX play important parts in this process . ^^^ Etk / Bmx activation requires FAK and Src and is critical for neurotrophic factor induced growth , as LNCaP cells transfected with a dominant negative Etk / BMX fail to respond to bombesin . ^^^ Etk ' s activation requires FAK , Src , but not phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although the Tyr kinases Src and FAK are known to activate ETK directly , Src is insensitive to AG 879 , and FAK is inhibited by 100 nM AG 879 , but not by 10 nM AG 879 . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although HUVECs express the non receptor tyrosine kinases Fak , Src , and Etk which mediate neuropeptide signaling in CaP , they are not activated by neuropeptides in HUVECs . . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Etk is physically associated with p 53 through its Src homology 3 domain and the proline rich domain of p 53 . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| The molecules discussed include Src family kinases , Syk , Grb 2 adaptor protein , and Tec family kinases Bmx and Btk . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| In endothelial cells overexpressing wild type platelet derived growth factor beta ( PDGFbeta ) receptors , which express Bmx and Src as their major Btk ( Bruton ' s tyrosine kinase ) family and Src family tyrosine kinases , respectively , PDGF can stimulate PI3K dependent tyrosine phosphorylation of DAPP 1 . ^^^ Transient overexpression of Src most effectively , compared with Bmx and Syk , augments basal and PDGF stimulated tyrosine phosphorylation of DAPP 1 , whereas overexpression of dominant negative Src , but not dominant negative Bmx , inhibits PDGF stimulated phosphorylation of DAPP 1 . ^^^ Finally , in vitro we find lipid modified Src to be the most effective DAPP 1 tyrosine kinase ( versus Syk , Lyn , Btk , and Bmx ) ; phosphorylation of DAPP 1 but not Src autophosphorylation is stimulated approximately 10 fold by PtdIns ( 3 , 4 , 5 ) P ( 3 ) ( IC ( 50 ) = 150 nm ) and phosphatidylinositol 3 , 4 bisphosphate but not by their nonbiological diastereoisomers and depends on PH domain mediated binding of DAPP 1 to PtdIns ( 3 , 4 , 5 ) P ( 3 ) containing membranes . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Members of the Tec kinase family ( Bmx , Btk , Itk , Rlk and Tec ) are primarily expressed in the hematopoietic system and form , after the Src kinase family , the second largest class of non receptor protein tyrosine kinases . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| Proteomics approaches permitted the identification of tyrosine kinases from three families : Src ( Lyn ) , Csk , and Tec ( Bmx , Btk ) . ^^^ |
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| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P51813 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|