| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| Src recruitment was mediated by beta arrestin , which functions as an adapter protein , binding both c Src and the agonist occupied receptor . beta Arrestin 1 mutants , impaired either in c Src binding or in the ability to target receptors to clathrin coated pits , acted as dominant negative inhibitors of beta 2 adrenergic receptor mediated activation of the MAP kinases Erk 1 and Erk 2 . ^^^ Src recruitment was mediated by beta arrestin , which functions as an adapter protein , binding both c Src and the agonist occupied receptor . beta Arrestin 1 mutants , impaired either in c Src binding or in the ability to target receptors to clathrin coated pits , acted as dominant negative inhibitors of beta 2 adrenergic receptor mediated activation of the MAP kinases Erk 1 and Erk 2 . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| Role of beta arrestin 1 dependent targeting of c SRC in receptor endocytosis . beta Arrestins can act as adapter molecules , coupling G protein coupled receptors to proteins involved in mitogenic as well as endocytic pathways . ^^^ We have previously identified c SRC as a molecule that is rapidly recruited to the beta 2 adrenergic receptor in a beta arrestin 1 dependent manner . ^^^ This recruitment of c SRC to the receptor involves an interaction between the amino terminal proline rich region of beta arrestin 1 and the Src homology 3 ( SH 3 ) domain of c SRC , but deletion of the proline rich domain does not totally ablate the interaction . ^^^ We have found that a major interaction also exists between beta arrestin 1 and the catalytic or kinase domain ( SH 1 ) of c SRC . ^^^ We therefore hypothesized that a catalytically inactive mutant of the isolated catalytic subunit , SH 1 ( kinase dead ) ( SH 1 ( KD ) ) , would specifically block those cellular actions of c SRC that are mediated by beta arrestin 1 recruitment to the G protein coupled receptor . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| We previously showed that c Src is required for ERK activation by beta ( 2 ) AR and that it is recruited to activated beta ( 2 ) AR through binding of the Src homology 3 ( SH 3 ) domain to proline rich regions of the adapter protein beta arrestin 1 . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| In co immunoprecipitation experiments , we found that beta arrestin 1 associated with the ETA receptor in an agonist dependent manner and that beta arrestin 1 recruited Src kinase to a molecular complex that included the ETA receptor . ^^^ In conclusion , 1 ) the Src kinase Yes can induce tyrosine phosphorylation of Galpha ( q / 11 ) in response to ET 1 stimulation , and 2 ) beta arrestin 1 and Src kinase form a molecular complex with the ETA receptor to mediate ET 1 signaling to Galpha ( q / 11 ) with subsequent glucose transport stimulation . . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| PI 3 kinase and Akt activities are also inhibited by expression of a beta arrestin 1 mutant , which impairs binding to c Src ( beta arrestin 1 ( P91G P121E ) ) , indicating the involvement of c Src in the rapid stimulation of the PI 3 kinase / Akt pathway . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| These results suggest that D2R mediated NF kappaB activation requires Gbetagamma and c Src , and possibly involves beta arrestin 1 . . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| Recent evidence indicates that beta arrestin 1 may act as an important mediator in G protein coupled receptor induced activation of c Src . ^^^ Here we report that PGE ( 2 ) induces the association of a prostaglandin E receptor 4 / beta arrestin 1 / c Src signaling complex resulting in the transactivation of the EGFR and downstream Akt ( PKB ) signaling . ^^^ The interaction of beta arrestin 1 and c Src is critical for the regulation of colorectal carcinoma cell migration in vitro as well as metastatic spread of disease to the liver in vivo . ^^^ These results show that the prostaglandin E / beta arrestin 1 / c Src signaling complex is a crucial step in PGE ( 2 ) mediated transactivation of the EGFR and may play a pivotal role in tumor metastasis . ^^^ |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P49407 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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